Philip Moons , Liesbet Van Bulck , Bo Daelman , Koen Luyckx
{"title":"Mental health in adult congenital heart disease","authors":"Philip Moons , Liesbet Van Bulck , Bo Daelman , Koen Luyckx","doi":"10.1016/j.ijcchd.2023.100455","DOIUrl":"10.1016/j.ijcchd.2023.100455","url":null,"abstract":"<div><p>Mental health issues are common in individuals with congenital heart disease (CHD), stemming from various factors such as traumatic experiences, existential questions, and genetic predisposition. This article provides an overview of the literature on mental disorders and mental health in adults with CHD (ACHD) and presents new data on mental health as a predictor of quality of life (QoL). Empirical data show that disorders such as depression, anxiety, bipolar disorder, psychosis, Attention Deficit Hyperactivity Disorder (ADHD), and autism spectrum disorders occur more often in people with CHD than in healthy counterparts (Graphical abstract). Further, mental health is a strong predictor of QoL. Therefore, psychological interventions should be integrated into CHD care to enhance mental health and QoL of afflicted patients.</p></div>","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48048460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Skeletal ystem in adult congenital heart disease","authors":"R. Alonso-Gonzalez, D. Massarella, L. Swan","doi":"10.1016/j.ijcchd.2023.100460","DOIUrl":"https://doi.org/10.1016/j.ijcchd.2023.100460","url":null,"abstract":"","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54357684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexia Karagianni , Zacharias Mandalenakis , Savvas Papadopoulos , Mikael Dellborg , Peter Eriksson
{"title":"Long-term outcome after closure of an atrial shunt in patients aged 60 years or older with ischemic stroke: A nationwide, registry-based, case-control study","authors":"Alexia Karagianni , Zacharias Mandalenakis , Savvas Papadopoulos , Mikael Dellborg , Peter Eriksson","doi":"10.1016/j.ijcchd.2022.100438","DOIUrl":"https://doi.org/10.1016/j.ijcchd.2022.100438","url":null,"abstract":"<div><h3>Background</h3><p>According to the current guidelines, evidence of the effects of transcatheter closure in patients aged ≥60 years with an atrial shunt and cryptogenic stroke is still limited.</p></div><div><h3>Methods</h3><p>Using Swedish health registries, patients aged ≥60 years who had previously developed a cryptogenic cerebrovascular event and undergone transcatheter closure were identified. Patients with atrial fibrillation were excluded, and the remaining patients were propensity score-matched with patients of the same age and risk profile who had only undergone medical treatment and with controls from the general population. They were then followed up until 2017 (mean period of 7.1 ± 3.9 years).</p></div><div><h3>Results</h3><p>In total, 100 patients of the intervention group were matched with 100 patients of the medical treatment group and with 100 controls and followed up. The hazard ratio for a recurrent ischemic stroke in the intervention group compared with the medical treatment group was 0.8 (95% confidence interval, 0.3–2.1), and that compared with the controls was 2.3 (95% confidence interval, 0.6–8.9). Atrial fibrillation occurred at the same rate in the two treatment groups (odds ratio, 0.8; 95% confidence interval, 0.4–1.7). However, patients in the intervention group developed vascular disease at a lower rate (odds ratio, 0.5; 95% confidence interval, 0.25–0.85).</p></div><div><h3>Conclusions</h3><p>Patients aged ≥60 years with cryptogenic stroke may undergo transcatheter closure of an atrial shunt after thorough screening for other potential causes of stroke. The incidence of vascular disease seems to be mitigated in these patients relative to medically treated patients.</p></div>","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49777409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Farah Akram , Madeleine Pidcock , Diane Oake , Gary F. Sholler , Michelle A. Farrar , Nadine A. Kasparian
{"title":"“The usual challenges of work are all magnified”: Australian paediatric health professionals’ experiences during the COVID-19 pandemic","authors":"Farah Akram , Madeleine Pidcock , Diane Oake , Gary F. Sholler , Michelle A. Farrar , Nadine A. Kasparian","doi":"10.1016/j.ijcchd.2022.100434","DOIUrl":"https://doi.org/10.1016/j.ijcchd.2022.100434","url":null,"abstract":"<div><h3>Background</h3><p>The COVID-19 pandemic has significantly increased stress and strain on health professionals. With a focus on paediatric cardiac care, this study explored health professionals’ concerns about COVID-19, perceptions of the impact of pandemic on healthcare, and experiences of psychological stress.</p></div><div><h3>Methods</h3><p>Paediatric health professionals working at a large quaternary hospital in Australia were invited to complete a survey between June 2020 and February 2021. Demographic factors, clinical role characteristics, and anxiety and depressive symptoms were assessed. Qualitative data on experiences and perceived effects of the pandemic on paediatric cardiac care were also collected.</p></div><div><h3>Results</h3><p>228 health professionals (152 nurses, 37 medical doctors, 22 allied and mental health professionals, 17 medical research and administrative staff) participated in the survey (54.4% response rate, 85% women). Half the sample (52.2%) endorsed ‘moderate’ to ‘extreme’ worry about COVID-19 and 38% of participants perceived healthcare services as adversely impacted by the pandemic to a ‘great’ or ‘very great’ extent. Almost one in five health professionals reported anxiety (18%) and 11% reported depressive symptoms indicative of a need for clinical intervention. Six themes were identified in the qualitative data: (1) Concern about the consequences of visitor restrictions and disrupted patient services, (2) Intensified strain on healthcare workers, (3) Feelings of fear and loss, (4) Social isolation and disconnection, (5) Adapting to change, and (6) Gratitude.</p></div><div><h3>Conclusion</h3><p>Timely, tailored policies, supports, and interventions are needed to address health professionals’ mental health needs during and beyond the pandemic, to minimize the far-reaching impact of situational stressors.</p></div>","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49777408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Callum Cherrett , David Baker , Mark Dennis , Irina Kotchetkova , David Celermajer , Rachael Cordina
{"title":"Late outcomes in adults with atrial switch for transposition of the great arteries according to risk factor profile at 30 years of age","authors":"Callum Cherrett , David Baker , Mark Dennis , Irina Kotchetkova , David Celermajer , Rachael Cordina","doi":"10.1016/j.ijcchd.2022.100427","DOIUrl":"10.1016/j.ijcchd.2022.100427","url":null,"abstract":"<div><h3>Objective</h3><p>To compare the late outcomes of adults who underwent atrial switch repair for dextro-transposition of the great arteries, based on their risk profile at age 30 years.</p></div><div><h3>Methods</h3><p>We performed a retrospective study of 67 participants who had undergone atrial switch repair. “Low risk” people were defined as those who reached age 30 years or beyond with normal or mildly impaired systemic right ventricular (RV) function with no or mild tricuspid regurgitation (TR). “High risk” people were defined as those who had moderate or severe systemic RV dysfunction, or moderate or severe tricuspid regurgitation by age 30. The primary outcome was transplant-free survival and the secondary outcome was a composite end-point including hospitalisations for heart failure, inotrope requirement, referral for transplantation and transplantation.</p></div><div><h3>Results</h3><p>52/67 (78%) were classified as “low risk” and 15/67 (22%) were classified as “high risk”. At 45 years, transplant-free survival was 31% for the “high risk” group compared to 87% for “low risk”. All “high risk” people met the composite endpoint at 45 years compared to only 18% of the “low risk” group (hazard ratio 6.3, p = 0.03).</p></div><div><h3>Conclusion</h3><p>Transplant-free survival is markedly reduced in “high risk” atrial switch patients. Risk stratification based on systemic right ventricular function and tricuspid regurgitation at age 30 may predict future health outcomes for atrial switch patients.</p></div>","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42642440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jason Chami , Geoff Strange , David Baker , Rachael Cordina , Leeanne Grigg , David S. Celermajer , Calum Nicholson
{"title":"Algorithmic complexity stratification for congenital heart disease patients","authors":"Jason Chami , Geoff Strange , David Baker , Rachael Cordina , Leeanne Grigg , David S. Celermajer , Calum Nicholson","doi":"10.1016/j.ijcchd.2022.100430","DOIUrl":"10.1016/j.ijcchd.2022.100430","url":null,"abstract":"<div><h3>Background</h3><p>Congenital Heart Disease (CHD) encompasses a huge variety of rare diagnoses that range in complexity and comorbidity. To help build clinical guidelines, plan health services and conduct statistically powerful research on such a disparate set of diseases there have been various attempts to group pathologies into mild, moderate, or severe disease. So far, however, these complexity scores have required manual specialist input for every case, and are therefore missing in large databases where this is impractical, or quickly outdated when guidelines are revised.</p></div><div><h3>Methods</h3><p>We used the up-to-date European Society of Cardiology guidelines to create an algorithm to assign complexity scores to CHD patients using only their diagnosis list. Two CHD specialists then independently assigned complexity scores to a random sample of patients.</p></div><div><h3>Results</h3><p>Our algorithm was 96% accurate where both specialists agreed on a complexity score; this occurred 68% of the time overall, and 79% of the time in moderate or complex CHD. The algorithm “failed” mainly when diagnoses were insufficiently specific, usually for septal defects (where size was unspecified), or where complexity depends on the procedure performed (e.g. atrial/arterial switch for transposition of the great arteries).</p></div><div><h3>Conclusions</h3><p>We were able to algorithmically determine the complexity scores of a majority of patients with CHD based on their diagnosis list alone. This could allow for automatic complexity scoring of most patients in large CHD databases, for example our own Registry of the Congenital Heart Alliance of Australia and New Zealand. This will facilitate targeted research into the management, outcomes and burden of CHD.</p></div>","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42050814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence of traditional and non-traditional cardiovascular risk factors in adults with congenital heart disease","authors":"Jacqueline Levene , Claire Cambron , Lidija McGrath , Ibett Colina Garcia , Craig Broberg , Katrina Ramsey , Abigail Khan","doi":"10.1016/j.ijcchd.2022.100424","DOIUrl":"10.1016/j.ijcchd.2022.100424","url":null,"abstract":"<div><h3>Background</h3><p>Adults with congenital heart disease (CHD) may be at increased risk of acquired cardiovascular disease (CVD). Understanding the prevalence of CV risk factors (CVRF) in this population is an important step in developing strategies to mitigate long-term risk.</p></div><div><h3>Methods</h3><p>The Oregon All Payer All Claims database for the years 2010–2017 was queried for adults with CHD International Classification of Diseases (ICD) codes. The prevalence of CVRF was measured, and we then evaluated the association with patient characteristics.</p></div><div><h3>Results</h3><p>There were 13,896 individuals with CHD. 72.8% (99% CI: 71.8–73.7) had at least one RF and 52.3% (99% CI: 51.2–53.4) had ≥2 RF. The prevalence of ≥1 RF increased with age (18–24: 39.6% (99% CI: 37.0–42.1) vs. 93.6% (99% CI: 92.6–94.6) in those 55–65). Hypertension (aOR 1.49 (99% CI: 1.36–1.63)), diabetes (aOR 1.24 (99% CI: 1.13–1.36)), sleep apnea (aOR 1.40 (99% CI 1.26–1.55)) and kidney disease (aOR 1.33 (99% CI:1.14–1.54)) were more prevalent in moderate-complex as opposed to simple CHD. When compared with a matched non-CHD population, there was higher prevalence of CVRF in ACHD (≥1 RF: 76.1 vs. 64.1%, OR 1.79 (99% CI: 1.69–1.89); ≥2 RF: 52.6 vs. 36.5%, OR 1.92 (99% CI: 1.83–2.03).</p></div><div><h3>Conclusions</h3><p>To our knowledge, this is the first comprehensive attempt to measure both traditional and non-traditional CVRF in US adults with CHD. We show that CVRF are common even in young adults. Given the additive effect of acquired CVD on CHD, addressing RF should be an important priority for in ACHD.</p></div>","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45666092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Margaret R. Ferrari , Michal Schäfer , Kendall S. Hunter , Michael V. Di Maria
{"title":"Coupled waveform patterns in the arterial and venous fontan circulation are related to parameters of pulmonary, lymphatic and cardiac function","authors":"Margaret R. Ferrari , Michal Schäfer , Kendall S. Hunter , Michael V. Di Maria","doi":"10.1016/j.ijcchd.2022.100429","DOIUrl":"https://doi.org/10.1016/j.ijcchd.2022.100429","url":null,"abstract":"<div><p>The lack of a sub-pulmonary ventricle in patients with a Fontan circulation contributes to circulatory decline, largely related to increased central venous pressure. Our group has determined that single-site waveform analysis correlates with clinical features of Fontan patients. The goal of this study was to determine if multi-site waveform analysis yielded additional associations with functional status or cardiac performance. Patients with a Fontan circulation (N = 95) that underwent free-breathing cardiac MRI were included in this study. Volumetric flow rate curves were sampled in the ascending aorta, superior vena cava, inferior vena cava and left pulmonary artery. Flow curves were interpolated to equal temporal phases and were then used to create three data matrices of arterial and venous waveforms. Principal component analysis was performed on each matrix and principal components that accounted for >10% variance were correlated to traditional clinical indices. Results indicate correlation of inferior and superior vena cava waveform patterns to parameters of pulmonary (RV/TLC %, lowest SaO<sub>2</sub>%), lymphatic (cystatin-c, BUN, alkaline phosphatase) and to ventricular function (CI, EF, EDVi, ESVi and VVCR). This study demonstrates that coupled waveform analysis of arterial and venous vessels relays additional information about Fontan patient status.</p></div>","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49818310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Salma Pardhan , Zacharias Mandalenakis , Kok Wai Giang , Maria Fedchenko , Peter Eriksson , Mikael Dellborg
{"title":"Healthcare consumption in congenital heart disease: A temporal life-course perspective following pediatric cases to adulthood","authors":"Salma Pardhan , Zacharias Mandalenakis , Kok Wai Giang , Maria Fedchenko , Peter Eriksson , Mikael Dellborg","doi":"10.1016/j.ijcchd.2023.100440","DOIUrl":"10.1016/j.ijcchd.2023.100440","url":null,"abstract":"<div><h3>Background</h3><p>Improvements in diagnosis, intervention, and care of congenital heart disease (CHD) have led to increased survivability and lifelong dependence on healthcare. This study aims to determine the extensiveness of inpatient care episodes across different life-stages and CHD severity compared to matched controls, and to explore how healthcare utilization among pediatric CHD cases have changed over time.</p></div><div><h3>Methodology</h3><p>National registry data was used to conduct a 1:9 matching analysis with age and sex matched controls. Then, Poisson timeseries analysis was used to conduct trend analysis for inpatient healthcare utilization among pediatric cases <18 years of age.</p></div><div><h3>Results</h3><p>Most CHD cases were non-complex (87.3%), with highest hospitalization rates occurring in infancy. Mean number of hospitalizations among complex cases were over twice that of non-complex cases. Also, as age progressed, mean hospitalization for non-complex cases began converging to the control population. In terms of trend analysis within this study period, healthcare utilization increased by 34% among the infant categories, but decreased by 12% and 32% among children between 1-9 years and 10–17 years, respectively. Also, utilization was not trending in one direction substantiating the claim that multiple time periods are required to assess temporal changes within this population.</p></div><div><h3>Conclusion</h3><p>Inpatient healthcare utilization among the CHD population appears to be decreasing over time in most cases, where non-complex cases transitioning to adult care are increasingly converging to the general population. Additionally, this study validates the need to use multiple time-periods when conducting longitudinal studies across the CHD population.</p></div>","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43492052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}