International journal of cardiology. Congenital heart disease最新文献

Corrigendum to [Int J Cardiol Congenit Heart Dis 9 September 2022 100394] 对[Int J Cardiol Congenit Heart Dis 9 September 2022 100394]的更正

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International journal of cardiology. Congenital heart disease Pub Date : 2024-09-01 DOI: 10.1016/j.ijcchd.2024.100516

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Corrigendum to “Exercise ventilatory reserve predicts survival in adult congenital heart disease associated pulmonary arterial hypertension with Eisenmenger physiology” [Int J Cardiol Congenit Heart Dis, Volume 7, March 2022, 100331] 运动通气储备可预测艾森曼格生理学成人先天性心脏病伴肺动脉高压患者的存活率》更正[《Int J Cardiol Congenit Heart Dis》，第 7 卷，2022 年 3 月，100331]

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International journal of cardiology. Congenital heart disease Pub Date : 2024-09-01 DOI: 10.1016/j.ijcchd.2024.100517

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Novel techniques for quantifying oxygen pulse curve characteristics during cardiopulmonary exercise testing in tetralogy of fallot 在法洛氏四联症心肺运动测试中量化氧脉搏曲线特征的新技术

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International journal of cardiology. Congenital heart disease Pub Date : 2024-09-01 DOI: 10.1016/j.ijcchd.2024.100539

{"title":"Novel techniques for quantifying oxygen pulse curve characteristics during cardiopulmonary exercise testing in tetralogy of fallot","authors":"","doi":"10.1016/j.ijcchd.2024.100539","DOIUrl":"10.1016/j.ijcchd.2024.100539","url":null,"abstract":"<div><h3>Background</h3><p>Cardiopulmonary exercise testing (CPET) is used in evaluation of repaired tetralogy of Fallot (rTOF), particularly for pulmonary valve replacement need. Oxygen pulse (O<sub>2</sub>P) is the CPET surrogate for stroke volume and peripheral oxygen extraction.</p></div><div><h3>Objectives</h3><p>This study assessed O<sub>2</sub>P curve properties against non-invasive cardiac output monitoring (NICOM) and clinical testing.</p></div><div><h3>Methods</h3><p>This cross-sectional study included 44 rTOF patients and 10 controls. Three new evaluations for O<sub>2</sub>P curve analysis during CPET were developed. Best fit early and late regression slopes of the O<sub>2</sub>P curve were used to calculate: 1) the early to late ratio, or “O<sub>2</sub> pulse response ratio” (O<sub>2</sub>PRR); 2) the portion of exercise until slope inflection, or “flattening fraction” (FF); 3) the area under the O<sub>2</sub>P response curve, or “O<sub>2</sub>P curve area”.</p></div><div><h3>Results</h3><p>rTOF patients (median age 35.2 (27.6–39.4); 61% female) had a lower VO<sub>2</sub> max (23.4 vs 45.6 ml/kg/min; p < 0.001) and O<sub>2</sub>P max (11.5 vs 19.1 ml/beat; p < 0.001) compared to controls. Those with a FF occurring <50% through exercise had a lower peak cardiac index and stroke volume, but not VO<sub>2</sub> max, compared to those >50%. FF and O<sub>2</sub>P curve area significantly correlated with peak cardiac index, stroke volume, left and right ventricular ejection fraction, and right ventricular systolic pressure.</p></div><div><h3>Conclusion</h3><p>CPET remains an integral part in the evaluation of rTOF. We introduce three non-invasive methods to assess exercise hemodynamics using the O<sub>2</sub>P curve data. These evaluations demonstrated significant correlations with stroke volume, cardiac output, and right ventricular pressure.</p></div>","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266666852400048X/pdfft?md5=7b84ac15bd2ec21c11b5fb7d8a372d86&pid=1-s2.0-S266666852400048X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142095696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A national Australian Congenital Heart Disease registry; methods and initial results 澳大利亚全国先天性心脏病登记；方法和初步结果

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International journal of cardiology. Congenital heart disease Pub Date : 2024-08-24 DOI: 10.1016/j.ijcchd.2024.100538

{"title":"A national Australian Congenital Heart Disease registry; methods and initial results","authors":"","doi":"10.1016/j.ijcchd.2024.100538","DOIUrl":"10.1016/j.ijcchd.2024.100538","url":null,"abstract":"<div><h3>Background</h3><p>Although several National Data Registries for Congenital Heart Disease (CHD) exist, few are comprehensive and contemporary. A National Australian CHD Registry has been developed that aims to redress this by creating the first comprehensive data collection for CHD children and adults, initially across Australia.</p></div><div><h3>Methods</h3><p>We defined and collected a minimum dataset of demographics, diagnoses, and procedures from people with CHD presenting at participating quaternary CHD services Australia-wide. Data were collected from a range of clinical data sources. Diagnoses and procedures were standardised to the European Paediatric Congenital Code – Short List. Methodological limitations were carefully documented.</p></div><div><h3>Results</h3><p>From 8 participating institutions, an initial 359,084 patient records were assessed for eligibility and 68,234 unique individuals with structural CHD have been included in the current dataset. There were 20,395 (30 %) people with mild CHD, 25,157 (37 %) with moderate CHD, and 13,530 (20 %) with severe CHD (6 % unknown complexity). The most common diagnoses were Ventricular Septal Defect (16,781, 25 %), Atrial Septal Defect (6,607, 10 %), Aortic Valve Disorders (5516 8 %), Coarctation of the Aorta (5,321, 8 %), Tetralogy of Fallot (4,489, 7 %), Transposition of the Great Arteries (4,009, 6 %).</p></div><div><h3>Conclusion</h3><p>The data presented here represents the most comprehensive cohort collected for the Australian CHD population thus far and is comparable with the largest contemporary CHD registries around the world. This Registry represents a key resource for improved understanding of the CHD population and will drive better care and outcomes for people living with CHD.</p></div>","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666668524000478/pdfft?md5=f7a86b652a555e39ec405957490f69c7&pid=1-s2.0-S2666668524000478-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142075884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Imaging in chronic thromboembolic pulmonary disease: Current practice and advances 慢性血栓栓塞性肺病的成像：当前实践与进展

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International journal of cardiology. Congenital heart disease Pub Date : 2024-08-10 DOI: 10.1016/j.ijcchd.2024.100536

{"title":"Imaging in chronic thromboembolic pulmonary disease: Current practice and advances","authors":"","doi":"10.1016/j.ijcchd.2024.100536","DOIUrl":"10.1016/j.ijcchd.2024.100536","url":null,"abstract":"<div><p>Chronic thromboembolic pulmonary disease (CTEPD) with or without pulmonary hypertension (PH) occurs when thromboemboli in pulmonary arteries fail to resolve completely. Pulmonary artery obstructions due to chronic thrombi and secondary microvasculopathy can increase pulmonary arterial pressure and resistance leading to chronic thromboembolic PH (CTEPH). Mechanical interventions and/or PH medications can improve cardiopulmonary haemodynamic, alleviate symptoms, and decrease mortality risk. Imaging is pivotal throughout the CTEPD management journey, spanning diagnosis, treatment planning, and assessing treatment outcome. With just computed tomography (CT) pulmonary angiogram and right heart catheterisation, an experienced multidisciplinary team can determine surgical candidacy in most cases. Dual energy CT, lung subtraction iodine mapping CT, and dynamic contrast-enhanced magnetic resonance imaging (MRI) offer comparable sensitivities with ventilation-perfusion scintigraphy in diagnosing CTEPD. Pulmonary angiogram with digital subtraction angiography although considered the gold standard for assessing thrombi extent and vasculature morphology is now mostly used to assess targets for balloon pulmonary angioplasty. Advancements in CT modalities and innovative MRI metrics offer better insight into CTEPD management but are limited by the availability of technology and expertise. Learning from current artificial intelligence application in medical imaging, there is promise in tapping the wealth of data provided by CTEPD imaging through automating cardiopulmonary and vascular morphology analysis.</p></div>","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666668524000454/pdfft?md5=00d52e64d87991bb3e2bcda91db0bbb9&pid=1-s2.0-S2666668524000454-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141991426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The latest definition and classification of pulmonary hypertension 肺动脉高压的最新定义和分类

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International journal of cardiology. Congenital heart disease Pub Date : 2024-07-31 DOI: 10.1016/j.ijcchd.2024.100534

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Subpulmonary ventricular function and inflammation are related to clinical heart failure in patients with a systemic right ventricle 肺下心室功能和炎症与系统性右心室患者的临床心力衰竭有关

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International journal of cardiology. Congenital heart disease Pub Date : 2024-07-31 DOI: 10.1016/j.ijcchd.2024.100535

{"title":"Subpulmonary ventricular function and inflammation are related to clinical heart failure in patients with a systemic right ventricle","authors":"","doi":"10.1016/j.ijcchd.2024.100535","DOIUrl":"10.1016/j.ijcchd.2024.100535","url":null,"abstract":"<div><h3>Background</h3><p>Timely diagnosis of heart failure (HF) in patients with a systemic right ventricle (sRV) is difficult but important since clinical deterioration is fast once HF develops. We aimed to compare echocardiography and biomarker profile between sRV patients with and without HF and patients with a systemic left ventricle diagnosed with HF (sLV-HF).</p></div><div><h3>Methods and results</h3><p>Eighty-seven sRV patients and 30 sLV-HF patients underwent echocardiographic evaluation and blood sampling. Compared to sRV patients without HF, sRV-HF patients had more remodeling of the subpulmonary LV (spLV) (internal diameter 3.9 cm [3.3–5.7] vs 3.4 cm [2.9–3.9], P = 0.03, posterior wall 0.93 cm [0.76–1.20] vs 0.71 cm [0.59–0.91], P = 0.006) and lower spLV systolic function: ejection fraction (59 % ± 14 vs 70 % ± 10, P = 0.011), mitral annular plane systolic excursion (1.7 cm ± 0.5 vs 2.1 cm ± 0.4, P = 0.003), fractional area change (47 % [38–58] vs 59 % [51–70], P = 0.002) and lateral strain rate (−1.2/s ± 0.46 vs −1.5/s ± 0.39, P = 0.016). Inflammatory biomarkers were higher in sRV-HF patients compared to those without HF: red cell distribution width (13.3 fL [12.8–14.1] vs 12.6 fL [12.3–13.1], P < 0.001), neutrophil lymphocyte ratio (NLR, 3.7 [2.2–4.9] vs 2.4 [1.9–3.0], P = 0.015), C-reactive protein (CRP, 2.5 mg/dL [1.0–4.2] vs 1.2 mg/dL [0.0–2.0], P = 0.005) and compared to sLV-HF patients (NLR (3.7 [2.2–4.9] vs 2.5 [1.7–3.3], P = 0.044) and CRP (2.5 mg/dL [1.0–4.2] vs 0.85 mg/dL [0.6–2.0], P = 0.006).</p></div><div><h3>Conclusion</h3><p>Biventricular echocardiographic evaluation with a focus on the subpulmonary LV together with assessing inflammatory status in sRV patients could help in an earlier detection of HF.</p></div>","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666668524000442/pdfft?md5=98391a18df1fea3bb58f2b154788fef1&pid=1-s2.0-S2666668524000442-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141991425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Outcomes, mortality risk factors, and functional status post-Norwood: A single-center study 结果、死亡率风险因素和诺伍德后的功能状态：单中心研究

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International journal of cardiology. Congenital heart disease Pub Date : 2024-07-26 DOI: 10.1016/j.ijcchd.2024.100533

{"title":"Outcomes, mortality risk factors, and functional status post-Norwood: A single-center study","authors":"","doi":"10.1016/j.ijcchd.2024.100533","DOIUrl":"10.1016/j.ijcchd.2024.100533","url":null,"abstract":"<div><h3>Background</h3><p>The Norwood operation (NO) for infants with univentricular physiology has high interstage mortality. This study evaluated outcomes and risk factors for mortality following NO.</p></div><div><h3>Methods</h3><p>Retrospective single-center study of patients undergoing NO from 2010 to 2020. Analysis used appropriate statistics.</p></div><div><h3>Results</h3><p>Of 269 patients undergoing NO, 213 (79.2 %) survived to discharge. Non-survivors had longer bypass times, delayed sternal closure, required nitric oxide, higher vasoactive scores, required post-operative catheterization, Extracorporeal Life Support (ECLS), and longer ventilation (p < 0.05). Logistic regression showed moderate-severe atrioventricular valve regurgitation on intraoperative TEE (OR 2.6), requiring nitric oxide (OR 2.63), delayed sternal closure (OR 2.94), post-operative catheterization (OR 10.48), and ECLS (OR 14.54) increased mortality odds (p < 0.05). Multivariable analysis confirmed catheterization (aOR 10.48) and ECLS (aOR 14.54) as significant predictors. Of survivors, 26 (12.3 %) developed new morbidity, 9 (4.2 %) had unfavorable outcomes. Functional status improved from 6.0 to 8.04, mainly in feeding and respiratory domains (p < 0.0001).</p></div><div><h3>Conclusions</h3><p>Norwood survival was 79.2 %. Requiring post-operative catheterization and ECLS significantly increased mortality risk. Multicenter evaluation of these modifiable risk factors is needed to improve outcomes in this high-risk population.</p></div>","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666668524000429/pdfft?md5=e08ecc7ded54dee64f3ee71a698dc086&pid=1-s2.0-S2666668524000429-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141852509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A rare presentation of pulmonary hypertension 肺动脉高压的罕见表现

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International journal of cardiology. Congenital heart disease Pub Date : 2024-07-25 DOI: 10.1016/j.ijcchd.2024.100531

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Congenital heart defects and consanguinity: An analysis of the Sidra cardiac registry data in Qatar 先天性心脏缺陷与血缘关系：卡塔尔 Sidra 心脏登记数据分析

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International journal of cardiology. Congenital heart disease Pub Date : 2024-07-20 DOI: 10.1016/j.ijcchd.2024.100529

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