慢性阻塞性肺疾病中的严重肺动脉高压--从临床角度到组织学证据

IF 0.8 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
Katarina Zeder , Teresa Sassmann , Vasile Foris , Philipp Douschan , Horst Olschewski , Gabor Kovacs
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引用次数: 0

摘要

理论依据目前,慢性阻塞性肺疾病(COPD)中的重度肺动脉高压(PH)是指平均肺动脉压升高和肺血管阻力剧增。在临床上,这些患者以男性居多,通常表现为非常严重的呼吸困难、严重的低氧血症、运动能力严重下降和预后不良,尽管临床表现往往与不太严重的气流阻塞有关。慢性阻塞性肺病和重度 PH 患者的肺部切片样本显示,肺小动脉发生严重重塑,主要发生在血管内膜和中层。在这篇简明扼要的综述中,我们将讨论慢性阻塞性肺病重度 PH 的临床和组织病理学证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Severe pulmonary hypertension in chronic obstructive pulmonary disease – From clinical perspective to histological evidence

Rationale

Severe pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) is currently defined by an elevated mean pulmonary arterial pressure and strongly elevated pulmonary vascular resistance >5 wood units. Clinically, these patients show a male predominance, and usually present with very severe dyspnea, severe hypoxemia, strongly decreased exercise capacity and poor prognosis, even though the clinical picture is frequently associated with less severe airflow obstruction. Explanted lung samples of patients with COPD and severe PH show severe remodeling of small pulmonary arterioles, predominantly in the intima and media of the vessels. In this concise review, we discuss the clinical and histopathological evidence of severe PH in COPD.

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来源期刊
International journal of cardiology. Congenital heart disease
International journal of cardiology. Congenital heart disease Cardiology and Cardiovascular Medicine
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