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[Psoriatic arthritis]. 银屑病关节炎。
IF 0.6
Innere Medizin (Heidelberg, Germany) Pub Date : 2026-07-01 Epub Date: 2026-06-12 DOI: 10.1007/s00108-026-02139-9
Michaela Köhm, Magdalena Figat, Nadia Ninosu, Frank Behrens
{"title":"[Psoriatic arthritis].","authors":"Michaela Köhm, Magdalena Figat, Nadia Ninosu, Frank Behrens","doi":"10.1007/s00108-026-02139-9","DOIUrl":"10.1007/s00108-026-02139-9","url":null,"abstract":"<p><p>Psoriatic arthritis (PsA) is not an isolated joint disease, but rather an expression of a systemic inflammatory disorder that affects multiple domains along the psoriatic disease continuum. New findings on the pathophysiology of the interleukin (IL)-23/IL-17 axis and the role of enthesitis, as well as the identification of subclinical transition phases between psoriasis and manifest arthritis, are fundamentally changing our understanding of psoriatic disease. The concepts of 'therapeutic windows' and 'interception' suggest that early targeted interventions could have a lasting positive effect on the progression of the disease. At the same time, clinical reality requires a differentiated therapy strategy that considers comorbidities and is oriented towards the individual patient. With a wide range of targeted therapies and an improved understanding of the disease's pathophysiology, personalized treatment strategies are becoming the focus of therapy management.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"741-750"},"PeriodicalIF":0.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Osteoartikuläre Erkrankungen – Internistinnen und Internisten sind gefragt! 骨关节疾病-需要内科医生！
IF 0.6
Innere Medizin (Heidelberg, Germany) Pub Date : 2026-07-01 Epub Date: 2026-06-29 DOI: 10.1007/s00108-026-02141-1
Elisabeth Märker-Hermann, Dagmar Führer-Sakel
{"title":"Osteoartikuläre Erkrankungen – Internistinnen und Internisten sind gefragt!","authors":"Elisabeth Märker-Hermann, Dagmar Führer-Sakel","doi":"10.1007/s00108-026-02141-1","DOIUrl":"https://doi.org/10.1007/s00108-026-02141-1","url":null,"abstract":"","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":"67 7","pages":"707-708"},"PeriodicalIF":0.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148347687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Extrapulmonary sarcoidosis with multiorgan involvement: a complex case with renal, neurological, and gastrointestinal manifestations]. [多器官累及肺外结节病：一例伴有肾脏、神经和胃肠道表现的复杂病例]。
IF 0.6
Innere Medizin (Heidelberg, Germany) Pub Date : 2026-07-01 Epub Date: 2026-03-30 DOI: 10.1007/s00108-026-02070-z
Julian Müller-Kühnle, Chantal Laboureur, Laura Wiedemann, Monika Patzak, Mathias Becker, Kerstin Amann, Anja Schieber, Benjamin Goeppert, Severin Schricker, Leonie Kraft, Jörg Latus, Moritz Schanz
{"title":"[Extrapulmonary sarcoidosis with multiorgan involvement: a complex case with renal, neurological, and gastrointestinal manifestations].","authors":"Julian Müller-Kühnle, Chantal Laboureur, Laura Wiedemann, Monika Patzak, Mathias Becker, Kerstin Amann, Anja Schieber, Benjamin Goeppert, Severin Schricker, Leonie Kraft, Jörg Latus, Moritz Schanz","doi":"10.1007/s00108-026-02070-z","DOIUrl":"10.1007/s00108-026-02070-z","url":null,"abstract":"<p><strong>Background: </strong>Systemic sarcoidosis can occur without pulmonary involvement and may present exclusively with extrapulmonary manifestations, thereby mimicking infections, autoimmune diseases, or malignancies.</p><p><strong>Case: </strong>The case of a 60-year-old female patient with pronounced cachexia (BMI 14 kg/m<sup>2</sup>), hypercalcemia, and multiorgan involvement is presented. Histology revealed non-caseating granulomas in gastric biopsies (granulomatous gastritis) as well as granulomatous interstitial nephritis with a tubular proteinuria pattern on renal biopsy. Imaging revealed no evidence of pulmonary involvement. Markedly elevated serum angiotensin-converting enzyme and soluble interleukin‑2 receptor levels, together with cerebrospinal fluid and MRI findings, were consistent with neurosarcoidosis. As the disease progressed, posterior reversible encephalopathy syndrome developed, presenting with seizures and transient cortical blindness. An extensive differential diagnostic workup, particularly for lymphoma, tuberculosis, and systemic vasculitis, was negative. The clinical course was complicated by percutaneous endoscopic gastrostomy-associated Enterococcus faecium peritonitis and Candida albicans sepsis. After stabilization and infection control, high-dose corticosteroid therapy was initiated, resulting in partial improvement of renal function and neurological symptoms.</p><p><strong>Conclusion: </strong>This case highlights the diagnostic and therapeutic challenges of life-threatening, purely extrapulmonary sarcoidosis with renal, gastrointestinal, and neurological manifestations. Early histological confirmation, thorough exclusion of relevant differential diagnoses, and multidisciplinary management are essential, particularly in balancing immunosuppression with infection control.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"804-813"},"PeriodicalIF":0.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fortbildungen des BDI. BDI培训。
IF 0.6
Innere Medizin (Heidelberg, Germany) Pub Date : 2026-06-01 DOI: 10.1007/s00108-026-02128-y
{"title":"Fortbildungen des BDI.","authors":"","doi":"10.1007/s00108-026-02128-y","DOIUrl":"https://doi.org/10.1007/s00108-026-02128-y","url":null,"abstract":"","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":"67 6","pages":"657-662"},"PeriodicalIF":0.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Management of patients with chronic obstructive pulmonary disease in routine clinical practice]. 慢性阻塞性肺疾病患者的临床常规管理
IF 0.6
Innere Medizin (Heidelberg, Germany) Pub Date : 2026-06-01 Epub Date: 2026-04-20 DOI: 10.1007/s00108-026-02111-7
Hendrik Pott, Bernd Schmeck, Peter Alter, Gernot Rohde
{"title":"[Management of patients with chronic obstructive pulmonary disease in routine clinical practice].","authors":"Hendrik Pott, Bernd Schmeck, Peter Alter, Gernot Rohde","doi":"10.1007/s00108-026-02111-7","DOIUrl":"10.1007/s00108-026-02111-7","url":null,"abstract":"<p><p>Chronic obstructive pulmonary disease (COPD) is among the leading causes of death worldwide and is characterized by chronic respiratory symptoms, persistent airflow limitation, and exacerbations. Diagnosis is confirmed by post-bronchodilator spirometry. Effective long-term management requires a structured assessment of relevant exposures, symptom burden, exacerbation history, and comorbidities. Key goals of treatment include reducing both symptom and disease burden and preventing future exacerbations, which are often associated with increased lung function decline. This article summarizes practical concepts for diagnostic work-up and therapeutic decision-making at the time of diagnosis, during follow-up, in acute exacerbations, and in the context of palliative care. It highlights individualized inhaled therapy, guided by symptoms, exacerbations, and blood eosinophil counts, as well as evidence-based non-pharmacological interventions such as smoking cessation, pulmonary rehabilitation, long-term oxygen therapy/non-invasive ventilation, and lung volume reduction strategies.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"640-650"},"PeriodicalIF":0.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147730824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Artificial intelligence-assisted diagnostics in the pathology of internal and oncological diseases]. [人工智能在内科和肿瘤疾病病理学中的辅助诊断]。
IF 0.6
Innere Medizin (Heidelberg, Germany) Pub Date : 2026-06-01 Epub Date: 2026-04-29 DOI: 10.1007/s00108-026-02120-6
Vincenzo Mitchell Barroso, Alexander Quaas, Reinhard Büttner, Yuri Tolkach
{"title":"[Artificial intelligence-assisted diagnostics in the pathology of internal and oncological diseases].","authors":"Vincenzo Mitchell Barroso, Alexander Quaas, Reinhard Büttner, Yuri Tolkach","doi":"10.1007/s00108-026-02120-6","DOIUrl":"10.1007/s00108-026-02120-6","url":null,"abstract":"<p><strong>Background: </strong>Artificial intelligence (AI) is increasingly being implemented in digital pathology to support the tissue classification, cell detection, biomarker quantification, the grading and prediction of clinically relevant molecular alterations.</p><p><strong>Objective: </strong>Current applications of AI in the pathology of internal and oncological diseases are summarized with a focus on the most important algorithm approaches, representative cases of diagnostic applications and current limits of clinical implementation.</p><p><strong>Material and methods: </strong>This narrative overview of the most recent advances describes the essential model forms, including tissue segmentation systems, algorithms for recognition of individual cells, unsupervised learning and foundation models, tools for the evaluation of immunohistochemistry and multimodal or language-based applications. Representative studies on renal, liver, pulmonary, gastrointestinal, hematological and thyroid gland pathologies are discussed.</p><p><strong>Results: </strong>In many situations AI improves the reproducibility, objectiveness and efficiency. Some systems achieve an accuracy that is comparable to that of experts. Most AI tools are still in the validation stage and only a few have been transferred to routine clinical use.</p><p><strong>Discussion: </strong>Artificial intelligence could further optimize the diagnostic and predictive histopathology. Their role remains assistive. A broad implementation is limited due to various hurdles and bottlenecks. The future progress depends on prospective validation and the integration into routine digital workflows.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"609-618"},"PeriodicalIF":0.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Broad cardiorenal protection with SGLT2 inhibitors : Evidence, indications and clinical practice]. SGLT2抑制剂具有广泛的心肾保护作用：证据、适应症和临床实践。
IF 0.6
Innere Medizin (Heidelberg, Germany) Pub Date : 2026-06-01 Epub Date: 2026-03-26 DOI: 10.1007/s00108-026-02098-1
Elias Rawish, Ingo Eitel
{"title":"[Broad cardiorenal protection with SGLT2 inhibitors : Evidence, indications and clinical practice].","authors":"Elias Rawish, Ingo Eitel","doi":"10.1007/s00108-026-02098-1","DOIUrl":"10.1007/s00108-026-02098-1","url":null,"abstract":"<p><strong>Background: </strong>Sodium-glucose cotransporter‑2 (SGLT2) inhibitors were developed as glucose-lowering drugs but provide robust cardiorenal protection in large outcome trials, including in people without diabetes.</p><p><strong>Objectives: </strong>To summarise the evidence-based indication spectrum and provide practical guidance (patient selection, estimated glomerular filtration rate [eGFR] thresholds, monitoring, adverse-event management).</p><p><strong>Current data: </strong>Across randomised trials in heart failure with reduced and preserved ejection fraction as well as chronic kidney disease (CKD), SGLT2 inhibitors consistently reduce heart failure hospitalisations and slow CKD progression. In type 2 diabetes, they lower the risk of heart failure events and, in part, atherosclerotic outcomes. Contemporary guidelines recommend SGLT2 inhibitors as foundational therapy in heart failure independent of left ventricular ejection fraction and in CKD largely independent of hemoglobin A1c (HbA1c), while considering eGFR and safety aspects. In large randomised outcome trials, SGLT2 inhibitors were shown to be safe overall, with a low and generally manageable risk of adverse events.</p><p><strong>Conclusions: </strong>SGLT2 inhibitors have become key organ-protective drugs in internal medicine. Early initiation in eligible patients and structured risk mitigation (volume status, infections, ketoacidosis) are critical.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"695-704"},"PeriodicalIF":0.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Künstliche Intelligenz in der Inneren Medizin. 人工智能在医学中的应用。
IF 0.6
Innere Medizin (Heidelberg, Germany) Pub Date : 2026-06-01 DOI: 10.1007/s00108-026-02126-0
Michael Hallek, Claus F Vogelmeier, Othman Al-Sawaf
{"title":"Künstliche Intelligenz in der Inneren Medizin.","authors":"Michael Hallek, Claus F Vogelmeier, Othman Al-Sawaf","doi":"10.1007/s00108-026-02126-0","DOIUrl":"https://doi.org/10.1007/s00108-026-02126-0","url":null,"abstract":"","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":"67 6","pages":"597-598"},"PeriodicalIF":0.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spargesetz. Spargesetz .
IF 0.6
Innere Medizin (Heidelberg, Germany) Pub Date : 2026-06-01 DOI: 10.1007/s00108-026-02132-2
{"title":"Spargesetz.","authors":"","doi":"10.1007/s00108-026-02132-2","DOIUrl":"https://doi.org/10.1007/s00108-026-02132-2","url":null,"abstract":"","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":"67 6","pages":"651-656"},"PeriodicalIF":0.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148140085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A typical myofascial pain syndrome, or perhaps not? : Rare differential diagnosis]. 这是典型的肌筋膜疼痛综合征，还是不是？[罕见鉴别诊断]。
IF 0.6
Innere Medizin (Heidelberg, Germany) Pub Date : 2026-06-01 Epub Date: 2025-12-17 DOI: 10.1007/s00108-025-02029-6
Ference van den Bos, Juliane Franz
{"title":"[A typical myofascial pain syndrome, or perhaps not? : Rare differential diagnosis].","authors":"Ference van den Bos, Juliane Franz","doi":"10.1007/s00108-025-02029-6","DOIUrl":"10.1007/s00108-025-02029-6","url":null,"abstract":"<p><p>A 55-year-old male patient presented with generalized myofascial complaints. The clinical and laboratory investigations were unremarkable apart from taut skin of the lower extremities and eosinophilia of the blood. Based on the enrichment of the fascias seen in magnetic resonance imaging (MRI) and the detection of inflammatory epifascial infiltrates in the muscle biopsy, the diagnosis of eosinophilic fasciitis was made. Treatment with glucocorticoids, methotrexate and tocilizumab led to a complete clinical and morphological regression of the fasciitis.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"684-688"},"PeriodicalIF":0.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13226399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145769974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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