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[New targeted treatment for tumor-associated cachexia : A breakthrough?] 肿瘤相关恶病质的新靶向治疗：一个突破？]
Innere Medizin (Heidelberg, Germany) Pub Date : 2025-06-19 DOI: 10.1007/s00108-025-01922-4
Andreas Neubauer, Camilla Leithold, Sirka Nitschmann, Karin Jordan
{"title":"[New targeted treatment for tumor-associated cachexia : A breakthrough?]","authors":"Andreas Neubauer, Camilla Leithold, Sirka Nitschmann, Karin Jordan","doi":"10.1007/s00108-025-01922-4","DOIUrl":"https://doi.org/10.1007/s00108-025-01922-4","url":null,"abstract":"","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Unilateral intermittent claudication after transfemoral TAVR procedure]. [经股TAVR手术后单侧间歇性跛行]。
Innere Medizin (Heidelberg, Germany) Pub Date : 2025-06-17 DOI: 10.1007/s00108-025-01930-4
Jan Lukas Prüser, Jörg Ukkat, Martin Mühlenweg, Daniel Sedding, Bettina-Maria Taute
{"title":"[Unilateral intermittent claudication after transfemoral TAVR procedure].","authors":"Jan Lukas Prüser, Jörg Ukkat, Martin Mühlenweg, Daniel Sedding, Bettina-Maria Taute","doi":"10.1007/s00108-025-01930-4","DOIUrl":"https://doi.org/10.1007/s00108-025-01930-4","url":null,"abstract":"<p><p>As part of a cardiological follow-up 3 months after transcatheter aortic valve repair (TAVR), an 83-year-old women reported that the attempt to resume postoperative Nordic walking failed due to new unilateral intermittent claudication. Duplex sonography revealed a filiform stenosis at the origin of the superficial femoral artery (SFA), caused by malposition of a plug-based vascular closure device (VCD), hemodynamically consistent with Rutherford I/1. The patient's wishes and high level of suffering justified surgical revascularization. Intraoperatively, subtotal occlusion of the SFA was confirmed by wedging the intravascular anchor of a MANTA VCD in the femoral bifurcation. During the postoperative course, the patient was able to resume her Nordic walking activities without any symptoms.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Same antibodies, new questions: interdisciplinary diagnosis in a 72-year-old female patient with encephalitis]. 【同样的抗体，新的问题：一名72岁女性脑炎患者的跨学科诊断】。
Innere Medizin (Heidelberg, Germany) Pub Date : 2025-06-16 DOI: 10.1007/s00108-025-01919-z
Christiane Kellner, Mihai Ceanga, Jakob Leicht, Christian Kühnel, Mina Piramoon, Christof Kloos, Nicolle Müller, Gunter Wolf
{"title":"[Same antibodies, new questions: interdisciplinary diagnosis in a 72-year-old female patient with encephalitis].","authors":"Christiane Kellner, Mihai Ceanga, Jakob Leicht, Christian Kühnel, Mina Piramoon, Christof Kloos, Nicolle Müller, Gunter Wolf","doi":"10.1007/s00108-025-01919-z","DOIUrl":"https://doi.org/10.1007/s00108-025-01919-z","url":null,"abstract":"<p><p>At 1.5 years after the diagnosis of glutamate decarboxylase(GAD)-associated encephalitis (highly positive GAD antibodies in cerebrospinal fluid and serum) in a 72-year-old patient, hyperglycemia above 40 mmol/l was the cause of progressive neurological symptoms. GAD is an important enzyme in the central nervous system and pancreatic β‑cells that convert L‑glutamate into γ‑aminobutyric acid (GABA). High GAD antibodies are associated with autoimmune diseases such as encephalitis and diabetes mellitus type 1, requiring interdisciplinary diagnostics and therapy.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Weight reduction with incretin mimetics-Opportunities and risks]. [用肠促胰岛素模拟减肥-机会和风险]。
Innere Medizin (Heidelberg, Germany) Pub Date : 2025-06-13 DOI: 10.1007/s00108-025-01918-0
Thomas J Zech, Benjamin Kirchweger, Robert Fürst
{"title":"[Weight reduction with incretin mimetics-Opportunities and risks].","authors":"Thomas J Zech, Benjamin Kirchweger, Robert Fürst","doi":"10.1007/s00108-025-01918-0","DOIUrl":"https://doi.org/10.1007/s00108-025-01918-0","url":null,"abstract":"<p><strong>Background: </strong>Obesity affects a growing number of people worldwide and is associated with severe metabolic, cardiovascular and oncological complications. Obesity not only represents an individual health burden but is also a socioeconomic challenge. With the incretin mimetics liraglutide, semaglutide and tirzepatide, a new class of drugs is now available that for the first time enables substantial and clinically relevant weight reduction.</p><p><strong>Objective: </strong>The article sheds light on the efficacy, safety and prospects of obesity treatment based on glucagon-like peptide 1 (GLP-1). In addition to the results of key clinical trials, potential risks, limitations of use, typical side effects and drug interactions are discussed. Economic aspects are also explained.</p><p><strong>Results: </strong>Clinical trials show an average weight reduction of 15-20%, with tirzepatide in particular being highly effective. Positive side effects of the treatment mainly concern metabolism (prediabetes and type 2 diabetes regression) and cardiovascular diseases. The main side effects are the frequently occurring gastrointestinal disorders, such as nausea and vomiting. The long-term safety of the substances has not yet been conclusively proven. High costs, limited access and the potential for abuse pose additional challenges. Combination preparations and orally available drugs are currently under development.</p><p><strong>Conclusion: </strong>Incretin mimetics represent a major advance in the treatment of obesity but require careful selection, close monitoring and long-term integration into lifestyle measures.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Efficacy of neuraminidase inhibitors against influenza]. 神经氨酸酶抑制剂抗流感的疗效
Innere Medizin (Heidelberg, Germany) Pub Date : 2025-06-06 DOI: 10.1007/s00108-025-01907-3
Theo Dähne, Sirka Nitschmann, Hartmut Hengel
{"title":"[Efficacy of neuraminidase inhibitors against influenza].","authors":"Theo Dähne, Sirka Nitschmann, Hartmut Hengel","doi":"10.1007/s00108-025-01907-3","DOIUrl":"https://doi.org/10.1007/s00108-025-01907-3","url":null,"abstract":"","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Springer CME Award 2024: catheter ablation for atrial fibrillation : Prof. Dr. Philipp Sommer is awarded the prize for the best continuing education article]. [b施普林格CME奖2024：房颤导管消融：Philipp Sommer教授获得最佳继续教育文章奖]。
Innere Medizin (Heidelberg, Germany) Pub Date : 2025-06-04 DOI: 10.1007/s00108-025-01921-5
Karen Klewer
{"title":"[Springer CME Award 2024: catheter ablation for atrial fibrillation : Prof. Dr. Philipp Sommer is awarded the prize for the best continuing education article].","authors":"Karen Klewer","doi":"10.1007/s00108-025-01921-5","DOIUrl":"https://doi.org/10.1007/s00108-025-01921-5","url":null,"abstract":"","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Can drug therapy for obstructive sleep apnea be expected after all?] 阻塞性睡眠呼吸暂停的药物治疗究竟能否实现？］
Innere Medizin (Heidelberg, Germany) Pub Date : 2025-06-01 Epub Date: 2025-05-12 DOI: 10.1007/s00108-025-01902-8
Ingo Fietze
{"title":"[Can drug therapy for obstructive sleep apnea be expected after all?]","authors":"Ingo Fietze","doi":"10.1007/s00108-025-01902-8","DOIUrl":"10.1007/s00108-025-01902-8","url":null,"abstract":"<p><p>Obstructive sleep apnea (OSA) is a very common sleep disorder and is usually a chronic disease. Indications for treatment depend on the severity of the nocturnal breathing disorder; the specific symptoms, such as daytime sleepiness; and the comorbidities, which, together with the breathing disorder, constitute the risk of sleep apnea. Standard treatment is nocturnal positive airway pressure therapy or, especially for mild to moderate sleep apnea, a mandibular advancement device. Surgical measures are only carried out if indicated. A specific and effective sleep apnea medication does not yet exist. The first approved medication for obese OSA sufferers is tirzepatide, which leads to a reduction in nocturnal breathing disorders through effective weight reduction. Alternative and in some cases more specific medications are currently being researched. These include, for example, carbonic anhydrase inhibitors, anticholinergics, serotonin-noradrenaline reuptake inhibitors, sympathomimetics, and cannabinoids. Drug therapy for sleep apnea will enrich an individualized therapy in the future that is geared toward the phenotype of sleep apnea.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"639-645"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Transition in gastroenterology and hepatology]. [胃肠病学和肝病学的过渡]。
Innere Medizin (Heidelberg, Germany) Pub Date : 2025-06-01 Epub Date: 2025-05-13 DOI: 10.1007/s00108-025-01908-2
Britta Siegmund, Philip Bufler
{"title":"[Transition in gastroenterology and hepatology].","authors":"Britta Siegmund, Philip Bufler","doi":"10.1007/s00108-025-01908-2","DOIUrl":"10.1007/s00108-025-01908-2","url":null,"abstract":"<p><p>Chronic diseases of the gastrointestinal tract or the liver manifest themselves in a significant number of patients as early as childhood or adolescence. The majority of these diseases require complex drug therapy and continuous care. This makes the transition to adult medicine all the more critical, as it is a challenging phase of life per se. This article will present examples from various gastroenterology and hepatology centers. Subsequently, position papers and guidelines from national and international specialist societies will be discussed. Finally, the Berlin Transition Program (Berliner TransitionsProgramm, BTP) will be presented as a possible model for gastroenterology.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"593-596"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[An abscess gone astray]. [脓肿偏离了方向]。
Innere Medizin (Heidelberg, Germany) Pub Date : 2025-06-01 Epub Date: 2025-02-19 DOI: 10.1007/s00108-025-01863-y
Hatti Seidl, Lena Thormählen, Marie Pollak, Thula Walter-Rittel, Robert Hättasch, Gerhard Hindricks
{"title":"[An abscess gone astray].","authors":"Hatti Seidl, Lena Thormählen, Marie Pollak, Thula Walter-Rittel, Robert Hättasch, Gerhard Hindricks","doi":"10.1007/s00108-025-01863-y","DOIUrl":"10.1007/s00108-025-01863-y","url":null,"abstract":"<p><p>A 69-year-old female patient with known recurrence of esophageal cancer presented with fever and elevated inflammatory markers. In the recent past, a suspicious mediastinal lymph node had been biopsied via bronchoscopy. Consequently, a lymph node abscess developed, leading to blood stream infection (pathogen: Streptococcus anginosus) via a fistula into the superior vena cava. Through a preexisting atrial septal defect, the infection also spread to the brain, causing multiple brain abscesses.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"651-655"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Organizing survivorship: transition and long-term care for childhood cancer survivors]. [组织幸存者：儿童癌症幸存者的过渡和长期护理]。
Innere Medizin (Heidelberg, Germany) Pub Date : 2025-06-01 Epub Date: 2025-05-19 DOI: 10.1007/s00108-025-01916-2
Madelaine Sleimann, Thorsten Langer, Judith Gebauer
{"title":"[Organizing survivorship: transition and long-term care for childhood cancer survivors].","authors":"Madelaine Sleimann, Thorsten Langer, Judith Gebauer","doi":"10.1007/s00108-025-01916-2","DOIUrl":"10.1007/s00108-025-01916-2","url":null,"abstract":"<p><strong>Background: </strong>Survivors of childhood or adolescent cancer have high long-term survival rates due to improved therapies but often suffer from complex late and long-term effects which should be diagnosed and treated early.</p><p><strong>Objective: </strong>Existing models of transition and long-term follow-up care for adult survivors of childhood and adolescent cancer in Germany are presented and perspectives for care and research in this field are outlined.</p><p><strong>Results: </strong>There is potential for improvement in the area of networking of the medical disciplines involved as well as in the involvement and education of patients.</p><p><strong>Conclusions: </strong>Nationwide harmonization and standardization of long-term follow-up care and transition is important to ensure that all childhood cancer survivors in Germany have access to care according to guideline recommendations.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"579-585"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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