Innere Medizin (Heidelberg, Germany)最新文献_第10页

[Immune complex- and complement-mediated glomerulonephritides]. [免疫复合物和补体介导的肾小球肾肽]。

IF 0.6

Innere Medizin (Heidelberg, Germany) Pub Date : 2026-05-01 Epub Date: 2026-04-21 DOI: 10.1007/s00108-026-02108-2

Vega Gödecke

{"title":"[Immune complex- and complement-mediated glomerulonephritides].","authors":"Vega Gödecke","doi":"10.1007/s00108-026-02108-2","DOIUrl":"10.1007/s00108-026-02108-2","url":null,"abstract":"Glomerulonephritis represents a heterogeneous group of kidney diseases characterized by inflammation of the glomeruli and capable of leading to acute or chronic kidney failure. In addition to the primary glomerulonephritides described elsewhere in this issue, there is a group of diseases in which immune complex deposition or disturbances in complement regulation play a central pathogenic role. Among the most important and clinically relevant forms of these immune complex- and complement-mediated glomerulonephritides are postinfectious glomerulonephritis (PIGN), lupus nephritis (LN), cryoglobulinemic glomerulonephritis, and C3 glomerulopathy (C3G). While PIGN, LN, and cryoglobulinemic glomerulonephritis are characterized by glomerular immune complex deposits, C3 glomerulopathy is primarily based on a dysregulation of the alternative complement pathway. These diseases require specialized treatment in university outpatient clinics in collaboration with nephrology practices. Renal biopsy is a key diagnostic tool, and histologically, a membranoproliferative pattern is frequently observed. This article provides a systematic overview of immune complex- and complement-mediated glomerulonephritis and compares their pathogenesis, clinical presentation, immunoserological profiles, histology, and available therapies.","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":"67 5","pages":"506-514"},"PeriodicalIF":0.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Lung tumor mimicking bronchial carcinoma in a 68-year-old female patient]. [68岁女性肺癌模拟支气管癌一例]。

IF 0.6

Innere Medizin (Heidelberg, Germany) Pub Date : 2026-04-22 DOI: 10.1007/s00108-026-02113-5

Clemens Stiegler, Christopher Kapitza, Claus Schäfer

引用次数: 0

Paradigmenwechsel in der Inneren Medizin – die Zukunft gestalten! : Die Innere Medizin als „Zukunftsmotor“. 改变内科的范式——塑造未来！：内科是“未来的引擎”。

IF 0.6

Innere Medizin (Heidelberg, Germany) Pub Date : 2026-04-01 Epub Date: 2026-03-24 DOI: 10.1007/s00108-026-02091-8

Dagmar Führer-Sakel

引用次数: 0

[The gut is where health begins : How gastroenterological diseases can be prevented]. [肠道是健康的起点：如何预防胃肠疾病]。

IF 0.6

Innere Medizin (Heidelberg, Germany) Pub Date : 2026-04-01 Epub Date: 2026-03-12 DOI: 10.1007/s00108-026-02085-6

Petra Lynen Jansen, Patrick Michl, Thomas Rösch, Thomas Seufferlein, Britta Siegmund, Frank Tacke, Heiner Wedemeyer

{"title":"[The gut is where health begins : How gastroenterological diseases can be prevented].","authors":"Petra Lynen Jansen, Patrick Michl, Thomas Rösch, Thomas Seufferlein, Britta Siegmund, Frank Tacke, Heiner Wedemeyer","doi":"10.1007/s00108-026-02085-6","DOIUrl":"10.1007/s00108-026-02085-6","url":null,"abstract":"Diseases of the digestive organs are among the most frequent diseases and at the same time diseases with the most severe consequences in Germany. They are widespread diseases in the proper sense. Around 2.5 million people are hospitalized annually due to gastroenterological diseases and approximately 140,000 deaths per year are directly attributed to them. In addition, there are substantial impairments in the quality of life, high periods of inability to work and an immense economic burden on the healthcare system with annual costs of over €60 billion. It is particularly relevant that a substantial proportion of these diseases could be avoided or at least the course could be favorably influenced. The gastrointestinal tract including the liver and pancreas undertakes a key management function for the whole organism. Disorders of the digestive organs not only have a local effect but also influence the metabolism, cardiovascular system, immune system and the brain. Therefore, prevention in gastroenterology always also means prevention of systemic diseases. A healthy gut is a prerequisite for a healthy life. Prevention in gastroenterology is also a success story. The introduction of screening coloscopy, the vaccination against hepatitis B, the introduction of hepatitis B and C screening and the eradication of Helicobacter pylori demonstrably reduce the morbidity and mortality risks and impressively show the potential of a consistently implemented preventive strategy. This article compiles the aims, evidence, success and current deficits in gastroenterological preventive measures, names potential improvements and provides a perspective of future developments.","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"57-61"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Two cases of complicated primary hyperparathyroidism during pregnancy]. 妊娠期并发原发性甲状旁腺功能亢进2例

IF 0.6

Innere Medizin (Heidelberg, Germany) Pub Date : 2026-04-01 Epub Date: 2025-10-10 DOI: 10.1007/s00108-025-02011-2

Anna-Lena Farwick, Mustafa Bačinović, Oleg Heizmann, Achim Meinhardt

引用次数: 0

[Preventive fields in endocrinology/diabetology-The big five]. [内分泌学/糖尿病学的五大预防领域]。

IF 0.6

Innere Medizin (Heidelberg, Germany) Pub Date : 2026-04-01 Epub Date: 2026-03-05 DOI: 10.1007/s00108-026-02094-5

Martin Pfohl, Martin Reincke, Jochen Seufert, Jochen Feldkamp, Martin Fassnacht, Martin Merkel, Jan Tuckermann

{"title":"[Preventive fields in endocrinology/diabetology-The big five].","authors":"Martin Pfohl, Martin Reincke, Jochen Seufert, Jochen Feldkamp, Martin Fassnacht, Martin Merkel, Jan Tuckermann","doi":"10.1007/s00108-026-02094-5","DOIUrl":"10.1007/s00108-026-02094-5","url":null,"abstract":"Preventive strategies in endocrinology focus on five major fields (the big five): thyroid gland disorders, obesity and diabetes mellitus, dyslipidemia, arterial hypertension and osteoporosis. These highly prevalent conditions have a high morbidity and mortality. As many can be prevented by relatively simple nonpharmacological measures or effectively mitigated by low-threshold pharmacological interventions, they represent model diseases for prevention in internal medicine. This article outlines the current options and discusses them in the context of current prevention strategies. Endocrine and diabetic diseases are among the most common and consequential chronic disorders in industrialized countries and essentially contribute to the total morbidity and mortality. Principal preventive strategies include structural prevention (environmental prevention), such as promoting anti-adipogenic and anti-diabetogenic social structures and behavioral prevention. The emphasis of preventive strategies is on population-related measures, structured screening programs and evidence-based lifestyle interventions. Based on current epidemiological data and guidelines, practical approaches are presented, ranging from iodine prophylaxis, lipid and blood pressure screening to promotion of healthy bone and obesity preventive structures. The concepts discussed demonstrate that effective endocrine and diabetological prevention requires coordinated action across clinical medicine, public health and health policy to realize its full potential.","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"30-34"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13056723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The general health examination as opportunity for preventive medicine]. 【以全身健康检查为契机进行预防医学】。

IF 0.6

Innere Medizin (Heidelberg, Germany) Pub Date : 2026-04-01 Epub Date: 2026-03-31 DOI: 10.1007/s00108-026-02089-2

Susanne Balzer, Madeleine Busch, Irmgard Landgraf

{"title":"[The general health examination as opportunity for preventive medicine].","authors":"Susanne Balzer, Madeleine Busch, Irmgard Landgraf","doi":"10.1007/s00108-026-02089-2","DOIUrl":"10.1007/s00108-026-02089-2","url":null,"abstract":"The Check-up 35 is designed for the early detection of cardiovascular diseases, diabetes and kidney diseases as common lifestyle diseases to prevent long-term damage. It also serves to identify personal risk factors, verify and update vaccination status and provide counseling on individually beneficial prevention strategies. To date, it has not been proven that regular check-ups reduce mortality or the utilization of medical services [1]. There are several reasons for this: first, the examinations included in the check-up are insufficient. Second, the individuals who would benefit most often do not participate. Furthermore, the impact of prevention is difficult to quantify. Nevertheless, the check-up is an excellent tool for identifying individual risk factors and lifestyle diseases at an early stage and to react appropriately. It helps bridge vaccination gaps, reduce or delay multimorbidity, the need for long-term care and frailty until later in life, and strengthens the health literacy of the population. In this context, it would be sensible to address the ecological responsibility of each individual as environmental protection is also health protection.","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"11-15"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Prevention of infectious diseases : The role of infectious disease specialists]. [预防传染病：传染病专家的作用]。

IF 0.6

Innere Medizin (Heidelberg, Germany) Pub Date : 2026-04-01 Epub Date: 2026-03-05 DOI: 10.1007/s00108-026-02071-y

M Vehreschild, K de With, E Kramme, C Lehmann, J Schelling, C Schenkel-Häger, G Fätkenheuer

{"title":"[Prevention of infectious diseases : The role of infectious disease specialists].","authors":"M Vehreschild, K de With, E Kramme, C Lehmann, J Schelling, C Schenkel-Häger, G Fätkenheuer","doi":"10.1007/s00108-026-02071-y","DOIUrl":"10.1007/s00108-026-02071-y","url":null,"abstract":"Background: Infectious diseases are among the most frequent diseases encountered in both inpatient and outpatient settings. Therefore, the prevention of infections is a central task for physicians across all medical specialties.Objectives: This article discusses various areas of prevention and highlights the pivotal role of infectious disease specialists.Results: Vaccines are among the most effective measures for disease prevention overall. They are used in primary as well as for secondary prevention; however, to achieve the preventive targets an improvement in the vaccination rates in Germany is urgently necessary. To increase vaccine utilization, improvements in the intersectoral and interdisciplinary cooperation of various medical disciplines are of major importance. For prevention of the further spread of antimicrobial resistance, antimicrobial stewardship (AMS) teams have successfully been established in hospitals and AMS should also increasingly play a role in outpatient care. Another major task of prevention is the avoidance of nosocomial infections.Conclusion: The frequency as well as the medical and social impact of infectious diseases in healthcare clearly demonstrate the importance of prevention in this field. Improvements in provision of care are necessary at various levels with a focus on intersectoral and interdisciplinary cooperation of the medical disciplines. Infectious disease specialists should play a key role in coordinating these initiatives.","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"26-29"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Design of early detection programs by the Federal Joint Committee]. [联邦联合委员会早期检测项目的设计]。

IF 0.6

Innere Medizin (Heidelberg, Germany) Pub Date : 2026-04-01 Epub Date: 2026-03-11 DOI: 10.1007/s00108-026-02074-9

Daniel Reuter, Bernhard van Treeck

引用次数: 0

[Clinician and medical scientists in internal medicine: endocrinology and immunology]. [内科的临床医生和医学科学家：内分泌学和免疫学]。

IF 0.6

Innere Medizin (Heidelberg, Germany) Pub Date : 2026-04-01 Epub Date: 2026-03-02 DOI: 10.1007/s00108-026-02082-9

Christina Wenzek

引用次数: 0