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[The European Rare Kidney Disease Reference Network]. [欧洲罕见肾病参考网络]。
Innere Medizin (Heidelberg, Germany) Pub Date : 2024-12-01 Epub Date: 2024-11-13 DOI: 10.1007/s00108-024-01810-3
Tanja Wlodkowski, Stefanie Haeberle, Franz Schaefer
{"title":"[The European Rare Kidney Disease Reference Network].","authors":"Tanja Wlodkowski, Stefanie Haeberle, Franz Schaefer","doi":"10.1007/s00108-024-01810-3","DOIUrl":"10.1007/s00108-024-01810-3","url":null,"abstract":"<p><p>Rare kidney diseases encompass a wide range of congenital, inherited and acquired conditions. Two million Europeans are affected by rare kidney diseases. The European Rare Kidney Disease Reference Network (ERKNet) aims to improve the clinical management of patients with these diseases. ERKNet encompasses 95 highly specialized adult and pediatric nephrology units at 72 sites in 24 European Union (EU) member states, as well as a group of patient advocates (European Patient Advocacy Group, ePAG). ERKNet centers care for more than 65,000 rare kidney disease patients and pursues a variety of activities. An online consultation service helps improve the management of complex cases. Expert working groups develop clinical practice guidelines for individual groups of rare kidney diseases. In a 3-year postgraduate program, junior physicians at ERKNet centers are trained by experts in the diagnosis and treatment of rare kidney diseases through webinars and case-based eLearning modules. Information brochures and online texts on rare kidney diseases for patients, relatives and the general public are produced and disseminated. Clinical research is supported by a European Registry for Rare Kidney Diseases (ERKReg), which provides important information on demographics and disease progression and facilitates the identification of patient cohorts for therapeutic studies. In addition, the registry provides clinical performance statistics of reference centers and allows benchmarking to promote the harmonization and standardization of care for rare kidney disease patients across Europe.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"1283-1292"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[What is confirmed in therapy of complicated urinary tract infections]. [治疗复杂性尿路感染的确诊方法]。
Innere Medizin (Heidelberg, Germany) Pub Date : 2024-12-01 Epub Date: 2024-09-27 DOI: 10.1007/s00108-024-01792-2
Sibylle von Vietinghoff, Florian Wagenlehner
{"title":"[What is confirmed in therapy of complicated urinary tract infections].","authors":"Sibylle von Vietinghoff, Florian Wagenlehner","doi":"10.1007/s00108-024-01792-2","DOIUrl":"10.1007/s00108-024-01792-2","url":null,"abstract":"<p><p>Urinary tract infections (UTI) rank among the most common bacterial infections worldwide. Clinical challenges include acute severe manifestations and frequently relapsing disease, both favored by urinary tract abnormalities and systemic immune defects. To judge morbidity during clinical infection, the ORENUC criteria assess clinical risk, likelihood of relapsing disease, extragenital manifestations, nephropathy, urologic and catheter-related factors. Additional diagnostic measures of severe and unusual manifestations include an extended history and specific clinical examination together with nephro-urological imaging, namely ultrasound, laboratory assessment of systemic disease, and removal or exchange of catheters and other foreign materials in the urinary tract. The current primary antibiotics recommended for uncomplicated pyelonephritis in Germany are gyrase inhibitors and cephalosporins. Microbiological diagnosis and resistance testing is central to improve efficacy and reduce side effects, especially in complex clinical situations. New antibiotic developments offer new options, especially in presence of proven antimicrobial resistance. Management of relapsing infections needs to aim at improvement of local urogenital and systemic immunological factors, which is however frequently challenging to impossible to achieve. Patient contributions including behavioral modifications and longterm or intermittent antibiotic and other drug therapy. Overall, therapeutic options are limited and new pathophysiological and antimicrobial strategies are urgently needed.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"1180-1187"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Acute polyarthritis after a stay in the Caribbean]. [在加勒比海逗留后出现急性多关节炎]。
Innere Medizin (Heidelberg, Germany) Pub Date : 2024-12-01 Epub Date: 2024-09-17 DOI: 10.1007/s00108-024-01773-5
Johannes Mayer, Michaela Köhm, Matthias Wahle
{"title":"[Acute polyarthritis after a stay in the Caribbean].","authors":"Johannes Mayer, Michaela Köhm, Matthias Wahle","doi":"10.1007/s00108-024-01773-5","DOIUrl":"10.1007/s00108-024-01773-5","url":null,"abstract":"<p><p>A 59-year-old female patient presented with acute polyarthritis after a holiday in the Caribbean. In addition, constitutional symptoms as well as myalgia and arthralgia were reported. Imaging demonstrated synovitis of the wrist and fingers without erosive changes. Immunoserological findings were normal with no evidence of autoimmune disease or vasculitis. Further evaluation revealed serological evidence of chikungunya virus infection.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"1270-1272"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142302611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Reversibility of a critical intraventricular conduction delay under flecainide and lacosamide by sodium bicarbonate]. [碳酸氢钠可逆转飞卡尼和拉科酰胺导致的心室内传导延迟临界]。
Innere Medizin (Heidelberg, Germany) Pub Date : 2024-12-01 Epub Date: 2024-08-21 DOI: 10.1007/s00108-024-01768-2
Anja Gallinger, Rahman Osei-Davies, F Hennersdorf
{"title":"[Reversibility of a critical intraventricular conduction delay under flecainide and lacosamide by sodium bicarbonate].","authors":"Anja Gallinger, Rahman Osei-Davies, F Hennersdorf","doi":"10.1007/s00108-024-01768-2","DOIUrl":"10.1007/s00108-024-01768-2","url":null,"abstract":"<p><p>The case of a 72-year-old female patient with arrhythmogenic syncope associated with a combination therapy of flecainide and lacosamide is presented. The authors believe in an additive effect of both drugs on myocardial voltage-gated sodium channels with extraordinary QRS widening, exit block with temporary pacing and complete reversibility through infusion of sodium bicarbonate as bail-out therapy.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"1266-1269"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Digital health apps : How to achieve the successful integration into healthcare]. [数字医疗应用程序：如何成功融入医疗保健]。
Innere Medizin (Heidelberg, Germany) Pub Date : 2024-12-01 Epub Date: 2024-10-10 DOI: 10.1007/s00108-024-01774-4
Alexandra Widmer
{"title":"[Digital health apps : How to achieve the successful integration into healthcare].","authors":"Alexandra Widmer","doi":"10.1007/s00108-024-01774-4","DOIUrl":"10.1007/s00108-024-01774-4","url":null,"abstract":"<p><p>Digital health applications (apps) have been available on prescription since 2019 and offer a multitude of functions in health monitoring, symptom recognition, follow-up monitoring and patient care. The Digital Care Act from 2023 strives for a comprehensive integration of apps into medical care. The utilization of artificial intelligence (AI) in health apps promises an earlier diagnosis, sensitive symptom monitoring, optimization of courses of treatment, more effective doctor-patient communication and saving of resources. The integration of health apps and AI can enable a stronger personalized high-value care.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"1261-1265"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A rare medical chameleon with fatal consequences]. [一种具有致命后果的罕见医学变色龙]。
Innere Medizin (Heidelberg, Germany) Pub Date : 2024-11-25 DOI: 10.1007/s00108-024-01814-z
Adrian Wullweber, Kristin Calaminus, Torsten Beyna
{"title":"[A rare medical chameleon with fatal consequences].","authors":"Adrian Wullweber, Kristin Calaminus, Torsten Beyna","doi":"10.1007/s00108-024-01814-z","DOIUrl":"https://doi.org/10.1007/s00108-024-01814-z","url":null,"abstract":"<p><p>The following case describes the relapsing and ultimately fatal outcome of DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome as an often misdiagnosed drug-induced hypersensitivity reaction. The disease was complicated by progressive worsening with involvement of multiple organs and profound agranulocytosis. The main goal of this article is to raise awareness of the syndrome and its potential severity. Moreover, it outlines a number of pitfalls that may face the clinician.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fortbildungen des BDI. BDI 组织的培训课程。
Innere Medizin (Heidelberg, Germany) Pub Date : 2024-11-01 DOI: 10.1007/s00108-024-01807-y
{"title":"Fortbildungen des BDI.","authors":"","doi":"10.1007/s00108-024-01807-y","DOIUrl":"https://doi.org/10.1007/s00108-024-01807-y","url":null,"abstract":"","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":"65 11","pages":"1116-1118"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BDI Hauptstadtforum 2024. 2024 年 BDI 资本论坛。
Innere Medizin (Heidelberg, Germany) Pub Date : 2024-11-01 DOI: 10.1007/s00108-024-01809-w
{"title":"BDI Hauptstadtforum 2024.","authors":"","doi":"10.1007/s00108-024-01809-w","DOIUrl":"https://doi.org/10.1007/s00108-024-01809-w","url":null,"abstract":"","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":"65 11","pages":"1109-1115"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Arterial hypertension-Current recommendations for action]. [动脉高血压--当前行动建议]。
Innere Medizin (Heidelberg, Germany) Pub Date : 2024-11-01 Epub Date: 2024-10-30 DOI: 10.1007/s00108-024-01803-2
Milen Babic, Oliver Vonend, Markus van der Giet
{"title":"[Arterial hypertension-Current recommendations for action].","authors":"Milen Babic, Oliver Vonend, Markus van der Giet","doi":"10.1007/s00108-024-01803-2","DOIUrl":"10.1007/s00108-024-01803-2","url":null,"abstract":"<p><p>Arterial hypertension (aHT) currently affects nearly 1 in every 3 persons in Germany and the number of those affected is steadily increasing. Only half of the patients treated show a controlled blood pressure in the follow-up. A suboptimal treatment involves the danger of cardiovascular and renal events that under certain circumstances can have a fatal course. The publication of the first national treatment guidelines (NVL) on hypertension and the new guidelines of the European Society of Hypertension (ESH) 2023 simultaneously represent two updates. Both emphasize the necessity to avoid hypertension-mediated organ damage (HMOD) and the identification of high blood pressure. The focussing on preventive measures and lifestyle recommendations as well as the simplification of target blood pressure values play important roles in the routine practice. This article provides a practical summary of the current recommendations of both guidelines on the diagnostics and treatment of aNT, discusses relevant differences and provides routinely applicable advice.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"1099-1108"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Anaphylactic shock after mistletoe therapy]. [槲寄生治疗后过敏性休克]。
Innere Medizin (Heidelberg, Germany) Pub Date : 2024-11-01 Epub Date: 2024-07-17 DOI: 10.1007/s00108-024-01746-8
Daniel Kaemmerer, Merten Hommann
{"title":"[Anaphylactic shock after mistletoe therapy].","authors":"Daniel Kaemmerer, Merten Hommann","doi":"10.1007/s00108-024-01746-8","DOIUrl":"10.1007/s00108-024-01746-8","url":null,"abstract":"<p><p>Life-threatening side effects of mistletoe therapy are mostly negated by physicians working in complementary medicine. This article reports on a case of life-threatening anaphylactic shock after carrying out mistletoe therapy. In patients with a carcinoid syndrome (flushes, diarrhea, bronchoconstriction) the diagnosis of anaphylactic shock can be masked by the findings of a neuroendocrine neoplasm. Before a planned complementary medicine mistletoe therapy patients should also be well-informed on rare life-threatening side effects.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"1147-1149"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141636059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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