{"title":"[Peripheral artery disease II: femoropopliteal lesions].","authors":"Christos Rammos, Tienush Rassaf, Grigorios Korosoglou","doi":"10.1007/s00108-025-01858-9","DOIUrl":"10.1007/s00108-025-01858-9","url":null,"abstract":"<p><p>The endovascular treatment of the femoropopliteal segment is the most frequent revascularization option in patients with peripheral arterial occlusive disease (PAOD); however, the plain old balloon angioplasty has limitations, especially in complex and calcified lesions, and can lead to dissections and recoil. In order to improve the technical success and the efficacy of the endovascular treatment in complex, sometimes severely calcified or thrombotic lesions or also in lesions in mobile segments, a lesion preparation strategy before the actual lesion treatment is frequently applied. Lesion preparation methods include atherectomy, thrombectomy or intravascular lithotripsy. Through lesion preparation plaques and/or organized thrombi can be minimally invasively removed or calcium deposits can be even fragmented with low threshold barotrauma, without damaging the vessel wall. Subsequently, the definitive treatment of the lesion can be carried out using drug-coated balloons (DCB), bare metal stents (BMS), drug-eluting stents (DES) or a combination of these. Due to the heterogeneity of patient and lesion characteristics, no 'one fits all' strategy is so far available; however, the choice of the appropriate instruments should be carried out based on the patient and lesion characteristics present, whereby for the lesion-specific parameters the extent of the morphology and underlying pathology plays an important role.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"258-267"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Non-Hodgkin's lymphomas: a short overview].","authors":"S Pudasaini, M Dreyling","doi":"10.1007/s00108-025-01856-x","DOIUrl":"10.1007/s00108-025-01856-x","url":null,"abstract":"<p><p>Non-Hodgkin's lymphomas constitute a highly heterogeneous group of neoplasms. Their origin lies in the lymphatic cells of our immune system. Despite their biological variance, they can be clinically classified into indolent and aggressive lymphomas. This categorization has prognostic and therapeutic implications. The goal of treatment in aggressive lymphoma is full remission, which usually requires an intensive treatment regimen. In cases of indolent lymphoma, cure is not the therapeutic goal, but rather disease control. Recent developments have led to novel therapeutic options in addition to the classic well-known chemotherapies and anti-CD20 antibodies. The use of a variety of targeted therapies, including cellular therapies such as chimeric antigen receptor (CAR) T cells, has led to significantly improved outcomes.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"290-298"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Monica Maria Novoa Usme, Iskandar Atmowihardjo, Sebastian Spencker
{"title":"[Periaortic gas and signs of dissection of a mycotic aneurysm in the descending thoracic aorta due to Clostridium septicum].","authors":"Monica Maria Novoa Usme, Iskandar Atmowihardjo, Sebastian Spencker","doi":"10.1007/s00108-024-01800-5","DOIUrl":"10.1007/s00108-024-01800-5","url":null,"abstract":"<p><p>The case of 92-year-old male with a history of sepsis due to Clostridium septicum is described. Since the bacteria were also found at the site of joint aspiration, the patient underwent knee prosthesis removal. Due to the association between colorectal cancer and Clostridium septicum, a colonoscopy was performed. An adenocarcinoma was extracted in situ. At 5 months, the patient presented again with shortness of breath, acute retrosternal pain and fever. CT revealed a mycotic aneurysm of the descending aorta with Stanford B dissection and periaortic gas. Due to the fragility of the patient, conservative treatment was initiated.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"325-327"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Endovascular treatment of chronic pelvic vein obstruction].","authors":"Michael Lichtenberg, Houman Jalaie","doi":"10.1007/s00108-025-01853-0","DOIUrl":"10.1007/s00108-025-01853-0","url":null,"abstract":"<p><p>Chronic venous obstructions frequently lead to a substantial reduction in the quality of life of affected patients and as a result to a burden on the healthcare system. Endovascular recanalization and stent implantation of iliofemoral venous obstructions are successful minimally invasive approaches; however, there are still open questions with respect to patient selection, technical procedures and long-term results. This review article summarizes the current state of knowledge on the interventional treatment of postthrombotic syndrome (PTS), particularly on the development of endovascular procedures and stent implantation. Criteria for the patient selection, details of the procedure and the characteristics of special venous stents are discussed.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"283-289"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Stenting of the extracranial internal carotid artery].","authors":"Ralf Langhoff","doi":"10.1007/s00108-025-01873-w","DOIUrl":"10.1007/s00108-025-01873-w","url":null,"abstract":"<p><p>The treatment of patients with stenosis of the internal carotid artery (ICA) is based on established guidelines, which includes both surgical and endovascular treatment options; however, the most recent advances, including the emergence of new endovascular treatment methods and techniques, combined with more recent clinical results, throw a new light on the optimal selection and treatment of patients in the current practice. This article deals with the most recent advances in the field of stenting of the extracranial internal carotid artery.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"274-282"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Distelmaier, Christian Gebhard, Antje Holzäpfel, Michael von Bergwelt-Baildon, Sebastian Theurich, Holger Cario, Karsten Spiekermann
{"title":"[Recurrent hemolysis and iron overload of unclear origin].","authors":"Laura Distelmaier, Christian Gebhard, Antje Holzäpfel, Michael von Bergwelt-Baildon, Sebastian Theurich, Holger Cario, Karsten Spiekermann","doi":"10.1007/s00108-024-01801-4","DOIUrl":"10.1007/s00108-024-01801-4","url":null,"abstract":"<p><p>The case of a 33-year-old male with recurrent icterus and hemolysis since childhood that was long mistaken for Gilbert disease is presented. Subsequently, the patient also developed splenomegaly and gallstones together with iron overload. Genetic testing revealed the diagnosis of hereditary xerocytosis, which is an erythrocyte membrane disorder causing recurrent hemolysis. Xerocytosis is often challenging to diagnose and the frequency of the condition might be underestimated as there are often no typical findings in the microscopic differential blood count, and Eosin-5-maleimide dye (EMA) test, which is used to diagnose other erythrocyte membrane disorders, is normal. In cases of splenomegaly, iron overload and recurrent hemolysis, or in the case of a clinical diagnosis of Gilbert disease together with one of the above-mentioned symptoms, further investigations and possibly also genetic testing should be considered.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":"328-330"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142360733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}