iMeta最新文献

{"title":"Decidual macrophage-mediated ferroptosis in trophoblasts leads to recurrent spontaneous abortion","authors":"Xin Chen,&nbsp;Xueqin Ma,&nbsp;Pengcheng Pang,&nbsp;Heng Zhou,&nbsp;Ruohan Li,&nbsp;Yan He,&nbsp;Yan Zhang,&nbsp;Jing Yang,&nbsp;Qianlin Song,&nbsp;Qingsong Ye","doi":"10.1002/imt2.70138","DOIUrl":"https://doi.org/10.1002/imt2.70138","url":null,"abstract":"<p>Recurrent spontaneous abortion (RSA) poses a significant challenge to successful early pregnancy, and trophoblast cell ferroptosis is an important pathogenic mechanism of RSA. However, it remains unclear whether decidual macrophages, as key immune regulators at the maternal–fetal interface, participate in the regulation of ferroptosis in trophoblast cells. This study observed significant ferroptosis in the placental trophoblast cells of patients with RSA and aborted mice. Transcriptomic sequencing results revealed that decidual macrophages derived from patients with RSA significantly promoted trophoblast cell ferroptosis while simultaneously impairing trophoblast cell function. Mechanistically, silencing heme oxygenase 1 (HMOX1) in trophoblast cells effectively reversed ferroptosis and restored trophoblast cell function, which was inhibited by decidual macrophages derived from patients with RSA. Notably, decidual macrophages regulate trophoblast ferroptosis and function by secreting C-X-C motif chemokine ligand 2 (CXCL2). Furthermore, the nuclear factor kappa-B (NF-κB) pathway was significantly enriched in trophoblast cells co-cultured with decidual macrophages derived from patients with RSA. Further reversal experiments indicated that the CXCL2/NF-κB/HMOX1 signaling axis may be a crucial mechanism by which decidual macrophages regulate trophoblast cell ferroptosis and function in RSA. Our subsequent findings demonstrated that trophoblast cells co-cultured with RSA-derived decidual macrophages promoted pro-inflammatory polarization in macrophages. This effect was mediated by the interleukin-6 (IL-6) deficiency-inhibited janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling axis. Finally, pharmacological analysis revealed Eriodictyol exhibits CXCL2-axis-associated protective effects in RSA. In conclusion, we observed that decidual macrophages in patients with RSA can induce ferroptosis in trophoblast cells, implying that targeting this mechanism may offer novel opportunities for reshaping maternal-fetal tolerance.</p>","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"5 3","pages":""},"PeriodicalIF":44.4,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/imt2.70138","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148533683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiviral defense systems drive persistence of antimicrobial-resistant bacteria but limit the transfer of antimicrobial resistance genes in anaerobic digestion","authors":"Junya Zhang,&nbsp;Tiedong Lu,&nbsp;Qihe Tang,&nbsp;Song-Can Chen,&nbsp;Daniel Rios Garza,&nbsp;Bin Liu,&nbsp;Yunwei Cui,&nbsp;Yuansong Wei,&nbsp;Hans Hermann Richnow","doi":"10.1002/imt2.70145","DOIUrl":"https://doi.org/10.1002/imt2.70145","url":null,"abstract":"<p>Phage–host interactions critically shape environmental antimicrobial resistance (AMR). Using swine manure anaerobic digestion and multi-omics (metagenomics, meta-transcriptomics, and Hi-C), we mapped the phage–bacteria arms race and its impact on AMR dynamics. We revealed that phage-mediated lysis overwhelmingly dominates transduction, while phages rarely carry antimicrobial resistance genes (ARGs), and phage-borne ARGs showed no expression, challenging the paradigm of phages as primary vectors of ARGs. Crucially, the intense on-going phage–host arms race drives the widespread presence and expression of antiviral defense systems (ADSs) in antimicrobial-resistant bacteria (ARB). These ADSs exhibit a vital ecological dual role: they protect ARBs from phage lysis promoting persistence while simultaneously suppressing horizontal gene transfer (HGT, e.g., conjugation), as validated by in vitro conjugation assays. Our findings elucidate this duality, offering a novel framework to harness phage lytic pressure and ADS-mediated HGT suppression for environmental AMR mitigation.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"5 3","pages":""},"PeriodicalIF":44.4,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/imt2.70145","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148522833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"5 2","pages":""},"PeriodicalIF":23.7,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148066841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"5 2","pages":""},"PeriodicalIF":23.7,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148063276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spinal cord injury induces acute microbiome shock and system-wide transcriptomic reprogramming.","authors":"Chi Zhang, Yufei Du, Mingxin Wu, Chuang Li, Ruizhi Jiang, Enlin Qi, Shaolong Li, Xianfu Yi, Bo Chu, Shiqing Feng, Hengxing Zhou","doi":"10.1002/imt2.70128","DOIUrl":"10.1002/imt2.70128","url":null,"abstract":"<p><p>This study investigates the systemic consequences of spinal cord injury (SCI), with a particular focus on alterations in the gut microbiome and multi-organ transcriptomic responses. We identify a rapid and severe disruption of the gut microbiota-termed \"microbiome shock\"-that emerges within 12 h post-SCI and persists before gradually resolving by 5 days post-injury. To support further research in this field, we established an open-access resource, the Spinal Cord Injury Gut Microbiome and Multi-Organ Gene Expression Atlas (SCIGAMA).</p>","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"5 2","pages":"e70128"},"PeriodicalIF":44.4,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FluNexus: A versatile web platform for antigenic prediction and visualization of influenza A viruses.","authors":"Xingyi Li, Chunyan Zhou, Han Wu, Kexin Xiao, Jun Hao, Dongmin Zhao, Guohua Deng, Yue Li, Jia Gu, Weigang Cai, Junnan Zhu, Jiajie Peng, Min Li, Yan Liu, Xuequn Shang, Hualan Chen, Huihui Kong","doi":"10.1002/imt2.70127","DOIUrl":"10.1002/imt2.70127","url":null,"abstract":"<p><p>FluNexus is a versatile platform for the antigenic prediction and visualization of influenza A viruses, including: (i) Online data preprocessing module. (ii) Online antigenic prediction module. (iii) Visualization module for mapping antigenic evolution.</p>","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"5 2","pages":"e70127"},"PeriodicalIF":44.4,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"5 2","pages":""},"PeriodicalIF":23.7,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148064156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial synthetic community ARC prevents aflatoxin and increases rhizobia-legume nodulation couplingly.","authors":"Qi Zhang, Tao Wang, Xiaoqian Tang, Xiaofeng Yue, Meijuan Liang, Xiaojun Zhang, Qin Han, Yang Zhou, Peiwu Li","doi":"10.1002/imt2.70125","DOIUrl":"10.1002/imt2.70125","url":null,"abstract":"<p><p>Develop a novel strategy for exploring a dual-functional microbial synthetic community. Invent the SynCom ARC, which achieves aflatoxin control and rhizobia nodulation induction coupling in peanut. SynCom ARC inhibits <i>A. flavu</i>s growth and reduces peanut aflatoxin levels by 85.6% in 4 year field trials. SynCom ARC enhances peanut nodulation and nitrogenase activity, retains active nodules at harvest, and boosts yield without super nodulation penalty in 325 sites of 19 provinces. SynCom ARC inhibits multiple targets in <i>A. flavus</i>, recruits and activates nodulation and nitrogen fixation in rhizobia and peanut, and improves photosynthesis and carbon supply for aflatoxin prevention and nodulation induction, balancing yield increase.</p>","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"5 2","pages":"e70125"},"PeriodicalIF":44.4,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"5 2","pages":""},"PeriodicalIF":23.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148095947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"5 2","pages":""},"PeriodicalIF":23.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148095948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}