IF 23.7

iMeta Pub Date : 2024-06-10 DOI: 10.1002/imt2.213

Yaohua Wei, Feng Shen, Huidong Song, Ruifang Zhao, Weiyue Feng, Yue Pan, Xiaobo Li, Huanling Yu, Giuseppe Familiari, Michela Relucenti, Michael Aschner, Hanping Shi, Rui Chen, Guangjun Nie, Hanqing Chen

引用次数: 0

Ms gene and Mr gene: Microbial-mediated spatiotemporal communication between plants Ms 基因和 Mr 基因：微生物介导的植物间时空交流

IF 23.7

iMeta Pub Date : 2024-06-07 DOI: 10.1002/imt2.210

Ming-Hao Lv, Wen-Chong Shi, Ming-Cong Li, Bo Zhou, Yong-Xin Liu, Zheng Gao

引用次数: 0

Robust CRISPR/Mb2Cas12a genome editing tools in cotton plants 棉花植物中强大的 CRISPR/Mb2Cas12a 基因组编辑工具

iMeta Pub Date : 2024-06-04 DOI: 10.1002/imt2.209

Fengjiao Hui, Xu Tang, Bo Li, Muna Alariqi, Zhongping Xu, Qingying Meng, Yongxue Hu, Guanying Wang, Yong Zhang, Xianlong Zhang, Shuangxia Jin

引用次数: 0

The feasibility of using pathobiome strains as live biotherapeutic products for human use 将病原生物菌株作为活体生物治疗产品供人类使用的可行性

iMeta Pub Date : 2024-05-26 DOI: 10.1002/imt2.202

Pengfei Jin, Xiong Lin, Wenfeng Xu, Kangning Li, Xiaoxiao Zhao, Sirui Guo, Zinan Zhao, Lujie Jiang, Feng Liao, Longgang Chang, Min Wang, Yanmin Liu, Shaolei Huang, Zhangran Chen, Fusui Ji

引用次数: 0

MASH-Ocean 1.0: Interactive platform for investigating microbial diversity, function, and biogeography with marine metagenomic data MASH-Ocean 1.0：利用海洋元基因组数据研究微生物多样性、功能和生物地理学的互动平台

iMeta Pub Date : 2024-05-19 DOI: 10.1002/imt2.201

Yinzhao Wang, Liuyang Li, Qiang Li, Yaoxun Hu, Wenjie Li, Zhile Wu, Hungchia Huang, Zhenbo Lv, Wan Liu, Ruifang Cao, Guoping Zhao, Fengping Wang, Guoqing Zhang

{"title":"MASH-Ocean 1.0: Interactive platform for investigating microbial diversity, function, and biogeography with marine metagenomic data","authors":"Yinzhao Wang, Liuyang Li, Qiang Li, Yaoxun Hu, Wenjie Li, Zhile Wu, Hungchia Huang, Zhenbo Lv, Wan Liu, Ruifang Cao, Guoping Zhao, Fengping Wang, Guoqing Zhang","doi":"10.1002/imt2.201","DOIUrl":"10.1002/imt2.201","url":null,"abstract":"A large number of oceanic metagenomic data and environmental metadata have been published. However, most studies focused on limited ecosystems using different analysis tools, making it challenging to integrate these data into robust results and comprehensive global understanding of marine microbiome. Here, we constructed a systematic and quantitative analysis platform, the Microbiome Atlas/Sino-Hydrosphere for Ocean Ecosystem (MASH-Ocean: https://www.biosino.org/mash-ocean/), by integrating global marine metagenomic data and a unified data processing flow. MASH-Ocean 1.0 comprises 2147 metagenomic samples with five analysis modules: sample view, diversity, function, biogeography, and interaction network. This platform provides convenient and stable support for researchers in microbiology, environmental science, and biogeochemistry, to ensure the integration of omics data generated from hydrosphere ecosystems, to bridge the gap between elusive omics data and biological, ecological, and geological discovery, ultimately to foster the formation of a comprehensive atlas for aquatic environments.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/imt2.201","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141123596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Duck gut metagenome reveals the microbiome signatures linked to intestinal regional, temporal development, and rearing condition 鸭肠道元基因组揭示了与肠道区域、时间发育和饲养条件相关的微生物组特征

IF 23.7

iMeta Pub Date : 2024-05-14 DOI: 10.1002/imt2.198

Lingyan Ma, Wentao Lyu, Tao Zeng, Wen Wang, Qu Chen, Jiangchao Zhao, Guolong Zhang, Lizhi Lu, Hua Yang, Yingping Xiao

{"title":"Duck gut metagenome reveals the microbiome signatures linked to intestinal regional, temporal development, and rearing condition","authors":"Lingyan Ma, Wentao Lyu, Tao Zeng, Wen Wang, Qu Chen, Jiangchao Zhao, Guolong Zhang, Lizhi Lu, Hua Yang, Yingping Xiao","doi":"10.1002/imt2.198","DOIUrl":"10.1002/imt2.198","url":null,"abstract":"The duck gastrointestinal tract (GIT) harbors an abundance of microorganisms that play an important role in duck health and production. Here, we constructed the first relatively comprehensive duck gut microbial gene catalog (24 million genes) and 4437 metagenome-assembled genomes using 375 GIT metagenomic samples from four different duck breeds across five intestinal segments under two distinct rearing conditions. We further characterized the intestinal region-specific microbial taxonomy and their assigned functions, as well as the temporal development and maturation of the duck gut microbiome. Our metagenomic analysis revealed the similarity within the microbiota of the foregut and hindgut compartments, but distinctive taxonomic and functional differences between distinct intestinal segments. In addition, we found a significant shift in the microbiota composition of newly hatched ducks (3 days), followed by increased diversity and enhanced stability across growth stages (14, 42, and 70 days), indicating that the intestinal microbiota develops into a relatively mature and stable community as the host duck matures. Comparing the impact of different rearing conditions (with and without water) on duck cecal microbiota communities and functions, we found that the bacterial capacity for lipopolysaccharide biosynthesis was significantly increased in ducks that had free access to water, leading to the accumulation of pathogenic bacteria and antibiotic-resistance genes. Taken together, our findings expand the understanding of the microbiome signatures linked to intestinal regional, temporal development, and rearing conditions in ducks, which highlight the significant impact of microbiota on poultry health and production.","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"3 4","pages":""},"PeriodicalIF":23.7,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/imt2.198","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140978338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding host immune responses in Clostridioides difficile infection: Implications for pathogenesis and immunotherapy 了解艰难梭菌感染中的宿主免疫反应：发病机制和免疫疗法的意义

iMeta Pub Date : 2024-05-11 DOI: 10.1002/imt2.200

Lamei Wang, Javier A. Villafuerte Gálvez, Christina Lee, Shengru Wu, Ciaran P. Kelly, Xinhua Chen, Yangchun Cao

{"title":"Understanding host immune responses in Clostridioides difficile infection: Implications for pathogenesis and immunotherapy","authors":"Lamei Wang, Javier A. Villafuerte Gálvez, Christina Lee, Shengru Wu, Ciaran P. Kelly, Xinhua Chen, Yangchun Cao","doi":"10.1002/imt2.200","DOIUrl":"10.1002/imt2.200","url":null,"abstract":"Clostridioides difficile (C. difficile) is the predominant causative agent of nosocomial diarrhea worldwide. Infection with C. difficile occurs due to the secretion of large glycosylating toxin proteins, which can lead to toxic megacolon or mortality in susceptible hosts. A critical aspect of C. difficile's biology is its ability to persist asymptomatically within the human host. Individuals harboring asymptomatic colonization or experiencing a single episode of C. difficile infection (CDI) without recurrence exhibit heightened immune responses compared to symptomatic counterparts. The significance of these immune responses cannot be overstated, as they play critical roles in the development, progression, prognosis, and outcomes of CDI. Nonetheless, our current comprehension of the immune responses implicated in CDI remains limited. Therefore, further investigation is imperative to elucidate their underlying mechanisms. This review explores recent advancements in comprehending CDI pathogenesis and how the host immune system response influences disease progression and severity, aiming to enhance our capacity to develop immunotherapy-based treatments for CDI.","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/imt2.200","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140989447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular disease therapeutics via engineered oral microbiota: Applications and perspective 通过工程化口腔微生物群治疗心血管疾病：应用与展望

iMeta Pub Date : 2024-05-09 DOI: 10.1002/imt2.197

Wenyu Zhen, Zifei Wang, Qing Wang, Wansu Sun, Rui Wang, Wenhao Zhang, Yulong Zhang, Wengang Qin, Bang Li, Qingqing Wang, Biao Hong, Yicheng Yang, Jing Xu, Siyu Ma, Ming Da, Linfei Feng, Xiaodong Zang, Xuming Mo, Xiaoyu Sun, Mingyue Wu, Junji Xu, Jianguang Xu, Yuan Huang, Hengguo Zhang

{"title":"Cardiovascular disease therapeutics via engineered oral microbiota: Applications and perspective","authors":"Wenyu Zhen, Zifei Wang, Qing Wang, Wansu Sun, Rui Wang, Wenhao Zhang, Yulong Zhang, Wengang Qin, Bang Li, Qingqing Wang, Biao Hong, Yicheng Yang, Jing Xu, Siyu Ma, Ming Da, Linfei Feng, Xiaodong Zang, Xuming Mo, Xiaoyu Sun, Mingyue Wu, Junji Xu, Jianguang Xu, Yuan Huang, Hengguo Zhang","doi":"10.1002/imt2.197","DOIUrl":"10.1002/imt2.197","url":null,"abstract":"Engineering bacteria are considered as a potential treatment for cardiovascular diseases and related risk factors. Oral bacteria are closely related to the occurrence and development of cardiovascular diseases, and their engineering has broad prospects and potential in the treatment of cardiovascular diseases. Oral pathogenic bacteria undergo protein and genetic engineering, including the incorporation of exogenous plasmids to yield therapeutic effects; genetically engineered oral probiotics can be harnessed to secrete cytokines and reactive oxygen species, offering novel therapeutic avenues for cardiovascular diseases.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/imt2.197","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140996777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new evaluation system for drug–microbiota interactions 药物与微生物群相互作用的新评估系统

iMeta Pub Date : 2024-05-07 DOI: 10.1002/imt2.199

Tian-Hao Liu, Chen-Yang Zhang, Hang Zhang, Jing Jin, Xue Li, Shi-Qiang Liang, Yu-Zheng Xue, Feng-Lai Yuan, Ya-Hong Zhou, Xiu-Wu Bian, Hong Wei

{"title":"A new evaluation system for drug–microbiota interactions","authors":"Tian-Hao Liu, Chen-Yang Zhang, Hang Zhang, Jing Jin, Xue Li, Shi-Qiang Liang, Yu-Zheng Xue, Feng-Lai Yuan, Ya-Hong Zhou, Xiu-Wu Bian, Hong Wei","doi":"10.1002/imt2.199","DOIUrl":"10.1002/imt2.199","url":null,"abstract":"The drug response phenotype is determined by a combination of genetic and environmental factors. The high clinical conversion failure rate of gene-targeted drugs might be attributed to the lack of emphasis on environmental factors and the inherent individual variability in drug response (IVDR). Current evidence suggests that environmental variables, rather than the disease itself, are the primary determinants of both gut microbiota composition and drug metabolism. Additionally, individual differences in gut microbiota create a unique metabolic environment that influences the in vivo processes underlying drug absorption, distribution, metabolism, and excretion (ADME). Here, we discuss how gut microbiota, shaped by both genetic and environmental factors, affects the host's ADME microenvironment within a new evaluation system for drug–microbiota interactions. Furthermore, we propose a new top-down research approach to investigate the intricate nature of drug–microbiota interactions in vivo. This approach utilizes germ-free animal models, providing foundation for the development of a new evaluation system for drug–microbiota interactions.","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/imt2.199","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141004407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal linoleic acid contributes to the protective effects of Akkermansia muciniphila against Listeria monocytogenes infection in mice 肠道亚油酸有助于提高Akkermansia muciniphila对小鼠李斯特菌感染的保护作用

iMeta Pub Date : 2024-04-27 DOI: 10.1002/imt2.196

Tong Jin, Yingying Zhang, Yanpeng Yang, Yue Teng, Chunhong Yan, Zhongguo Shan, Jianghong Meng, Xiaodong Xia

引用次数: 0

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