IJC metabolic & endocrine最新文献

{"title":"Short-term caloric restriction in db/db mice improves myocardial function and increases high molecular weight (HMW) adiponectin","authors":"X. Julia Xu ,&nbsp;Erma Babo ,&nbsp;Fuzhong Qin ,&nbsp;Dominique Croteau ,&nbsp;Wilson S. Colucci","doi":"10.1016/j.ijcme.2016.10.002","DOIUrl":"10.1016/j.ijcme.2016.10.002","url":null,"abstract":"<div><h3>Background</h3><p>Obesity and metabolic syndrome lead to the development of metabolic heart disease (MHD) that is characterized by left ventricular hypertrophy (LVH), diastolic dysfunction, and increased mitochondrial ROS. Caloric restriction (CR) is a nutritional intervention that protects against obesity, diabetes, and cardiovascular disease. Healthy adipose tissue is cardioprotective <em>via</em> releasing adipokines such as adiponectin. We tested the hypothesis that CR can ameliorate MHD and it is associated with improved adipose tissue function as reflected by increased circulating levels of high molecular weight (HMW) adiponectin and AMP-activated protein kinase (AMPK) in <em>db/db</em> mice.</p></div><div><h3>Methods</h3><p>Genetically obese <em>db/db</em> and lean <em>db/</em>+ male mice were fed either <em>ad libitum</em> or subjected to 30% CR for 5<!--> <!-->weeks. At the end of the study period, echocardiography was carried out to assess diastolic function. Blood, heart, and epididymal fat pads were harvested for mitochondrial study, ELISA, and Western blot analyses.</p></div><div><h3>Results</h3><p>CR reversed the development of LVH, prevented diastolic dysfunction, and decreased cardiac mitochondrial H₂O₂ in <em>db/db</em> (<em>vs. ad lib</em>) mice. These beneficial effects on the heart were associated with increased circulating level of HMW adiponectin. Furthermore, CR increased AMPK and eNOS activation in white adipose tissue of <em>db/db</em> mice, but not in the heart.</p></div><div><h3>Conclusions</h3><p>These findings indicate that even short-term CR protects the heart from MHD. Whether the beneficial effects of CR on the heart could be related to the improved adipose tissue function warrants future investigation.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"13 ","pages":"Pages 28-34"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.10.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75795953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Net cholesterol efflux capacity of HDL enriched serum and coronary atherosclerosis in rheumatoid arthritis","authors":"Michelle J. Ormseth ,&nbsp;Patricia G. Yancey ,&nbsp;Suguru Yamamoto ,&nbsp;Annette M. Oeser ,&nbsp;Tebeb Gebretsadik ,&nbsp;Ayumi Shintani ,&nbsp;MacRae F. Linton ,&nbsp;Sergio Fazio ,&nbsp;Sean S. Davies ,&nbsp;L. Jackson Roberts II ,&nbsp;Kasey C. Vickers ,&nbsp;Paolo Raggi ,&nbsp;Valentina Kon ,&nbsp;C. Michael Stein","doi":"10.1016/j.ijcme.2016.08.002","DOIUrl":"10.1016/j.ijcme.2016.08.002","url":null,"abstract":"<div><h3>Background/objectives</h3><p>Cardiovascular (CV) risk is increased in patients with rheumatoid arthritis (RA), but not fully explained by traditional risk factors such as LDL and HDL cholesterol concentrations. The cholesterol efflux capacity of HDL may be a better CV risk predictor than HDL concentrations. We hypothesized that HDL's cholesterol efflux capacity is impaired and inversely associated with coronary atherosclerosis in patients with RA.</p></div><div><h3>Methods</h3><p>We measured the net cholesterol efflux capacity of apolipoprotein B depleted serum and coronary artery calcium score in 134 patients with RA and 76 control subjects, frequency-matched for age, race and sex. The relationship between net cholesterol efflux capacity and coronary artery calcium score and other clinical variables of interest was assessed in patients with RA.</p></div><div><h3>Results</h3><p>Net cholesterol efflux capacity was similar among RA (median [IQR]: 34% removal [28, 41%]) and control subjects (35% removal [27%, 39%]) (P<!--> <!-->=<!--> <!-->0.73). In RA, increasing net cholesterol efflux capacity was not significantly associated with decreased coronary calcium score (OR<!--> <!-->=<!--> <!-->0.78 (95% CI 0.51–1.19), P<!--> <!-->=<!--> <!-->0.24, adjusted for age, race and sex, Framingham risk score and presence of diabetes). Net cholesterol efflux capacity was not significantly associated with RA disease activity score, C-reactive protein, urinary F₂-isoprostanes, or degree of insulin resistance in RA.</p></div><div><h3>Conclusions</h3><p>Net cholesterol efflux capacity is not significantly altered in patients with relatively well-controlled RA nor is it significantly associated with coronary artery calcium score.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"13 ","pages":"Pages 6-11"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.08.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34770093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Worsening of myocardial performance index in beta-thalassemia patients despite permanently normal iron load at MRI: A simple and cheap index reflecting cardiovascular involvement?","authors":"Umberto Barbero MD ,&nbsp;Filomena Longo MD ,&nbsp;Paola Destefanis MD ,&nbsp;Carmen Maria Gaglioti MD ,&nbsp;Roberto Pozzi MD ,&nbsp;Antonio Piga MD, Prof","doi":"10.1016/j.ijcme.2016.09.003","DOIUrl":"10.1016/j.ijcme.2016.09.003","url":null,"abstract":"<div><h3>Background</h3><p>Iron Overload Cardiomyopathy (IOC) due to repeated transfusions still represents the main cause of death in Thalassemia major (TM) patients. Because iron overload remains asymptomatic for long time, it is important to stratify the patients based on the risk of developing IOC before the appearance of clinical signs of heart failure. The magnetic resonance imaging (MRI) T2* may be useful but it is expensive and its MRI software has limited availability; conventional echocardiographic parameters, although easy availability, remain normal until advanced stages of IOC. Tissue Doppler Imaging (TDI) opened a new way to explore systolic and diastolic function directly or through derived index such as myocardial performance index (MPI) which has a prognostic value in different cardiomyopathies.</p></div><div><h3>Methods</h3><p>We enrolled 46 consecutive β-TM patients without clinical signs of heart failure and we tested them with echocardiography in 2011 and again in 2015. MPI of left and right ventricular lateral wall was calculated by TDI. All TM patients had a T2* MRI evaluation of the heart in the year before.</p></div><div><h3>Results</h3><p>Despite the absence of significant changes in morphological data at echo and at T2* evaluation, S′ waves of the lateral ventricular wall decrease while time passed, MPI worsened during the follow-up period and the derived systolic pulmonary artery systolic pressure (PAPs) increased in 2015 with respect to 2011.</p></div><div><h3>Conclusion</h3><p>TDI and MPI may reveal very early myocardial dysfunction in TM patients despite a normal T2* value. Together with PAPs they should be periodically checked in these patients.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"13 ","pages":"Pages 41-44"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.09.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90330941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is vitamin E supplementation effective in reducing mortality related to cardiovascular events in people with type 2 diabetes mellitus? A systematic review","authors":"Nirav Patel ,&nbsp;Payal Amin ,&nbsp;Abishek Shenoy","doi":"10.1016/j.ijcme.2016.06.003","DOIUrl":"10.1016/j.ijcme.2016.06.003","url":null,"abstract":"<div><h3>Objective</h3><p>To determine the effect of vitamin E in reducing cardiovascular mortality in diabetic patients.</p></div><div><h3>Data source</h3><p>Review of several English language primary studies published from 2004 to 2015.</p></div><div><h3>Outcome measured</h3><p>The primary outcomes measure by all studies included 30-day mortality due to congestive heart failure, myocardial infarction, stroke, and HDL function as it relates to cardiovascular outcomes. The secondary outcomes included hospitalization for CHF and coronary revascularization.</p></div><div><h3>Results</h3><p>Five Randomized, double-blind, placebo-controlled trials and 11 studies were used for this review. The study published by Jaxa-Chamiec et al. showed that vitamin E is beneficial along with vitamin C but is not effective when used alone. The study facilitated by Marchioli et al., showed that vitamin E supplementation is associated with a statistically non-significant (p<!--> <!-->=<!--> <!-->0.18) increased risk of developing CHF. Finally, a study by Milman et al. showed that vitamin E supplementation is beneficial compared with a placebo group. This was a recurring theme and common finding among the studies explored within the context of this review.</p></div><div><h3>Conclusions</h3><p>Although, two studies showed no benefit from vitamin E supplementation, the remaining studies demonstrated that vitamin E supplementation provided cardiovascular benefits in a specific diabetic subpopulation. The study population that derived a favorable outcome from vitamin E supplementation consisted of diabetic patients with the Hp 2–2 genotype. Hence, further studies should be conducted in diabetic populations with the Hp 2–2 genotype for identifying the definitive effects of vitamin E.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"12 ","pages":"Pages 42-45"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.06.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73205391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From bench to bedside: Chronic inflammation and cardiovascular risks","authors":"Angel López-Candales ,&nbsp;David Harris","doi":"10.1016/j.ijcme.2016.05.004","DOIUrl":"10.1016/j.ijcme.2016.05.004","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"12 ","pages":"Pages 1-2"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.05.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81129198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased body mass index is associated with ST elevation myocardial infarction occurrence under conditions of high environmental temperature","authors":"Hiroki Usuku MD, PhD ,&nbsp;Eiichiro Yamamoto MD, PhD ,&nbsp;Kazumasa Kurogi MD ,&nbsp;Yasuhiro Izumiya MD, PhD ,&nbsp;Kenichi Tsujita MD, PhD ,&nbsp;Megumi Yamamuro MD, PhD ,&nbsp;Sunao Kojima MD, PhD ,&nbsp;Hirofumi Soejima MD, PhD ,&nbsp;Koichi Kaikita MD, PhD ,&nbsp;Nobuyasu Yamamoto MD, PhD ,&nbsp;Seiji Hokimoto MD, PhD ,&nbsp;Katsuo Noda MD, PhD ,&nbsp;Hiroshige Yamabe MD, PhD ,&nbsp;Shuichi Oshima MD, PhD ,&nbsp;Hisao Ogawa MD, PhD","doi":"10.1016/j.ijcme.2016.07.001","DOIUrl":"10.1016/j.ijcme.2016.07.001","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"12 ","pages":"Pages 52-54"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.07.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90123321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Takotsubo syndrome – A close connection to the brain: A prospective study investigating neuropsychiatric traits","authors":"Kristina N. Mayer ,&nbsp;Jelena-Rima Ghadri ,&nbsp;Milosz Jaguszewski ,&nbsp;Frank Scherff ,&nbsp;Ardan M. Saguner ,&nbsp;Elycia Kazemian ,&nbsp;Christian R. Baumann ,&nbsp;Josef Jenewein ,&nbsp;Manos Tsakiris ,&nbsp;Thomas F. Lüscher ,&nbsp;Peter Brugger ,&nbsp;Christian Templin","doi":"10.1016/j.ijcme.2016.06.001","DOIUrl":"10.1016/j.ijcme.2016.06.001","url":null,"abstract":"<div><h3>Background</h3><p>Takotsubo syndrome (TTS) is frequently triggered by a stressful event. Overactivation of the sympathetic nervous system has been hypothesized as the underlying mechanism. In a prospective, cross-sectional, single center study we aimed to investigate neuropsychiatric traits in patients with TTS.</p></div><div><h3>Methods</h3><p>Twenty-six patients with TTS with a median latency of 17.5<!--> <!-->months from their index event underwent detailed medical examination, neuropsychologic examination, and Holter-ECG and were screened for psychiatric comorbidities, chronic stress and personality traits with questionnaires.</p></div><div><h3>Results</h3><p>38.5% (10/26) of patients suffered from a neurological disease, and 50.0% (13/26) from at least one mental disorder. In 23.1% (6/26) the hospital anxiety scale (HADS–A) was suspicious for an anxiety disorder. There was a high prevalence of left-handedness (19.2%; 5/26). Despite good performance in cognitive testing, 11 patients had an abnormal score in the fatigue severity scale. Recovery of cardiac function was documented, although symptoms in 69.2% of patients persisted. An increase in the root mean square of the successive differences (RMSSD) (p<!--> <!-->=<!--> <!-->0.01) was noted on the Holter-ECG.</p></div><div><h3>Conclusion</h3><p>The study highlights a high prevalence of psychiatric and neurologic comorbidities in patients with TTS, which so far have been under-diagnosed. Future studies will have to show whether these patients might benefit from a combined psychocardiologic rehabilitation.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"12 ","pages":"Pages 36-41"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.06.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83849404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial fibrosis pathology in Anderson–Fabry disease: Evaluation of autopsy cases in the long- and short-term enzyme replacement therapy, and non-therapy case","authors":"Teruaki Nagano ,&nbsp;Shin-ichi Nakatsuka ,&nbsp;Shigeki Fujita ,&nbsp;Takashi Kanda ,&nbsp;Masaaki Uematsu ,&nbsp;Yoshihiko Ikeda ,&nbsp;Hatsue Ishibashi-Ueda ,&nbsp;Chikao Yutani","doi":"10.1016/j.ijcme.2016.06.002","DOIUrl":"10.1016/j.ijcme.2016.06.002","url":null,"abstract":"<div><h3>Aims</h3><p>Enzyme replacement therapy (ERT) has been shown to be effective in the treatment of Anderson–Fabry disease (AFD). However, there have thus far been few reports on the histological findings of the heart in cases treated with ERT for more than 10<!--> <!-->years. We had an opportunity to examine the heart of an AFD patient that had received ERT for more than 10<!--> <!-->years, as well as those of two other patients, by autopsy, and compare the pathological findings.</p></div><div><h3>Methods and results</h3><p>Three AFD patients who had received ERT for different durations underwent autopsy. Marked left ventricular hypertrophy was observed in all three cases. The myocardial fibrosis of the patient that had been administered ERT for more than 10<!--> <!-->years was much slighter when compared with the remaining two cases. We further observed significant differences in globotriaosylceramide (Gb3) deposition and mitochondria in the cytoplasm of myocytes by electron microscopy.</p></div><div><h3>Conclusion</h3><p>ERT may not reduce left ventricular hypertrophy in AFD, but does prevent myocardial fibrosis when initiated before progression of fibrotic change.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"12 ","pages":"Pages 46-51"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.06.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81800933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes, hypertension, overweight and hyperlipidemia and 7-day case-fatality in first myocardial infarction","authors":"H.K. Quintana ,&nbsp;I. Janszky ,&nbsp;B. Gigante ,&nbsp;H. Druid ,&nbsp;A. Ahlbom ,&nbsp;J. Hallqvist ,&nbsp;U. de Faire ,&nbsp;K. Leander","doi":"10.1016/j.ijcme.2016.05.009","DOIUrl":"10.1016/j.ijcme.2016.05.009","url":null,"abstract":"<div><h3>Background</h3><p>Out-of-hospital deaths due to a first myocardial infarction (MI) are frequent and a big challenge for prevention. Increased knowledge about factors influencing MI fatality is needed. Metabolic risk factors have been studied in relation to MI fatality in-hospital but studies considering also out-of-hospital deaths are few.</p></div><div><h3>Aim</h3><p>To assess how diabetes and other metabolic risk factors associate with death within 7<!--> <!-->days after first time MI among subjects aged between 45 and 70 identified in Stockholm County 1992–1994.</p></div><div><h3>Methods</h3><p>Data were collected using questionnaires (close relatives of fatal cases were asked to fill the questionnaire), physical examinations, national registers and autopsy reports. Risk ratios (RR) of 7-day MI fatality with 95% confidence intervals (CI) associated with the risk factors under study were calculated using binomial regression with log link.</p></div><div><h3>Results</h3><p>Out of 1905 first time MI cases included, 524 died within 7<!--> <!-->days. After adjustments for age, sex, current smoking, education and general comorbidity, diabetes, but not hypertension and hyperlipidemia, was associated with MI fatality (RR 1.68, 95% CI 1.20–2.28). Overweight, as compared to normal BMI, was inversely associated with MI fatality (multiple adjusted RR 0.68, 95% CI 0.49–0.94); obesity results pointed in the same direction (multiple adjusted RR 0.79, 0.52–1.16).</p></div><div><h3>Conclusions</h3><p>In this population-based inception cohort study, diabetes but not hypertension and hyperlipidemia were associated with MI fatality. This further emphasizes the importance of diabetes as a cardiovascular risk factor and the need for close surveillance of diabetic patients. Overweight was however associated with decreased MI fatality.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"12 ","pages":"Pages 30-35"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.05.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86039580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between skeletal muscle and ventilatory response to exercise in myocardial infarction","authors":"Hideki Hayashi ,&nbsp;Kohji Iwai ,&nbsp;Ryo Tobita ,&nbsp;Tetsuya Matsumoto ,&nbsp;Minoru Horie","doi":"10.1016/j.ijcme.2016.05.007","DOIUrl":"10.1016/j.ijcme.2016.05.007","url":null,"abstract":"<div><h3>Background</h3><p>Skeletal muscle is important to determine physical activity and exercise capacity in cardiovascular disease. This study aims to investigate the relationship between skeletal muscle volume measured by bioelectrical impedance analysis and ventilation indices assessed by cardiopulmonary exercise test in patients with myocardial infarction.</p></div><div><h3>Methods</h3><p>A total of 60 patients (57 men; 59<!--> <!-->±<!--> <!-->9<!--> <!-->years) who underwent percutaneous coronary intervention for ST-elevation myocardial infarction were enrolled into this study. All patients performed cardiac rehabilitation and then achieved physical activity of daily life. No patient was complicated by diabetes mellitus. In symptom-limited cardiopulmonary exercise test, minute ventilation (<span><math><mover><mi>V</mi><mo>̇</mo></mover></math></span>E), oxygen consumption (<span><math><mover><mi>V</mi><mo>̇</mo></mover></math></span>O₂), and carbon dioxide production (<span><math><mover><mi>V</mi><mo>̇</mo></mover></math></span>CO₂) were continuously obtained. A volume of skeletal muscle measured by bioelectrical impedance analysis was normalized for height (skeletal muscle index).</p></div><div><h3>Results</h3><p>The skeletal muscle index showed a significant inverse correlation with peak <span><math><mover><mi>V</mi><mo>̇</mo></mover></math></span>E/<span><math><mover><mi>V</mi><mo>̇</mo></mover></math></span>O₂ (p<!--> <!-->=<!--> <!-->0.02, r<!--> <!-->=<!--> <!-->−<!--> <!-->0.39) and peak <span><math><mover><mi>V</mi><mo>̇</mo></mover></math></span>E/<span><math><mover><mi>V</mi><mo>̇</mo></mover></math></span>CO₂ (p<!--> <!-->=<!--> <!-->0.02, r<!--> <!-->=<!--> <!-->−<!--> <!-->0.30). In addition, the skeletal muscle index inversely correlated with <span><math><mover><mi>V</mi><mo>̇</mo></mover></math></span>E/<span><math><mover><mi>V</mi><mo>̇</mo></mover></math></span>CO2 slope (p<!--> <!-->=<!--> <!-->0.02, r<!--> <!-->=<!--> <!-->−<!--> <!-->0.30). On the other hand, the skeletal muscle index did not significantly correlate with peak <span><math><mover><mi>V</mi><mo>̇</mo></mover></math></span>O₂ (p<!--> <!-->=<!--> <!-->0.56, r<!--> <!-->=<!--> <!-->0.08) and peak <span><math><mover><mi>V</mi><mo>̇</mo></mover></math></span>CO₂ (p<!--> <!-->=<!--> <!-->0.99, r<!--> <!-->=<!--> <!-->0.001). Besides, the skeletal muscle index did not significantly correlate with Δ<span><math><mover><mi>V</mi><mo>̇</mo></mover></math></span>O₂/Δwork rate slope (p<!--> <!-->=<!--> <!-->0.60, r<!--> <!-->=<!--> <!-->0.07).</p></div><div><h3>Conclusions</h3><p>The increase in skeletal muscle index was associated with the amelioration of ventilatory efficacy to exercise at the peak level. Furthermore, the increase in skeletal muscle index may account for favorable prognosis. These findings could strengthen the role of skeletal muscle in exercise capacity of patients with m","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"12 ","pages":"Pages 14-18"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.05.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89223598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}