IJC metabolic & endocrine最新文献

{"title":"Pulmonary vein isolation in absence and presence of mild to moderate mitral valve regurgitation in patients with paroxysmal AF: A sub group analysis","authors":"Márcio Galindo Kiuchi , Shaojie Chen","doi":"10.1016/j.ijcme.2016.11.006","DOIUrl":"10.1016/j.ijcme.2016.11.006","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"14 ","pages":"Pages 6-8"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.11.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78244699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention of Adriamycin induced cardiotoxicity in rats — A comparative study with subacute angiotensin-converting enzyme inhibitor and nonselective beta blocker therapy","authors":"Ajay Godwin Potnuri ,&nbsp;Sundar Kumar Kondru ,&nbsp;Pavan Kumar Samudrala ,&nbsp;Lingesh Allakonda","doi":"10.1016/j.ijcme.2017.01.001","DOIUrl":"10.1016/j.ijcme.2017.01.001","url":null,"abstract":"<div><h3>Back ground</h3><p>Cardiotoxicity confines the usage of Adriamycin in clinical practice as it can develop cardiac impediments up to 10<!--> <!-->years after the termination of therapy. Even though, no specific therapeutic strategies are available for treating adriamycin-induced cardiotoxicity, beta-adrenergic blockers (βB) and angiotensin-converting enzyme (ACE) inhibitors are known to prevent its progression into failure. In this scenario, we attempted to compare the pharmacological outcome of sub-acute βB and ACE inhibitor treatments in preventing adriamycin-induced cardiotoxicity by analysing the differences between them.</p></div><div><h3>Methods</h3><p>Rats received a single bolus dose of adriamycin (10<!--> <!-->mg/kg) on day one and treated with either Carvedilol (10<!--> <!-->mg/kg) (CAR) or Captopril (50<!--> <!-->mg/kg) (CAP) once daily for 28<!--> <!-->days. Cardiac morphology, systolic and diastolic functions were evaluated by 2D trans-thoracic echocardiography. Cardiac Troponin and Ck MB levels were measured to analyse the myocyte damage. Myocardial lipid peroxidation, IL1β levels and caspase 3 activity were evaluated as the markers of oxidative stress, inflammation and apoptosis respectively.</p></div><div><h3>Results</h3><p>Both treatments had reduced the adriamycin induced cardiotoxicity. Whereas CAP treatment showed a better reduction of inflammation, superior preservation of posterior wall architecture and enhanced improvement in relative wall thickness when compared to CAR. Oxidative stress, caspase 3 activity and markers of myocyte damage were better recovered with CAR treatment while other parameters were found to be identically attenuated.</p></div><div><h3>Conclusion</h3><p>The present study found an identical therapeutic outcome from ACE inhibition and β blockade with a better attenuation of inflammation and structural preservation with ACE inhibition and superior antioxidant and antiapoptotic effect with βB treatment.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"14 ","pages":"Pages 59-64"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2017.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82913696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omeprazole and atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation in patients undergoing percutaneous coronary intervention in a tertiary health care system: A prospective drug–drug interaction study","authors":"Jinesh Bahubali Nagavi ,&nbsp;Bannimath Gurupadayya ,&nbsp;Preethi Gotadake Anantharaju","doi":"10.1016/j.ijcme.2016.09.004","DOIUrl":"10.1016/j.ijcme.2016.09.004","url":null,"abstract":"<div><h3>Background</h3><p>Clopidogrel, a prodrug is found to be less effective in inhibiting the platelet aggregation when administered along with PPI's in patients undergoing cardiac stent, ST segment elevated Myocardial infarction (STEMI) followed by percutaneous coronary intervention (PCI). Clopidogrel binds to CYP2C19, a hepatic enzyme to get converted to its active metabolite in order to achieve desired pharmacological activity. The cytochrome P450 3A4 which is partially involved in the metabolism of clopidogrel also metabolizes statins, mainly atorvastatin to the greater extent.</p></div><div><h3>Methodology</h3><p>In the current study patients on PPI's with dual antiplatelet therapy and patients on PPI's and statins with dual antiplatelet therapy are considered to understand the potential drug–drug interactions (pDDI) among the South Asian population. Platelet aggregation was measured in 61 patients undergoing coronary artery stent implantation treated with clopidogrel and aspirin along with PPI's and statins.</p></div><div><h3>Results</h3><p>It was observed that omeprazole and atorvastatin, but not pantoprazole and rosuvastatin, inhibited the antiplatelet activity of clopidogrel. The percent platelet aggregation was 72<!--> <!-->±<!--> <!-->6 (p<!--> <!-->=<!--> <!-->0.001) and 43<!--> <!-->±<!--> <!-->23 (p<!--> <!-->=<!--> <!-->0.027) in the presence of clopidogrel with omeprazole and pantoprazole respectively. Aggregation was found to be 91<!--> <!-->±<!--> <!-->4 (p<!--> <!-->=<!--> <!-->0.001) and 12<!--> <!-->±<!--> <!-->23 (p<!--> <!-->=<!--> <!-->0.031) in the presence of clopidogrel with atorvastatin and rosuvastatin respectively.</p></div><div><h3>Conclusion</h3><p>A prominent drug–drug interaction was observed with patients on dual antiplatelet therapy along with omeprazole and atorvastatin.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"13 ","pages":"Pages 35-40"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.09.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78722918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-invasive programmed stimulation vs. electrophysiological study in patients with pacemaker","authors":"Márcio Galindo Kiuchi ,&nbsp;Shaojie Chen","doi":"10.1016/j.ijcme.2016.10.001","DOIUrl":"10.1016/j.ijcme.2016.10.001","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"13 ","pages":"Pages 26-27"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.10.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73129288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary vein isolation alone and combined with renal sympathetic denervation in CKD patients with paroxysmal AF: A sub group analysis","authors":"Márcio Galindo Kiuchi ,&nbsp;Shaojie Chen","doi":"10.1016/j.ijcme.2016.09.002","DOIUrl":"10.1016/j.ijcme.2016.09.002","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"13 ","pages":"Pages 12-14"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.09.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80632641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrical left ventricular mapping in patients with and without CKD: Differences of voltage","authors":"Márcio Galindo Kiuchi ,&nbsp;Shaojie Chen","doi":"10.1016/j.ijcme.2016.09.005","DOIUrl":"10.1016/j.ijcme.2016.09.005","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"13 ","pages":"Pages 17-19"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.09.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82138631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aerobic exercise can ameliorate heart function in patients with myocardial infarction through up-regulating M3 receptor","authors":"Wang Chengji,&nbsp;Huang Shoujun","doi":"10.1016/j.ijcme.2016.08.001","DOIUrl":"10.1016/j.ijcme.2016.08.001","url":null,"abstract":"<div><p>Objective cardioprotective effect and mechanism of exercise training up-regulating the expression of M3 receptor on myocardial infarction. Methods 48 male Sprague-Dawley rats were randomly assigned to three groups (n<!--> <!-->=<!--> <!-->16, per group):control group (C), myocardial infarction group (MI), moderate-intensity aerobic exercise with myocardial infarction group (ME). Rats in C group were breed normally. MI was induced by ligation of the left anterior descending (LAD) coronary artery in MI group. Rats in ME group took treadmill exercise for 8<!--> <!-->weeks. after 1<!--> <!-->week post-operation. ME group running began at the speed of 10<!--> <!-->m/min for 5<!--> <!-->min, then accelerated from 3<!--> <!-->m/min to 16<!--> <!-->m/min. The total time of ME is 60<!--> <!-->min, 5<!--> <!-->d/week, for 8<!--> <!-->weeks. LVSP, LVEDP, ±<!--> <!-->dp/dtmax and the cardiac function changes were measured after training. Myocardial collagen fibers were observed histological section and Masson staining. The expression of myocardial M3 R was observed and analyzed by immunofluorescence. The myocardial protein content of M3 R, MEK_1/2,P-ERK_1/2,ERK_1/2 and apoptosis related Bcl-2 and Bax was assayed by Western blot. Results Compared with the C group, MI increased CVF and LVEDP (P<!--> <!-->˂<!--> <!-->0.01), but decreased LVSP and −<!--> <!-->dp/dtmax (P<!--> <!-->˂<!--> <!-->0.01). After MI myocardial M3 positive staining, after MI M3 protein expression significantly higher compared with the C group (P<!--> <!-->˂<!--> <!-->0.01), MEK_1/2,P-ERK_1/2/ERK_1/2 protein expression were significantly increased compared with the C group (P<!--> <!-->˂<!--> <!-->0.01, P<!--> <!-->˂<!--> <!-->0.01), after the MI the Bcl-2/Bax expression significantly reduced compared with the C group (P<!--> <!-->˂<!--> <!-->0.01). ME group CVF%, LVEDP significantly reduced compared with the MI group (P<!--> <!-->˂<!--> <!-->0.01), but −<!--> <!-->dp/dtmax significantly increased (P<!--> <!-->˂<!--> <!-->0.01). ME group was identified myocardial M3, compared with the MI group, M3 protein expression significantly increased (P<!--> <!-->˂<!--> <!-->0.01), but Bcl-2/Bax expression significantly reduced (P<!--> <!-->˂<!--> <!-->0.01). Conclusions moderate-intensity aerobic exercise can up-regulated the M3 R-MEK_1/2-ERK_1/2 signaling pathway, thus inhibit the apoptosis of myocardial cells, reduced myocardial interstitial fibrosis and promote cardiac function after MI.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"13 ","pages":"Pages 1-5"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.08.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80127341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of atrial fibrillation in patients with mild to severe obstructive sleep apnea and pacemakers","authors":"Márcio Galindo Kiuchi MD, MSc, PhD ,&nbsp;Shaojie Chen MD, PhD","doi":"10.1016/j.ijcme.2016.09.001","DOIUrl":"10.1016/j.ijcme.2016.09.001","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"13 ","pages":"Pages 15-16"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.09.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73822644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic impact of cardiac rehabilitation exercise on cardiac Fabry woman treated with enzyme replacement therapy","authors":"Hitomi Kitai ,&nbsp;Etsushi Kyuno ,&nbsp;Ayaka Nogi ,&nbsp;Hideyuki Maezawa ,&nbsp;Mio Ebato ,&nbsp;Takeyuki Sambe ,&nbsp;Hiroshi Suzuki ,&nbsp;Yoshitaka Iso","doi":"10.1016/j.ijcme.2016.09.007","DOIUrl":"10.1016/j.ijcme.2016.09.007","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"13 ","pages":"Pages 23-25"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.09.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88421620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When the first and the second renal sympathetic denervation in resistant hypertensive patients failure: What to do?","authors":"Márcio Galindo Kiuchi MD, PhD ,&nbsp;Shaojie Chen MD, PhD (Prof.) ,&nbsp;Helmut Pürerfellner MD, PhD","doi":"10.1016/j.ijcme.2016.09.006","DOIUrl":"10.1016/j.ijcme.2016.09.006","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"13 ","pages":"Pages 20-22"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.09.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88404571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}