IJC metabolic & endocrine最新文献

{"title":"Effects of dipeptidyl peptidase-4 inhibitor sitagliptin on coronary atherosclerosis as assessed by intravascular ultrasound in type 2 diabetes mellitus with coronary artery disease","authors":"Yuta Kato ,&nbsp;Atsushi Iwata ,&nbsp;Bo Zhang ,&nbsp;Shin-ichiro Miura ,&nbsp;Satoshi Imaizumi ,&nbsp;Takashi Kuwano ,&nbsp;Amane Ike ,&nbsp;Makoto Sugihara ,&nbsp;Hiroaki Nishikawa ,&nbsp;Shin'ichiro Yasunaga ,&nbsp;Keijiro Saku","doi":"10.1016/j.ijcme.2017.06.005","DOIUrl":"10.1016/j.ijcme.2017.06.005","url":null,"abstract":"<div><h3>Background</h3><p>It is unclear whether the addition of dipeptidyl peptidase-4 inhibitors (DPP4-I) to statins may cause coronary plaque regression in type 2 diabetes mellitus (T2DM) patients with coronary artery disease (CAD).</p></div><div><h3>Methods and results</h3><p>Seventy-five T2DM patients with CAD who underwent percutaneous coronary intervention under intravascular ultrasound (IVUS) guidance were randomized to receive DPP4-I sitagliptin (sitagliptin group) or not to receive DPP4-I (non-DPP4-I group) as an add-on treatment to statins, and were followed-up for 8–12<!--> <!-->months. Patients with analyzable IVUS examinations of the non-culprit segment were included in the primary analysis. Sitagliptin group (<em>n</em> <!-->=<!--> <!-->28) and non-DPP4-I group (<em>n</em> <!-->=<!--> <!-->24) had significant (<em>p</em> <!-->&lt;<!--> <!-->0.05) and similar reduction in low-density lipoprotein cholesterol levels (−<!--> <!-->12<!--> <!-->±<!--> <!-->24 and −<!--> <!-->12<!--> <!-->±<!--> <!-->23<!--> <!-->mg/dL), and had no significant changes in hemoglobin A_1c levels. Nominal change in percent atheroma volume (PAV), the primary endpoint, was not significant in both the sitagliptin and non-DPP4-I groups [mean (95% CI): +<!--> <!-->1.1% (−<!--> <!-->0.5 to 2.7%) and 0.2% (−<!--> <!-->1.5 to 1.9%)]. The difference in change in PAV between sitagliptin and non-DPP4-I groups was also not significant [0.89% (−<!--> <!-->1.46%–3.25%)].</p></div><div><h3>Conclusions</h3><p>The addition of sitagliptin to statins did not cause coronary plaque regression in T2DM with CAD.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"16 ","pages":"Pages 1-9"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2017.06.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83917338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Always think of medications","authors":"Babar Muhammad Munir","doi":"10.1016/j.ijcme.2017.06.008","DOIUrl":"10.1016/j.ijcme.2017.06.008","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"16 ","pages":"Page 15"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2017.06.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73712970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors for high incidence of premature ventricular contractions in chronic kidney disease patients","authors":"Márcio Galindo Kiuchi ,&nbsp;Shaojie Chen","doi":"10.1016/j.ijcme.2017.06.007","DOIUrl":"10.1016/j.ijcme.2017.06.007","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"16 ","pages":"Pages 21-23"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2017.06.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87148794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upgrade system device in use of new oral anticoagulants vs. antiplatelet agents","authors":"Márcio Galindo Kiuchi ,&nbsp;Shaojie Chen","doi":"10.1016/j.ijcme.2017.06.006","DOIUrl":"10.1016/j.ijcme.2017.06.006","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"16 ","pages":"Pages 10-11"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2017.06.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81286622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term follow-up of rivaroxaban use in Japanese patients with non-valvular atrial fibrillation","authors":"Makoto Suzuki ,&nbsp;Akira Mizukami ,&nbsp;Shunsuke Kuroda ,&nbsp;Maki Ohno ,&nbsp;Ryota Iwatsuka ,&nbsp;Akihiko Matsumura ,&nbsp;Yuji Hashimoto","doi":"10.1016/j.ijcme.2017.06.004","DOIUrl":"10.1016/j.ijcme.2017.06.004","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"16 ","pages":"Pages 12-14"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2017.06.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84176338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statins use and the risk of liver dysfunction: A Chinese cohort study in real world clinical practice","authors":"Ying Gao ,&nbsp;Yao Wang ,&nbsp;Na-Qiong Wu,&nbsp;Cheng-Gang Zhu,&nbsp;Yuan-Lin Guo,&nbsp;Ping Qing,&nbsp;Geng Liu,&nbsp;Qian Dong,&nbsp;Jian-Jun Li","doi":"10.1016/j.ijcme.2017.06.003","DOIUrl":"10.1016/j.ijcme.2017.06.003","url":null,"abstract":"<div><h3>Background</h3><p>The risk of liver injury is greatly of concern in China due to higher prevalence of hepatitis. In this study, we evaluated the association between the use of statins and the elevation of aminotransferase (ALT) in “real-world” clinical practice.</p></div><div><h3>Methods</h3><p>4489 patients were divided into statins group (62%) and no statins group (38%) according to their status of medications. Detections of ALT were performed within 24<!--> <!-->h after admission. The association of elevation of ALT and statins was analyzed.</p></div><div><h3>Results</h3><p>The percentage of patients with ALT<!--> <!-->&gt;<!--> <!-->1<!--> <!-->×<!--> <!-->ULN(Upper Limit of Normal), was higher in statins group than that in no statins group (OR<!--> <!-->=<!--> <!-->1.27, 95%CI 1.08–1.493), but after adjusting risk factors the OR value was 1.043(95%CI 0.851–1.278) with no statistical difference. Similarly, no differences were found regarding percentages of patients with ALT<!--> <!-->&gt;<!--> <!-->3<!--> <!-->×<!--> <!-->ULN. Types of statins were usual in clinical practice and dosages of statins used were moderate in &gt;<!--> <!-->90% of patient. We failed to find differences among the types and the dosage of statins except lovastatin. In addition, the relation of statin use duration to elevated ALT was evaluated. The higher proportion of elevated ALT in patients with stain use &lt;<!--> <!-->1<!--> <!-->month was detected compared those with stain use ≥<!--> <!-->3<!--> <!-->months (OR<!--> <!-->=<!--> <!-->1.408, 95%CI 1.111–1.783).</p></div><div><h3>Conclusion</h3><p>The data, firstly, provided two important information regarding the real status of liver dysfunction in Chinese patients who used moderate statins: 1) no relations between statin variety and ALT elevation; 2)statin-induced liver dysfunction frequently found in &lt;<!--> <!-->1<!--> <!-->month. Further study may be needed to confirm our findings.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"16 ","pages":"Pages 16-20"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2017.06.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83503905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crazy-paving pattern and hemoptysis: A case of congestive heart failure","authors":"Ashley Young, J. Maaskant","doi":"10.1016/J.IJCME.2017.06.002","DOIUrl":"https://doi.org/10.1016/J.IJCME.2017.06.002","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73548981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Beck's triad: A case report of cardiac tamponade in a “super-super” obese patient","authors":"Jian-dong Zhang, Yuxuan Mao","doi":"10.1016/J.IJCME.2017.03.001","DOIUrl":"https://doi.org/10.1016/J.IJCME.2017.03.001","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"75 1","pages":"4-5"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86026854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of vitamin D on the percentage time of cardiac resynchronization in patients with heart failure, premature ventricular complexes, and chronic kidney disease","authors":"M. G. Kiuchi, Luis Marcelo Rodrigues Paz, Shaojie Chen, N. Hoye","doi":"10.1016/J.IJCME.2017.06.001","DOIUrl":"https://doi.org/10.1016/J.IJCME.2017.06.001","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"20 1","pages":"6-9"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82405771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary vein reconnection in patients with and without CKD","authors":"M. G. Kiuchi, Shaojie Chen","doi":"10.1016/J.IJCME.2017.03.002","DOIUrl":"https://doi.org/10.1016/J.IJCME.2017.03.002","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"19 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74909008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}