IJC metabolic & endocrine最新文献

{"title":"Pulmonary vein reconnection in patients with and without CKD","authors":"Márcio Galindo Kiuchi , Shaojie Chen","doi":"10.1016/j.ijcme.2017.03.002","DOIUrl":"https://doi.org/10.1016/j.ijcme.2017.03.002","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"15 ","pages":"Pages 1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2017.03.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72257682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of vitamin D on the percentage time of cardiac resynchronization in patients with heart failure, premature ventricular complexes, and chronic kidney disease","authors":"Márcio Galindo Kiuchi ,&nbsp;Luis Marcelo Rodrigues Paz ,&nbsp;Shaojie Chen ,&nbsp;Neil Alexander Hoye","doi":"10.1016/j.ijcme.2017.06.001","DOIUrl":"https://doi.org/10.1016/j.ijcme.2017.06.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Recent studies have shown that in chronic kidney disease (CKD) 25(OH)D deficiency or insufficiency are a significant risk factor for cardiovascular diseases, sudden cardiac death and mortality. The high incidence of premature ventricular complexes (PVCs) have increasingly been recognized as a primary cause for worsening left ventricular systolic function and heart failure in some patients, specialty when these subjects are under optimal treatment and have implantable cardiac defibrillator (ICD) with cardiac resynchronization therapy (CRT), because the great amount of PVCs reduces the percentage of cardiac resynchronization.</p></div><div><h3>Aim</h3><p>Our aim was to evaluate the influence of reposition of cholecalciferol in patients with deficiency of vitamin D in the changes of the numbers of PVCs, and consequently in the percentage of cardiac resynchronization time, during 6<!--> <!-->months of follow-up.</p></div><div><h3>Methods and results</h3><p>We conducted a prospective, longitudinal study of 56 patients with high incidence of PVCs, heart failure under optimal treatment, ICD<!--> <!-->+<!--> <!-->CRT, deficiency of vitamin D (≤<!--> <!-->20<!--> <!-->ng/mL) and CKD (estimated glomerular filtration rate measured by MDRD equation, between 16 and 59<!--> <!-->mL/min/1.73<!--> <!-->m²). All patients were treated with cholecalciferol. We observed significant ameliorating after cholecalciferol onset in the number of PVCs, CRT % time, renal function, vitamin D levels and plasmatic ions at the 6th month of follow-up vs. baseline.</p></div><div><h3>Conclusions</h3><p>We suggest that the effectiveness of cholecalciferol reposition for subjects with high incidence of PVCs, heart failure under optimal treatment, ICD<!--> <!-->+<!--> <!-->CRT, deficiency of vitamin D and CKD, restoring the function of the CRT, bringing the biventricular pacing to nearby 97%.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"15 ","pages":"Pages 6-9"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2017.06.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72257681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Beck's triad: A case report of cardiac tamponade in a “super-super” obese patient","authors":"Jiandong Zhang,&nbsp;Yuxuan Mao","doi":"10.1016/j.ijcme.2017.03.001","DOIUrl":"https://doi.org/10.1016/j.ijcme.2017.03.001","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"15 ","pages":"Pages 4-5"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2017.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72257683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of admission blood glucose level in prediction of short-term course and extent of coronary artery occlusion in non-diabetic patients with ST segment elevation myocardial infarction","authors":"Tamer M. Moustafa","doi":"10.1016/j.ijcme.2016.11.004","DOIUrl":"10.1016/j.ijcme.2016.11.004","url":null,"abstract":"<div><h3>Objective</h3><p>Our aim was to determine the association between admission glucose level and short-term outcome and extent of coronary artery occlusion in non-diabetic patients with ST segment elevation myocardial infarction (STEMI).</p></div><div><h3>Methods</h3><p>250 consecutive patients were included in this study without known diabetes mellitus admitted with STEMI. Both glucose and HbA1c were measured on admission. All included patients had hemoglobin A (1c) less than 6.5%. In-hospital and 3 months' major cardiac events MACE (mortality, heart failure, arrhythmias, cardiogenic shock and recurrent ischemia) were documented. They were classified into two groups according to the admission mean glucose level (group A with glucose level<!--> <!-->≥<!--> <!-->160<!--> <!-->±<!--> <!-->52<!--> <!-->mg/dl and group B included those glucose level<!--> <!-->&lt;<!--> <!-->160<!--> <!-->±<!--> <!-->52<!--> <!-->mg/dl).</p></div><div><h3>Results</h3><p>Cardiac events were significantly higher in group A versus group-B (P<!--> <!-->&lt;<!--> <!-->0.001). In-hospital and 3-month mortality was higher in group-A than group-B patients (p<!--> <!-->&lt;<!--> <!-->0.01). Elevated admission glucose was associated with larger infarct size (P<!--> <!-->&lt;<!--> <!-->0.002). The prevalence of coronary lesions and the multi-vessels disease was significantly higher in group-A versus group-B patients (P<!--> <!-->&lt;<!--> <!-->0.01). After multivariate analysis, glucose level was independently associated with short-term mortality, and MACE (OR<!--> <!-->=<!--> <!-->6.9; P<!--> <!-->&lt;<!--> <!-->0.03 and 2.4; P<!--> <!-->&lt;<!--> <!-->0.02, respectively). ROC analysis showed that the admission blood glucose level of 160<!--> <!-->mg/dl is an independent cut-off value (AUC<!--> <!-->=<!--> <!-->0.68; p<!--> <!-->&lt;<!--> <!-->0.001) in prediction of outcome of non-diabetic patients presented with STEMI.</p></div><div><h3>Conclusions</h3><p>In non-diabetic patients presented with STEMI, elevated admission glucose level was associated with adverse outcome and more severe multi-vessel coronary lesions. The cut-off value was &gt;<!--> <!-->160<!--> <!-->mg/dl and was considered an independent factor in prediction of outcome of non-diabetics presented with SEMI. Measurement of admission blood glucose level enables identification of this high-risk group for aggressive secondary risk prevention.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"14 ","pages":"Pages 16-20"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.11.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88668576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homozygous familiar hypercholesterolemia in China: Case series from the national lipid clinics and literature review","authors":"Cheng-Gang Zhu ,&nbsp;Sha Li ,&nbsp;Zhi-Fu Wang ,&nbsp;Kun-Lun Yin ,&nbsp;Na-Qiong Wu ,&nbsp;Yuan-Lin Guo ,&nbsp;Ying Gao ,&nbsp;Xiao-Lin Li ,&nbsp;Ping Qing ,&nbsp;Geng Liu ,&nbsp;Qian Dong ,&nbsp;Zhou Zhou ,&nbsp;Jian-Jun Li","doi":"10.1016/j.ijcme.2017.01.004","DOIUrl":"10.1016/j.ijcme.2017.01.004","url":null,"abstract":"<div><h3>Objective</h3><p>Familial hypercholesterolemia (FH), an autosomal dominant genetic disorder, is often diagnosed in young age and cholesterol accumulation in tissues produces common clinical manifestations including cutaneous xanthomas, premature atherosclerosis, and poor response to medical therapy. The main objective was to investigate the patients of hoFH from China.</p></div><div><h3>Patients</h3><p>Over the past 4<!--> <!-->years, a cohort of 8 patients with severe FH phenotype due to the characteristic cutaneous xanthomas and extremely high low density lipoprotein cholesterol (LDL-C) levels from the national lipid clinics were enrolled. Genotype information was obtained.</p></div><div><h3>Results</h3><p>Of them, 7 patients had severe coronary atherosclerosis, 6 had family history of hypercholesterolemia, 2 had family history of premature coronary atherosclerosis. The patients had untreated LDL-C of &gt;<!--> <!-->13<!--> <!-->mmol/L, and received maximal medical therapy. Importantly but not surprisingly, the lipid profile was not significantly improved by the current available concomitant use of rosuvastatin and ezetimibe. In genetic analysis, all patients had the mutations responsible to the FH phenotype and showed to be more heterogeneous than their clinical phenotype.</p></div><div><h3>Conclusion</h3><p>In a conclusion, we found a relatively common recruitment of this type of patients in our hospital, which might have an important clinical implication for the identification and management of the patients with FH in China.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"14 ","pages":"Pages 75-80"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2017.01.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75194125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of renal sympathetic denervation on heart rate variability in uncontrolled hypertensive patients with chronic kidney disease","authors":"Márcio Galindo Kiuchi ,&nbsp;Shaojie Chen ,&nbsp;Neil Alexander Hoye","doi":"10.1016/j.ijcme.2016.11.010","DOIUrl":"10.1016/j.ijcme.2016.11.010","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"14 ","pages":"Pages 29-32"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.11.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88768978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement of renal function after renal sympathetic denervation vs. deterioration of renal function in CKD patients with uncontrolled hypertension","authors":"Márcio Galindo Kiuchi ,&nbsp;Shaojie Chen","doi":"10.1016/j.ijcme.2016.11.008","DOIUrl":"10.1016/j.ijcme.2016.11.008","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"14 ","pages":"Pages 38-39"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.11.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84553638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-density lipoprotein cholesterol lowering by adding ezetimibe to statin is associated with improvement of postprandial hyperlipidemia in diabetic patients with coronary artery disease","authors":"Akihiro Nakamura ,&nbsp;Shoko Kajitani ,&nbsp;Yuto Monma ,&nbsp;Kenjiro Sato ,&nbsp;Yosuke Terui ,&nbsp;Masanori Kanazawa ,&nbsp;Kazuki Noda ,&nbsp;Hideaki Endo ,&nbsp;Tohru Takahashi ,&nbsp;Eiji Nozaki","doi":"10.1016/j.ijcme.2016.11.001","DOIUrl":"10.1016/j.ijcme.2016.11.001","url":null,"abstract":"<div><h3>Objective and methods</h3><p>We investigated the hypothesis that serum low-density lipoprotein cholesterol (LDL-C) reduction by ezetimibe is associated with the improvement in postprandial hyperlipidemia by performing an oral fat loading test before and 24<!--> <!-->weeks after ezetimibe treatment in diabetic (n<!--> <!-->=<!--> <!-->29) and non-diabetic (n<!--> <!-->=<!--> <!-->30) male patients with coronary artery disease (CAD).</p></div><div><h3>Results</h3><p>Serum LDL-C levels were significantly reduced by ezetimibe in both groups (diabetic, from 120.3<!--> <!-->±<!--> <!-->39.4 to 79.5<!--> <!-->±<!--> <!-->23.2<!--> <!-->mg/dL, p<!--> <!-->&lt;<!--> <!-->0.001; non-diabetic, from 98.2<!--> <!-->±<!--> <!-->41.7 to 76.7<!--> <!-->±<!--> <!-->29.2<!--> <!-->mg/dL, p<!--> <!-->&lt;<!--> <!-->0.001), and the mean reduction in serum LDL-C was greater in diabetic than non-diabetic patients (−<!--> <!-->32.0 vs. −<!--> <!-->19.0%, p<!--> <!-->=<!--> <!-->0.004). The area under the curve (AUC) for triglyceride (TG) and remnant-like particle cholesterol (RLP-C) decreased significantly in both groups. When compared with the reduction before and after treatment in AUC of TG (∆<!--> <!-->AUC_{0–6<!--> <!-->h} TG) and RLP-C (∆<!--> <!-->AUC_{0–6<!--> <!-->h} RLP-C), they were significantly greater in diabetic than non-diabetic patients (∆<!--> <!-->AUC_0–6h TG, −<!--> <!-->28.9 vs. −<!--> <!-->12.2%, p<!--> <!-->=<!--> <!-->0.028; ∆<!--> <!-->AUC_0–6h RLP-C, −<!--> <!-->27.8 vs. −<!--> <!-->12.3%, p<!--> <!-->=<!--> <!-->0.007). In diabetic patients, ∆<!--> <!-->AUC_{0–6<!--> <!-->h} TG and ∆<!--> <!-->AUC_{0–6<!--> <!-->h} RLP-C in the highest tertile of serum LDL-C reduction were significantly greater than those in the lowest tertile (∆<!--> <!-->AUC_0-6h TG, −<!--> <!-->34.1 vs. −<!--> <!-->20.9%, p<!--> <!-->=<!--> <!-->0.012; ∆<!--> <!-->AUC_0-6h RLP-C, −<!--> <!-->34.5 vs. −<!--> <!-->15.1%, p<!--> <!-->=<!--> <!-->0.024).</p></div><div><h3>Conclusions</h3><p>These findings suggest that serum LDL-C reduction by ezetimibe might be associated with the improvement of postprandial hyperlipidemia in diabetic patients with CAD.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"14 ","pages":"Pages 9-15"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79542206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of vitamin D levels on the treatment of premature ventricular complexes in patients with chronic kidney disease","authors":"Márcio Galindo Kiuchi ,&nbsp;Gustavo Ramalho e Silva ,&nbsp;Luis Marcelo Rodrigues Paz ,&nbsp;Shaojie Chen ,&nbsp;Neil Alexander Hoye ,&nbsp;Gladyston Luiz Lima Souto","doi":"10.1016/j.ijcme.2017.01.002","DOIUrl":"10.1016/j.ijcme.2017.01.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Recent studies have shown that in chronic kidney disease (CKD) 25(OH)D deficiency or insufficiency is a significant risk factor for cardiovascular diseases (CVDs), sudden cardiac death (SCD) and mortality. Premature ventricular complexes (PVCs) are very common in patients with CKD, hypertension, obesity, sleep apnea, and structural heart disease. Often PVCs in the structurally normal heart are considered benign, although they seem to be associated with a more than two-fold higher risk of cardiovascular complications, including stroke disease and death.</p></div><div><h3>Aim</h3><p>In the present study we aimed to evaluate the influence of different 25(OH)D levels on the changes of the numbers of PVCs in all patients, assessed by 24-hour-Holter monitoring 3<!--> <!-->months after β-blocker onset.</p></div><div><h3>Methods and results</h3><p>We conducted a prospective, longitudinal study of 824 patients with PVCs and CKD (estimated glomerular filtration rate measured by MDRD equation, between 16 and 59<!--> <!-->mL/min/1.73<!--> <!-->m²). All patients were treated with a β-blocker (bisoprolol 10<!--> <!-->mg daily). We observed that the 3 groups presented a significant decrease in the number of PVCs from baseline 26,091<!--> <!-->±<!--> <!-->3327 (25(OH)D deficiency group), 25,902<!--> <!-->±<!--> <!-->3501 (25(OH)D insufficiency group), and 25,554<!--> <!-->±<!--> <!-->3637 (25(OH)D sufficiency group) to 20,554<!--> <!-->±<!--> <!-->3782, 19,885<!--> <!-->±<!--> <!-->3945 and 15,433<!--> <!-->±<!--> <!-->4059, respectively, after 3<!--> <!-->months of β-blocker therapy (<em>P</em> <!-->&lt;<!--> <!-->0.0001 for the comparisons between time points in the same group). However at the 3rd month after bisoprolol onset, comparisons between 25(OH)D deficiency <em>vs.</em> 25(OH)D sufficiency groups showed a mean difference of 5121 PVCs (<em>P</em> <!-->&lt;<!--> <!-->0.0001), and comparisons between 25(OH)D insufficiency <em>vs.</em> 25(OH)D sufficiency groups showed a mean difference of 4452 PVCs (<em>P</em> <!-->&lt;<!--> <!-->0.0001). No difference was observed between 25(OH)D deficiency <em>vs.</em> 25(OH)D insufficiency groups (<em>P</em> <!-->=<!--> <!-->0.3181).</p></div><div><h3>Conclusions</h3><p>We suggest that the effectiveness of β-blocker treatment for PVCs in CKD patients was observed in all 25(OH)D levels. However, the responsiveness was higher in patients with a normal range of 25(OH)D in comparison to patients with deficiency or insufficiency in 25(OH)D levels. Whether vitamin D supplementation increases the efficacy of beta-blocker mediated suppression of PVCs requires further evaluation.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"14 ","pages":"Pages 53-58"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2017.01.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84492864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of new oral anticoagulants in mild to moderate CKD patients with atrial fibrillation","authors":"Márcio Galindo Kiuchi ,&nbsp;Shaojie Chen","doi":"10.1016/j.ijcme.2016.11.009","DOIUrl":"10.1016/j.ijcme.2016.11.009","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"14 ","pages":"Pages 26-28"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.11.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75051829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}