IJC metabolic & endocrine最新文献

{"title":"Inspiratory muscle weakness in patients with Chagas heart disease: Echocardiographic and functional predictors","authors":"Henrique S. Costa ,&nbsp;Marcia Maria O. Lima ,&nbsp;Maria Carmo P. Nunes ,&nbsp;Giovane Rodrigo Sousa ,&nbsp;Fernanda R. de Almeida ,&nbsp;Pedro Henrique S. Figueiredo ,&nbsp;Manoel Otavio C. Rocha","doi":"10.1016/j.ijcme.2016.11.007","DOIUrl":"10.1016/j.ijcme.2016.11.007","url":null,"abstract":"<div><h3>Background</h3><p>Patients with Chagas heart disease (CHD) usually present progressive fatigue and dyspnea. The inspiratory muscle weakness (IMW) may be a marker of exercise intolerance during disease progression. However, the factors related to IMW in CHD patients still remain unknown.</p></div><div><h3>Methods</h3><p>Forty-eight CHD patients aged 56.4 (53.3–59.5) years were selected and underwent respiratory muscle strength, echocardiography, Cardiopulmonary Exercise Testing and International Physical Activity Questionnaire (IPAQ). The sample was stratified according to the percentage (%) of maximum inspiratory pressure (MIP) achieved in preserved muscle strength (MIP<!--> <!-->&gt;<!--> <!-->70%) or IMW (MIP<!--> <!-->≤<!--> <!-->70%). Chi-square and Poisson regression analysis was performed to verify the predictors of IMW.</p></div><div><h3>Results</h3><p>The %MIP predicted correlated with left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVDd) and minute ventilation-carbon dioxide production slope (VE/VCO₂ slope). Significant differences in the IPAQ scores (p<!--> <!-->=<!--> <!-->0.036), LVEF (p<!--> <!-->=<!--> <!-->0.020) and VE/VCO₂ slope (p<!--> <!-->=<!--> <!-->0.008) were found between groups with preserved inspiratory muscle strength and with IMW. In multivariate analysis, sedentary patients and those with reduced LVEF and impaired VE/VCO₂ slope had 6.3, 5.5 and 1.2-fold increased risk for IMW, respectively.</p></div><div><h3>Conclusion</h3><p>The sedentary lifestyle, reduced LVEF and impaired VE/VCO₂ slope showed to be independent predictors of IMW, probably by the association between these variables and the presence of inflammation in CHD patients. The detection of IMW may be helpful in identifying patients at high risk based on echocardiographic and functional aspects without much operating costs.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"14 ","pages":"Pages 21-25"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.11.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76157332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of oxygen on the outcomes of non-ST-segment elevation acute coronary syndromes","authors":"Fatemeh Heidari ,&nbsp;Kobra Rahzani ,&nbsp;Daryoush Iranpoor ,&nbsp;Korosh Rezaee","doi":"10.1016/j.ijcme.2016.12.002","DOIUrl":"10.1016/j.ijcme.2016.12.002","url":null,"abstract":"<div><h3>Background</h3><p>This study aims to investigate the effect of oxygen in patients with non-ST-segment elevation acute coronary syndromes(NSTE-ACS) and those without hypoxia.</p></div><div><h3>Methods</h3><p>In this clinical trial, the study population includes 72 patients (41 men and 31 women) aged 18 to 84<!--> <!-->years old who were admitted to the emergency ward, diagnosed with NSTE-ACS, and had oxygen saturation level above 90% at the time of admission. By using the random sampling methods, the patients were divided into two groups: the intervention group (36) and the control group (36). In addition to the usual treatment in the first 6<!--> <!-->h of admission to the emergency ward, the subjects in the intervention group received oxygen with nasal cannula at a rate of 4 to 6<!--> <!-->l per minute, whereas the control group was given the same treatment with room air. Then we compared the incidence of some outcomes in the two groups.</p></div><div><h3>Results</h3><p>The Mann–Whitney <em>U</em> test indicated no significant difference between the means of dysrhythmia (<em>p</em> <!-->=<!--> <!-->0.141) during the first 24<!--> <!-->h, troponin (<em>p</em> <!-->=<!--> <!-->0.911), left ventricular ejection fraction (<em>p</em> <!-->=<!--> <!-->0.419), frequency of angina (<em>p</em> <!-->=<!--> <!-->0.214), and consumption of opioid analgesics (<em>p</em> <!-->=<!--> <!-->0.297) during the second 24<!--> <!-->h and duration of hospitalization (<em>p</em> <!-->=<!--> <!-->0.887).</p></div><div><h3>Conclusion</h3><p>The use of supplemental oxygen (FiO₂: 40–45%) has no significant impact on clinical outcomes in patients with NSTE-ACS without hypoxia. Therefore, it is recommended that its routine use in patients without hypoxia be limited.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"14 ","pages":"Pages 67-71"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.12.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79043095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autophagy, dysglycemia and myocardial infarction","authors":"Tian Xiao-Fang ,&nbsp;Yang Shi-Wei ,&nbsp;Zhou Yu-Jie","doi":"10.1016/j.ijcme.2016.12.001","DOIUrl":"10.1016/j.ijcme.2016.12.001","url":null,"abstract":"<div><p>Autophagy has been thought as a novel cell death mechanism involving in the pathophysiological process of myocardial infarction (MI), and modulation of autophagy may be considered as a promising treatment modality for MI. Dysglycemia was associated with higher mortality in patients with MI. We hypothesize that autophagy may be a potential pathway through which dysglycemia has an impact on the outcomes of MI. In this review, we summarize the function of autophagy in the conditions of MI and the regulatory effects of dysglycemia on autophagy. Four main impacts of autophagy on MI under dysglycemia have been revealed. The first one is that autophagy limits the infarct size via inhibited mTOR. The second one is that autophagy promotes the survival of cardiomyocytes through depleted ATP. The third one is that autophagy protects cardiac myocytes from imparing by way of degradation. The last one is that autophagy maintenance of LV function through FoxO1. Therefore, the ability to modulate autophagy may represent as a potential and promising therapeutic strategy in limiting MI caused by dysglycemia. However, elucidation of precise ways of autophagy in mediating MI caused by dysglycemia, as well as when and how autophagy is manipulated remains us to research.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"14 ","pages":"Pages 40-44"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.12.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87947198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal nervous stimulation vs. electrophysiological study in controlled hypertensive patients with systolic dysfunction and chronic kidney disease","authors":"Márcio Galindo Kiuchi ,&nbsp;Shaojie Chen","doi":"10.1016/j.ijcme.2016.12.003","DOIUrl":"10.1016/j.ijcme.2016.12.003","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"14 ","pages":"Pages 45-47"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.12.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84921280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of standard treatment and renal sympathetic denervation in patients with controlled hypertension and variant angina","authors":"Márcio Galindo Kiuchi ,&nbsp;Shaojie Chen","doi":"10.1016/j.ijcme.2017.01.006","DOIUrl":"10.1016/j.ijcme.2017.01.006","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"14 ","pages":"Pages 81-83"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2017.01.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83724020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statins usage and target achievement of LDL-C level in Chinese patients with coronary artery disease impacted by 2013 ACC/AHA cholesterol guideline","authors":"Na-Qiong Wu ,&nbsp;Yuan-Lin Guo ,&nbsp;Ping Ye ,&nbsp;Hong Chen ,&nbsp;Yan-Fang Li ,&nbsp;Qi Hua ,&nbsp;Cheng-Gang Zhu ,&nbsp;Ying Gao ,&nbsp;Ping Qing ,&nbsp;Xiao-Lin Li ,&nbsp;Yao Wang ,&nbsp;Geng Liu ,&nbsp;Qian Dong ,&nbsp;Jian-Jun Li","doi":"10.1016/j.ijcme.2016.11.002","DOIUrl":"10.1016/j.ijcme.2016.11.002","url":null,"abstract":"<div><h3>Background</h3><p>Hypercholesterolemia is the accepted causal risk factor for atherosclerotic cardiovascular disease (ASCVD). 2013 ACC/AHA guideline on the treatment of cholesterol advised to tailor high-intensity statin for patients with coronary artery disease (CAD). However, its impact of real clinical practice has not been examined in China.</p></div><div><h3>Methods</h3><p>In this cross-sectional study, 3592 patients with CAD were consecutively enrolled who were receiving statins in outpatient department (at least 4<!--> <!-->weeks) before they were admitted to the ward at five University hospitals from April 2011 to December 2015. Patients were divided into two groups according to the admission time before (group A, n<!--> <!-->=<!--> <!-->1521) or after (group B, n<!--> <!-->=<!--> <!-->2071) online announcement date of 2013 ACC/AHA guideline. The situation of statin application and LDL-C target achievement (LDL-C<!--> <!-->&lt;<!--> <!-->1.8<!--> <!-->mmol/L) in both groups were compared.</p></div><div><h3>Results</h3><p>Data indicated that the constituent ratio of different kinds of statins usage was significantly different between the two groups (p<!--> <!-->&lt;<!--> <!-->0.05), and the proportion of rosuvastatin application grew up in group B (20.00%) when compared with group A (10.50%, p<!--> <!-->&lt;<!--> <!-->0.05). However, the mean dosage of atorvastatin or rosuvastatin had no significant change. More importantly, the achievement of LDL-C target in both groups was still extremely low (27.9% in group A vs. 26.9% in group B, p<!--> <!-->=<!--> <!-->0.5077).</p></div><div><h3>Conclusion</h3><p>No much change of clinical practice with regard to cholesterol management was found in Chinese patients with CAD, accompanied by very low achievement of LDL-C target, suggesting that there is a great room for the improvement of cholesterol control in Chinese patients with CAD.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"14 ","pages":"Pages 33-37"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.11.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90872118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atrial electromechanical delay, and left ventricular strain in pre-diabetic patients","authors":"Ragab A. Mahfouz MD,&nbsp;Tamer M. Moustafa MD,&nbsp;Mohamed Goda MD,&nbsp;Marwa Gad MD","doi":"10.1016/j.ijcme.2016.11.003","DOIUrl":"10.1016/j.ijcme.2016.11.003","url":null,"abstract":"<div><h3>Objectives</h3><p>The aim of this study was to investigate the subclinical myocardial affection in prediabetics with the evaluation of left ventricular (LV) systolic strain and strain rate by speckle tracking echocardiography (STE), and atrial electromechanical delay.</p></div><div><h3>Study design</h3><p>Global Longitudinal strain (GLS) and strain rate (GLSR) were assessed by STE, and Intra- and interatrial electromechanical delay (EMD) were measured utilizing tissue Doppler imaging (TDI) in 108 pre-diabetic patients and 72 age and gender matched healthy volunteers.</p></div><div><h3>Results</h3><p>The GLS (−<!--> <!-->19.4<!--> <!-->±<!--> <!-->2.8 vs. 23.8<!--> <!-->±<!--> <!-->2.1%; p<!--> <!-->&lt;<!--> <!-->0.001) and GLSR () were significantly lower in prediabetics when compared with the healthy control. Pre-diabetic patients had significantly prolonged PA lateral, PA septum and PA tricuspid. The intra- (PA septum-PA tricuspid) and interatrial (PA lateral-PA tricuspid) electromechanical delays were prolonged compared to controls (p<!--> <!-->&lt;<!--> <!-->0.0001, p<!--> <!-->&lt;<!--> <!-->0.05, p<!--> <!-->&lt;<!--> <!-->0.001, and p<!--> <!-->&lt;<!--> <!-->0.002, respectively). The GLS%, GLSR and atrial electromechanical delay were highly significantly correlated with fasting blood glucose, and modestly correlated to systolic blood pressure, total cholesterol, triglycerides, and left ventricular mass index.</p></div><div><h3>Conclusion</h3><p>GLS%; GLSR assessed by STE was decreased; intra- and interatrial electromechanical delays were prolonged, in pre-diabetic subjects. These non-invasive indices broaden the spectrum of subclinical myocardial dysfunction in pre-diabetic patients.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"14 ","pages":"Pages 1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.11.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84017763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of VE/VCO2 and interleukin-6 in chronic heart failure subjects","authors":"Danielle Pereira ,&nbsp;Victor Neves ,&nbsp;Dayane Montemezzo ,&nbsp;Verônica Parreira ,&nbsp;Maria Clara Alencar ,&nbsp;Liliane Mendes ,&nbsp;Leani Pereira ,&nbsp;Raquel Britto","doi":"10.1016/j.ijcme.2017.01.003","DOIUrl":"10.1016/j.ijcme.2017.01.003","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"14 ","pages":"Pages 65-66"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2017.01.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74285877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma free fatty acids in relation with the severity of coronary artery disease in non-diabetics: A Gensini score assessment","authors":"Jing-Lu Jin,&nbsp;Yuan-Lin Guo,&nbsp;Jian-Jun Li","doi":"10.1016/j.ijcme.2016.12.004","DOIUrl":"10.1016/j.ijcme.2016.12.004","url":null,"abstract":"<div><h3>Objectives</h3><p>Free fatty acids (FFAs) have been reported to be a marker in the development of atherosclerosis. However, no data is currently available with regard to the relation of FFA to the severity of atherosclerosis. The aim of the present study was to evaluate the relation of free fatty acids levels to the severity of coronary artery disease (CAD) in non-diabetic patients.</p></div><div><h3>Methods</h3><p>A total of 766 consecutive individuals (496 CAD and 266 controls) who had a angina-like chest pain and received coronary angiography were enrolled in the study. FFA was measured using enzymatic assay and the severity of coronary arteries was assessed by Gensini score system. The association of plasma FFAs levels with the severity of CAD was finally investigated.</p></div><div><h3>Results</h3><p>There were significantly higher FFAs levels in CAD group compared with those in control group (p<!--> <!-->=<!--> <!-->0.040). FFAs levels were positively correlated with Gensini score (r<!--> <!-->=<!--> <!-->0.120, p<!--> <!-->=<!--> <!-->0.008) and elevated according to the tertiles of Gensini score (p for trend 0.002). Multivariate leaner regression analysis also proved that FFAs levels were independently associated with the Gensini score (β<!--> <!-->=<!--> <!-->0.106, p<!--> <!-->=<!--> <!-->0.018) after adjusting for traditional cardiovascular risk factors.</p></div><div><h3>Conclusions</h3><p>The present study showed that FFAs levels were positively and independently associated with the severity of CAD, suggested that further study may be needed to confirm our findings.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"14 ","pages":"Pages 48-52"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2016.12.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81811743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between heart rate variability and the voltage left ventricular mapping in patients with and without CKD","authors":"Márcio Galindo Kiuchi ,&nbsp;Shaojie Chen","doi":"10.1016/j.ijcme.2017.01.005","DOIUrl":"10.1016/j.ijcme.2017.01.005","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"14 ","pages":"Pages 72-74"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2017.01.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73823127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}