Hermes A. S. Kamimura;Niloufar Saharkhiz;Stephen A. Lee;Elisa E. Konofagou
{"title":"Synchronous Temperature Variation Monitoring During Ultrasound Imaging and/or Treatment Pulse Application: A Phantom Study","authors":"Hermes A. S. Kamimura;Niloufar Saharkhiz;Stephen A. Lee;Elisa E. Konofagou","doi":"10.1109/OJUFFC.2021.3085539","DOIUrl":"10.1109/OJUFFC.2021.3085539","url":null,"abstract":"Ultrasound attenuation through soft tissues can produce an acoustic radiation force (ARF) and heating. The ARF-induced displacements and temperature evaluations can reveal tissue properties and provide insights into focused ultrasound (FUS) bio-effects. In this study, we describe an interleaving pulse sequence tested in a tissue-mimicking phantom that alternates FUS and plane-wave imaging pulses at a 1 kHz frame rate. The FUS is amplitude modulated, enabling the simultaneous evaluation of tissue-mimicking phantom displacement using harmonic motion imaging (HMI) and temperature rise using thermal strain imaging (TSI). The parameters were varied with a spatial peak temporal average acoustic intensity (\u0000<inline-formula> <tex-math>$I_{spta}$ </tex-math></inline-formula>\u0000) ranging from 1.5 to 311 W.cm\u0000<sup>−2</sup>\u0000, mechanical index (MI) from 0.43 to 4.0, and total energy (\u0000<inline-formula> <tex-math>$E$ </tex-math></inline-formula>\u0000) from 0.24 to 83 J.cm\u0000<sup>−2</sup>\u0000. The HMI and TSI processing could estimate displacement and temperature independently for temperatures below 1.80°C and displacements up to \u0000<inline-formula> <tex-math>$sim -117 mu {text{m}}$ </tex-math></inline-formula>\u0000 (\u0000<inline-formula> <tex-math>$I_{spta} < 311 text{ W.cm}^{-2}$ </tex-math></inline-formula>\u0000, \u0000<inline-formula> <tex-math>$MI < 4.0$ </tex-math></inline-formula>\u0000, and \u0000<inline-formula> <tex-math>$E < 83 text{ J.cm}^{-2}$ </tex-math></inline-formula>\u0000) indicated by a steady-state tissue-mimicking phantom displacement throughout the sonication and a comparable temperature estimation with simulations in the absence of tissue-mimicking phantom motion. The TSI estimations presented a mean error of ±0.03°C versus thermocouple estimations with a mean error of ±0.24°C. The results presented herein indicate that HMI can operate at diagnostictemperature levels (i.e., <1°C)> <tex-math>$720 text{ mW.cm}^{-2} < I_{spta} < 207 text{ W.cm}^{-2}$ </tex-math></inline-formula>\u0000). In addition, the combined HMI and TSI can potentially be used for simultaneous evaluation of safety during tissue elasticity imaging as well as FUS mechanism involved in novel ultrasound applications such as ultrasound neuromodulation and tumor ablation.","PeriodicalId":73301,"journal":{"name":"IEEE open journal of ultrasonics, ferroelectrics, and frequency control","volume":"1 ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2021-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/OJUFFC.2021.3085539","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9298198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andreas Hefele;Christoph Strobl;Erik Baigar;Georg Kurzmaier;Alexander Reiner;Andreas L. Hörner;Achim Wixforth
{"title":"Fluid Independent Flow Determination by Surface Acoustic Wave Driven Ultrasonic Techniques","authors":"Andreas Hefele;Christoph Strobl;Erik Baigar;Georg Kurzmaier;Alexander Reiner;Andreas L. Hörner;Achim Wixforth","doi":"10.1109/OJUFFC.2021.3120234","DOIUrl":"https://doi.org/10.1109/OJUFFC.2021.3120234","url":null,"abstract":"A fluid-independent ultrasonic approach for flow determination in microchannels in the harsh environment of an ultra high pressure liquid chromatography (UHPLC) system is presented. Ultrasonic waves in the fluid are excited by separate media surface acoustic waves (SAW) of Rayleigh-Wave type. The LiNbO3 SAW chip being equipped with interdigitated transducers for SAW excitation also marks the bottom of the fluid channel and thus allows for very effective SAW coupling to the fluid. The channel ceiling acts as an acoustical mirror for longitudinal ultrasonic waves propagating through the fluid. To deduce the fluid flow from the ultrasonic transmission after reflection, we employ a combination of time differential phase and time of flight measurements with a two port vector network analyzer. To verify and assign our experimental results, we use an adapted time explicit finite element method. In the simulation, both the piezoelectric single crystal and the fluid are included and we solve the linear Navier-Stokes equation to evaluate the background flow. By changing the ultrasonic propagation direction, we are able to deduce the fluid volume flow over time with very high accuracy, independent of the actual liquid in the channel.","PeriodicalId":73301,"journal":{"name":"IEEE open journal of ultrasonics, ferroelectrics, and frequency control","volume":"1 ","pages":"11-20"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/iel7/9292640/9377491/09576509.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49907714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"IEEE OPEN JOURNAL OF ULTRASONICS, FERROELECTRICS, AND FREQUENCY CONTROL","authors":"","doi":"10.1109/OJUFFC.2022.3157415","DOIUrl":"https://doi.org/10.1109/OJUFFC.2022.3157415","url":null,"abstract":"","PeriodicalId":73301,"journal":{"name":"IEEE open journal of ultrasonics, ferroelectrics, and frequency control","volume":"1 ","pages":"C2-C2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/iel7/9292640/9377491/09735133.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49907483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}