HRB open research最新文献

{"title":"Protocol for a systematic search and critical discourse analysis of research on national HIV pre-exposure prophylaxis programmes among gay, bisexual, and other men who have sex with men.","authors":"David Comer, Chris Noone","doi":"10.12688/hrbopenres.13841.2","DOIUrl":"10.12688/hrbopenres.13841.2","url":null,"abstract":"<p><strong>Background: </strong>HIV pre-exposure prophylaxis (PrEP) is a medication that prevents the acquisition of HIV, most commonly taken in the form of a pill. PrEP is an efficacious tool for HIV prevention, including among gay, bisexual, and other men who have sex with men (gbMSM). PrEP is often provided through formal PrEP programmes. Research on these programmes may employ discourses shaped by heteronormativity and homophobia. Given that expert language influences how HIV prevention is understood and delivered, problematic discourses in research likely extend into PrEP implementation. This study will use critical discourse analysis (CDA) to explore research on PrEP programme implementation for gbMSM. Within this literature, we will identify interpretive repertoires used to discuss gbMSM; the subject positions afforded to gbMSM; and the implications of these interpretive repertoires and subject positions for gbMSM engaging with HIV PrEP programmes.</p><p><strong>Methods: </strong>Systematic search methods identified relevant articles through timebound searching (2012-2023) in ProQuest ASSIA, EBSCOhost PsycInfo, OVID Medline, OVID Embase, and EBSCOhost CINAHL, with forward and backward citation searching of included studies. Grey literature will be identified through ProQuest and Google Scholar. Screening will be conducted by two independent reviewers, who will conduct random partial double screening for titles and abstracts and for all full text articles. Data will be analysed and synthesised using CDA informed by critical realism (CR). CDA focuses on relationships between language and power, including how language enables inequality. The analytic process will explore the background of included studies, identify themes, and analyse external and internal relations in included studies.</p><p><strong>Conclusions: </strong>Highlighting issues with discourses in PrEP implementation may enhance reflective engagement with assumptions underlying this research, preventing further stigmatisation of gbMSM's sexual and protective practices. As PrEP programmes become more common, diverse and inclusive perspectives in PrEP programme research may inform interventions that enhance their acceptability and implementation.</p>","PeriodicalId":73254,"journal":{"name":"HRB open research","volume":"7 ","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altmetric coverage of health research in Ireland 2017-2023: a protocol for a cross-sectional analysis.","authors":"Melissa K Sharp, Patricia Logullo, Pádraig Murphy, Prativa Baral, Sara Burke, David Robert Grimes, Máirín Ryan, Barbara Clyne","doi":"10.12688/hrbopenres.13895.3","DOIUrl":"10.12688/hrbopenres.13895.3","url":null,"abstract":"<p><strong>Background: </strong>Scientific publications have been growing exponentially, contributing to an oversaturated information environment. Quantifying a research output's impact and reach cannot be solely measured by traditional metrics like citation counts as these have a lag time and are largely focused on an academic audience. There is increasing recognition to consider 'alternative metrics' or altmetrics to measure more immediate and broader impacts of research. Better understanding of altmetrics can help researchers better navigate evolving information environments and changing appetites for different types of research.</p><p><strong>Objectives: </strong>Our study aims to: 1) analyse the amount and medium of Altmetric coverage of health research produced by Irish organisations (2017 - 2023), identifying changes over time and 2) investigate differences in the amount of coverage between clinical areas (e.g., nutrition vs. neurology).</p><p><strong>Methods: </strong>Using Altmetric institutional access, we will gather data on research outputs published 1 January 2017 through 31 December 2023 from active Irish organisations with Research Organisation Registry (ROR) IDs. Outputs will be deduplicated and stratified by their Australian and New Zealand Standard Research Classification relating to ≥1 field of health research: Biological Sciences, Biomedical and Clinical Sciences, Chemical Sciences, Health Sciences, and Psychology. We will clean data using R and perform descriptive analyses, establishing counts and frequencies of coverage by clinical area and medium (e.g., traditional news, X, etc.); data will be plotted on a yearly and quarterly basis where appropriate.</p><p><strong>Results and conclusions: </strong>Improved understanding of one's information environment can help researchers better navigate their local landscapes and identify pathways for more effective communication to the public. All R code will be made available open-source, allowing researchers to adapt it to evaluate their local landscapes.</p>","PeriodicalId":73254,"journal":{"name":"HRB open research","volume":"7 ","pages":"36"},"PeriodicalIF":0.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142360731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using nominal group technique to compare patients' and clinicians' perspectives on symptoms in multiple myeloma to inform the development of a self management tool for patients with relapsed myeloma.","authors":"Orlaith Cormican, Maura Dowling","doi":"10.12688/hrbopenres.12863.3","DOIUrl":"https://doi.org/10.12688/hrbopenres.12863.3","url":null,"abstract":"<p><strong>Background: </strong>The nominal group technique (NGT) allows stakeholders to directly generate items for needs assessment. The objective was to demonstrate the use of NGT to inform the development of a healthcare app in patients with relapsed myeloma. Healthcare professionals with experience in the care of patients with relapsed/refractory myeloma were invited to participate.</p><p><strong>Methods: </strong>One NGT group was conducted. In the group, health care professionals working in haematology were asked to vote anonymously in order of highest priority, on symptoms previously highlighted by relapsed/refractory myeloma patients in four focus groups.</p><p><strong>Results: </strong>A total of 18 healthcare professionals working in the area of haematology participated in the NGT discussion; consultants (n=6), haematology registrars (n=2), specialist nurses [Advanced Nurse Practitioner/Clinical Nurse Specialist] (haematology) (n=3), staff nurse (n=1), and \"other\" health care professionals (n=6). Participants ranged in experience of working with myeloma patients from 2 years to over 27 years. The symptoms voted in highest priority were: Pain, Fatigue, Peripheral Neuropathy, Infection Risk and Steroid Induced Side Effects.</p><p><strong>Conclusions: </strong>The NGT was an efficient method for obtaining information to inform a healthcare app.</p>","PeriodicalId":73254,"journal":{"name":"HRB open research","volume":"1 ","pages":"21"},"PeriodicalIF":0.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11372347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Initial Implementation of a Clinical Monitoring Strategy in a Non-regulated Trial: a research note from the ReStOre II Trial.","authors":"Linda O'Neill, Fiona Murphy, Derval Reidy, Camille Poisson, Juliette Hussey, Emer Guinan","doi":"10.12688/hrbopenres.13763.3","DOIUrl":"10.12688/hrbopenres.13763.3","url":null,"abstract":"<p><strong>Background: </strong>Data and Safety Monitoring is integral to quality assurance of clinical trials. Although monitoring is a core legal component of regulated clinical trials, non-regulated trials are not mandated to incorporate monitoring. Consequently, the monitoring process has been underutilised and underreported in this setting. This research report outlines the development and plans for implementing a bespoke Clinical Monitoring Strategy within the ' <i>Rehabilitation Strategies Following Oesophagogastric and Hepatopancreaticobiliary Cancer (ReStOre II) Trial'</i>, a non-regulated trial comparing a 12-week multidisciplinary programme of rehabilitation to standard care in a cohort of 120 cancer survivors.</p><p><strong>Methods: </strong>This research note provides a detailed overview of the ReStOre II Clinical Monitoring Strategy and describes the development of the strategy pre and post awarding of the grant. The strategy consists of the establishment and implementation of a comprehensive trial governance structure, inclusive of a Trial Management Group, Trial Steering Committee Meeting, and Independent Data Monitoring Committee. In addition, external trial monitoring by the Clinical Research Facility at St James's Hospital. Three monitoring visits will be conducted during the trial; i) site initiation visit, ii) interim monitoring visit, and iii) close our visit.</p><p><strong>Results: </strong>The Clinical Monitoring Strategy has been finalised and is currently being implemented within the ReStOre II Trial. Two site initiation visits and one interim monitoring visit have been completed to date.</p><p><strong>Conclusion: </strong>This research note provides a template for implementation of a Clinical Monitoring Strategy in a non-regulated clinical trial.</p><p><strong>Registration: </strong>ReStOre II Trial: https://clinicaltrials.gov/ct2/show/NCT03958019.</p>","PeriodicalId":73254,"journal":{"name":"HRB open research","volume":"6 ","pages":"46"},"PeriodicalIF":0.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11401978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142302591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Competencies and learning outcomes for healthcare professionals in climate change and sustainability: A protocol for a scoping review.","authors":"Emer Galvin, Anél Wiese, Niamh Coakley, Deborah Heaphy, Marah Elfghi, Caoimhe O'Brien, Claudia Osborne, Rory Mulcaire, Deirdre Bennett","doi":"10.12688/hrbopenres.13966.1","DOIUrl":"10.12688/hrbopenres.13966.1","url":null,"abstract":"<p><strong>Rationale: </strong>The planetary crisis is a serious threat to human health. Healthcare professionals need to be trained to adapt to and mitigate against this crisis. Competencies, curricular frameworks and learning outcomes relating to climate change and sustainability (CC&S) have been proposed for healthcare professionals. A synthesis of these competencies, learning outcomes and frameworks is necessary to identify commonalities and differences, understand the process of their development and highlight areas for future development.</p><p><strong>Objective: </strong>The objective of this scoping review is to identify and synthesise the evidence on competencies, curricular frameworks and learning outcomes for healthcare professionals in climate change and sustainability.</p><p><strong>Inclusion criteria: </strong>Sources relating to healthcare professionals and healthcare students, describing competencies, curricular frameworks and learning outcomes in CC&S, will be included. Sources in all healthcare contexts will be included. Sources in the English language, published from 2014 to June 2024 will be considered for inclusion.</p><p><strong>Methods: </strong>The review will be conducted in line with the Joanna Briggs Institute guidance for scoping reviews. The following electronic databases will be searched: PubMed, Embase, CINAHL, PsycINFO, SocINDEX, Academic Search Complete, Business Source Complete, British Education Index, Australian Education Index, Scopus and ERIC. A search of the grey literature will also be conducted. Two reviewers will independently screen the titles and abstracts and full texts for eligibility. Data extraction will be conducted independently by two reviewers. A narrative summary and tables will be presented. Key stakeholders will be consulted throughout the review.</p><p><strong>Discussion: </strong>This review will summarise the range of competencies, curricular frameworks and learning outcomes proposed internationally for various healthcare professionals. The findings will be used to inform core competencies for all healthcare professions in CC&S, in addition to highlighting gaps in the literature and areas for future development. The findings will be disseminated at conferences and in a peer-reviewed publication.</p><p><strong>Registration: </strong>This protocol was registered on 31 ^st July 2024 on the Open Science Framework ( https://osf.io/vnx2g).</p>","PeriodicalId":73254,"journal":{"name":"HRB open research","volume":"7 ","pages":"66"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol to develop a specialised curriculum in primary care cancer research in an Irish medical school.","authors":"Logan Verlaque, Benjamin Jacob, Kurdo Araz, Aileen Barrett, Fiona Kent, Patrick Redmond","doi":"10.12688/hrbopenres.13911.1","DOIUrl":"10.12688/hrbopenres.13911.1","url":null,"abstract":"<p><strong>Background: </strong>The increasing necessity for specialised training in primary care cancer research stems from GPs' pivotal role in cancer detection and holistic care coupled with the unique primary care context. This has led to the development of the PRiCAN Scholars Network, an initiative to enhance the research capabilities of Graduate Entry Medicine (GEM) students in RCSI University of Medicine and Health Sciences, Dublin, Ireland. This protocol outlines a proposal for the systematic development, implementation, and evaluation of a curriculum aimed at improving the primary care cancer research skills of this cohort.</p><p><strong>Methods: </strong>The curriculum development process will be guided by Kern's six-step approach. Initial stages involve comprehensive needs assessments via surveys and focus groups to identify educational needs. Subsequently, targeted learning objectives and aligned educational strategies will be defined to maximise learning opportunities and impact. The curriculum's impact will be evaluated in a pilot phase with selected students and faculty, utilising both qualitative and quantitative feedback to drive continuous improvements.</p><p><strong>Conclusion: </strong>This protocol describes a detailed method for establishing a primary care cancer research curriculum within the PRiCAN Scholars Network. Designed with a focus on sustainability and adaptability, the curriculum will be structured to develop and support a generation of medical professionals' literate in primary care research, contributing to the advancement of medical education and cancer research.</p>","PeriodicalId":73254,"journal":{"name":"HRB open research","volume":"7 ","pages":"64"},"PeriodicalIF":0.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The emerging role of a Stroke Clinical Nurse Specialist (CNS) in Early Supported Discharged: Developing a pathway for stroke nursing for secondary prevention in the community.  A scoping review protocol.","authors":"Sarah-Jane Byrne, David J Williams, Declan Patton, Paul J Murphy, Frances Horgan","doi":"10.12688/hrbopenres.13818.2","DOIUrl":"10.12688/hrbopenres.13818.2","url":null,"abstract":"<p><strong>Background: </strong>Stroke represents a major source of mortality and morbidity globally. The role of a stroke Clinical Nurse Specialist (CNS) as an expert team member in early supported discharge (ESD) for stroke, is not well defined or described although it is well established in other models of after-hospital and out-reach specialist care in the community. A greater focus has been on patients receiving rehabilitation post-stroke, however there is a need for a more holistic approach to care which clinical nurse specialists can offer to patients as part of ESD. Nurses are often the cohesive point of contact for other after-hospital services, managing many aspects of secondary prevention.</p><p><strong>Objective: </strong>The aim of this scoping review is to explore the evidence in relation to the role of the stroke nurse providing secondary prevention interventions to stroke patients in a community setting.</p><p><strong>Methods: </strong>We will conduct a scoping review in accordance with the Arksey and O'Malley, 2005 ¹ scoping review framework and the PRISMA-ScR guidelines to map available literature on the role of the stroke nurse in post-stroke care of patients in the community. The Cochrane Central Register of Controlled Trials and Systematic literature searches including databases MEDLINE, EMBASE, CINAHL, google scholar and grey literature will be searched using keyword searches. Data will be charted and synthesised and a narrative synthesis will be conducted.</p><p><strong>Conclusions: </strong>This scoping review will be used to identify gaps in the current literature and identify areas for future research in the role of the stroke nurse in ESD in relation to secondary prevention for stroke patients and inform the development of a pathway for stroke nursing in ESD.</p>","PeriodicalId":73254,"journal":{"name":"HRB open research","volume":"7 ","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11544196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining the Choosing Health Infant feeding for Infant Health intervention and implementation strategy: Re-CHErIsH Study Protocol.","authors":"Eibhlín Looney, Moira Duffy, Helen Ahern Galvin, Molly Byrne, Rebecca Golley, Catherine Hayes, Tony Heffernan, Aisling Jennings, Brittany Johnson, Patricia M Kearney, Colette Kelly, Patricia Leahy-Warren, Marian McBride, Sheena McHugh, Kate O'Neill, Sarah Redsell, Anna Lene Seidler, Elaine Toomey, Karen Matvienko-Sikar","doi":"10.12688/hrbopenres.13935.1","DOIUrl":"10.12688/hrbopenres.13935.1","url":null,"abstract":"<p><strong>Background: </strong>Childhood obesity is a significant global public health challenge, with significant adverse effects on both mental and physical health outcomes. During the period from birth to one-year, modifiable caregiver behaviours, such as what, how and when infants are fed, can influence obesity development and prevention. The Choosing Healthy Eating for Infant Health (CHErIsH) intervention was developed to support healthy infant feeding practices to prevent childhood obesity in the first year. A feasibility study examined acceptability and feasibility of the CHErIsH intervention in primary care and identified key challenges and possible areas for refinement of the intervention and trial processes. The current project aims to refine delivery of the CHErIsH intervention and trial processes to maximise the likelihood of successful future implementation and evaluation.</p><p><strong>Methods: </strong>This study will utilise a mixed-methods approach and will be conducted in three phases. In Phase 1 potential refinements to the CHErIsH intervention delivery and trial processes will be developed from a review of the feasibility study findings and input from the multidisciplinary team. An online mixed-methods survey will be conducted in Phase 2 to evaluate caregiver attitudes about the proposed refinements from Phase 1. Participants will be pregnant women, their partners, and/or parents/primary caregivers of infants up to 2-years of age, based in Ireland. Participants will be recruited using convenience and snowball sampling. In Phase 3 a stakeholder consensus meeting, using the nominal group technique, will be conducted to agree the refined intervention and trial processes. Stakeholders will include healthcare professionals, researchers, policymakers, and parents/caregivers, who will discuss and rate refinements in terms of preference.</p><p><strong>Conclusions: </strong>Findings from this study will address uncertainties in the intervention delivery and trial processes of the CHErIsH intervention, with the potential to maximise the likelihood of successful future implementation and evaluation of a primary-care based obesity prevention intervention.</p>","PeriodicalId":73254,"journal":{"name":"HRB open research","volume":"7 ","pages":"59"},"PeriodicalIF":0.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11808839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tracking aspects of healthcare activity during the first nine months of COVID-19 in Ireland: a secondary analysis of publicly available data.","authors":"Domhnall McGlacken-Byrne, Sarah Parker, Sara Burke","doi":"10.12688/hrbopenres.13372.3","DOIUrl":"https://doi.org/10.12688/hrbopenres.13372.3","url":null,"abstract":"<p><strong>Background: </strong>Sláintecare aims to introduce universal healthcare in Ireland. The COVID-19 pandemic poses both challenges and opportunities to this process. This study explored the impact of COVID-19 on aspects of Irish healthcare during the first nine months of the pandemic and considers the implications for Sláintecare implementation.</p><p><strong>Methods: </strong>Secondary analysis was undertaken on publicly available data on three key domains of the Irish healthcare system: primary care, community-based allied healthcare, and hospitals. Descriptive statistics were computed using Microsoft Excel 2016.</p><p><strong>Results: </strong>Up to March 2021, 3.76 million COVID-19 tests were performed by Ireland's public healthcare system, 2.48 million (66.0%) of which were referred from the community. General practitioners delivered 2.31 million telephone triages of COVID-19 symptoms, peaking in December 2020 when 416,607 consultations occurred. Patient numbers across eight allied healthcare specialties fell by 35.1% versus previous years, with the greatest reductions seen in speech and language therapy (49.0%) and audiology (46.1%). Hospital waiting lists increased from 729,937 to 869,676 (or by 19.1%) from January 2019 to January 2021. In January 2021, 629,919 patients awaited a first outpatient clinic appointment, with 170,983 (27.1%) waiting longer than 18 months. The largest outpatient lists were observed in orthopaedic surgery (n=77,257); ear, nose and throat surgery (n=68,073); and ophthalmology (n=47,075). The proportion of patients waiting more than 12 months for a day-case gastrointestinal endoscopy rose from 6.0% in January 2020 to 19.0% in January 2021.</p><p><strong>Conclusions: </strong>Healthcare activity has been significantly disrupted by COVID-19, leading to increased wait times and greater barriers to healthcare access during the pandemic. Yet, Ireland's health system responses also revealed strong willingness and ability to adapt and to implement novel solutions for healthcare delivery, rapidly and at scale. This has demonstrated what is achievable under Sláintecare and provides a unique opportunity to 'build back better' towards sustainable recovery.</p>","PeriodicalId":73254,"journal":{"name":"HRB open research","volume":"4 ","pages":"98"},"PeriodicalIF":0.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic test accuracy of screening tools for the detection of neurocognitive disorders in older adults post-trauma: A protocol for a systematic review.","authors":"Niamh A Merriman, Mary E Walsh, Niamh O'Regan, Marie Carrigan, Pamela Hickey, Louise Brent, Catherine Blake","doi":"10.12688/hrbopenres.13894.2","DOIUrl":"https://doi.org/10.12688/hrbopenres.13894.2","url":null,"abstract":"<p><strong>Background: </strong>Neurocognitive disorders (NCDs), including delirium, cognitive impairment, or dementia are prevalent in up to 39% of older adults in acute care, particularly older trauma patients. Undiagnosed NCDs result in poor outcomes, such as increased incidence of depressive symptoms, longer length of stay, and mortality.</p><p><strong>Objective: </strong>This study aims to identify the diagnostic test accuracy of screening tools for the detection of NCDs in older trauma patients in acute settings.</p><p><strong>Design: </strong>Systematic review protocol.</p><p><strong>Literature search: </strong>Electronic databases (MEDLINE, Embase, CINAHL, PsycInfo, Cochrane Library) will be searched for journal articles. Search terms related to NCDs, delirium and cognitive screening tools, and diagnostic accuracy will be included.</p><p><strong>Study selection criteria: </strong>Cross-sectional, prospective, or retrospective cohort studies of adults aged ≥60 post-trauma, in an acute setting, will be included where the study aimed to validate a screening tool for detection of 1) delirium or 2) cognitive impairment, or dementia against a reference standard of a clinical decision, based on standardised diagnostic criteria or a validated tool.</p><p><strong>Data synthesis: </strong>Two review authors will conduct study selection, data extraction, and appraisal. Data will be extracted based on the Preferred Reporting Items for a Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies (PRISMA-DTA) checklist. Studies will be assessed for methodological quality by two independent review authors using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. Narrative summaries will be generated describing risk of bias and concerns regarding applicability. Quantitative synthesis of study findings will be conducted.</p><p><strong>Conclusion: </strong>This systematic review will aim to identify screening tools with the best diagnostic accuracy for detection of 1) delirium and 2) cognitive impairment or dementia in adults aged ≥60 post-trauma in acute care settings. Results will inform clinical practice to enhance the probability of patients with NCDs receiving appropriate care and management.</p><p><strong>Registration: </strong>PROSPERO https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024518730 (11/03/2024).</p>","PeriodicalId":73254,"journal":{"name":"HRB open research","volume":"7 ","pages":"33"},"PeriodicalIF":0.0,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11437317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}