HRB open research最新文献

{"title":"Protocol for Establishing a Stakeholder Group for Primary Care Research into Cancer Using a Modified 7P Framework and an e-Delphi Process","authors":"Benjamin Jacob, Heather Burns, Ming Chuen Chong, Barbara Clyne, Laura O'Connor, Kathleen Bennett, Patrick Redmond","doi":"10.12688/hrbopenres.13750.2","DOIUrl":"https://doi.org/10.12688/hrbopenres.13750.2","url":null,"abstract":"Introduction Currently, no group specifically supports and coordinates primary care focused cancer research in Ireland. The aim of this project is to establish an inclusive stakeholder group for primary care focused cancer research in Ireland, to coordinate research efforts and build capacity in researchers and institutions. Methods We will convene a stakeholder group, recruiting individuals with personal and professional experience of cancer care in a community setting. “Core stakeholders”—patients, clinicians, researchers, and policymakers—will attend regularly. Additional “specialist stakeholders”, such as representatives of secondary care, private healthcare, health insurance, industry, cancer charities, and health research funders, will participate on an ad hoc basis. An e-Delphi consensus process will be used to assess the stakeholders’ views on: (1) the relevance and importance of primary care focused cancer research; (2) the potential role and scope of the stakeholder group; (3) how best to engage with lived experience stakeholders and healthcare professionals affected by the research; (4) how to encourage the dissemination of results and the translation of findings into practice. Round 1 will be open-ended and will invite the independent suggestions of stakeholders; in Round 2 and 3, group members will vote on the inclusion of these suggestions in a position statement by the group, with consensus defined as ≥75% agreement. Discussion The formation of a broad stakeholder group to support primary care focused cancer research will ensure research is relevant, patient centered, and more readily translated into practice. It is also hoped that the group will support capacity building and strategic planning in this important research space.","PeriodicalId":73254,"journal":{"name":"HRB open research","volume":" 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138962352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An EDucation and eXercise intervention for gluteal tendinopathy in an Irish setting: a protocol for a feasibility randomised clinical trial (LEAP-Ireland RCT)","authors":"S. Almousa, B. Vicenzino, Rebecca Mellor, Alison Grimaldi, K. Bennett, Frank Doyle, Geraldine M. McCarthy, Suzanne M. McDonough, Jennifer M. Ryan, Karen Lynch, Jan Sorensen, Helen P. French","doi":"10.12688/hrbopenres.13796.1","DOIUrl":"https://doi.org/10.12688/hrbopenres.13796.1","url":null,"abstract":"Background Gluteal tendinopathy (GT) is a degenerative tendon condition characterised by pain over the greater trochanter of the hip. A randomised controlled trial (RCT) in Australia found that 14 sessions of EDucation on load management plus eXercise (EDX) delivered over 8 weeks resulted in greater improvements in global rating of change and pain outcomes at 8 and 52 weeks, compared with corticosteroid injection or ‘wait and see’. Typically, 5-6 physiotherapy sessions are provided in public and private physiotherapy settings in Ireland, therefore, the aim of this study is to examine the feasibility of conducting an RCT to investigate effectiveness of 6 sessions of the EDX programme compared to usual care. Methods We will randomly allocate 64 participants with GT to physiotherapist-administered EDX or usual care. The EDX intervention (EDX-Ireland) will be delivered in 6 sessions over 8 weeks. To determine feasibility of an RCT, we will assess recruitment and retention and outcome measure completion. The health status outcomes to be assessed at baseline, 8 weeks and 3 months include: Global Rating of Change, pain severity, the Victorian Institute of Sport Assessment-Gluteal Questionnaire (VISA-G), the Patient-Specific Functional Scale, the Pain Catastrophizing Scale, Patient Health Questionnaire (PHQ), Pain Self-Efficacy Questionnaire, the EQ-5D-5L, the Central Sensitisation Inventory and hip abductor muscle strength. We will explore acceptability of the EDX-Ireland intervention from the perspective of patients and treatment providers, and the perspective of referrers to the trial. A Study Within A Trial will be also applied to compare recording of exercise adherence using app-based technology to paper-based diary. Discussion There is a need to establish effective treatments for GT that potentially can be implemented into existing health systems. The findings of this feasibility trial will inform development of a future definitive RCT. Registration The trial is registered prospectively on ClinicalTrials.gov (NCT05516563, 27/10/2022).","PeriodicalId":73254,"journal":{"name":"HRB open research","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139001148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social exclusion and its impact on health over the life course: A realist review protocol.","authors":"Rikke Siersbaek, Chris O'Donnell, Sarah Parker, John Ford, Sara Burke, Clíona Ní Cheallaigh","doi":"10.12688/hrbopenres.13746.2","DOIUrl":"10.12688/hrbopenres.13746.2","url":null,"abstract":"<p><strong>Background: </strong>Social exclusion is a process whereby certain individuals are born into or pushed to the margins of society and prevented from participating in social, cultural, economic, and political life. People who experience social exclusion are not afforded the same rights and privileges as other population groups. Socially excluded people often experience poorer outcomes in a variety of domains including health, education, employment, and housing than people with socio-economic privilege. People experiencing social exclusion frequently have higher and more complex health needs and poorer access to healthcare than the general population. The aim of this study is to better understand and explain how social exclusion occurs and how it impacts health over the life course.</p><p><strong>Methods: </strong>A realist review will be undertaken. Data will be collected via a systematic search of databases of peer-reviewed literature and further iterative searches of peer-reviewed and other literatures as needed. The following data bases will be searched: MEDLINE, Embase, CINAHL, and ASSIA, using both indexed subject headings in each database and relevant key words. Grey literature will be searched via Google Scholar and relevant websites of organisations that work with populations affected by social exclusion.</p><p><strong>Conclusion: </strong>A realist review will be conducted to explain the underlying societal mechanisms which produce social exclusion and related health outcomes in particular contexts affecting excluded population groups across the life course. The study has the potential to inform policy makers and service managers of how and why social exclusion occurs and potential key intervention points to prevent exclusion from happening.</p>","PeriodicalId":73254,"journal":{"name":"HRB open research","volume":"6 ","pages":"34"},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The short-, medium-, and long-term prevalence of physical health comorbidities in first-episode psychosis: a systematic review protocol","authors":"Anna Zierotin, Jennifer Murphy, Brian O'Donoghue, Karen O'Connor, M. Norton, Mary Clarke","doi":"10.12688/hrbopenres.13810.1","DOIUrl":"https://doi.org/10.12688/hrbopenres.13810.1","url":null,"abstract":"Background Individuals with first-episode psychosis (FEP) face an increased risk of physical comorbidities, notably cardiovascular diseases, metabolic disorders, respiratory disorders, and certain types of cancer. Previous reviews report pooled physical health prevalence from chronic psychosis and FEP groups. By contrast, this review will focus on antipsychotic-naïve FEP cohorts and incorporate data from observational longitudinal studies and antipsychotic intervention studies to understand the progression of physical health comorbidities from the onset to later stages of psychosis. This review aims to systematically examine the short-, medium-, and long-term period prevalence of these comorbidities in FEP and variations related to demographic factors. Methods A systematic review will be conducted using the PRISMA and MOOSE guidelines. Medline, Embase, PsycINFO, and CINAHL+, as well as Clinical Trials gov.uk, OpenGrey, WHO International Clinical Trials Registry Platform, Current Controlled Trials, United States National Institute of Health Trials Registry, and the Irish Health Repository, will be searched from inception. Longitudinal studies exploring physical health outcomes in FEP cohorts and antipsychotic intervention studies monitoring health outcomes in antipsychotic naïve FEP individuals will be eligible for inclusion. Two reviewers will independently screen titles, abstracts, and full-text articles. Bias in individual studies will be assessed using the JBI Critical Appraisal Checklist. A meta-analysis of the short-, medium-, and long-term prevalence of cardiovascular, metabolic, cancer, and respiratory outcomes and a narrative synthesis will be conducted. If possible, a meta-regression on the impact of demographic variables will be conducted. Conclusions This systematic review will clarify the progression of physical health comorbidities in FEP, informing early intervention strategies and policies for this population. Subsequent findings will be submitted to a leading journal, supplemented by a recovery education module for patient groups and a lay summary for wider dissemination. Registration The study was registered in PROSPERO, the International Prospective Register of Systematic Reviews (CRD42023431072; 17/06/2023).","PeriodicalId":73254,"journal":{"name":"HRB open research","volume":"45 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138593593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ADvAnced PhysioTherapy in MuSculosKeletal Triage: Investigating prognostic factors, healthcare utilisation and clinical outcomes (ADAPT MSK) - a cohort study protocol.","authors":"Fiona Callan, Louise Keating, Sarah Casserley-Feeney, Helen P. French","doi":"10.12688/hrbopenres.13769.1","DOIUrl":"https://doi.org/10.12688/hrbopenres.13769.1","url":null,"abstract":"Background: Clinical specialist physiotherapist-led musculoskeletal triage clinics were introduced nationally in Ireland in 2011 to improve patient care and reduce waiting times for secondary care orthopaedics and rheumatology. Evidence has shown them to be effective in reducing waiting lists, however there are currently no data on longitudinal patient outcomes following clinic attendance. The primary aim of this cohort study is to identify predictors of pain and function outcomes up to one year following musculoskeletal triage review. Secondary aims include measuring self-reported use of healthcare resources over the 12-month follow-up period and to explore musculoskeletal phenotypes based on established prognostic factors for musculoskeletal pain. This is a prospective cohort study. Methods: ADvAnced PhysioTherapy in MuSculosKeletal Triage (ADAPT MSK) will recruit a cohort of 252 adults through musculoskeletal triage clinics across five secondary care sites in Ireland. The STrengthening the Reporting of Observational studies in Epidemiology (STROBE) guidelines will be adhered to for future reporting. Adults (≥ 18 years old) attending physiotherapist-led musculoskeletal triage clinics with musculoskeletal pain, who do not require surgical or consultant-led medical care will be considered for participation. Participant demographics, health literacy, healthcare utilisation, and self-report questionnaires on pain, function, musculoskeletal health, musculoskeletal risk stratification, fear of movement, and psychological distress will be obtained at baseline, with follow-ups at three, six, and 12 months. Primary outcomes are pain intensity and function. Secondary outcomes include musculoskeletal risk stratification status, musculoskeletal health, healthcare utilisation, and work-related factors. Descriptive statistics will be used to profile the participants and predictors of outcome will be assessed using multivariable linear regression. Musculoskeletal phenotypes will be explored using latent class analysis. Results: Results will be disseminated via peer-reviewed journal publication and presentation at national and international conferences. Engagement with a public patient involvement (PPI) panel will explore dissemination strategies for public and service user engagement.","PeriodicalId":73254,"journal":{"name":"HRB open research","volume":"87 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138595815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scoping review of the use of music as an arts-based method in migrant health research","authors":"Fran Garry, Anne MacFarlane, Sylvia Murphy Tighe, Pattie Punch, Helen Phelan","doi":"10.12688/hrbopenres.13817.1","DOIUrl":"https://doi.org/10.12688/hrbopenres.13817.1","url":null,"abstract":"Background There is a growing awareness of the need to include people’s lived experiences in health decision-making. While much progress has been made in this field, exclusionary patterns persist regarding migrant participation in health research. The aim of this scoping review was to examine the available literature around the use of music as an arts-based research (ABR) method in migrant health research in order to extend knowledge of creative methods and tools used for migrant participation in health research. Methods Our review follows a scoping review methodology. Searches were conducted in 11 electronic databases between June and August, 2020. We identified 14 eligible references published between January 2009 and August 2020. We analysed how music is utilised as an arts-based research method in community-based health and wellbeing contexts primarily with refugees, asylum seekers, undocumented migrants, and members of resettled immigrant communities. Results The findings show that music’s role is most prominent as a tool for recruitment and engagement followed by its use as a tool for dissemination. Music is effective as a means to co-produce and communicate knowledge of lived experiences of migration and related wellbeing issues. Recommendations and conclusions Our recommendations for further research include the need for increased detail on the musical element in ABR projects; Explicit identification of such research as ABR; Greater recognition of a multi-arts understanding of music in the context of ABR; Harnessing the potential of music in ABR across the research cycle. We conclude that arts-based research using music shows promise for capturing the complexity of migrants’ lives and health issues in an ethical way. It warrants further investigation in empirical studies in multiple clinical and community settings to understand its processes and impacts on the evidence base for migrant health.","PeriodicalId":73254,"journal":{"name":"HRB open research","volume":"75 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138596165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profiling the characteristics of people after stroke in Ireland discharged home with and without Early Supported Discharge: Analysis of a nationally representative cohort study","authors":"Elaine O Connor, Eamon Dolan, F. Horgan, Margaret O’Connor, Joan McCormack, Olga Brych, Katie Robinson, Rose Galvin","doi":"10.12688/hrbopenres.13808.1","DOIUrl":"https://doi.org/10.12688/hrbopenres.13808.1","url":null,"abstract":"Background Early Supported Discharge (ESD) after stroke has demonstrated cost savings, reducing hospital length of stay (LOS) and long-term dependency. ESD discharges people after stroke from hospital earlier than conventional care with rehabilitation continuing at home. The Irish National Stroke Strategy 2022–2027 aims for ESD to be available to 92% of the stroke inpatient population. This study aims to profile the clinical characteristics and rehabilitation needs of those referred to ESD on discharge versus those discharged home without it in Ireland. Methods This study represents secondary analysis of an anonymised nationally representative prospective cohort study; the Irish National Audit of Stroke (INAS). Data were retrieved for 2018–2020 inclusive. A subset of 20 variables were used to profile the clinical characteristics and rehabilitation needs of those referred to ESD on discharge versus those discharged home without it. Data were analysed descriptively. Results In 2018, 139 people were discharged home with ESD, representing 3.8% of all people after stroke discharged home. This increased to 207 (4.9%) in 2019 and to 325 (6.6%) in 2020. More men were discharged home with and without ESD. Those aged 65–79 years represented the largest proportion of those discharged home with and without ESD. For those discharged with ESD, the mean LOS reduced each year from 17 days (SD=20) in 2018, 16 days (SD=16) in 2019 to 13 days (SD=13) in 2020. Those with a modified Rankin Scale score of 1, 2 at discharge represented the highest proportion of those returning home with ESD (59.3%) and without ESD (40.8%). Of those returning home with ESD, 10.8% were seen by a psychologist. Conclusions There is a need for significant scale-up of ESD to meet National Stroke Strategy targets. Consensus on ESD eligibility criteria nationally needs to be established and access to psychology services for people after stroke needs expansion.","PeriodicalId":73254,"journal":{"name":"HRB open research","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138626318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"General practice focussed strategies to increase participation in lung cancer screening – a systematic review protocol","authors":"Priya Patel, Benjamin Jacob, Barbara Clyne, Alice Le Bonniec, Samantha L. Quaife, Stephen H. Bradley, Patrick Redmond","doi":"10.12688/hrbopenres.13767.1","DOIUrl":"https://doi.org/10.12688/hrbopenres.13767.1","url":null,"abstract":"Background Lung cancer is the leading cause of cancer-related mortality worldwide. Despite this, the uptake of lung cancer screening (LCS) using low-dose CT is substantially low in comparison to established cancer screening programmes. Additionally, those at higher risk of the disease are the least likely to participate in screening, including current smokers and those experiencing socioeconomic deprivation. General practice (which may be referred to as primary care or family medicine depending on location) plays a vital role in screening through the identification of eligible individuals, overcoming participation barriers, and facilitating shared decision-making. Given the low rates of participation, it is important to understand which, if any, strategies from general practice could improve the effectiveness of a national programme. Objectives To assess and quantify the effects of strategies implemented in general practice to increase participation in LCS. Method A systematic review and meta-analysis, where possible, will be conducted following PRISMA reporting guidelines. Searches of PubMed, Embase, CINAHL, Cochrane Library, Web of Science, ClinicalTrials.gov, and the WHO International Clinical Trials Registry Platform will be conducted. All randomised trials, non-randomised studies, and quantitative descriptive studies that report recruitment strategies based in general practice and LCS outcomes will be eligible. Screening and data extraction will be conducted independently by two reviewers. The risk of bias and overall certainty of findings will be assessed using the MMAT and GRADE tools, respectively. The Template for Intervention Description and Replication (TIDieR) checklist will be used for data extraction and the Behavioural Change Techniques (BCT) Taxonomy for data analysis of the components of interventions. Conclusion This review will provide data on the most effective general practice-based recruitment strategies aimed at improving LCS participation. Understanding the most effective and equitable strategies is important in the development of successful LCS and ensuring individuals at the greatest risk can participate.","PeriodicalId":73254,"journal":{"name":"HRB open research","volume":" 64","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138611880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contextual factors and intentional rounding in acute hospitals: understanding what works, for whom, in what settings: a realist synthesis protocol","authors":"Aileen Hetherton, F. Horgan, Jan Sorensen, Siobhan E. Mc Carthy","doi":"10.12688/hrbopenres.13792.1","DOIUrl":"https://doi.org/10.12688/hrbopenres.13792.1","url":null,"abstract":"Background This study aims to understand and explain the influence of contextual factors on the implementation of Intentional Rounding in acute hospitals using the realist synthesis methodology. Falls of hospital admitted patients are one of the most frequent concerns for patient safety in the acute hospital environment. The reasons why people fall are complex. International guidelines recommend a multifactorial assessment and effective prevention and management of identified risk factors in order to reduce the number of falls. One approach for delivering this is by Intentional Rounding (IR). IR is an umbrella term, understood as a structured process whereby nurses or care staff carry out regular checks with individual patients using a standardised protocol to address such issues as positioning, pain, personal needs and placement of possessions. Methods This study will use realist synthesis to understand what works, for whom, in what circumstances and in what settings. Realist synthesis is a theory driven interpretive approach to evidence synthesis. It is the intention of the researchers to analyse IR as an intervention, which aims to enhance patient care and safety in hospital settings. The synthesis forms part of a larger implementation study examining interventions that reduce the number of falls that occur in hospitals. Search terms will include intentional rounding, purposeful rounding, comfort rounding and hourly rounding and will encompass search terms beyond IR and falls rates in order not to limit the synthesis. This synthesis will conform to the RAMESES (realist and meta-narrative evidence synthesis group) publication and reporting quality standards for a realist synthesis. Conclusions The findings will inform the next phase of an implementation study on IR in acute hospital settings, namely selection of an IR approach and evidence informed barriers and enablers to its implementation. The results will be disseminated in a peer-reviewed journal and through presentations.","PeriodicalId":73254,"journal":{"name":"HRB open research","volume":" 38","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138618098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol for a systematic review and systems-based exploration of interventions to reduce medicines wastage","authors":"Áine Harris, Ryan Jayesinghe, Lorna Bonnici West, Derek Stewart, T. Grimes, Patrick Redmond","doi":"10.12688/hrbopenres.13800.1","DOIUrl":"https://doi.org/10.12688/hrbopenres.13800.1","url":null,"abstract":"Introduction A reduction in medicines wastage is an important objective in promoting appropriate use of finite resources. The objective of this systematic review is to both assess the effectiveness of interventions to reduce medicines wastage, and apply a systems based exploration of the factors affecting implementation of interventions. Methods A systematic review will be conducted following PRISMA reporting guidelines. Searches will be performed in Cumulated Index to Nursing and Allied Health Literature (CINAHL), Embase, Medline, PubMed, Science Citation Index, PsycInfo, Scopus, the Cochrane Library, grey literature, and trials registries. Data extraction and critical appraisal will be completed independently by two reviewers. If studies are sufficiently homogenous in terms of design and comparators, we will conduct a meta-analysis. Where this is not possible, we will provide a narrative synthesis of results grouping studies with similar interventions together. The barriers and enablers of the described interventions will then be analysed using the Systems Engineering Initiative in Patient Safety (SEIPS 101) model. Conclusions This review will describe the effectiveness of interventions to reduce medicines wastage and issues associated with their implementation in order to inform policy development and intervention implementation in the future. This will have the potential to reduce both the economic and environmental burden of medicines wastage on the health service. PROSPERO registration CRD42022335848 (12/06/2022)","PeriodicalId":73254,"journal":{"name":"HRB open research","volume":" 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138617953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}