Hepatitis research and treatment最新文献_第3页

Prediction of Sustained Virological Response to Telaprevir-Based Triple Therapy Using Viral Response within 2 Weeks. 用2周内的病毒反应预测以特拉普利韦为基础的三联疗法的持续病毒学反应。

Hepatitis research and treatment Pub Date : 2014-01-01 Epub Date: 2014-09-28 DOI: 10.1155/2014/748935

Hideyuki Tamai, Ryo Shimizu, Naoki Shingaki, Yoshiyuki Mori, Shuya Maeshima, Junya Nuta, Yoshimasa Maeda, Kosaku Moribata, Yosuke Muraki, Hisanobu Deguchi, Izumi Inoue, Takao Maekita, Mikitaka Iguchi, Jun Kato, Masao Ichinose

{"title":"Prediction of Sustained Virological Response to Telaprevir-Based Triple Therapy Using Viral Response within 2 Weeks.","authors":"Hideyuki Tamai, Ryo Shimizu, Naoki Shingaki, Yoshiyuki Mori, Shuya Maeshima, Junya Nuta, Yoshimasa Maeda, Kosaku Moribata, Yosuke Muraki, Hisanobu Deguchi, Izumi Inoue, Takao Maekita, Mikitaka Iguchi, Jun Kato, Masao Ichinose","doi":"10.1155/2014/748935","DOIUrl":"https://doi.org/10.1155/2014/748935","url":null,"abstract":"The aim of the present study was to predict sustained virological response (SVR) to telaprevir with pegylated interferon (PEG-IFN) and ribavirin using viral response within 2 weeks after therapy initiation. Thirty-six patients with genotype 1 hepatitis C virus (HCV) and high viral load were treated by telaprevir-based triple therapy. SVR was achieved in 72% (26/36) of patients. Significant differences between the SVR group and non-SVR group were noted regarding response to prior PEG-IFN plus ribavirin, interleukin (IL)28B polymorphism, amino acid substitution at core 70, cirrhosis, hyaluronic acid level, and HCV-RNA reduction within 2 weeks. Setting 4.56 logIU/mL as the cut-off value for HCV-RNA reduction at 2 weeks, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for predicting SVR were 77%, 86%, 95%, 50%, and 79%, respectively, and for neither the IL28B minor allele nor core 70 mutant were 80%, 71%, 91%, 50%, and 78%, respectively. In conclusion, evaluation of viral reduction at 2 weeks or the combination of IL28B polymorphism and amino acid substitution at core 70 are useful for predicting SVR to telaprevir with PEG-IFN and ribavirin therapy. ","PeriodicalId":73232,"journal":{"name":"Hepatitis research and treatment","volume":"2014 ","pages":"748935"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/748935","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32757946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Transplacental Transfer of Hepatitis B Neutralizing Antibody during Pregnancy in an Animal Model: Implications for Newborn and Maternal Health. 在动物模型中妊娠期间乙型肝炎中和抗体的经胎盘转移：对新生儿和产妇健康的影响

Hepatitis research and treatment Pub Date : 2014-01-01 Epub Date: 2014-03-27 DOI: 10.1155/2014/159206

Li Ma, Malgorzata G Norton, Iftekhar Mahmood, Zhong Zhao, Lilin Zhong, Pei Zhang, Evi B Struble

{"title":"Transplacental Transfer of Hepatitis B Neutralizing Antibody during Pregnancy in an Animal Model: Implications for Newborn and Maternal Health.","authors":"Li Ma, Malgorzata G Norton, Iftekhar Mahmood, Zhong Zhao, Lilin Zhong, Pei Zhang, Evi B Struble","doi":"10.1155/2014/159206","DOIUrl":"10.1155/2014/159206","url":null,"abstract":"Despite the success of postexposure prophylaxis (PEP) of the newborn in preventing mother-to-child transmission of hepatitis B virus), in non-US clinical trials, administering hepatitis B immune globulin (HBIG) to mothers at the end of pregnancy (in addition to passive-active PEP of the newborn) only partially improved outcomes. That is, a significant percentage of newborns became infected during their first year of life. We used a relevant animal model for human IgG transplacental transfer to study dose, time and subclass dependence of HBV neutralizing antibody (nAb) maternal, and fetal levels at the end of pregnancy. Pregnant guinea pigs received 50 or 100 IU/kg HBIGIV 2-5 days before delivery. Human total IgG, IgG subclasses, and nAb in mothers and their litters were measured. In vitro analyses of guinea pig Fc neonatal receptor binding to HBIGIV, as well as to all human IgG subclasses, were also performed. Our study showed that nAb transferred transplacentally from the pregnant guinea pigs to their litters; no transfer occurred during parturition. The amount of the transferred nAb was dose and time dependent. Thus, selection of an efficacious dose in the clinic is important: microdosing may be underdosing, particularly in cases of high viraemia. ","PeriodicalId":73232,"journal":{"name":"Hepatitis research and treatment","volume":"2014 ","pages":"159206"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32318073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Portraying persons who inject drugs recently infected with hepatitis C accessing antiviral treatment: a cluster analysis. 描绘近期感染丙型肝炎并接受抗病毒治疗的注射吸毒者：聚类分析。

Hepatitis research and treatment Pub Date : 2014-01-01 Epub Date: 2014-10-01 DOI: 10.1155/2014/631481

Jean-Marie Bamvita, Elise Roy, Geng Zang, Didier Jutras-Aswad, Andreea Adelina Artenie, Annie Levesque, Julie Bruneau

{"title":"Portraying persons who inject drugs recently infected with hepatitis C accessing antiviral treatment: a cluster analysis.","authors":"Jean-Marie Bamvita, Elise Roy, Geng Zang, Didier Jutras-Aswad, Andreea Adelina Artenie, Annie Levesque, Julie Bruneau","doi":"10.1155/2014/631481","DOIUrl":"10.1155/2014/631481","url":null,"abstract":"Objectives. To empirically determine a categorization of people who inject drug (PWIDs) recently infected with hepatitis C virus (HCV), in order to identify profiles most likely associated with early HCV treatment uptake. Methods. The study population was composed of HIV-negative PWIDs with a documented recent HCV infection. Eligibility criteria included being 18 years old or over, and having injected drugs in the previous 6 months preceding the estimated date of HCV exposure. Participant classification was carried out using a TwoStep cluster analysis. Results. From September 2007 to December 2011, 76 participants were included in the study. 60 participants were eligible for HCV treatment. Twenty-one participants initiated HCV treatment. The cluster analysis yielded 4 classes: class 1: Lukewarm health seekers dismissing HCV treatment offer; class 2: multisubstance users willing to shake off the hell; class 3: PWIDs unlinked to health service use; class 4: health seeker PWIDs willing to reverse the fate. Conclusion. Profiles generated by our analysis suggest that prior health care utilization, a key element for treatment uptake, differs between older and younger PWIDs. Such profiles could inform the development of targeted strategies to improve health outcomes and reduce HCV infection among PWIDs. ","PeriodicalId":73232,"journal":{"name":"Hepatitis research and treatment","volume":"2014 ","pages":"631481"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32775713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and seroincidence of hepatitis B and hepatitis C infection in high risk people who inject drugs in china and Thailand. 中国和泰国注射毒品高危人群乙型和丙型肝炎感染的患病率和血清发病率

Hepatitis research and treatment Pub Date : 2014-01-01 Epub Date: 2014-03-27 DOI: 10.1155/2014/296958

J Brooks Jackson, Liu Wei, Fu Liping, Apinun Aramrattana, David D Celentano, Louise Walshe, Yi Xing, Paul Richardson, Ma Jun, Geetha Beauchamp, Deborah Donnell, Yuhua Ruan, Liying Ma, David Metzger, Yiming Shao

{"title":"Prevalence and seroincidence of hepatitis B and hepatitis C infection in high risk people who inject drugs in china and Thailand.","authors":"J Brooks Jackson, Liu Wei, Fu Liping, Apinun Aramrattana, David D Celentano, Louise Walshe, Yi Xing, Paul Richardson, Ma Jun, Geetha Beauchamp, Deborah Donnell, Yuhua Ruan, Liying Ma, David Metzger, Yiming Shao","doi":"10.1155/2014/296958","DOIUrl":"https://doi.org/10.1155/2014/296958","url":null,"abstract":"We determined the prevalence and incidence of HBV and HCV infection in people who inject drugs (PWIDs) at high risk for HIV in China and Thailand and determined the association of HBV and HCV incidence with urine opiate test results and with short-term versus long-term buprenorphine-naloxone (B-N) treatment use in a randomized clinical trial (HPTN 058). 13.8% of 1049 PWIDs in China and 13.9% of 201 PWIDs in Thailand were HBsAg positive at baseline. Among HBsAg negative participants, the HBsAg incidence rate was 2.7/100 person years in China and 0/100 person years in Thailand. 81.9% of 1049 PWIDs in China and 59.7% of 201 in Thailand were HCV antibody positive at baseline. The HCV confirmed seroincidence rate among HCV antibody negative PWIDs was 22/100 person years in China and 4.6/100 person years in Thailand. Incident HBsAg was not significantly different in the short-term versus long-term B-N arm in China or Thailand. Participants with positive opiate results in at least 75% of their urines during the time period were at increased risk of incident HBsAg (HR = 5.22; 95% CI, 1.08 to 25.22; P = 0.04) in China, but not incident HCV conversion in China or Thailand. ","PeriodicalId":73232,"journal":{"name":"Hepatitis research and treatment","volume":"2014 ","pages":"296958"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/296958","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32367215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Serum Inter-Alpha-Trypsin Inhibitor Heavy Chain 4 (ITIH4) in Children with Chronic Hepatitis C: Relation to Liver Fibrosis and Viremia. 慢性丙型肝炎患儿血清α -胰蛋白酶抑制剂重链4 (ITIH4)与肝纤维化和病毒血症的关系

Hepatitis research and treatment Pub Date : 2014-01-01 Epub Date: 2014-09-14 DOI: 10.1155/2014/307942

Mostafa M Sira, Behairy E Behairy, Azza M Abd-Elaziz, Sameh A Abd Elnaby, Ehab E Eltahan

{"title":"Serum Inter-Alpha-Trypsin Inhibitor Heavy Chain 4 (ITIH4) in Children with Chronic Hepatitis C: Relation to Liver Fibrosis and Viremia.","authors":"Mostafa M Sira, Behairy E Behairy, Azza M Abd-Elaziz, Sameh A Abd Elnaby, Ehab E Eltahan","doi":"10.1155/2014/307942","DOIUrl":"https://doi.org/10.1155/2014/307942","url":null,"abstract":"Liver fibrosis and viremia are determinant factors for the treatment policy and its outcome in chronic hepatitis C virus (HCV) infection. We aimed to investigate serum level of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) and its relation to liver fibrosis and viremia in children with chronic HCV. ITIH4 was measured by ELISA in 33 treatment-naive children with proved chronic HCV and compared according to different clinical, laboratory and histopathological parameters. Liver histopathological changes were assessed using Ishak score and compared with aspartate transaminase-to-platelet ratio (APRI) and FIB-4 indices as simple noninvasive markers of fibrosis. ITIH4 was measured in a group of 30 age- and sex-matched healthy controls. ITIH4 was significantly higher in patients than in controls (54.2 ± 30.78 pg/mL versus 37.21 ± 5.39 pg/mL; P = 0.021). ITIH4, but not APRI or FIB-4, had a significant direct correlation with fibrosis stage (P = 0.015, 0.961, and 0.389, resp.), whereas, the negative correlation of ITIH4 with HCV viremia was of marginal significance (P = 0.071). In conclusion, ITIH4 significantly correlated with higher stages of fibrosis indicating a possible relation to liver fibrogenesis. The trend of higher ITIH4 with lower viremia points out a potential antiviral properties and further studies in this regard are worthwhile. ","PeriodicalId":73232,"journal":{"name":"Hepatitis research and treatment","volume":"2014 ","pages":"307942"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/307942","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32728774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Spectrum of Histomorphologic Findings in Liver in Patients with SLE: A Review. 系统性红斑狼疮患者肝脏组织形态学研究综述

Hepatitis research and treatment Pub Date : 2014-01-01 Epub Date: 2014-07-21 DOI: 10.1155/2014/562979

Shrruti Grover, Archana Rastogi, Jyotsna Singh, Apurba Rajbongshi, Chhagan Bihari

{"title":"Spectrum of Histomorphologic Findings in Liver in Patients with SLE: A Review.","authors":"Shrruti Grover, Archana Rastogi, Jyotsna Singh, Apurba Rajbongshi, Chhagan Bihari","doi":"10.1155/2014/562979","DOIUrl":"https://doi.org/10.1155/2014/562979","url":null,"abstract":"Collagen vascular diseases (CVDs) like systemic lupus erythematosus (SLE), rheumatoid arthritis, Sjogren syndrome (SS), and scleroderma are immunologically mediated disorders that typically have multisystem involvement. Although clinically significant liver involvement is rare, liver enzyme abnormalities are common in these patients. The reported prevalence of hepatic involvement in SLE, histopathologic findings, and its significance is very variable in the existing literature. It is important to be familiar with the causes of hepatic involvement in SLE along with histomorphological features which aid in distinguishing hepatitis of SLE from other hepatic causes as they would alter the patient management and disease course. Histopathology of liver in SLE shows a wide morphological spectrum commonly due to a coexisting pathology. Drug induced hepatitis, viral etiology, and autoimmune overlap should be excluded before attributing the changes to SLE itself. Common histopathologic findings in SLE include fatty liver, portal inflammation, and vascular changes like hemangioma, congestion, nodular regenerative hyperplasia, arteritis, and abnormal vessels in portal tracts. ","PeriodicalId":73232,"journal":{"name":"Hepatitis research and treatment","volume":"2014 ","pages":"562979"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/562979","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32596864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Hepatitis viruses in heamodialysis patients: an added insult to injury? 血透患者的肝炎病毒:对损伤的又一次侮辱?

Hepatitis research and treatment Pub Date : 2013-01-01 Epub Date: 2013-03-06 DOI: 10.1155/2013/860514

Kranthi Kosaraju, Sameer Singh Faujdar, Aashima Singh, Ravindra Prabhu

{"title":"Hepatitis viruses in heamodialysis patients: an added insult to injury?","authors":"Kranthi Kosaraju, Sameer Singh Faujdar, Aashima Singh, Ravindra Prabhu","doi":"10.1155/2013/860514","DOIUrl":"https://doi.org/10.1155/2013/860514","url":null,"abstract":"Hepatitis B (HBV) and hepatitis C (HCV) viruses are the most important causes of chronic liver disease in patients with end stage renal disease on hemodialysis. The prevalence of hepatitis infection among hemodialysis patients is high and varies between countries and between dialysis units within a single country. This case-control study was undertaken to estimate the occurrence of HBV and HCV infections in patients undergoing hemodialysis in our tertiary care center. All patients receving hemodialysis at our centre with HCV or HBV infection were included in the study. The total number of patients admitted for hemodialysis during the study period was 1710. Among these, 26 patients were positive for HBV, 19 were positive for HCV, and 2 were positive for both HCV and HBV. Mean age of the infected cases in our study was 48.63 years. Mean duration of dialysis for infected cases was 4.8 years while that of the noninfected controls was 3.18 years. The mean dialysis interval was twice a week. Interventions to reduce the occurrence of these infections are of utmost need to reduce the risk of long-term complications among hemodialysis patients.","PeriodicalId":73232,"journal":{"name":"Hepatitis research and treatment","volume":" ","pages":"860514"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/860514","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40227417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Elevation in Serum Concentration of Bone-Specific Alkaline Phosphatase without Elevation in Serum Creatinine Concentration Secondary to Adefovir Dipivoxil Therapy in Chronic Hepatitis B Virus Infection. 慢性乙型肝炎病毒感染阿德福韦酯治疗后骨特异性碱性磷酸酶血清浓度升高而血清肌酐浓度未升高

Hepatitis research and treatment Pub Date : 2013-01-01 Epub Date: 2013-09-09 DOI: 10.1155/2013/739247

Hiroshi Abe, Nobuyoshi Seki, Tomonori Sugita, Yuta Aida, Haruya Ishiguro, Tamihiro Miyazaki, Munenori Itagaki, Satoshi Sutoh, Yoshio Aizawa

{"title":"Elevation in Serum Concentration of Bone-Specific Alkaline Phosphatase without Elevation in Serum Creatinine Concentration Secondary to Adefovir Dipivoxil Therapy in Chronic Hepatitis B Virus Infection.","authors":"Hiroshi Abe, Nobuyoshi Seki, Tomonori Sugita, Yuta Aida, Haruya Ishiguro, Tamihiro Miyazaki, Munenori Itagaki, Satoshi Sutoh, Yoshio Aizawa","doi":"10.1155/2013/739247","DOIUrl":"https://doi.org/10.1155/2013/739247","url":null,"abstract":"Of 168 patients with chronic hepatitis B virus (HBV) infection-related liver disease, 20 patients who had received 100 mg of lamivudine plus 10 mg/day of adefovir dipivoxil (ADV) (ADV group) and 124 patients who had received 0.5 mg/day of entecavir or 100 mg/day of lamivudine (non-ADV group) for >1 year were enrolled. For comparative analyses, 19 well-matched pairs were obtained from the groups by propensity scores. At the time of enrollment, serum creatinine and phosphate concentrations were similar between the ADV and non-ADV groups; however, urinary phosphate (P = 0.0424) and serum bone-specific alkaline phosphatase (BAP) (P = 0.0228) concentrations were significantly higher in the ADV group than in the non-ADV group. Serum BAP was significantly higher at the time of enrollment than before ADV administration in the ADV group (P = 0.0001), although there was no significant change in serum BAP concentration in the non-ADV group. There was a significant positive correlation between the period of ADV therapy and ΔBAP (R (2) = 0.2959, P = 0.0160). Serum BAP concentration increased before increase in serum creatinine concentration and was useful for early detection of adverse events and for developing adequate measures for continuing ADV for chronic HBV infection-related liver disease. ","PeriodicalId":73232,"journal":{"name":"Hepatitis research and treatment","volume":"2013 ","pages":"739247"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/739247","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31791010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

HD-03/ES: A Herbal Medicine Inhibits Hepatitis B Surface Antigen Secretion in Transfected Human Hepatocarcinoma PLC/PRF/5 Cells. 中药HD-03/ES抑制转染人肝癌PLC/PRF/5细胞分泌乙型肝炎表面抗原

Hepatitis research and treatment Pub Date : 2013-01-01 Epub Date: 2013-04-10 DOI: 10.1155/2013/125398

Sandeep R Varma, R Sundaram, S Gopumadhavan, Satyakumar Vidyashankar, Pralhad S Patki

{"title":"HD-03/ES: A Herbal Medicine Inhibits Hepatitis B Surface Antigen Secretion in Transfected Human Hepatocarcinoma PLC/PRF/5 Cells.","authors":"Sandeep R Varma, R Sundaram, S Gopumadhavan, Satyakumar Vidyashankar, Pralhad S Patki","doi":"10.1155/2013/125398","DOIUrl":"https://doi.org/10.1155/2013/125398","url":null,"abstract":"HD-03/ES is a herbal formulation used for the treatment of hepatitis B. However, the molecular mechanism involved in the antihepatitis B (HBV) activity of this drug has not been studied using in vitro models. The effect of HD-03/ES on hepatitis B surface antigen (HBsAg) secretion and its gene expression was studied in transfected human hepatocarcinoma PLC/PRF/5 cells. The anti-HBV activity was tested based on the inhibition of HBsAg secretion into the culture media, as detected by HBsAg-specific antibody-mediated enzyme assay (ELISA) at concentrations ranging from 125 to 1000 μ g/mL. The effect of HD-03/ES on HBsAg gene expression was analyzed using semiquantitative multiplex RT-PCR by employing specific primers. The results showed that HD-03/ES suppressed HBsAg production with an IC50 of 380 μ g/mL in PLC/PRF/5 cells for a period of 24 h. HD-03/ES downregulated HBsAg gene expression in PLC/PRF/5 cells. In conclusion, HD-03/ES exhibits strong anti-HBV properties by inhibiting the secretion of hepatitis B surface antigen in PLC/PRF/5 cells, and this action is targeted at the transcription level. Thus, HD-03/ES could be beneficial in the treatment of acute and chronic hepatitis B infections.","PeriodicalId":73232,"journal":{"name":"Hepatitis research and treatment","volume":"2013 ","pages":"125398"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/125398","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31445425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Evaluation of the significance of pretreatment liver biopsy and baseline mental health disorder diagnosis on hepatitis C treatment completion rates at a veterans affairs medical center. 评价前肝活检和基线心理健康障碍诊断对退伍军人医疗中心丙型肝炎治疗完成率的意义

Hepatitis research and treatment Pub Date : 2013-01-01 Epub Date: 2013-05-16 DOI: 10.1155/2013/653976

Joseph Kluck, Rose M O'Flynn, David E Kaplan, Kyong-Mi Chang

{"title":"Evaluation of the significance of pretreatment liver biopsy and baseline mental health disorder diagnosis on hepatitis C treatment completion rates at a veterans affairs medical center.","authors":"Joseph Kluck, Rose M O'Flynn, David E Kaplan, Kyong-Mi Chang","doi":"10.1155/2013/653976","DOIUrl":"https://doi.org/10.1155/2013/653976","url":null,"abstract":"Objectives. This study was performed to define the overall treatment response rates and treatment completion rates among the population of Hepatitis C infected patients at an urban VA Medical Center. Additionally, we examined whether pretreatment liver biopsy is a positive predictor for treatment completion and if the presence of mental health disorders is a negative predictor for treatment completion. Methods. Retrospective chart review was performed on the 375 patients that were treated for HCV and met the study inclusion parameters between January 1, 2003 and April 1, 2008 at our institution. Clinical data was obtained from the computerized patient record system and was analyzed for respective parameters. Results. Sustained virological response was achieved in 116 (31%) patients. 169 (45%) patients completed a full treatment course. Also, 44% of patients who received a pre-treatment liver biopsy completed treatment versus 46% completion rates for patients who did not receive a pretreatment liver biopsy. Baseline ICD9 diagnosis of a mental health disorder was not associated with higher treatment discontinuation rates. Conclusions. In conclusion, pretreatment liver biopsy was not a positive predictor for treatment completion, and the presence of mental health disorders was not a negative predictor for treatment completion.","PeriodicalId":73232,"journal":{"name":"Hepatitis research and treatment","volume":"2013 ","pages":"653976"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/653976","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31503618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1