G Jaya Pragadeesh, Sheik Asik Abu Sali, S Rajesh Kumar, Dhanashri Babu, D Dheepthi
{"title":"Gliptin induced acute pancreatitis: a literature review.","authors":"G Jaya Pragadeesh, Sheik Asik Abu Sali, S Rajesh Kumar, Dhanashri Babu, D Dheepthi","doi":"10.51821/88.1.13722","DOIUrl":"10.51821/88.1.13722","url":null,"abstract":"<p><p>The association between dipeptidyl peptidase-4 (DPP-4) inhibitors, known as gliptins, and acute pancreatitis raises growing concern. A systematic search of PubMed, Scopus and Web of Science was conducted for studies published between January 2005 and July 2024. Studies focusing on gliptin-induced pancreatitis were selected based on predefined criteria. While gliptins are effective in managing type 2 diabetes mellitus, several case reports and observational studies suggest a potential risk for inducing acute pancreatitis. Proposed mechanisms include increased pancreatic activity and cellular stress. Clinical presentation often includes abdominal pain and elevated pancreatic enzymes, necessitating prompt diagnosis and discontinuation of the offending agent. Early recognition and management, including discontinuation of the drug and supportive care, are crucial. Balancing benefits and risks of gliptin therapy is essential for ensuring patient safety and optimal outcomes. This review underscores the importance of vigilance among healthcare providers and the need for further research to develop safer therapeutic strategies.</p>","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"88 2","pages":"151-155"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Venous malformations as a rare cause of lower gastrointestinal bleeding in a young patient with Blue Rubber Bleb Nevus Syndrome.","authors":"A Mahajan, M Verma","doi":"10.51821/88.2.13406","DOIUrl":"10.51821/88.2.13406","url":null,"abstract":"","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"88 2","pages":"217-218"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D Naudts, B Van Overberghe, F De Maeyer, M Peeters, T Vanwolleghem
{"title":"Acute hepatitis E-related Guillain-Barré syndrome.","authors":"D Naudts, B Van Overberghe, F De Maeyer, M Peeters, T Vanwolleghem","doi":"10.51821/88.1.13825","DOIUrl":"https://doi.org/10.51821/88.1.13825","url":null,"abstract":"","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"88 2","pages":"1-2"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Essential reading from the editorial board.","authors":"H De Schepper, A Marot","doi":"10.51821/88.1.14571","DOIUrl":"https://doi.org/10.51821/88.1.14571","url":null,"abstract":"","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"88 2","pages":"87-88"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T Halbart, C Maris, S Laurent, T-H Trieu, J-B Zeevaert, E Wain
{"title":"Successful Endoscopic Management of Gastric Volvulus: A Case Report Highlighting Effective Treatment Strategies.","authors":"T Halbart, C Maris, S Laurent, T-H Trieu, J-B Zeevaert, E Wain","doi":"10.51821/88.1.13090","DOIUrl":"10.51821/88.1.13090","url":null,"abstract":"<p><p>Gastric volvulus is a rare entity which lacks evidence in the literature, characterized by the abnormal twisting or rotation of the stomach on itself of at least 180 degrees along its transverse or longitudinal axis. This rotation can lead to the obstruction of the stomach and interfere with its blood supply, causing a variety of symptoms and potentially serious complications. Some patients may be managed temporarily or definitively with conservative or endoscopic treatment, the latest including reduction and percutaneous gastropexy, but most patients benefit from surgery. The authors report three cases of gastric volvulus seen in a six-months period.</p>","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"88 2","pages":"195-197"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J Collin, H Thanh Trieu, S Vieujean, C Reenaers, E Louis, C Van Kemseke
{"title":"A multifaceted disease.","authors":"J Collin, H Thanh Trieu, S Vieujean, C Reenaers, E Louis, C Van Kemseke","doi":"10.51821/88.1.13972","DOIUrl":"https://doi.org/10.51821/88.1.13972","url":null,"abstract":"","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"88 2","pages":"213-214"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case report on use of TIPS for ectopic variceal bleeding.","authors":"E Brusselle, J Van Ongeval, W Pauwels, A Geerts","doi":"10.51821/88.1.13326","DOIUrl":"10.51821/88.1.13326","url":null,"abstract":"<p><strong>Background: </strong>Ectopic varices may develop anywhere in the abdomen except in the cardioesophageal junction and cause only 5% of all variceal bleeding. Considering the low prevalence of this disease, management is challenging and low-evidence based. By means of a case report, we reviewed literature on the treatment of ectopic varices using TIPS (Transjugular Intrahepatic Portosystemic Shunt).</p><p><strong>Case presentation: </strong>A 65-year old patient presented to the emergency department with massive hematochezia and haemorrhagic shock. A CT angiography reported liver cirrhosis, a portal vein thrombosis (PVT) and colonic varices without active bleeding. The patient was transferred to the intensive care unit where colonoscopy confirmed the presence of ascending colonic varices with a red whale sign. He successfully underwent a TIPS placement and was discharged after five days from the hospital.</p><p><strong>Conclusion: </strong>In this case, TIPS placement proved to be an effective treatment for ectopic variceal bleeding.</p>","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"88 2","pages":"199-201"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D L Cohen, J Ghantus, R Tome, B Hijazi, F Abu Baker, H Shirin, D Carter, F Shibli, T Khoury, A Mari
{"title":"Assessment of Esophageal Emptying in Patients with Dysphagia: Differences Between High-Resolution Impedance Manometry and Timed Barium Esophagram.","authors":"D L Cohen, J Ghantus, R Tome, B Hijazi, F Abu Baker, H Shirin, D Carter, F Shibli, T Khoury, A Mari","doi":"10.51821/88.1.13772","DOIUrl":"10.51821/88.1.13772","url":null,"abstract":"<p><strong>Background/aims: </strong>Assessment of esophageal emptying is important in the evaluation of patients with dysphagia. As several modalities can evaluate this, we aimed to compare two tests frequently used for assessing esophageal emptying-highresolution impedance manometry (HRiM) and timed barium esophagram (TBE).</p><p><strong>Methods: </strong>A retrospective study compared the results of HRiM and TBE in patients with dysphagia between 2018 and 2022. Abnormal esophageal clearance was defined as ≥30% swallows with incomplete bolus clearance on HRiM and as residual barium ≥2 cm at 5 minutes on TBE.</p><p><strong>Results: </strong>77 patients were included in the study (mean age 51.6; 69% female). The most common HRiM diagnoses were normal motility (37.7%), ineffective esophageal motility (28.6%), and achalasia (19.5%). Effective esophageal clearance was noted on HRiM in only 44 subjects (57.1%), while it was seen on TBE in 57 subjects (74.0%)(P=0.027). There was agreement between the studies in 58 subjects (75.3%). Agreement was significantly affected by the HRiM diagnosis with the highest rate (86.7%) among achalasia patients (P=0.032). The only other factor correlated to agreement between the studies was a lack of alcohol use (P=0.048).</p><p><strong>Conclusions: </strong>According to the parameters used in this study, TBE is more likely to reveal esophageal emptying than HRiM in patients with dysphagia. While there is fair agreement between the results of the two studies, results are especially concordant in achalasia patients suggesting that either study may be useful in evaluating esophageal emptying in that population.</p>","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"88 2","pages":"89-95"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dupilumab in an adolescent with eosinophilic esophagitis and eosinophilic duodenitis, a valuable treatment option.","authors":"S Vande Velde, A Hoorens, S Van Biervliet","doi":"10.51821/88.1.13767","DOIUrl":"https://doi.org/10.51821/88.1.13767","url":null,"abstract":"<p><p>The authors report the first adolescent (to our knowledge) in Belgium to receive duplimumab for eosinophilic esophagitis (EoE) and eosinophilic duodenitis (EoD). EoE was diagnosed in 2020 in a 13-year-old boy by endoscopy with biopsies following complaints of abdominal pain. Several treatments (omeprazole, topical steroids, and elemental diet) have been tried without adequate and sustained success. In 2023, in addition to the diagnosis of EoE, a diagnosis of mucosal EoD with significant ulceration was established. In January 2023, the EMA approved the use of dupilumab for EoE in children above the age of 12. Weekly subcutaneous dupilumab 300mg was started in November 2023. After three months, a complete endoscopic and histologic normalization of the esophagus and duodenum was achieved. He reported no further clinical signs or adverse events to date.</p>","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"88 2","pages":"207-210"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Potential Benefits of Akkermansia muciniphila as a Next-Generation Probiotic in the Maintenance of Overall Liver Health.","authors":"K Rachwal, K Mierczak, T Poplawski","doi":"10.51821/88.1.13037","DOIUrl":"https://doi.org/10.51821/88.1.13037","url":null,"abstract":"<p><strong>Background and study aim: </strong>The gut-liver axis and gut microbiota, with a particular focus on Akkermansia muciniphila, a next-generation probiotic, have been identified as significant factors in preventing the development and progression of liver diseases. This review aims to discuss the potential therapeutic role of A. muciniphila in maintaining liver health, focusing on the latest findings from preclinical and clinical studies.</p><p><strong>Methods: </strong>To achieve the review's purpose, the most common keywords were searched in three online databases (PubMed, bioRxiv, and Google Scholar).</p><p><strong>Results: </strong>The search approach identified 49 references. Studies have shown that the gut microbiota, including A. muciniphila, has the potential to be a therapeutic target for many hepatic disorders. Several studies have demonstrated A. muciniphila's beneficial effects on improving metabolic parameters, including insulin resistance, blood cholesterol levels, and overall liver function.</p><p><strong>Conclusions: </strong>Further research is necessary to determine the optimal dosage, duration, and administration route of A. muciniphila for managing hepatic disorders. While there are promising findings, a more thorough understanding of the underlying mechanisms and the development of effective therapeutic strategies are necessary for successful treatment of liver diseases.</p>","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"88 2","pages":"141-150"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}