Acta gastro-enterologica Belgica最新文献_第6页

Clinical characteristics of hepatocellular carcinoma in patients with cirrhosis: a comparative cohort study. 肝硬化患者肝细胞癌的临床特征：一项比较队列研究。

IF 1.5 4区医学

Acta gastro-enterologica Belgica Pub Date : 2023-07-01 DOI: 10.51821/86.3.11867

E Kaze, J Henrion

{"title":"Clinical characteristics of hepatocellular carcinoma in patients with cirrhosis: a comparative cohort study.","authors":"E Kaze, J Henrion","doi":"10.51821/86.3.11867","DOIUrl":"10.51821/86.3.11867","url":null,"abstract":"Background and study aims: The epidemiology of cirrhosis has changed over the last two decades. We aimed to assess whether the epidemiology and clinical presentation of hepatocellular carcinoma (HCC) occurring in cirrhosis has changed.Patients and methods: The patients were recruited from the Cirrhosis Registry. This database included patients with cirrhosis who had attended the outpatient' liver clinic at the Centre Hospitalier Jolimont in La Louvière, Belgium, since January 1995. We extracted data on two cohorts of patients with cirrhosis collected over an identical time period and followed up for the same duration.Results: Cohort 1 included 504 patients enrolled from 1995 to 2005; among them, 89 patients developed HCC during the defined follow-up period (group 1). Cohort 2 included 566 patients enrolled from 2006 to 2016, among whom 73 patients developed HCC during the defined follow-up period (group 2). When patients with HCC in both groups were compared, no differences were found in the age at HCC diagnosis, the test that alerted on the presence of HCC, the extension, and the stage of the lesion at diagnosis. In the group 1, hepatitis C virus-related HCC occurred in 53% of the cases compared with 18% in the group 2 (P<0.001). Alcohol-related HCC occurred in 27% in the group 1 compared with 60% in the group 2 (P<0.001). The prevalence of metabolic dysfunction-associated steatotic liver disease-related HCC accounted for 10% in all groups.Conclusion: The general epidemiology of HCC has not changed; however the etiology of underlying cirrhosis has changed.","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41181781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical evaluation of the severity of acute pancreatitis in elderly patients. 老年患者急性胰腺炎严重程度的临床评价。

IF 1.5 4区医学

Acta gastro-enterologica Belgica Pub Date : 2023-07-01 DOI: 10.51821/86.3.11290

A Çalim

{"title":"Clinical evaluation of the severity of acute pancreatitis in elderly patients.","authors":"A Çalim","doi":"10.51821/86.3.11290","DOIUrl":"10.51821/86.3.11290","url":null,"abstract":"Background and study aims: Acute pancreatitis incidence in geriatric patients has increased in recent years. The aim of this study is to compare the clinical outcomes, laboratory findings of acute pancreatitis among patients aged 65-74 years, 75-84 years and ≥85 years.Patients and methods: This retrospective study analyzed 500 patients aged 65 years and above, who were diagnosed with acute pancreatitis between 2012 and 2022. They were categorized into three groups based on their age: 65-74 years, 75-84 years, and ≥85 years. The primary outcome of the study focused on comparing the hospital mortality rates among the three age groups. The secondary outcomes involved comparing the length of hospital stay, intensive care unit admission, rates of endoscopic retrograde cholangiopancreatography (ERCP), and cholecystectomy requirement among the three age groups.Results: The study's primary outcome is the significantly higher mortality rate in the oldest age group (p=0.002). In addition, patients with a Bedside index score ≥3, severe pancreatitis according to the revised Atlanta criteria, necrotizing pancreatitis, and drug-induced pancreatitis had significantly higher mortality rates. Hospitalized patients in the intensive care unit also showed a statistically significant increase in mortality rates. Interestingly, the rate of cholecystectomy operations was significantly lower in the group with higher mortality (p=0.030). When evaluated in terms of secondary outcomes, no significant difference was found in all three age groups.Conclusions: The findings of this study indicate that the oldest age group had a significantly higher mortality rate compared to the other age groups. As a result, early diagnosis and prompt treatment are of utmost importance to enhance outcomes in this vulnerable population.","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41181782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel corticosteroid formulations in the treatment of eosinophilic esophagitis: what is the evidence? 治疗嗜酸性食管炎的新型皮质类固醇制剂：证据是什么？

IF 1.5 4区医学

Acta gastro-enterologica Belgica Pub Date : 2023-07-01 DOI: 10.51821/86.3.11757

S Walgraeve, T Vanuytsel

{"title":"Novel corticosteroid formulations in the treatment of eosinophilic esophagitis: what is the evidence?","authors":"S Walgraeve, T Vanuytsel","doi":"10.51821/86.3.11757","DOIUrl":"10.51821/86.3.11757","url":null,"abstract":"Background and study aims: Eosinophilic esophagitis (EoE) is a food allergen-induced disease of the esophagus. Chronic, eosinophil-predominant inflammation eventually leads to fibrosis, esophageal dysfunction and severe morbidity. Swallowed topical corticosteroids (STCs) are a mainstay of anti-inflammatory therapy in the treatment of active EoE. Data on the efficacy of novel corticosteroid formulations, developed specifically for esophageal delivery, have recently become available.Methods: A comprehensive review was performed aiming to summarize evidence on the role of STCs in the treatment of EoE. Two biomedical bibliographic databases (PubMED, EMBASE) were searched for articles providing original information on the efficacy and safety of STCs in adult EoE patients.Results: Budesonide orodispersible tablet (BOT) and budesonide oral suspension (BOS) both surpassed placebo formulations regarding the efficacy of inducing and maintaining histologic, symptomatic and endoscopic remission. Overall, BOT displayed the highest grade of efficacy with clinico-histologic remission rates up to 75% after 1 year. Fluticasone propionate (APT-1011) achieved and maintained histologic and endoscopic responses in the majority of patients, whereas only a positive trend was demonstrated for symptomatic improvement. Mometasone and ciclesonide were studied in a limited number of smaller-scale trials and placebo-controlled data are required to substantiate the promising findings. All STCs displayed a similar side effects profile and were generally considered safe and well-tolerated.Conclusions: Current evidence supports long-term treatment with novel corticosteroid formulations, challenging the established treatment paradigm of EoE. BOT appears to be the most effective steroid therapy, although head-to-head comparative trials between STCs are needed.","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41181703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-esophageal eosinophilic gastrointestinal diseases: a narrative review. 非食管嗜酸性粒细胞性胃肠道疾病：叙述性综述。

IF 1.5 4区医学

Acta gastro-enterologica Belgica Pub Date : 2023-07-01 DOI: 10.51821/86.3.11869

J Janssens, T Vanuytsel

{"title":"Non-esophageal eosinophilic gastrointestinal diseases: a narrative review.","authors":"J Janssens, T Vanuytsel","doi":"10.51821/86.3.11869","DOIUrl":"10.51821/86.3.11869","url":null,"abstract":"Eosinophilic gastrointestinal disorders are a group of rare diseases characterized by the infiltration of eosinophils in the gastrointestinal wall in a greater amount than in homeostatic conditions. 'Non-esophageal eosinophilic gastrointestinal disorders' is the umbrella term for all eosinophilic gastrointestinal disorders outside of the well known eosinophilic esophagitis. This includes eosinophilic gastritis, eosinophilic enteritis and eosinophilic colitis. The clinical presentation is atypical and not very different for the three disorders. The depth of infiltration has a bigger influence on the presenting symptoms than the disease location. Although the frequency of diagnosis and research in this subject is increasing over time, non-esophageal eosinophilic disorders are rare and high quality evidence is limited to date. In this narrative review, we provide an overview of the latest insights in the pathophysiology, diagnostic approach and available treatment options. Transcriptome studies have found the pathogenesis to be T helper type 2 driven. Various laboratory findings can be used to trigger raised suspicion and investigation with endoscopy. As the endoscopic appearance of the mucosa is normal in most cases, multiple biopsies in each segment are needed to quantify the amount of eosinophils in the tissue. Eosinophilic cut-offs for diagnosis are a controversial topic and a consensus is still lacking. A recently developed tissue based diagnostic platform which measures differentially expressed genes might be available in the future to classify patients with intermediate eosinophilic tissue levels under the cut-off. For the treatment, corticosteroids are still the cornerstone of treatment but promising research suggests a role of biologicals, such as Lirentelimab (anti-siglec 8) in particular.","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41181702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An underrecognized cause of hepatomegaly in uncontrolled type I diabetes. 未经控制的I型糖尿病引起肝肿大的一个未被充分认识的原因。

IF 1.5 4区医学

Acta gastro-enterologica Belgica Pub Date : 2023-07-01 DOI: 10.51821/86.3.12257

K Ferdinande, J Decaestecker, L Seynhaeve, E Steenkiste, C De Vloo

引用次数: 0

An unusual cause of abdominal pain: spontaneous bilateral adrenal hemorrhage. 腹痛的一个不寻常原因：自发性双侧肾上腺出血。

IF 1.5 4区医学

Acta gastro-enterologica Belgica Pub Date : 2023-07-01 DOI: 10.51821/86.3.11251

A Rodriguez Tebar, J Panza-Nduli, B Gubin, P-A Rogghe, P Oriot

引用次数: 0

Local and systemic autoimmune manifestations linked to hepatitis A infection. 与甲型肝炎感染相关的局部和全身自身免疫表现。

IF 1.5 4区医学

Acta gastro-enterologica Belgica Pub Date : 2023-07-01 DOI: 10.51821/86.3.11299

M Doulberis, A Papaefthymiou, S A Polyzos, E Vardaka, M Tzitiridou-Chatzopoulou, D Chatzopoulos, A Koffas, V Papadopoulos, F Kyrailidi, J Kountouras

{"title":"Local and systemic autoimmune manifestations linked to hepatitis A infection.","authors":"M Doulberis, A Papaefthymiou, S A Polyzos, E Vardaka, M Tzitiridou-Chatzopoulou, D Chatzopoulos, A Koffas, V Papadopoulos, F Kyrailidi, J Kountouras","doi":"10.51821/86.3.11299","DOIUrl":"10.51821/86.3.11299","url":null,"abstract":"Hepatitis A virus (HAV) represents a global burdening infectious agent causing in the majority of cases a self-limiting acute icteric syndrome, the outcome is related to the hepatic substrate and the potential pre-existing damage, whereas a plethora of extra-hepatic manifestations has also been reported. Despite the absence of post- HAV chronicity it has been associated with an additional burden on existing chronic liver diseases. Moreover, the induced immune response and the antigenic molecular mimicry are considered as triggering factors of autoimmunity with regional and distal impact. Diseases such as autoimmune hepatitis, Guillain-Barré syndrome, rheumatoid arthritis, Still's syndrome, Henoch-Schönlein purpura, autoimmune hemolytic anemia, antiphospholipid syndrome, systematic lupus erythematosus or cryoglobulinemic vasculitis have been described in patients with HAV infection. Although the exact mechanisms remain unclear, this review aims to accumulate and clarify the pathways related to this linkage.","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41181700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Melanoma of the gallbladder. 胆囊黑色素瘤。

IF 1.5 4区医学

Acta gastro-enterologica Belgica Pub Date : 2023-07-01 DOI: 10.51821/86.3.12020

A Boca, N Bletard, R Materne

引用次数: 0

An unusual cause of extrahepatic cholestasis associated with solid liver lesions: a case report. 肝外胆汁淤积合并实体肝病变的一个不寻常原因：一例报告。

IF 1.5 4区医学

Acta gastro-enterologica Belgica Pub Date : 2023-07-01 DOI: 10.51821/86.3.10393

L Caverenne, L Weichselbaum, M Van Hoof, P Deltenre

引用次数: 0

Biliary papillomatosis. 胆道乳头状瘤病。

IF 1.5 4区医学

Acta gastro-enterologica Belgica Pub Date : 2023-07-01 DOI: 10.51821/86.3.11733

F Gelders, M Struyve, H van Malenstein

引用次数: 0