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Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults: Big Data from Seven Randomized Controlled Trials Worldwide. 饮食/生活方式干预和TCF7L2基因型对超重或肥胖成人血糖控制和肥胖的相互作用:来自全球7项随机对照试验的大数据
Health data science Pub Date : 2021-11-03 eCollection Date: 2021-01-01 DOI: 10.34133/2021/9897048
Tao Huang, Zhenhuang Zhuang, Yoriko Heianza, Dianjianyi Sun, Wenjie Ma, Wenxiu Wang, Meng Gao, Zhe Fang, Emilio Ros, Liana C Del Gobbo, Jordi Salas-Salvadó, Miguel A Martínez-González, Jan Polak, Markku Laakso, Arne Astrup, Dominique Langin, Jorg Hager, Gabby Hul, Torben Hansen, Oluf Pedersen, Jean-Michel Oppert, Wim H M Saris, Peter Arner, Montserrat Cofán, Sujatha Rajaram, Jaakko Tuomilehto, Jaana Lindström, Vanessa D de Mello, Alena Stancacova, Matti Uusitupa, Mathilde Svendstrup, Thorkild I A Sørensen, Christopher D Gardner, Joan Sabaté, Dolores Corella, J Alfredo Martinez, Lu Qi
{"title":"Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults: Big Data from Seven Randomized Controlled Trials Worldwide.","authors":"Tao Huang, Zhenhuang Zhuang, Yoriko Heianza, Dianjianyi Sun, Wenjie Ma, Wenxiu Wang, Meng Gao, Zhe Fang, Emilio Ros, Liana C Del Gobbo, Jordi Salas-Salvadó, Miguel A Martínez-González, Jan Polak, Markku Laakso, Arne Astrup, Dominique Langin, Jorg Hager, Gabby Hul, Torben Hansen, Oluf Pedersen, Jean-Michel Oppert, Wim H M Saris, Peter Arner, Montserrat Cofán, Sujatha Rajaram, Jaakko Tuomilehto, Jaana Lindström, Vanessa D de Mello, Alena Stancacova, Matti Uusitupa, Mathilde Svendstrup, Thorkild I A Sørensen, Christopher D Gardner, Joan Sabaté, Dolores Corella, J Alfredo Martinez, Lu Qi","doi":"10.34133/2021/9897048","DOIUrl":"10.34133/2021/9897048","url":null,"abstract":"<p><p><i>Objective</i>. The strongest locus which associated with type 2 diabetes (T2D) by the common variant rs7903146 is the transcription factor 7-like 2 gene (<i>TCF7L2</i>). We aimed to quantify the interaction of diet/lifestyle interventions and the genetic effect of <i>TCF7L2</i> rs7903146 on glycemic traits, body weight, or waist circumference in overweight or obese adults in several randomized controlled trials (RCTs).<i>Methods</i>. From October 2016 to May 2018, a large collaborative analysis was performed by pooling individual-participant data from 7 RCTs. These RCTs reported changes in glycemic control and adiposity of the variant rs7903146 after dietary/lifestyle-related interventions in overweight or obese adults. Gene treatment interaction models which used the genetic effect encoded by the allele dose and common covariates were applicable to individual participant data in all studies.<i>Results</i>. In the joint analysis, a total of 7 eligible RCTs were included (<math><mi>n</mi><mo>=</mo><mn>4,114</mn></math>). Importantly, we observed a significant effect modification of diet/lifestyle-related interventions on the <i>TCF7L2</i> variant rs7903146 and changes in fasting glucose. Compared with the control group, diet/lifestyle interventions were related to lower fasting glucose by -3.06 (95% CI, -5.77 to -0.36) mg/dL (test for heterogeneity and overall effect: <math><msup><mrow><mi>I</mi></mrow><mrow><mn>2</mn></mrow></msup><mo>=</mo><mn>45.1</mn><mi>%</mi></math>, <math><mi>p</mi><mo><</mo><mn>0.05</mn></math>; <math><mi>z</mi><mo>=</mo><mn>2.20</mn></math>, <math><mi>p</mi><mo>=</mo><mn>0.028</mn></math>) per one copy of the <i>TCF7L2</i> T risk allele. Furthermore, regardless of genetic risk, diet/lifestyle interventions were associated with lower waist circumference. However, there was no significant change for diet/lifestyle interventions in other glycemic control and adiposity traits per one copy of <i>TCF7L2</i> risk allele.<i>Conclusions</i>. Our findings suggest that carrying the <i>TCF7L2</i> T risk allele may have a modestly greater benefit for specific diet/lifestyle interventions to improve the control of fasting glucose in overweight or obese adults.</p>","PeriodicalId":73207,"journal":{"name":"Health data science","volume":" ","pages":"9897048"},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10904069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45494578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implications of Delayed Reopening in Controlling the COVID-19 Surge in Southern and West-Central USA. 推迟重新开放对控制美国南部和中西部COVID-19激增的影响。
Health data science Pub Date : 2021-10-28 eCollection Date: 2021-01-01 DOI: 10.34133/2021/9798302
Raj Dandekar, Emma Wang, George Barbastathis, Chris Rackauckas
{"title":"Implications of Delayed Reopening in Controlling the COVID-19 Surge in Southern and West-Central USA.","authors":"Raj Dandekar,&nbsp;Emma Wang,&nbsp;George Barbastathis,&nbsp;Chris Rackauckas","doi":"10.34133/2021/9798302","DOIUrl":"https://doi.org/10.34133/2021/9798302","url":null,"abstract":"<p><p>In the wake of the rapid surge in the COVID-19-infected cases seen in Southern and West-Central USA in the period of June-July 2020, there is an urgent need to develop robust, data-driven models to quantify the effect which early reopening had on the infected case count increase. In particular, it is imperative to address the question: How many infected cases could have been prevented, had the worst affected states not reopened early? To address this question, we have developed a novel COVID-19 model by augmenting the classical SIR epidemiological model with a neural network module. The model decomposes the contribution of quarantine strength to the infection time series, allowing us to quantify the role of quarantine control and the associated reopening policies in the US states which showed a major surge in infections. We show that the upsurge in the infected cases seen in these states is strongly corelated with a drop in the quarantine/lockdown strength diagnosed by our model. Further, our results demonstrate that in the event of a stricter lockdown without early reopening, the number of active infected cases recorded on 14 July could have been reduced by more than 40% in all states considered, with the actual number of infections reduced being more than 100,000 for the states of Florida and Texas. As we continue our fight against COVID-19, our proposed model can be used as a valuable asset to simulate the effect of several reopening strategies on the infected count evolution, for any region under consideration.</p>","PeriodicalId":73207,"journal":{"name":"Health data science","volume":"2021 ","pages":"9798302"},"PeriodicalIF":0.0,"publicationDate":"2021-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40477811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Providing Timely, Trustworthy Guidance to Frontline Clinicians during a Pandemic. 在大流行病期间为一线临床医生提供及时、可信的指导。
Health data science Pub Date : 2021-10-20 eCollection Date: 2021-01-01 DOI: 10.34133/2021/9854894
Yngve Falck-Ytter, Rebecca L Morgan
{"title":"Providing Timely, Trustworthy Guidance to Frontline Clinicians during a Pandemic.","authors":"Yngve Falck-Ytter, Rebecca L Morgan","doi":"10.34133/2021/9854894","DOIUrl":"10.34133/2021/9854894","url":null,"abstract":"","PeriodicalId":73207,"journal":{"name":"Health data science","volume":"2021 ","pages":"9854894"},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40502456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Space-Time-Stratified Case-Crossover Design in Environmental Epidemiology Study. 环境流行病学研究中的时空分层病例交叉设计
Health data science Pub Date : 2021-10-07 eCollection Date: 2021-01-01 DOI: 10.34133/2021/9870798
Yao Wu, Shanshan Li, Yuming Guo
{"title":"Space-Time-Stratified Case-Crossover Design in Environmental Epidemiology Study.","authors":"Yao Wu, Shanshan Li, Yuming Guo","doi":"10.34133/2021/9870798","DOIUrl":"10.34133/2021/9870798","url":null,"abstract":"","PeriodicalId":73207,"journal":{"name":"Health data science","volume":" ","pages":"9870798"},"PeriodicalIF":0.0,"publicationDate":"2021-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10880144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49597444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The COVID-19 Pandemic and Mental Health Concerns on Twitter in the United States 新冠肺炎疫情与美国推特上的心理健康问题
Health data science Pub Date : 2021-08-30 DOI: 10.1101/2021.08.23.21262489
Senqi Zhang, Li Sun, Daiwei Zhang, Pin Li, Yue Liu, A. Anand, Zidian Xie, Dongmei Li
{"title":"The COVID-19 Pandemic and Mental Health Concerns on Twitter in the United States","authors":"Senqi Zhang, Li Sun, Daiwei Zhang, Pin Li, Yue Liu, A. Anand, Zidian Xie, Dongmei Li","doi":"10.1101/2021.08.23.21262489","DOIUrl":"https://doi.org/10.1101/2021.08.23.21262489","url":null,"abstract":"Background: Mental health illness is a growing problem in recent years. During the COVID-19 pandemic, mental health concerns (such as fear and loneliness) have been actively discussed on social media. Objective: In this study, we aim to examine mental health discussions on Twitter during the COVID-19 pandemic in the United States and infer the demographic composition of Twitter users who had mental health concerns. Methods: COVID-19 related tweets from March 5th, 2020 to January 31st, 2021 were collected through Twitter streaming API using COVID-19 related keywords (e.g., \"corona\", \"covid19\", \"covid\"). By further filtering using mental health keywords (e.g., \"depress\", \"failure\", \"hopeless\"), we extracted mental health-related tweets from the US. Topic modeling using the Latent Dirichlet Allocation model was conducted to monitor users' discussions surrounding mental health concerns. Demographic inference using deep learning algorithms (including Face++ and Ethnicolr) was performed to infer the demographic composition of Twitter users who had mental health concerns during the COVID-19 pandemic. Results: We observed a positive correlation between mental health concerns on Twitter and the COVID-19 pandemic in the US. Topic modeling showed that \"stay-at-home\", \"death poll\" and \"politics and policy\" were the most popular topics in COVID-19 mental health tweets. Among Twitter users who had mental health concerns during the pandemic, Males, White, and 30-49 age group people were more likely to express mental health concerns. In addition, Twitter users from the east and west coast had more mental health concerns. Conclusions: The COVID-19 pandemic has a significant impact on mental health concerns on Twitter in the US. Certain groups of people (such as Males, White) were more likely to have mental health concerns during the COVID-19 pandemic.","PeriodicalId":73207,"journal":{"name":"Health data science","volume":"2022 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47536357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Characterizing Discourse about COVID-19 Vaccines: A Reddit Version of the Pandemic Story. 描述关于新冠肺炎疫苗的话语:大流行病故事的Reddit版本。
Health data science Pub Date : 2021-08-27 eCollection Date: 2021-01-01 DOI: 10.34133/2021/9837856
Wei Wu, Hanjia Lyu, Jiebo Luo
{"title":"Characterizing Discourse about COVID-19 Vaccines: A Reddit Version of the Pandemic Story.","authors":"Wei Wu, Hanjia Lyu, Jiebo Luo","doi":"10.34133/2021/9837856","DOIUrl":"10.34133/2021/9837856","url":null,"abstract":"<p><p>It has been one year since the outbreak of the COVID-19 pandemic. The good news is that vaccines developed by several manufacturers are being actively distributed worldwide. However, as more and more vaccines become available to the public, various concerns related to vaccines become the primary barriers that may hinder the public from getting vaccinated. Considering the complexities of these concerns and their potential hazards, this study is aimed at offering a clear understanding about different population groups' underlying concerns when they talk about COVID-19 vaccines-particularly those active on Reddit. The goal is achieved by applying LDA and LIWC to characterize the pertaining discourse with insights generated through a combination of quantitative and qualitative comparisons. Findings include the following: (1) during the pandemic, the proportion of Reddit comments predominated by conspiracy theories outweighed that of any other topics; (2) each subreddit has its own user bases, so information posted in one subreddit may not reach that from other subreddits; and (3) since users' concerns vary across time and subreddits, communication strategies must be adjusted according to specific needs. The results of this study manifest challenges as well as opportunities in the process of designing effective communication and immunization programs.</p>","PeriodicalId":73207,"journal":{"name":"Health data science","volume":"2021 ","pages":"9837856"},"PeriodicalIF":0.0,"publicationDate":"2021-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40477813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Framework for Assessing Import Costs of Medical Supplies and Results for a Tuberculosis Program in Karakalpakstan, Uzbekistan. 乌兹别克斯坦卡拉卡尔帕克斯坦结核病计划医疗用品进口成本和结果评估框架》。
Health data science Pub Date : 2021-08-25 eCollection Date: 2021-01-01 DOI: 10.34133/2021/9813732
Stefan Kohler, Norman Sitali, Nicolas Paul
{"title":"A Framework for Assessing Import Costs of Medical Supplies and Results for a Tuberculosis Program in Karakalpakstan, Uzbekistan.","authors":"Stefan Kohler, Norman Sitali, Nicolas Paul","doi":"10.34133/2021/9813732","DOIUrl":"10.34133/2021/9813732","url":null,"abstract":"<p><p><i>Background</i>. Import of medical supplies is common, but limited knowledge about import costs and their structure introduces uncertainty to budget planning, cost management, and cost-effectiveness analysis of health programs. We aimed to estimate the import costs of a tuberculosis (TB) program in Uzbekistan, including the import costs of specific imported items.<i>Methods</i>. We developed a framework that applies costing and cost accounting to import costs. First, transport costs, customs-related costs, cargo weight, unit weights, and quantities ordered were gathered for a major shipment of medical supplies from the Médecins Sans Frontières (MSF) Procurement Unit in Amsterdam, the Netherlands, to a TB program in Karakalpakstan, Uzbekistan, in 2016. Second, air freight, land freight, and customs clearance cost totals were estimated. Third, total import costs were allocated to different cargos (standard, cool, and frozen), items (e.g., TB drugs), and units (e.g., one tablet) based on imported weight and quantity. Data sources were order invoices, waybills, the local MSF logistics department, and an MSF standard product list.<i>Results</i>. The shipment contained 1.8 million units of 85 medical items of standard, cool, and frozen cargo. The average import cost for the TB program was 9.0% of the shipment value. Import cost varied substantially between cargos (8.9-28% of the cargo value) and items (interquartile range 4.5-35% of the item value). The largest portion of the total import cost was caused by transport (82-99% of the cargo import cost) and allocated based on imported weight. Ten (14%) of the 69 items imported as standard cargo were associated with 85% of the standard cargo import cost. Standard cargo items could be grouped based on contributing to import costs predominantly through unit weight (e.g., fluids), imported quantity (e.g., tablets), or the combination of unit weight and imported quantity (e.g., items in powder form).<i>Conclusion</i>. The cost of importing medical supplies to a TB program in Karakalpakstan, Uzbekistan, was sizable, variable, and driven by a subset of imported items. The framework used to measure and account import costs can be adapted to other health programs.</p>","PeriodicalId":73207,"journal":{"name":"Health data science","volume":"1 1","pages":"9813732"},"PeriodicalIF":0.0,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10904066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69807167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Social and Behavioral Determinants of Health in the Era of Artificial Intelligence with Electronic Health Records: A Scoping Review. 人工智能时代健康的社会和行为决定因素与电子健康记录:范围审查
Health data science Pub Date : 2021-08-24 eCollection Date: 2021-01-01 DOI: 10.34133/2021/9759016
Anusha Bompelli, Yanshan Wang, Ruyuan Wan, Esha Singh, Yuqi Zhou, Lin Xu, David Oniani, Bhavani Singh Agnikula Kshatriya, Joyce Joy E Balls-Berry, Rui Zhang
{"title":"Social and Behavioral Determinants of Health in the Era of Artificial Intelligence with Electronic Health Records: A Scoping Review.","authors":"Anusha Bompelli, Yanshan Wang, Ruyuan Wan, Esha Singh, Yuqi Zhou, Lin Xu, David Oniani, Bhavani Singh Agnikula Kshatriya, Joyce Joy E Balls-Berry, Rui Zhang","doi":"10.34133/2021/9759016","DOIUrl":"10.34133/2021/9759016","url":null,"abstract":"<p><p><i>Background</i>. There is growing evidence that social and behavioral determinants of health (SBDH) play a substantial effect in a wide range of health outcomes. Electronic health records (EHRs) have been widely employed to conduct observational studies in the age of artificial intelligence (AI). However, there has been limited review into how to make the most of SBDH information from EHRs using AI approaches.<i>Methods</i>. A systematic search was conducted in six databases to find relevant peer-reviewed publications that had recently been published. Relevance was determined by screening and evaluating the articles. Based on selected relevant studies, a methodological analysis of AI algorithms leveraging SBDH information in EHR data was provided.<i>Results</i>. Our synthesis was driven by an analysis of SBDH categories, the relationship between SBDH and healthcare-related statuses, natural language processing (NLP) approaches for extracting SBDH from clinical notes, and predictive models using SBDH for health outcomes.<i>Discussion</i>. The associations between SBDH and health outcomes are complicated and diverse; several pathways may be involved. Using NLP technology to support the extraction of SBDH and other clinical ideas simplifies the identification and extraction of essential concepts from clinical data, efficiently unlocks unstructured data, and aids in the resolution of unstructured data-related issues.<i>Conclusion</i>. Despite known associations between SBDH and diseases, SBDH factors are rarely investigated as interventions to improve patient outcomes. Gaining knowledge about SBDH and how SBDH data can be collected from EHRs using NLP approaches and predictive models improves the chances of influencing health policy change for patient wellness, ultimately promoting health and health equity.</p>","PeriodicalId":73207,"journal":{"name":"Health data science","volume":" ","pages":"9759016"},"PeriodicalIF":0.0,"publicationDate":"2021-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10880156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46471378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of COVID-19 Guideline Quality and Change of Recommendations: A Systematic Review. COVID-19 指南质量和建议变更分析:系统回顾。
Health data science Pub Date : 2021-07-22 eCollection Date: 2021-01-01 DOI: 10.34133/2021/9806173
Siya Zhao, Shuya Lu, Shouyuan Wu, Zijun Wang, Qiangqiang Guo, Qianling Shi, Hairong Zhang, Juanjuan Zhang, Hui Liu, Yunlan Liu, Xianzhuo Zhang, Ling Wang, Mengjuan Ren, Ping Wang, Hui Lan, Qi Zhou, Yajia Sun, Jin Cao, Qinyuan Li, Janne Estill, Joseph L Mathew, Hyeong Sik Ahn, Myeong Soo Lee, Xiaohui Wang, Chenyan Zhou, Yaolong Chen
{"title":"Analysis of COVID-19 Guideline Quality and Change of Recommendations: A Systematic Review.","authors":"Siya Zhao, Shuya Lu, Shouyuan Wu, Zijun Wang, Qiangqiang Guo, Qianling Shi, Hairong Zhang, Juanjuan Zhang, Hui Liu, Yunlan Liu, Xianzhuo Zhang, Ling Wang, Mengjuan Ren, Ping Wang, Hui Lan, Qi Zhou, Yajia Sun, Jin Cao, Qinyuan Li, Janne Estill, Joseph L Mathew, Hyeong Sik Ahn, Myeong Soo Lee, Xiaohui Wang, Chenyan Zhou, Yaolong Chen","doi":"10.34133/2021/9806173","DOIUrl":"10.34133/2021/9806173","url":null,"abstract":"<p><strong>Background: </strong>Hundreds of coronavirus disease 2019 (COVID-19) clinical practice guidelines (CPGs) and expert consensus statements have been developed and published since the outbreak of the epidemic. However, these CPGs are of widely variable quality. So, this review is aimed at systematically evaluating the methodological and reporting qualities of COVID-19 CPGs, exploring factors that may influence their quality, and analyzing the change of recommendations in CPGs with evidence published.</p><p><strong>Methods: </strong>We searched five electronic databases and five websites from 1 January to 31 December 2020 to retrieve all COVID-19 CPGs. The assessment of the methodological and reporting qualities of CPGs was performed using the AGREE II instrument and RIGHT checklist. Recommendations and evidence used to make recommendations in the CPGs regarding some treatments for COVID-19 (remdesivir, glucocorticoids, hydroxychloroquine/chloroquine, interferon, and lopinavir-ritonavir) were also systematically assessed. And the statistical inference was performed to identify factors associated with the quality of CPGs.</p><p><strong>Results: </strong>We included a total of 92 COVID-19 CPGs developed by 19 countries. Overall, the RIGHT checklist reporting rate of COVID-19 CPGs was 33.0%, and the AGREE II domain score was 30.4%. The overall methodological and reporting qualities of COVID-19 CPGs gradually improved during the year 2020. Factors associated with high methodological and reporting qualities included the evidence-based development process, management of conflicts of interest, and use of established rating systems to assess the quality of evidence and strength of recommendations. The recommendations of only seven (7.6%) CPGs were informed by a systematic review of evidence, and these seven CPGs have relatively high methodological and reporting qualities, in which six of them fully meet the Institute of Medicine (IOM) criteria of guidelines. Besides, a rapid advice CPG developed by the World Health Organization (WHO) of the seven CPGs got the highest overall scores in methodological (72.8%) and reporting qualities (83.8%). Many CPGs covered the same clinical questions (it refers to the clinical questions on the effectiveness of treatments of remdesivir, glucocorticoids, hydroxychloroquine/chloroquine, interferon, and lopinavir-ritonavir in COVID-19 patients) and were published by different countries or organizations. Although randomized controlled trials and systematic reviews on the effectiveness of treatments of remdesivir, glucocorticoids, hydroxychloroquine/chloroquine, interferon, and lopinavir-ritonavir for patients with COVID-19 have been published, the recommendations on those treatments still varied greatly across COVID-19 CPGs published in different countries or regions, which may suggest that the CPGs do not make sufficient use of the latest evidence.</p><p><strong>Conclusions: </strong>Both the methodological and repor","PeriodicalId":73207,"journal":{"name":"Health data science","volume":"2021 ","pages":"9806173"},"PeriodicalIF":0.0,"publicationDate":"2021-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40477812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cognitive Computing-Based CDSS in Medical Practice. 基于认知计算的CDSS在医疗实践中的应用
Health data science Pub Date : 2021-07-22 eCollection Date: 2021-01-01 DOI: 10.34133/2021/9819851
Jun Chen, Chao Lu, Haifeng Huang, Dongwei Zhu, Qing Yang, Junwei Liu, Yan Huang, Aijun Deng, Xiaoxu Han
{"title":"Cognitive Computing-Based CDSS in Medical Practice.","authors":"Jun Chen, Chao Lu, Haifeng Huang, Dongwei Zhu, Qing Yang, Junwei Liu, Yan Huang, Aijun Deng, Xiaoxu Han","doi":"10.34133/2021/9819851","DOIUrl":"10.34133/2021/9819851","url":null,"abstract":"<p><p><i>Importance</i>. The last decade has witnessed the advances of cognitive computing technologies that learn at scale and reason with purpose in medicine studies. From the diagnosis of diseases till the generation of treatment plans, cognitive computing encompasses both data-driven and knowledge-driven machine intelligence to assist health care roles in clinical decision-making. This review provides a comprehensive perspective from both research and industrial efforts on cognitive computing-based CDSS over the last decade.<i>Highlights</i>. (1) A holistic review of both research papers and industrial practice about cognitive computing-based CDSS is conducted to identify the necessity and the characteristics as well as the general framework of constructing the system. (2) Several of the typical applications of cognitive computing-based CDSS as well as the existing systems in real medical practice are introduced in detail under the general framework. (3) The limitations of the current cognitive computing-based CDSS is discussed that sheds light on the future work in this direction.<i>Conclusion</i>. Different from medical content providers, cognitive computing-based CDSS provides probabilistic clinical decision support by automatically learning and inferencing from medical big data. The characteristics of managing multimodal data and computerizing medical knowledge distinguish cognitive computing-based CDSS from other categories. Given the current status of primary health care like high diagnostic error rate and shortage of medical resources, it is time to introduce cognitive computing-based CDSS to the medical community which is supposed to be more open-minded and embrace the convenience and low cost but high efficiency brought by cognitive computing-based CDSS.</p>","PeriodicalId":73207,"journal":{"name":"Health data science","volume":" ","pages":"9819851"},"PeriodicalIF":0.0,"publicationDate":"2021-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10880153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49223838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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