Yiqun Han, Tao Xue, Frank J Kelly, Yixuan Zheng, Yao Yao, Jiajianghui Li, Jiwei Li, Chun Fan, Pengfei Li, Tong Zhu
{"title":"降低 PM 2.5 与改善肾功能的关系:一项针对中国成年人的全国性准实验。","authors":"Yiqun Han, Tao Xue, Frank J Kelly, Yixuan Zheng, Yao Yao, Jiajianghui Li, Jiwei Li, Chun Fan, Pengfei Li, Tong Zhu","doi":"10.34133/2022/9846805","DOIUrl":null,"url":null,"abstract":"<p><p><i>Background</i>. Increasing evidence from human studies has revealed the adverse impact of ambient fine particles (PM <sub>2.5</sub>) on health outcomes related to metabolic disorders and distant organs. Whether exposure to ambient PM <sub>2.5</sub> leads to kidney impairment remains unclear. The rapid air quality improvement driven by the clean air actions in China since 2013 provides an opportunity for a quasiexperiment to investigate the beneficial effect of PM <sub>2.5</sub> reduction on kidney function.<i>Methods</i>. Based on two repeated nationwide surveys of the same population of 5115 adults in 2011 and 2015, we conducted a difference-in-difference study. Variations in long-term exposure to ambient PM <sub>2.5</sub> were associated with changes in kidney function biomarkers, including estimated glomerular filtration rate by serum creatinine (GFR <sub>scr</sub>) or cystatin C (GFR <sub>cys</sub>), blood urea nitrogen (BUN), and uric acid (UA).<i>Results</i>. For a 10 <i>μ</i>g/m <sup>3</sup> reduction in PM <sub>2.5</sub>, a significant improvement was observed for multiple kidney functional biomarkers, including GFR <sub>scr</sub>, BUN and UA, with a change of 0.42 (95% confidence interval [CI]: 0.06, 0.78) mL/min/1.73m <sup>2</sup>, -0.38 (-0.64, -0.12) mg/dL, and -0.06 (-0.12, -0.00) mg/dL, respectively. A lower socioeconomic status, indicated by rural residence or low educational level, enhanced the adverse effect of PM <sub>2.5</sub> on kidney function.<i>Conclusions</i>. These results support a significant nephrotoxicity of PM <sub>2.5</sub> based on multiple serum biomarkers and indicate a beneficial effect of improved air quality on kidney function.</p>","PeriodicalId":73207,"journal":{"name":"Health data science","volume":"2022 ","pages":"9846805"},"PeriodicalIF":0.0000,"publicationDate":"2022-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10904065/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association of PM <sub>2.5</sub> Reduction with Improved Kidney Function: A Nationwide Quasiexperiment among Chinese Adults.\",\"authors\":\"Yiqun Han, Tao Xue, Frank J Kelly, Yixuan Zheng, Yao Yao, Jiajianghui Li, Jiwei Li, Chun Fan, Pengfei Li, Tong Zhu\",\"doi\":\"10.34133/2022/9846805\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Background</i>. Increasing evidence from human studies has revealed the adverse impact of ambient fine particles (PM <sub>2.5</sub>) on health outcomes related to metabolic disorders and distant organs. Whether exposure to ambient PM <sub>2.5</sub> leads to kidney impairment remains unclear. The rapid air quality improvement driven by the clean air actions in China since 2013 provides an opportunity for a quasiexperiment to investigate the beneficial effect of PM <sub>2.5</sub> reduction on kidney function.<i>Methods</i>. Based on two repeated nationwide surveys of the same population of 5115 adults in 2011 and 2015, we conducted a difference-in-difference study. Variations in long-term exposure to ambient PM <sub>2.5</sub> were associated with changes in kidney function biomarkers, including estimated glomerular filtration rate by serum creatinine (GFR <sub>scr</sub>) or cystatin C (GFR <sub>cys</sub>), blood urea nitrogen (BUN), and uric acid (UA).<i>Results</i>. For a 10 <i>μ</i>g/m <sup>3</sup> reduction in PM <sub>2.5</sub>, a significant improvement was observed for multiple kidney functional biomarkers, including GFR <sub>scr</sub>, BUN and UA, with a change of 0.42 (95% confidence interval [CI]: 0.06, 0.78) mL/min/1.73m <sup>2</sup>, -0.38 (-0.64, -0.12) mg/dL, and -0.06 (-0.12, -0.00) mg/dL, respectively. A lower socioeconomic status, indicated by rural residence or low educational level, enhanced the adverse effect of PM <sub>2.5</sub> on kidney function.<i>Conclusions</i>. These results support a significant nephrotoxicity of PM <sub>2.5</sub> based on multiple serum biomarkers and indicate a beneficial effect of improved air quality on kidney function.</p>\",\"PeriodicalId\":73207,\"journal\":{\"name\":\"Health data science\",\"volume\":\"2022 \",\"pages\":\"9846805\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10904065/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Health data science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.34133/2022/9846805\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Health data science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.34133/2022/9846805","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Association of PM 2.5 Reduction with Improved Kidney Function: A Nationwide Quasiexperiment among Chinese Adults.
Background. Increasing evidence from human studies has revealed the adverse impact of ambient fine particles (PM 2.5) on health outcomes related to metabolic disorders and distant organs. Whether exposure to ambient PM 2.5 leads to kidney impairment remains unclear. The rapid air quality improvement driven by the clean air actions in China since 2013 provides an opportunity for a quasiexperiment to investigate the beneficial effect of PM 2.5 reduction on kidney function.Methods. Based on two repeated nationwide surveys of the same population of 5115 adults in 2011 and 2015, we conducted a difference-in-difference study. Variations in long-term exposure to ambient PM 2.5 were associated with changes in kidney function biomarkers, including estimated glomerular filtration rate by serum creatinine (GFR scr) or cystatin C (GFR cys), blood urea nitrogen (BUN), and uric acid (UA).Results. For a 10 μg/m 3 reduction in PM 2.5, a significant improvement was observed for multiple kidney functional biomarkers, including GFR scr, BUN and UA, with a change of 0.42 (95% confidence interval [CI]: 0.06, 0.78) mL/min/1.73m 2, -0.38 (-0.64, -0.12) mg/dL, and -0.06 (-0.12, -0.00) mg/dL, respectively. A lower socioeconomic status, indicated by rural residence or low educational level, enhanced the adverse effect of PM 2.5 on kidney function.Conclusions. These results support a significant nephrotoxicity of PM 2.5 based on multiple serum biomarkers and indicate a beneficial effect of improved air quality on kidney function.