Global health journal (Amsterdam, Netherlands)最新文献

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Impact of community-based rehabilitation on quality of life and self-esteem of persons with physical disabilities and their family members 社区康复对身体残疾者及其家庭成员的生活质量和自尊的影响
Global health journal (Amsterdam, Netherlands) Pub Date : 2023-06-01 DOI: 10.1016/j.glohj.2023.04.001
Joseph Umunnah , Babatunde Adegoke , Chigozie Uchenwoke , Chinonso Igwesi-Chidobe , Grace Alom
{"title":"Impact of community-based rehabilitation on quality of life and self-esteem of persons with physical disabilities and their family members","authors":"Joseph Umunnah ,&nbsp;Babatunde Adegoke ,&nbsp;Chigozie Uchenwoke ,&nbsp;Chinonso Igwesi-Chidobe ,&nbsp;Grace Alom","doi":"10.1016/j.glohj.2023.04.001","DOIUrl":"10.1016/j.glohj.2023.04.001","url":null,"abstract":"<div><h3>Objective</h3><p>Community-based rehabilitation (CBR) is a strategy by which persons living with disability (PWDs) access comprehensive rehabilitation services with limited evidence regarding its impact on the quality of life (QOL) and self-esteem (SE) of PWDs and their family members. This study compared the QOL and SE of Nigerian PWDs in communities with and without a CBR programme (CBR and non-CBR respectively), and the family quality of life (FQOL) of their family members.</p></div><div><h3>Methods</h3><p>Cross-sectional study involving 2 604 PWDs (1 302 in CBR and 1 302 in non-CBR); 5 208 family members of PWDs (2 604 in CBR and 2 604 non-CBR), recruited from four randomly selected geo-political zones in Nigeria, purposive/consecutive selection of eight CBR programmes, PWDs and their family members (CBR and non-CBR). Outcomes assessed using Rosenberg Self-Esteem Scale (RSES), World Health Organization Quality of Life Instrument- short form (WHOQOL-BREF) and Beach Centre Family Quality of Life Instrument (BCFQOL). Mann-Whitney <em>U</em> test and Spearman's rank order correlation were used to analyse data at <em>P</em> &lt; 0.05.</p></div><div><h3>Results</h3><p>PWDs in CBR scored higher in all domains of WHOQOL-BREF (<em>P</em> &lt; 0.0001 in all cases) and RSES than non-CBR group (<em>P</em> &lt; 0.0001). The CBR families scored significantly higher than non-CBR families in all domains (<em>P</em> &lt; 0.05) except Emotional Well-Being of the BCFQOL. The CBR group scores on Psychological and Social Health domains of the WHOQOL-BREF showed significant positive correlation with CBR families’ Family Interaction (<em>P</em> = 0.06) and Parenting (<em>P</em> = 0.07) domains and total FQOL (<em>P</em> = 0.07).</p></div><div><h3>Conclusion</h3><p>Community-based rehabilitation positively impacted on SE and QOL of PWDs and their family members.</p></div>","PeriodicalId":73164,"journal":{"name":"Global health journal (Amsterdam, Netherlands)","volume":"7 2","pages":"Pages 87-93"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47641520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal perceived self-efficacy, perceived vulnerability and child health outcome in Ibadan, South-West Nigeria 尼日利亚西南部伊巴丹的产妇自我效能感、脆弱性和儿童健康结果
Global health journal (Amsterdam, Netherlands) Pub Date : 2023-06-01 DOI: 10.1016/j.glohj.2023.04.002
Tosin Yinka Akintunde
{"title":"Maternal perceived self-efficacy, perceived vulnerability and child health outcome in Ibadan, South-West Nigeria","authors":"Tosin Yinka Akintunde","doi":"10.1016/j.glohj.2023.04.002","DOIUrl":"10.1016/j.glohj.2023.04.002","url":null,"abstract":"<div><h3>Objective</h3><p>The problems associated with child health continue to constitute a global concern, and child morbidity and mortality remain problematic in Sub-Sahara Africa (SSA). Utilizing a community-based survey conducted in Ibadan North Local government, Southwest Nigeria the study examined the influences of maternal perceived self-efficacy (MPSE) and maternal perceived vulnerability (MPV) on child health outcomes (CHO).</p></div><div><h3>Methods</h3><p>The study appraised data from 683 nursing mothers aged 15‒45 obtained from 20 major primary healthcare centers in the region undergoing routine health checks for their children. Three regression models were fitted to examine the effects of MPV, MPSE, and confounding variables of maternal preventive actions such as insecticide-treated nets (ITN) usage and child immunization, among other maternal and child sociodemographic attributes on CHO.</p></div><div><h3>Results</h3><p>The study finds that MPV has no correlation with CHO and MPSE but positively correlates with maternal age (<em>r</em> = 0.123, <em>P</em> &lt; 0.05). However, CHO has a negative correlation with MPSE (<em>r</em> = −0.200, <em>P</em> &lt; 0.05) while positively correlated with child age (<em>r</em> = 0.134, <em>P</em> &lt; 0.05). MPSE has a unique effect on CHO (<em>β</em> = −0.203, <em>P</em> &lt; 0.05), maternal preventive action of ITN usage show a positive association with CHO in the study Model 2 (<em>β</em> = −0.163, <em>P</em> &lt; 0.05), while in Model 3, child's age has a positive association with CHO (<em>β</em> = 0.180, <em>P</em> &lt; 0.05). The net effect of the study models accounted for approximately 10% of the variance in CHO reported among the children.</p></div><div><h3>Conclusion</h3><p>Overall, MPSE and ITN usage are essential factors for understanding and reducing the potential adverse CHO. Global effort must continue to improve maternal education to support child health and preventive care practices in SSA.</p></div>","PeriodicalId":73164,"journal":{"name":"Global health journal (Amsterdam, Netherlands)","volume":"7 2","pages":"Pages 94-100"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42376175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Applications of nanotechnology in medical field: a brief review 纳米技术在医学领域的应用综述
Global health journal (Amsterdam, Netherlands) Pub Date : 2023-06-01 DOI: 10.1016/j.glohj.2023.02.008
Abid Haleem , Mohd Javaid , Ravi Pratap Singh , Shanay Rab , Rajiv Suman
{"title":"Applications of nanotechnology in medical field: a brief review","authors":"Abid Haleem ,&nbsp;Mohd Javaid ,&nbsp;Ravi Pratap Singh ,&nbsp;Shanay Rab ,&nbsp;Rajiv Suman","doi":"10.1016/j.glohj.2023.02.008","DOIUrl":"https://doi.org/10.1016/j.glohj.2023.02.008","url":null,"abstract":"<div><p>Nanotechnology has extensive application as nanomedicine in the medical field. Some nanoparticles have possible applications in novel diagnostic instruments, imagery and methodologies, targeted medicinal products, pharmaceutical products, biomedical implants, and tissue engineering. Today treatments of high toxicity can be administered with improved safety using nanotechnology, such as chemotherapeutic cancer drugs. Further, wearable gadgets can detect crucial changes in vital signs, cancer cell conditions, and infections that are genuinely happening in the body. We anticipate these technologies to provide doctors with considerably much better direct access to critical data on the reasons for changes in the signs of life or illness because of the technological presence at the source of the problem. Biomedicine can be utilised for therapies with predictive analytics and artificial intelligence. For carrying out this study, relevant papers on Nanotechnology in the medical field from Scopus, Google scholar, ResearchGate, and other research platforms are identified and studied. The study discusses different types of Nanoparticles used in the medical field. This paper discusses nanotechnology applications in the medical field. The class, features, and characteristics of Nanotechnology for medicine are also briefed. Scientists, governments, civil society organisations, and the general public will need to collaborate across sectors to assess the significance of nanotechnology and guide its advancement in various fields. The current research includes several possible Nanotechnology uses in the medical field. As a result, the study provides a brief and well-organised report on nanotechnology that should be valuable to researchers, engineers, and scientists for future research projects.</p></div>","PeriodicalId":73164,"journal":{"name":"Global health journal (Amsterdam, Netherlands)","volume":"7 2","pages":"Pages 70-77"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49881733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Public health progression and related challenges 公共卫生进展和相关挑战
Global health journal (Amsterdam, Netherlands) Pub Date : 2023-03-01 DOI: 10.1016/j.glohj.2023.02.007
Amit Sharma, Ian Osoro
{"title":"Public health progression and related challenges","authors":"Amit Sharma,&nbsp;Ian Osoro","doi":"10.1016/j.glohj.2023.02.007","DOIUrl":"10.1016/j.glohj.2023.02.007","url":null,"abstract":"","PeriodicalId":73164,"journal":{"name":"Global health journal (Amsterdam, Netherlands)","volume":"7 1","pages":"Pages 1-2"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48871390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global pattern and determinants of coronavirus disease 2019 (COVID-19) vaccine coverage and progression: a global ecological study 2019冠状病毒病(COVID-19)疫苗覆盖和进展的全球格局和决定因素:一项全球生态学研究
Global health journal (Amsterdam, Netherlands) Pub Date : 2023-03-01 DOI: 10.1016/j.glohj.2023.02.003
Huihao Wang , Bin Yu , Xinguang Chen , Hong Yan
{"title":"Global pattern and determinants of coronavirus disease 2019 (COVID-19) vaccine coverage and progression: a global ecological study","authors":"Huihao Wang ,&nbsp;Bin Yu ,&nbsp;Xinguang Chen ,&nbsp;Hong Yan","doi":"10.1016/j.glohj.2023.02.003","DOIUrl":"10.1016/j.glohj.2023.02.003","url":null,"abstract":"<div><h3>Background</h3><p>Understanding and minimizing existing global coronavirus disease 2019 <strong>(</strong>COVID-19) vaccination disparities is critical to global population health and eliminating health inequities. The study aims to investigate the disparities of vaccination coverage and progression and the associated economic and educational determinants to inform global COVID-19 vaccination strategies.</p></div><div><h3>Methods</h3><p>COVID-19 vaccination coverage data from 206 countries used in the study were derived from “Our World in Data” website. After obtaining the vaccination coverage indicators, we fitted the progression indicators for vaccination. Correlation and multiple linear regression analysis were used to examine the effects of gross domestic product (GDP) per capita, Gini index, education, and their interactions on the coverage and progression of the COVID-19 vaccination.</p></div><div><h3>Results</h3><p>The coverage of COVID-19 vaccination ranged from less than 30 doses to more than 150 doses per hundred people, from less than 15% to more than 75% for proportion of people vaccinated, from less than 15% to more than 60% for proportion of people fully vaccinated. Similarly, the progression of vaccination ranged from less than 0.1 to more than 0.6 for progression of total number of doses, from less than 0.1 to more than 0.3 for progression of proportion of people vaccinated, and from less than 0.1 to more than 0.4 for progression of proportion of people fully vaccinated. GDP per capita and education were positively associated with the coverage and progression, while Gini index was negatively associated with the coverage and progression. Negative interaction between GDP per capita and education was also observed for coverage (<em>β</em> = −0.012 to −0.011, <em>P</em> &lt; 0.05) and progression (<em>β</em> = −0.012 to −0.011, <em>P</em> &lt; 0.05).</p></div><div><h3>Conclusions</h3><p>Substantial geographic disparities existed for the coverage and progression of COVID-19 vaccination. Economy and education are two important factors contributing to the disparities. Different countries may adopt varied strategies to promote the national distribution and vaccination of COVID-19 vaccines.</p></div>","PeriodicalId":73164,"journal":{"name":"Global health journal (Amsterdam, Netherlands)","volume":"7 1","pages":"Pages 18-23"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9273365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Identifying barriers to early diagnosis of breast cancer and perception of women in Malwa region of Punjab, India 印度旁遮普邦马尔瓦地区识别癌症早期诊断障碍和妇女认知
Global health journal (Amsterdam, Netherlands) Pub Date : 2023-03-01 DOI: 10.1016/j.glohj.2023.02.006
Kuljinder Kaur , Rachana Jajoo , Subh Naman , Tanushka Kandwal , Gunteshwar Singh Brar , Pardeep Garg , Pritpal Singh Bhullar , Ashish Baldi
{"title":"Identifying barriers to early diagnosis of breast cancer and perception of women in Malwa region of Punjab, India","authors":"Kuljinder Kaur ,&nbsp;Rachana Jajoo ,&nbsp;Subh Naman ,&nbsp;Tanushka Kandwal ,&nbsp;Gunteshwar Singh Brar ,&nbsp;Pardeep Garg ,&nbsp;Pritpal Singh Bhullar ,&nbsp;Ashish Baldi","doi":"10.1016/j.glohj.2023.02.006","DOIUrl":"10.1016/j.glohj.2023.02.006","url":null,"abstract":"<div><h3>Objective</h3><p>The aim of present study is to identify the breast cancer screening barriers among the women with breast cancer of Malwa region of Punjab, India. The study was conducted at three government hospitals representing almost all districts of Malwa region.</p></div><div><h3>Methods</h3><p>The quantitative research design was followed using empirical research methods. Study was carried out by one-to-one interview by the field investigator and research assistant. Total of 363 breast cancer patient has been interviewed through the scheduled questionnaire and results has been recorded for further analysis. In this study, five barriers are described namely as personal barriers, socio-cultural barriers, economic barriers, health-system barriers, and treatment barriers which contains various questions regarding barriers to breast cancer screening. Univariate analysis methods have been used for the analysis to access the socio-demographic profile of women. Data has been obtained with the help of 5-point liker scale. Binary logistic model was chosen.</p></div><div><h3>Results</h3><p>Majority of participants were in the age groups 50–&lt; 60 years (38.6%, 140/363) and ≥ 60 years (31.1%, 112/363). Majority of these women (47.4%, 171/363) were illiterate and most of them were housewives. The major barriers to breast cancer screening faced by most of the women were having no knowledge about screening services (90.9%, 329/363), the importance of early diagnosis (90.9%, 329/363), different screening methods (95.5%, 347/363) and place of availing screening services (91.2%, 330/363) misguided belief in God and fate (81.5%, 295/363) and preferring duties than taking care of health (70.2%, 254/363). Education qualification (odds ratio [<em>OR</em>] 0.74, <em>β’</em> = −0.309, <em>t</em> = −5.357, <em>P</em> <em>=</em> 0.000) and socioeconomic class (<em>OR</em> 1.43, <em>β’</em> = 0.354, <em>t</em> = 3.399, <em>P</em> <em>=</em> 0.001) were found to be significant determinant of the barriers among women.</p></div><div><h3>Conclusion</h3><p>The survey was conducted in the women between the age 40–60 years and as an outcome, the unawareness about screening services, fatalistic attitude, fear of being diagnosed with the cancer, low per capita income was found out significant factors that restricted the women for early check-up for the breast cancer.</p></div>","PeriodicalId":73164,"journal":{"name":"Global health journal (Amsterdam, Netherlands)","volume":"7 1","pages":"Pages 34-42"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46661015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Prevalence of emotional and behavioral problems among schoolchildren in Herat City, Afghanistan 阿富汗赫拉特市学童情绪和行为问题的患病率
Global health journal (Amsterdam, Netherlands) Pub Date : 2023-03-01 DOI: 10.1016/j.glohj.2023.02.005
Mina Alekozay , Aziz-ur-Rahman Niazi , Abdul Fattah Najm
{"title":"Prevalence of emotional and behavioral problems among schoolchildren in Herat City, Afghanistan","authors":"Mina Alekozay ,&nbsp;Aziz-ur-Rahman Niazi ,&nbsp;Abdul Fattah Najm","doi":"10.1016/j.glohj.2023.02.005","DOIUrl":"https://doi.org/10.1016/j.glohj.2023.02.005","url":null,"abstract":"<div><h3>Background</h3><p>The prevalence of pediatric mental illnesses has been increasing in recent years, with a great potential to impact on individual's functionality and adaptation in adulthood.</p></div><div><h3>Objective</h3><p>This study aims to assess emotional and behavioral problems among schoolchildren in Herat City of Afghanistan.</p></div><div><h3>Methods</h3><p>This cross-sectional study was conducted on schoolchildren (grade 5‒10), between September and November 2021. Sociodemographic data was collected using a paper-based 14-item structured questionnaire. Data on emotional and behavioral problems was collected using the Strengths and Difficulties Questionnaire (SDQ) based on teachers’ and children's report. Statistical analyses were performed in IBM SPSS Statistics (version 27).</p></div><div><h3>Results</h3><p>A total of 418 students, including 190 (45.5%) males and 228 (54.5%) females with a mean age of 14.1 ± 1.7 (11‒&lt; 18 ) years were included in the study. The prevalence of students’ self-reported total difficulties and prosocial problem were 5.7% and 1.2%, respectively. An insignificant difference was observed between mean total difficulties scores between students’ self-reported and teachers’ reported SDQ. Gender, grade, concern about shortage of food, and concern about losing house were significantly predicting students’ self-reported total difficulties scores.</p></div><div><h3>Conclusion</h3><p>This is the first study to report the prevalence of emotional and behavioral problems among schoolchildren in Herat City, Afghanistan. This, together with relevant global literature, highlight the need to address pediatric mental health, and provide services aimed at preventing, and treating children with these problems around the world.</p></div>","PeriodicalId":73164,"journal":{"name":"Global health journal (Amsterdam, Netherlands)","volume":"7 1","pages":"Pages 55-60"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49810772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The role of drug utilization evaluation in medical sciences 药物利用评价在医学中的作用
Global health journal (Amsterdam, Netherlands) Pub Date : 2023-03-01 DOI: 10.1016/j.glohj.2023.02.002
Ruby Gangwar, Arvind Kumar, Abrar Ahmed Zargar, Amit Sharma, Ranjeet Kumar
{"title":"The role of drug utilization evaluation in medical sciences","authors":"Ruby Gangwar,&nbsp;Arvind Kumar,&nbsp;Abrar Ahmed Zargar,&nbsp;Amit Sharma,&nbsp;Ranjeet Kumar","doi":"10.1016/j.glohj.2023.02.002","DOIUrl":"10.1016/j.glohj.2023.02.002","url":null,"abstract":"<div><h3>Background</h3><p>Drug utilization evaluation (DUE) is defined by the World Health Organization (WHO) and focuses on the medical, social, and economic consequences of pharmaceutical marketing, distribution, prescribing, and usage in society. The WHO recommends a physician to every 1 000 people. According to the recent data from the Health Ministry in 2019, in which 1.16 million doctors are of active population with just 80%, or 0.9 million, practicing. As a result, a ratio of 0.68 doctors for every 1 000 people, which is much below as per the WHO reports. This article describes history, types, WHO guidelines, need and purpose of DUE.</p></div><div><h3>Objective</h3><p>The main aim of this paper is to provide information about the rational use of medication in outpatient and inpatient department with special emphasis of DUEs. It also provides awareness directly to healthcare professionals, researchers, academicians, pharmacist and nurses to reduce the irrationality of medicines.</p></div><div><h3>Methods</h3><p>The method used to compile this review information gathered from websites, Google scholar, PubMed, Research gate, and studies published on DUE from July 20 to Oct 22 were included as source of information.</p></div><div><h3>Results</h3><p>We studied more than 35 published study on DUE, that reveals most of the physicians prescribed branded drugs not generic drugs, but WHO prescribing indicator allows to prescribe generic drugs in the hospital pharmacy to maintain better inventory control. It may also help to prevent pharmacist misunderstanding during dispensing.</p></div><div><h3>Conclusion</h3><p>The use of generic prescription names avoids the possibility of medication product duplication and lowers patient costs. It is important to remember that incorrect medication prescriptions have impact on both patients and their family members. WHO indicators identify irrational prescribing behaviours to make therapy more rational and cost-effective.</p></div>","PeriodicalId":73164,"journal":{"name":"Global health journal (Amsterdam, Netherlands)","volume":"7 1","pages":"Pages 3-8"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43025753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Prions: a threat to health security and the need for effective medical countermeasures 朊病毒:对健康安全的威胁和有效医疗对策的必要性
Global health journal (Amsterdam, Netherlands) Pub Date : 2023-03-01 DOI: 10.1016/j.glohj.2023.02.004
Ying-Chiang J. Lee
{"title":"Prions: a threat to health security and the need for effective medical countermeasures","authors":"Ying-Chiang J. Lee","doi":"10.1016/j.glohj.2023.02.004","DOIUrl":"10.1016/j.glohj.2023.02.004","url":null,"abstract":"<div><p>Prions are infectious conformations of certain naturally occurring proteins. These misfolded proteins can structurally alter healthy protein, creating misfolded copies that repeat the process and form protein aggregates that lead to neuronal cell death. Although years can pass from initial prion infection to clinical presentation of symptoms, onset of symptoms is typically followed by rapid neurological decline resulting in death. Prion diseases have been characterized in animals ranging from sheep and cattle to cervids and humans, with notable cross-species infections such as the variant Creutzfeldt-Jakob disease. Thus, prions present a health risk with the potential to disrupt major food sources as well affect human health through animal to human and human to human transmission events. While human to human prion transmission is rare and the immediate risks for a prion-facilitated pandemic are low, prions are a class of pathogens for which we are underprepared. In addition, prions, and prion disease-like approaches, have also been discussed in the context of biological weapons and toxins, adding another layer of complexity surrounding biosecurity and biodefense. These threats underscore the need for increased scrutiny and research on prions. Here, pharmaceutical and nonpharmaceutical prion-specific interventions are discussed. Recent advances in prion therapeutic development are also briefly highlighted, and a set of policy recommendations are given that aims to provide high level suggestions for the prevention and mitigation of prion diseases.</p></div>","PeriodicalId":73164,"journal":{"name":"Global health journal (Amsterdam, Netherlands)","volume":"7 1","pages":"Pages 43-48"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48058876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Influence of quarantine during the coronavirus disease 2019 (COVID-19) pandemic on physical and psychosocial aspects: perceptions of 214 Brazilian athletes 2019冠状病毒病(COVID-19)大流行期间隔离对身体和心理社会方面的影响:214名巴西运动员的看法
Global health journal (Amsterdam, Netherlands) Pub Date : 2023-03-01 DOI: 10.1016/j.glohj.2023.01.001
Eliane de Morais Machado , Leonardo Luiz Barretti Secchi , Paula Rezende Camargo , Luciana De Michelis Mendonça
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引用次数: 1
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