Acta Odontologica Scandinavica最新文献_第6页

Immediate or delayed direct restoration does not significantly influence additional endodontic treatments and 5-year tooth survival of first molars. 立即或延迟直接修复对第一磨牙的后续根管治疗和5年牙齿存活无显著影响。

IF 1.9 4区医学

Acta Odontologica Scandinavica Pub Date : 2025-10-10 DOI: 10.2340/aos.v84.44804

Sara Olsson, Maria Pigg, Jesper Gustavsson, Emil Ekblom, Helena Fransson

{"title":"Immediate or delayed direct restoration does not significantly influence additional endodontic treatments and 5-year tooth survival of first molars.","authors":"Sara Olsson, Maria Pigg, Jesper Gustavsson, Emil Ekblom, Helena Fransson","doi":"10.2340/aos.v84.44804","DOIUrl":"10.2340/aos.v84.44804","url":null,"abstract":"Objective: In vitro leakage studies suggest that temporary restorations only provide a short-term seal. However, it remains unclear whether the clinical outcome is impacted by the time elapsing between the completion of a root canal treatment (RCT) and the placement of a direct permanent coronal restoration. The aim was to investigate any time-dependent difference in frequencies of endodontic orthograde retreatment, apical surgery and extractions during the subsequent 5 years following root filling of first molars restored with a direct restoration depending on immediate or delayed time between completion of RCT and placement of a direct restoration.Material and methods: Data from the Swedish Social Insurance Agency was collected. In 2009, 50,314 direct restorations were registered after RCT of the first molars in individuals aged 20 years or older. The teeth were divided into five time intervals depending on time from completion of root filling to placement of direct restoration for comparisons of frequencies of orthograde retreatment, apical surgery and extractions, during the following 5 years. The time interval categories were compared using Pearson's Chi-square test.Results: No statistically significant time-dependent differences in registrations were found for orthograde retreatment (p = 0.089), with or without apical surgery (p = 0.161) and with or without extraction (p = 0.737).Conclusion: The time elapsed from the completion of RCT and the placement of a direct restoration did not affect the 5-year outcome of the RCT.","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"84 ","pages":"544-548"},"PeriodicalIF":1.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12519887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors associated with nurses' challenges in providing oral care at Oulu University Hospital, Finland. 芬兰奥卢大学医院护士在提供口腔护理方面面临的挑战相关因素。

IF 1.9 4区医学

Acta Odontologica Scandinavica Pub Date : 2025-10-10 DOI: 10.2340/aos.v84.44806

Roosa-Maria Kivilahti, Hannu Vähänikkilä, Marja-Liisa Laitala, Vuokko Anttonen, Anna-Maija Syrjälä

{"title":"Factors associated with nurses' challenges in providing oral care at Oulu University Hospital, Finland.","authors":"Roosa-Maria Kivilahti, Hannu Vähänikkilä, Marja-Liisa Laitala, Vuokko Anttonen, Anna-Maija Syrjälä","doi":"10.2340/aos.v84.44806","DOIUrl":"10.2340/aos.v84.44806","url":null,"abstract":"Objective: To investigate factors associated with nurses' challenges in providing oral care to infection- sensitive patients. Material and methods: A total of 114 nurses from four internal medicine wards and one oncology ward participated in the study. Data were collected using a questionnaire containing six items about challenges in providing oral care to patients. A multivariate linear regression model was used to analyze the association between explanatory variables and challenges in oral care. Results: Practical nurses reported more challenges in evaluating patients' oral problems compared to registered nurses (B = 1.8, p ≤ 0.01). Nurses reporting fairly good or poor oral health reported more challenges in managing resisting patients than those who reported good oral health (B = 1.1, p < 0.05). Higher self- efficacy in Practical skills was associated with fewer challenges related to having a lack of knowledge about cleaning a patient's mouth (B= -0.9, p ≤ 0.01) and evaluating patients' oral problems (B = -0.5, p ≤ 0.01). Higher self-efficacy in Confidence to detect oral problems was associated with fewer challenges in managing resisting patients (B= -0.6, p ≤ 0.01) and evaluating patients' oral problems (B = -0.5, p ≤ 0.001). Conclusions: Nursing education, self-perceived oral health, and self-efficacy were associated with perceived challenges.","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"84 ","pages":"535-543"},"PeriodicalIF":1.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12519886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of 3D planning in orthognathic surgery. 三维规划在正颌手术中的评价。

IF 1.9 4区医学

Acta Odontologica Scandinavica Pub Date : 2025-10-10 DOI: 10.2340/aos.v84.44805

Klas Strindlund, Payam Farzad, Lars Rasmusson, Carina Cardemil

{"title":"Evaluation of 3D planning in orthognathic surgery.","authors":"Klas Strindlund, Payam Farzad, Lars Rasmusson, Carina Cardemil","doi":"10.2340/aos.v84.44805","DOIUrl":"10.2340/aos.v84.44805","url":null,"abstract":"Objective: The use of virtual surgical planning (VSP) in orthognathic surgery is increasing. The aim of this study was to investigate which type of dentofacial deformity makes the surgeon choose VSP and if VSP influences the choice of surgical techniques. Furthermore, we sought to evaluate if use of VSP affects surgical time and blood loss during surgery.Material and methods: Patients having undergone orthognathic surgery and registered in the Swedish quality registry for orthognathic surgery (NROK) between 2018 and 2019 were eligible for inclusion in this study. An evaluation of the usage of VSP was performed together with an analysis of operation time and bleeding during surgery. A total of 862 patients were evaluated.Results: Out of the 862 patients who had orthognathic surgery, 224 were VSP cases. Patients diagnosed with maxillary retrusion (p = 0.0024), maxillary vertical hyperplasia (p < 0.001), mandibular protrusion (p = 0.0031), laterogenia (p < 0.001) or craniofacial deformity (p = 0.0033) were more often digitally planned. Patients who underwent VSP and bimaxillary surgery showed a tendency of reduced operating time andless bleeding during surgery; however, the results were inconclusive.Conclusion: The present study shows that VSP was used more frequently in patients with maxillary retrusion, maxillary vertical hyperplasia, mandibular protrusion, laterogenia, and craniofacial deformity in comparison with other diagnoses. Alongside the findings that VSP cases had more diagnoses per patient and that a larger number of surgical procedures were performed in this group, this indicates a preference for using digital planning in more complex orthognathic cases.","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"84 ","pages":"549-553"},"PeriodicalIF":1.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12519888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145754991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implant treatment modalities of non-syndromic congenitally missing premolars: a retrospective case series of 74 specialist care patients over an 11-year-cohort. 非综合征性先天性前磨牙缺失的种植治疗方式：回顾性分析74例专科护理患者11年的队列研究。

IF 1.9 4区医学

Acta Odontologica Scandinavica Pub Date : 2025-09-04 DOI: 10.2340/aos.v84.44657

Sarwat Jabeen Hassan, Olli-Pekka Lappalainen, Ojala-Alasuutari Marleena, Virpi Harila, Ritva Näpänkangas

{"title":"Implant treatment modalities of non-syndromic congenitally missing premolars: a retrospective case series of 74 specialist care patients over an 11-year-cohort.","authors":"Sarwat Jabeen Hassan, Olli-Pekka Lappalainen, Ojala-Alasuutari Marleena, Virpi Harila, Ritva Näpänkangas","doi":"10.2340/aos.v84.44657","DOIUrl":"10.2340/aos.v84.44657","url":null,"abstract":"Objective: The study aims to evaluate the course of implant treatment for congenitally missing lower -second premolars in patients referred to publicly funded specialist care over an 11-year period.Material and methods: This retrospective, register-based cohort study selected patient data on dental implant treatment in the lower second premolar region from 2009 to 2019 (n = 146). After applying exclusion criteria, the final sample included 74 patients. Data on retained deciduous teeth, orthodontic treatment prior to implant placement, and implantation procedures were gathered from patient files. Results were presented using descriptive statistics, t-test, and Chi-square analyses (p < 0.05).Results: The most common orthodontic treatment was space optimization before dental implant placement. Most retained deciduous teeth were extracted between ages 21 and 29, with a median of 6 months before implant placement. Bone grafting was performed at 23% of implant sites. The mean implant diameter was 4.0 mm, and the mean implant length was 9.6 mm. Good primary stability was achieved in all cases.Conclusion: Individually planned orthodontic and surgical treatments are essential in managing congenitally missing lower premolars, particularly when implant placement is indicated. Early diagnosis and collaboration between dental specialists are key elements in the treatment. A multidisciplinary approach ensures optimal space for implant, bone preservation, and optimal implant alignment.","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"84 ","pages":"528-534"},"PeriodicalIF":1.9,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of mandibular bone abnormalities in patients with chronic kidney disease using cone beam computed tomography: A retrospective study. 锥形束计算机断层扫描对慢性肾病患者下颌骨异常的评估：一项回顾性研究。

IF 1.9 4区医学

Acta Odontologica Scandinavica Pub Date : 2025-09-03 DOI: 10.2340/aos.v84.44619

Heelim Lee, Jae Suk Jung, Jiwoo Lee, Seung Il Song, Jeong Keun Lee, Ji Min Kim, Bumhee Park, Inwhee Park, Suk Ji

{"title":"Evaluation of mandibular bone abnormalities in patients with chronic kidney disease using cone beam computed tomography: A retrospective study.","authors":"Heelim Lee, Jae Suk Jung, Jiwoo Lee, Seung Il Song, Jeong Keun Lee, Ji Min Kim, Bumhee Park, Inwhee Park, Suk Ji","doi":"10.2340/aos.v84.44619","DOIUrl":"10.2340/aos.v84.44619","url":null,"abstract":"Objective: This study evaluated mandibular cortical thickness and morphological changes in chronic kidney disease (CKD) patients using cone beam computed tomography (CBCT) and their correlation with bone metabolism markers.Methods: CKD patients were divided into CKD-I (eGFR (estimated glomerular filtration rate) < 30) and CKD-II (eGFR ≥ 30) groups, with healthy controls for comparison. Mental index (MI), antegonial index (AI), and panoramic mandibular index (PMI) were compared using Kruskal-Wallis test. Mandibular cortical index (MCI) classifications, lamina dura loss, and soft tissue calcifications were assessed using Fisher's test. Relationships between serum bone metabolism markers and radiomorphometric indices were analyzed by linear regression.Results: The study included 94 CKD patients (56 CKD-I, 38 CKD-II) and 88 controls. MI and AI were significantly lower in CKD-I versus controls (p < 0.05). MCI class I was less prevalent in CKD-I (5.4%) than controls (35.2%) (p < 0.001). Lamina dura loss (p = 0.006) and soft tissue calcifications (p = 0.009) occurred more frequently in CKD groups. Elevated alkaline phosphatase was associated with reduced cortical thickness (p < 0.01).Conclusions: Although findings should be interpreted considering the retrospective design's limitations, CBCT revealed significant bone abnormalities in CKD patients, with compromised bone quality and reduced mandibular cortical thickness, especially in advanced renal impairment, suggesting its value for pre-implant bone quality assessment in CKD patients.","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"84 ","pages":"517-526"},"PeriodicalIF":1.9,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction of author list for article: A retrospective study analysing outcomes of the coronectomy procedure at a university dental teaching clinic in Norway. 对文章作者名单的更正：挪威一所大学牙科教学诊所冠状切除术结果的回顾性研究分析。

IF 1.9 4区医学

Acta Odontologica Scandinavica Pub Date : 2025-09-03 DOI: 10.2340/aos.v84.44706

Umar Sharif, Johannes Finne, Nourhanim Fadul, Stein Atle Lie, Cecilie Gudveig Gjerde

引用次数: 0

Awareness of erosive tooth wear and the consumption of acidic beverages among a group of Finnish adolescents. 一群芬兰青少年对牙齿侵蚀磨损和酸性饮料消费的认识。

IF 1.9 4区医学

Acta Odontologica Scandinavica Pub Date : 2025-09-02 DOI: 10.2340/aos.v84.44568

Elisa Lind, Auli Suominen, Vuokko Loimaranta, Marja Pöllänen, Merja Laine

{"title":"Awareness of erosive tooth wear and the consumption of acidic beverages among a group of Finnish adolescents.","authors":"Elisa Lind, Auli Suominen, Vuokko Loimaranta, Marja Pöllänen, Merja Laine","doi":"10.2340/aos.v84.44568","DOIUrl":"10.2340/aos.v84.44568","url":null,"abstract":"Objective: Adolescents belong to the high-risk group of erosive tooth wear (ETW), but by contrast, they are reported to lack knowledge about this condition and its association with the intake of acidic beverages. This study aimed to survey the awareness of ETW and the consumption of beverages among a group of Finnish adolescents.Material and methods: A survey was conducted using an online questionnaire for the students in two upper comprehensive schools in the province of Southwest Finland. The awareness of ETW and the consumption frequencies of 14 beverages according to gender and school grade were analysed using chi-square or Fisher's exact test. The associations of the awareness of ETW with gender, school grade and acidic beverage consumption were analysed by logistic regression.Results: Most of the 230 respondents consumed acidic beverages more than once a week. The consumption of lemonades (OR [odds ratio] 2.79-3.05, p = 0.008-0.018, 95% CI 1.19-7.00) and energy drinks (OR 5.59, p = 0.0008, 95% CI 2.06-15.2) was more common among those who assumed that ETW is not preventable. However, 45-47% of the respondents have not received information about ETW or its prevention from dental care professionals.Conclusion: The studied Finnish adolescents have a lack of knowledge about ETW and the acidic beverage consumption among them requires intervention.","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"84 ","pages":"509-516"},"PeriodicalIF":1.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12534842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Poor oral health, related quality of life, and use of dental care system among vulnerable migrants in Denmark - a cross-sectional study. 丹麦弱势移民的口腔健康状况不佳、相关生活质量和牙科保健系统的使用-一项横断面研究

IF 1.9 4区医学

Acta Odontologica Scandinavica Pub Date : 2025-09-02 DOI: 10.2340/aos.v84.44658

Josefina Salazar, Hanne Winther Frederiksen, Hanne Nødgaard Christensen, Esben Boeskov Øzhayat

{"title":"Poor oral health, related quality of life, and use of dental care system among vulnerable migrants in Denmark - a cross-sectional study.","authors":"Josefina Salazar, Hanne Winther Frederiksen, Hanne Nødgaard Christensen, Esben Boeskov Øzhayat","doi":"10.2340/aos.v84.44658","DOIUrl":"10.2340/aos.v84.44658","url":null,"abstract":"Objective: The study aims to describe the oral status, oral health-related quality of life (OHRQoL), and oral-health behaviours of vulnerable adult migrants with complex health problems.Methods: We conducted a descriptive cross-sectional study at the Section of Immigrant Medicine, Hvidovre Hospital, Denmark. We conducted clinical examinations to assess participants' number of teeth, caries, oral hygiene, and periodontal status. Participants also completed a questionnaire to evaluate OHRQoL, oral-health related behaviours (e.g. use of dental care system), and perceived barriers to access dental treatment and maintaining oral hygiene.Results: We included 50 participants, with a mean age of 49.4 (SD 7.4) years, 82% of whom were women, and 40% were from the Middle East and North Africa. Regarding oral status, 28% of participants had a full dentition, 54% had decayed teeth, 12% had good oral hygiene, and 46% had periodontal disease. Regarding OHRQoL, 92% of participants reported that their oral health negatively impacted one or more daily activities. Around 40% of participants had visited the dentist in Denmark the previous year, and 95% reported the costs as a barrier to dental care.Conclusions: There is a high prevalence of oral disease with a massive impact on the OHRQoL of this group of vulnerable migrants. Despite the need for essential dental treatments, participants rarely used the Danish dental care system. Our findings highlight the need for multi-sectoral interventions for this population.","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"84 ","pages":"501-508"},"PeriodicalIF":1.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The three-dimensional influence and clinical significance of anterior traction with rapid expansion during dental replacement. 快速扩张前牙牵引在牙置换中的三维影响及临床意义。

IF 1.9 4区医学

Acta Odontologica Scandinavica Pub Date : 2025-08-27 DOI: 10.2340/aos.v84.44580

Naizheng Gou, Xiaoqin Wang, Haiyan Li, Zuoying Dong

{"title":"The three-dimensional influence and clinical significance of anterior traction with rapid expansion during dental replacement.","authors":"Naizheng Gou, Xiaoqin Wang, Haiyan Li, Zuoying Dong","doi":"10.2340/aos.v84.44580","DOIUrl":"https://doi.org/10.2340/aos.v84.44580","url":null,"abstract":"Objectives: This study aimed to investigate the effects of rapid maxillary expansion using a Hyrax-type appliance (RME-Hyrax) with anterior traction on the maxillary arch during mixed dentition and its clinical significance, focusing on changes in arch dimensions, occlusal stability, and masticatory function.Materials and methods: Forty-two patients with transverse maxillary deficiency were treated with RME-Hyrax, while an untreated control group of 40 received no treatment. Pre- and post-treatment dental casts were analyzed using a 3D scanner. Arch length, width, and occlusal stability were measured. Statistical analysis was performed using paired t-tests and linear regression.Results: RME significantly increased maxillary arch widths at all measured points: 3CW: +4.06 mm, 4CW: +4.88 mm, 5CW: +4.09 mm, 6MCW: +3.00 mm (all p < 0.001). Mandibular arch widths similarly increased (3CW: +3.18 mm, 4CW: +4.00 mm, 5CW: +4.61 mm, 6MCW: +3.07 mm; all p < 0.001). Buccal movement of first permanent molars was significant in both arches (maxillary: 1.61-1.78 mm, mandibular: 1.52-1.68 mm; all p < 0.001). Occlusal stability improved clinically, evidenced by increased maximum bite area (+19.66 mm², exceeding the 15% threshold for functional gain; p < 0.001) and force (+1.06 kg, surpassing the 0.5 kg minimum meaningful change; p < 0.001), with reduced asymmetry index (-22.03%, p < 0.001). Masticatory efficiency improved from 54.22 to 84.61% (Δ30.39%, < 25% threshold; p < 0.001).Conclusions: Hyrax-type RME is effective for correcting transverse maxillary deficiencies, expanding both the maxillary and mandibular arches, and improving occlusal and masticatory function. Early intervention can significantly enhance dental and functional health.","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"84 ","pages":"491-500"},"PeriodicalIF":1.9,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regenerative potential of the intermediate filaments of albino rat parotid glands subjected to fractionated radiotherapy: an immunohistochemical analysis. 分级放疗后白化大鼠腮腺中间丝的再生潜能：免疫组织化学分析。

IF 1.9 4区医学

Acta Odontologica Scandinavica Pub Date : 2025-08-21 DOI: 10.2340/aos.v84.44182

Sherif S Hassan, Ehab T Azab, Alaa W Alqutub, Mashael S Alqahtani, Abrar K Demyati, Abdullah A Holdar, Fatma M Alkassimi, Mahmoud A Attia, Reda A Nofal

{"title":"Regenerative potential of the intermediate filaments of albino rat parotid glands subjected to fractionated radiotherapy: an immunohistochemical analysis.","authors":"Sherif S Hassan, Ehab T Azab, Alaa W Alqutub, Mashael S Alqahtani, Abrar K Demyati, Abdullah A Holdar, Fatma M Alkassimi, Mahmoud A Attia, Reda A Nofal","doi":"10.2340/aos.v84.44182","DOIUrl":"https://doi.org/10.2340/aos.v84.44182","url":null,"abstract":"Objectives: Radiotherapy is a common treatment for head and neck malignancies; however, it frequently affects salivary glands, leading to xerostomia. This study evaluated the effects of radiotherapy on cytokeratin localization in the parotid gland, examining whether changes indicate recovery or progressive damage over a year.Methods: The study included eight control rats and 16 irradiated rats exposed to 30 Gy of radiation over 6 days. The experiment was conducted from January 2023 to April 2024. Subgroup IIa rats were sacrificed 1 month after radiation exposure, while subgroup IIb rats were sacrificed after 1 year. The parotid gland was prepared for histological and immunohistochemical analysis of intermediate filaments.Results: In the control parotid gland, immunohistochemical analysis revealed mild cytokeratin in ductal and serous cells. Subgroup IIa exhibited strong cytokeratin expression in the acini and duct cells, which was significantly different from the control group. One year after radiation, the cytokeratin of subgroup IIb was comparable to that of the control, with no significant difference.Conclusion: In subgroup IIa, cytokeratin staining was notably stronger in ductal and acinar cells, leading to disrupted distribution that impaired saliva production and transport. In subgroup IIb, the redistribution of cytokeratin exhibited distinct recovery patterns in ductal and acinar cells.","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"84 ","pages":"472-478"},"PeriodicalIF":1.9,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12382380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0