Acta Odontologica Scandinavica最新文献_第5页

Efficacy of immediate loading compared to conventional loading in implant-supported removable prostheses: a systematic review and meta-analysis. 种植体支持的可摘除修复体中即刻加载与传统加载的功效比较：系统回顾和荟萃分析。

IF 1.4 4区医学

Acta Odontologica Scandinavica Pub Date : 2024-10-01 DOI: 10.2340/aos.v83.42027

Zhongke Wang, Sihui Li, Hongmei Chen, Ling Guo

{"title":"Efficacy of immediate loading compared to conventional loading in implant-supported removable prostheses: a systematic review and meta-analysis.","authors":"Zhongke Wang, Sihui Li, Hongmei Chen, Ling Guo","doi":"10.2340/aos.v83.42027","DOIUrl":"10.2340/aos.v83.42027","url":null,"abstract":"Purpose: This systematic review and meta-analysis aimed to evaluate the efficacy of two different loading methods in implant-supported removable prostheses (partial dentures and full-maxillary dentures).Methods: As of August 2023, three electronic databases and nine oral implant-related journals had been searched. Only randomised controlled trials (RCTs) that compare immediate loading with conventional loading in implant-supported removable prostheses were included. The primary outcome was the implant survival rate. At the same time, a meta-analysis of bone-level changes was performed. Cochrane risk-of-bias tool for randomised trials (RoB 2) was used to evaluate the risk of bias in the included trials.Results: A total of 16 RCTs were included, including 543 participants with 1595 implants. The included trials compared immediate loading and conventional loading in implant-supported removable prostheses. Regarding implants as the statistical unit, the immediate loading group had a statistically significant lower survival rate (RR = 0.950; 95% confidence interval [CI], (0.926, 0.974); P = 0.027; I² = 47%). When patients were regarded as statistical units, a statistically significant lower survival rate was also observed in the immediate loading group (RR = 0.929; 95% CI, (0.897, 0.961); P = 0.590; I² = 0%). When we analysed the bone level changes, a statistically significant decrease was observed in bone level in the immediate loading group compared with the conventional loading group (weighted mean difference [WMD] = -0.127; 95% CI, (-0.195, -0.059); P < 0.00001).Conclusion: Lower implant survival rates and a decrease in marginal bone level was observed compared to immediate loading with conventional loading.","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"83 ","pages":"553-563"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of citric acid on mineralisation and vascular endothelial growth factor secretion from apical papilla stem cells. 柠檬酸对顶端乳头干细胞矿化和血管内皮生长因子分泌的影响

IF 1.4 4区医学

Acta Odontologica Scandinavica Pub Date : 2024-10-01 DOI: 10.2340/aos.v83.42026

Krasimir Hristov, Nikolay Ishkitiev, Marina Miteva, Violeta Dimitrova, Ralitsa Gigova, Nataliya Gateva, Liliya Angelova

{"title":"The effect of citric acid on mineralisation and vascular endothelial growth factor secretion from apical papilla stem cells.","authors":"Krasimir Hristov, Nikolay Ishkitiev, Marina Miteva, Violeta Dimitrova, Ralitsa Gigova, Nataliya Gateva, Liliya Angelova","doi":"10.2340/aos.v83.42026","DOIUrl":"10.2340/aos.v83.42026","url":null,"abstract":"Objective: To investigate the influence of citric acid on the osteogenic and angiogenic potential of stem cells from apical papillae (SCAPs).Materials and methods: Stem cells from apical papillae were isolated from freshly extracted third permanent molars. These cells were treated with 20 and 100 μM citric acid. Alizarin red staining was used to evaluate mineral deposition. The secreted levels of vascular endothelial growth factor (VEGF) were assessed by ELISA on days 18, 24 and 28. Immunofluorescence analysis was performed to assess the expression of surface markers after exposure to 20 and 100 μM citric acid.Results: Different mineralisation patterns were observed. Supplemented with citric acid, media showed more diffuse and less dense crystals. On day 18, most VEGF was secreted from the cells with no added citric acid. On day 24, there was a significant increase (p < 0.05) in the levels of VEGF secreted from cells treated with 20 μM citric acid. On day 28, cells from the control group did not secrete VEGF. There was a reduction in the levels of VEGF secreted by cells treated with 20 μM citric acid and a significant increase in the cells exposed to 100 μM citric acid (p < 0.05).Conclusion: Citric acid can promote the differentiation of SCAPs and angiogenesis.","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"83 ","pages":"546-552"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical use of cone-beam computed tomography in Western Norway: a referral-based retrospective study. 挪威西部锥形束计算机断层扫描的临床应用：一项以转诊为基础的回顾性研究。

IF 1.4 4区医学

Acta Odontologica Scandinavica Pub Date : 2024-09-26 DOI: 10.2340/aos.v83.41943

Marianne L Vollan, Linda Cecilie Kleppe Hasselgren, Xie-Qi Shi, Malin V Jonsson

{"title":"Clinical use of cone-beam computed tomography in Western Norway: a referral-based retrospective study.","authors":"Marianne L Vollan, Linda Cecilie Kleppe Hasselgren, Xie-Qi Shi, Malin V Jonsson","doi":"10.2340/aos.v83.41943","DOIUrl":"https://doi.org/10.2340/aos.v83.41943","url":null,"abstract":"Objective: To elucidate cone-beam computed tomography (CBCT) referral profiles in Western Norway.Materials and methods: In all, 3,031 referrals to oral- and maxillofacial radiologist were reviewed. Patient data were retrieved retrospectively from electronic charts. The patient's age, gender, and perceived clinical indication were noted, as well as relevant medical and dental history and whether the referring clinician was a general dentist or held a clinical dental specialty.Results: A total of 2,680 referrals fulfilled the inclusion criteria (UiB n = 1,471, and TkVestland, n = 1,209). The female:male ratio was 1,427:1,253. Mean age was 33 years - 35 years for females compared to 31 years for males (p < 0.001). The most common clinical indications were related to impacted teeth (29%), endodontic issues (17%), cleft lip palate (12%), and resorptions (10%). Less common were bone lesions, implant planning, trauma to the teeth or jaws, atypical orofacial pain, and temporo-mandibular joint (TMJ). The patient age-profiles mirrored differences in indications within the cohort. Most referrals were from specialist dentists such as orthodontists, oral surgeons, and endodontists. Interestingly, 543/2,680 (20%) referrals were from general dentists. Conclusions: Specialist dentists such as orthodontists, oral surgeons, and endodontists refer most patients for clinical indications such as impacted teeth, endodontic issues, and resorptions.","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"83 ","pages":"537-545"},"PeriodicalIF":1.4,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of self-perceived oral health and socio-economic factors on oral health-related behavior in Estonian adults. 爱沙尼亚成年人自我感觉口腔健康和社会经济因素对口腔健康相关行为的影响。

IF 1.4 4区医学

Acta Odontologica Scandinavica Pub Date : 2024-09-25 DOI: 10.2340/aos.v83.41902

Marjo Sinijärv, Jana Olak, Rein Murakas, Riina Runnel

{"title":"Impact of self-perceived oral health and socio-economic factors on oral health-related behavior in Estonian adults.","authors":"Marjo Sinijärv, Jana Olak, Rein Murakas, Riina Runnel","doi":"10.2340/aos.v83.41902","DOIUrl":"https://doi.org/10.2340/aos.v83.41902","url":null,"abstract":"Objective: To identify which socioeconomic factors are affecting oral health-related behavior and to provide suggestions for improving the population's oral health. Materials and methods: The survey includes population groups from age 35 and older from all 15 Estonian counties and major cities (n = 2,376). The study is based on data from a nationwide Estonian Adult Oral Health Survey questionnaire. In addition to analyzing eight aspects of oral health-related behavior and self-perceived oral health variables, the survey also includes participants' socio-economic and demographic characteristics. The study utilizes frequency tables (including cumulative distributions), means, correlations, and regression analysis as its methods.Results: The mean number of beneficial behaviors reported by the participant was 4.2 (SD 1.6). The value of the oral health-related behavior index (OHBI, the number of reported behaviors from the eight) is initially determined by the optimal timing between meals, abstinence from smoking, and the choice of drinking water or refraining from any intake between meals. Participants with higher OHBI tended to rate their self-perceived oral health better. Adherence to beneficial dental health-related behavior in Estonian adults is primarily influenced by gender, educational level, type of settlement, and household income level.Conclusions: In order to significantly improve oral health and related behaviors, it is imperative to integrate dental services into universal health coverage and deliver ongoing oral health education for adults.","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"83 ","pages":"522-530"},"PeriodicalIF":1.4,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary chronic osteomyelitis of the jaw - a descriptive study of the condition and its occurrence in Sweden between 2012 and 2018. 原发性慢性颌骨骨髓炎--对2012年至2018年期间瑞典的病情及其发生率的描述性研究。

IF 1.4 4区医学

Acta Odontologica Scandinavica Pub Date : 2024-09-25 DOI: 10.2340/aos.v83.41989

Caroline Robertsson, Carina Cardemil

引用次数: 0

Exploring the relationship between cycle threshold values and oral manifestations in COVID-19: a comprehensive overview. 探索 COVID-19 中周期阈值与口腔表现之间的关系：全面概述。

IF 1.4 4区医学

Acta Odontologica Scandinavica Pub Date : 2024-09-23 DOI: 10.2340/aos.v83.41390

Dalit Porat Ben Amy, Hanan Rohana, Maya Azrad, Michael V Joachim, Ori Bar, Imad Abu El-Naaj, Avi Peretz

{"title":"Exploring the relationship between cycle threshold values and oral manifestations in COVID-19: a comprehensive overview.","authors":"Dalit Porat Ben Amy, Hanan Rohana, Maya Azrad, Michael V Joachim, Ori Bar, Imad Abu El-Naaj, Avi Peretz","doi":"10.2340/aos.v83.41390","DOIUrl":"10.2340/aos.v83.41390","url":null,"abstract":"Objective: This cross-sectional study aimed to compare oral manifestations between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-positive and SARS-CoV-2-negative patients and to examine associations between oral symptoms, Ct values of E and N SARS-CoV-2 viral genes, and the implications of low Ct values indicating a high viral load, which is a predictive factor for the outcome of COVID-19.Methods: A total of 353 participating patients were aged ≥18 years with clinical manifestations of COVID-19 infection and tested for SARS-CoV-2 carriage at the medical center, by reverse transcriptase polymerase chain reaction (RT-PCR). All patients filled out an anonymous digital questionnaire regarding oral and general symptoms and overall medical health. Results: A significant association was found between SARS-CoV-2 carriage and dry mouth, unpleasant taste and changes in taste (p < 0.001); for example, 37.4% of the 147 SARS-CoV-2- positive participants had a dry mouth, compared to 18.9% of the 206 SARS-CoV-2- negative participants. Oral blisters were experienced by patients with an E gene Ct value of 10-20 (50%) or 21-30 (50%) (p = 0.041). Bad breath, dry mouth, unpleasant taste and changes in taste were mostly present in participants whose Ct values of both E and N genes were between 21 and 30. Conclusions: This study found significant associations between low Ct values of E and N SARS-CoV-2 viral genes and high viral load, indicating that Ct values can serve as predictive factors for COVID-19 outcomes. The findings suggest that while oral symptoms are present, the Ct values and associated high viral loads are more critical indicators of disease severity and prognosis.","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"83 ","pages":"516-521"},"PeriodicalIF":1.4,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sedation of Adults with Orally Administered Midazolam in Dentistry - A Retrospective Study. 牙科口服咪达唑仑对成人的镇静作用 - 一项回顾性研究。

IF 1.4 4区医学

Acta Odontologica Scandinavica Pub Date : 2024-09-19 DOI: 10.2340/aos.v83.41403

Marika Storskrubb, Pia Gabre

{"title":"Sedation of Adults with Orally Administered Midazolam in Dentistry - A Retrospective Study.","authors":"Marika Storskrubb, Pia Gabre","doi":"10.2340/aos.v83.41403","DOIUrl":"10.2340/aos.v83.41403","url":null,"abstract":"Objective: The use of midazolam (MZ) has increased in dentistry, but the effect in adults is sparsely studied. The aim of this study was to investigate doses, effects, and side effects of orally administered MZ as a sedative for adults in a dental care organization.Material and methods: A retrospective record review was performed including all adult patients in the dental care organization ≥20 years receiving MZ, identified through a logbook for addictive drugs, during 2020. From patients' records, the following data were extracted: age, gender, medical history, reason for sedation, performed treatments, doses, effects, and side effects of MZ. Results: In total, 265 patients on 418 occasions had been sedated, which constituted 2.3 sedations per 1,000 visits and 3.3 sedations per 1,000 treated patients. Mean age was 40.8 years and 67.7% were females. The most common reason for sedation was anxiety. Mean dose in primary dental clinics was 7.9 mg and in specialist clinics, 6.8 mg (p < 0.001). Older patients (>70 years) had lower doses than younger (p < 0.001), while no difference was found between ages 55-70 years and those who were younger. Dental treatment was completed in 91.9% of occasions, and side effects were registered in 2.2%. Successful dental treatment was related to type of treatment performed.Conclusions: Sedation is rarely used, particularly in primary dental care, and the use varies widely between clinics. MZ administered by dentists seems to be safe and effective. A sedation record should be used to make patient data such as weight and medical conditions available.","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"83 ","pages":"507-515"},"PeriodicalIF":1.4,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11425061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chewing Side Preference, Facial Asymmetry and Related Factors in the Northern Finland Birth Cohort 1986. 1986 年北芬兰出生队列中的咀嚼侧偏好、面部不对称及相关因素。

IF 2 4区医学

Acta Odontologica Scandinavica Pub Date : 2024-09-18 DOI: 10.2340/aos.v83.41392

Elina V Heikkinen,Ville Vuollo,Tuomo Heikkinen,Virpi Harila

{"title":"Chewing Side Preference, Facial Asymmetry and Related Factors in the Northern Finland Birth Cohort 1986.","authors":"Elina V Heikkinen,Ville Vuollo,Tuomo Heikkinen,Virpi Harila","doi":"10.2340/aos.v83.41392","DOIUrl":"https://doi.org/10.2340/aos.v83.41392","url":null,"abstract":"OBJECTIVEThe aim of this study was to find out how the preferred chewing side (PCS) affects facial asymmetry, what kind of factors affect PCS, and whether there are differences in facial asymmetry between symmetrical and asymmetrical masticators.MATERIAL AND METHODSThe study included 748 subjects (females n=452, males n=296) born in 1985-1986 in Northern Finland (Northern Finland Birth Cohort 1986, NFBC 1986). Subjects' faces were captured in facial 3D images with stereophotogrammetry technology, and they filled in a questionnaire concerning oral health. A comprehensive dental examination was done by a dentist. Subject´s chewing side preference was studied by chewing a piece of paraffin, cotton roll or parafilm. Asymmetry was measured from 3D images with different asymmetry measurements and facial landmarks.RESULTSReduced number of teeth on contralateral side affects PCS (OR = 2.44 in the case of one tooth is missing). Being female increased the whole face and lower face symmetry (p values <0.001-0.824). Self-reported TMD pain has an effect on the sidedness of the chin; there is more pain in the larger side of the chin (OR = 9.45). Different chewing materials had no significant effect on the proportion of chewing sides.CONCLUSIONSFemales have a more symmetrical face compared to males. PCS does not have a statistically significant effect on facial asymmetry, but the variable affecting PCS itself is extracted teeth.","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"49 1","pages":"500-506"},"PeriodicalIF":2.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142268057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A retrospective study on the influence of inclination of cusp on implant marginal bone height in patients with periodontal disease. 牙周病患者尖牙倾斜度对种植体边缘骨高度影响的回顾性研究。

IF 1.4 4区医学

Acta Odontologica Scandinavica Pub Date : 2024-09-12 DOI: 10.2340/aos.v83.41226

Runsheng Pei, Cong Xiao, Jian Chen, Hao Liu, Jinting Chen, Haixia Ge, Nana Cai, Yihua Wu, Yan Zhou

{"title":"A retrospective study on the influence of inclination of cusp on implant marginal bone height in patients with periodontal disease.","authors":"Runsheng Pei, Cong Xiao, Jian Chen, Hao Liu, Jinting Chen, Haixia Ge, Nana Cai, Yihua Wu, Yan Zhou","doi":"10.2340/aos.v83.41226","DOIUrl":"10.2340/aos.v83.41226","url":null,"abstract":"Purpose: To investigate the correlation between the marginal bone height of implants in the posterior maxilla of patients with periodontal disease and the inclination of cusp, providing a theoretical basis for the occlusal design of implant restorations in such patients. Methods: A total of 80 patients with periodontal disease who underwent implant restoration in the posterior maxilla (55 men and 25 women; mean age 56.66 ± 12.70 years) were selected, with a total of 80 implant restorations (one implant restoration per patient). In addition to recording the main research factor of the inclination of cusp, general patient information, implant characteristics and restoration characteristics were taken, and retrospective analysis of the case data and imaging data of the 80 patients from over 3 years was conducted. Cone beam computed tomography was performed preoperatively and 3 years after implant loading to measure and calculate the marginal bone height of the implants using the One Volume Viewer software. Correlation analysis was performed to determine the relationship between the inclination of the cusp and marginal bone height. Results: There was a positive correlation between the inclination of cusp and the marginal bone height of the implants, with a correlation coefficient of 0.661 (p < 0.001); the diameter of the implants, implant type and restoration type were negatively correlated with the marginal bone height of the implants, with correlation coefficients of -0.364 (p = 0.001), -0.232 (p = 0.038) and -0.298 (p = 0.007), respectively. Conclusion: When designing the occlusion of implant restorations in the posterior maxilla of patients with periodontal disease, it is advisable to appropriately reduce the restoration's inclination of cusp.","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"83 ","pages":"493-499"},"PeriodicalIF":1.4,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11423694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The expression of signal regulatory protein alpha (SIRPα) in periodontal cells and tissue. 牙周细胞和组织中信号调节蛋白α（SIRPα）的表达。

IF 2 4区医学

Acta Odontologica Scandinavica Pub Date : 2024-09-11 DOI: 10.2340/aos.v83.41391

Cecilia Koskinen Holm,Sara Rosendahl,Per-Arne Oldenborg,Pernilla Lundberg

{"title":"The expression of signal regulatory protein alpha (SIRPα) in periodontal cells and tissue.","authors":"Cecilia Koskinen Holm,Sara Rosendahl,Per-Arne Oldenborg,Pernilla Lundberg","doi":"10.2340/aos.v83.41391","DOIUrl":"https://doi.org/10.2340/aos.v83.41391","url":null,"abstract":"Signal regulatory protein alpha (SIRPα) is mainly expressed by cells of myeloid origin. This membrane glycoprotein is shown to be involved in regulation of different inflammatory conditions, such as colitis and arthritis. However, SIRPα has not been investigated in relationship to periodontitis, an inflammatory condition affecting the tooth supporting tissues. We aim to investigate if resident cells in the periodontium express SIRPα and whether a possible expression is affected by inflammatory conditions. Primary human keratinocytes, fibroblasts, periodontal ligament cells, and osteoblasts were cultured with or without the pro-inflammatory cytokines tumor necrosis factor alpha (TNF-α) or interleukin-1-beta (IL-1β). All different periodontal cell types showed a basal mRNA expression of SIRPα. Pro-inflammatory cytokines induced a 2-3-fold significant increase in SIRPα expression in both cultured human gingival fibroblasts and osteoblasts but neither in keratinocytes nor in periodontal ligament cells. Tissue sections from human gingival tissue biopsies were histochemically stained for SIRPα. Epithelial keratinocytes and gingival fibroblasts stained positive in sections from periodontally healthy as well as in sections from periodontitis. In periodontitis sections, infiltrating leukocytes stained positive for SIRPα. We highlight our finding that oral keratinocytes, gingival fibroblasts, and periodontal ligament cells do express SIRPα, as this has not been presented before. The fact that inflammatory stimulation of gingival fibroblasts increased the expression of SIRPα, while an increased expression by gingival fibroblasts in periodontitis tissue in situ could not be detected, is indeed contradictory.","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"95 1","pages":"486-492"},"PeriodicalIF":2.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142198537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0