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A Conversation with Biotech Pioneer Robert Langer 与生物技术先驱罗伯特·兰格的对话
GEN biotechnology Pub Date : 2022-12-01 DOI: 10.1089/genbio.2022.29063.rla
R. Langer, J. Sterling, Anjali A. Sarkar
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引用次数: 0
Inferring Conditional Probability Distributions of Noisy Gene Expression from Limited Observations by Deep Learning 用深度学习从有限的观测推断噪声基因表达的条件概率分布
GEN biotechnology Pub Date : 2022-12-01 DOI: 10.1089/genbio.2022.0030
Shangying Wang, S. Capponi, Simone Bianco
{"title":"Inferring Conditional Probability Distributions of Noisy Gene Expression from Limited Observations by Deep Learning","authors":"Shangying Wang, S. Capponi, Simone Bianco","doi":"10.1089/genbio.2022.0030","DOIUrl":"https://doi.org/10.1089/genbio.2022.0030","url":null,"abstract":"","PeriodicalId":73134,"journal":{"name":"GEN biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41469184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Songs in the Key of Life 生命之钥中的歌曲
GEN biotechnology Pub Date : 2022-12-01 DOI: 10.1089/genbio.2022.29069.awo
A. Woolfson
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引用次数: 0
The Microbial Borg: New Allies Against Climate Change? 微生物博格:对抗气候变化的新盟友?
GEN biotechnology Pub Date : 2022-12-01 DOI: 10.1089/genbio.2022.29067.osw
O. Snoeyenbos-West, P. Carini
{"title":"The Microbial Borg: New Allies Against Climate Change?","authors":"O. Snoeyenbos-West, P. Carini","doi":"10.1089/genbio.2022.29067.osw","DOIUrl":"https://doi.org/10.1089/genbio.2022.29067.osw","url":null,"abstract":"","PeriodicalId":73134,"journal":{"name":"GEN biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42749639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multidimensional Beings Drive Scientific Innovation 多维生命驱动科学创新
GEN biotechnology Pub Date : 2022-12-01 DOI: 10.1089/genbio.2022.29065.ski
Samira Kiani
{"title":"Multidimensional Beings Drive Scientific Innovation","authors":"Samira Kiani","doi":"10.1089/genbio.2022.29065.ski","DOIUrl":"https://doi.org/10.1089/genbio.2022.29065.ski","url":null,"abstract":"","PeriodicalId":73134,"journal":{"name":"GEN biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46444222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Current State of Sickle Cell Disease Treatments [Part I] 镰状细胞病的治疗现状[上]
GEN biotechnology Pub Date : 2022-12-01 DOI: 10.1089/genbio.2022.29073.asa
Anjali A. Sarkar
{"title":"The Current State of Sickle Cell Disease Treatments [Part I]","authors":"Anjali A. Sarkar","doi":"10.1089/genbio.2022.29073.asa","DOIUrl":"https://doi.org/10.1089/genbio.2022.29073.asa","url":null,"abstract":"","PeriodicalId":73134,"journal":{"name":"GEN biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49336993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simple Low-Cost Production of DNA MS2 Virus-Like Particles As Molecular Diagnostic Controls. 简单低成本生产DNA MS2病毒样颗粒作为分子诊断控制。
GEN biotechnology Pub Date : 2022-12-01 DOI: 10.1089/genbio.2022.0033
Michael A Crone, Paul S Freemont
{"title":"Simple Low-Cost Production of DNA MS2 Virus-Like Particles As Molecular Diagnostic Controls.","authors":"Michael A Crone,&nbsp;Paul S Freemont","doi":"10.1089/genbio.2022.0033","DOIUrl":"https://doi.org/10.1089/genbio.2022.0033","url":null,"abstract":"<p><p>Suitable controls are integral for the validation and continued quality assurance of diagnostic workflows. Plasmids, DNA, or <i>in vitro</i> transcribed RNA are often used to validate novel diagnostic workflows, however, they are poorly representative of clinical samples. RNA phage virus-like particles (VLPs) packaged with exogenous RNA have been used in clinical diagnostics as workflow controls, serving as surrogates for infectious viral particles. Comparable controls for DNA viruses are more challenging to produce, with analogous DNA phages being infectious and packaging of DNA within RNA phages requiring complex purification procedures and expensive chemical linkers. We present a simple and inexpensive method to produce <i>Emesvirus zinderi</i> (MS2) VLPs, packaged with DNA, that makes use of affinity chromatography for purification and enzymatic production of exogenous DNA suitable for packaging. The produced VLPs were packaged with hepatitis B virus DNA and were then quantified using droplet digital PCR and calibrated against the WHO international standard using a commercial assay in an accredited clinical laboratory.</p>","PeriodicalId":73134,"journal":{"name":"GEN biotechnology","volume":"1 6","pages":"496-503"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10590110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Made in Britain: Venture Fund Boosts Synthetic Biology 英国制造:风险基金促进合成生物学
GEN biotechnology Pub Date : 2022-12-01 DOI: 10.1089/genbio.2022.29068.aph
A. Philippidis
{"title":"Made in Britain: Venture Fund Boosts Synthetic Biology","authors":"A. Philippidis","doi":"10.1089/genbio.2022.29068.aph","DOIUrl":"https://doi.org/10.1089/genbio.2022.29068.aph","url":null,"abstract":"","PeriodicalId":73134,"journal":{"name":"GEN biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42358706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vanquishing the Virus 战胜病毒
GEN biotechnology Pub Date : 2022-12-01 DOI: 10.1089/genbio.2022.29074.jle
Julianna LeMieux
{"title":"Vanquishing the Virus","authors":"Julianna LeMieux","doi":"10.1089/genbio.2022.29074.jle","DOIUrl":"https://doi.org/10.1089/genbio.2022.29074.jle","url":null,"abstract":"","PeriodicalId":73134,"journal":{"name":"GEN biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41434503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PacBio Seeks to Maroon the Competition in the Crowded Sequencing Space PacBio寻求在拥挤的测序空间中竞争
GEN biotechnology Pub Date : 2022-12-01 DOI: 10.1089/genbio.2022.29066.jle
Julianna LeMieux
{"title":"PacBio Seeks to Maroon the Competition in the Crowded Sequencing Space","authors":"Julianna LeMieux","doi":"10.1089/genbio.2022.29066.jle","DOIUrl":"https://doi.org/10.1089/genbio.2022.29066.jle","url":null,"abstract":"","PeriodicalId":73134,"journal":{"name":"GEN biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44200846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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