GEN biotechnologyPub Date : 2023-02-01DOI: 10.1089/genbio.2022.29070.ack
{"title":"Acknowledgment of Reviewers 2022","authors":"","doi":"10.1089/genbio.2022.29070.ack","DOIUrl":"https://doi.org/10.1089/genbio.2022.29070.ack","url":null,"abstract":"GEN BiotechnologyVol. 2, No. 1 AcknowledgmentFree AccessAcknowledgment of Reviewers 2022Published Online:15 Feb 2023https://doi.org/10.1089/genbio.2022.29070.ackAboutSectionsPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail Critical evaluations of articles by expert reviewers make a vital contribution to ensuring the high quality of a journal's content. The editorial leadership of GEN Biotechnology is very grateful for the support of the highly qualified peer reviewers who have dedicated their time and effort to reviewing our articles. We would like to show our appreciation by thanking the following individuals for their assistance with the review of articles for the journal in 2022.Kiana AranSimone BiancoHenk BuckWeidong ChenYu-Chih ChenNathalie ClementJamie DaviesGozde DemirerStacey FinleyKaitlin FoggTimothy FreiBruno GailletHector Garcia MartinPerry HackettXucheng HouKejin HuLesley JonesAhmad KhalilBen KleinstiverAlexis KomorSimon LillicoJulius LucksJianzhu MaShaohua MaDaniel MaedaGus McFarlaneMaryam MoarefianSarah MojaradVaskar MukherjeeKen NishimuraTony NolanAlessandro PoggiKrishanu SahaMaurizio ScarpaMichael SmanskiLaura SoucekYing TangKaren UsdinKristin WhitworthStephanie M. WillerthLulu XueVikramaditya YadavPeter ZandstraBernd ZetscheMin ZhaoFiguresReferencesRelatedDetails Volume 2Issue 1Feb 2023 InformationCopyright 2023, Mary Ann Liebert, Inc., publishersTo cite this article:Acknowledgment of Reviewers 2022.GEN Biotechnology.Feb 2023.57-57.http://doi.org/10.1089/genbio.2022.29070.ackPublished in Volume: 2 Issue 1: February 15, 2023PDF download","PeriodicalId":73134,"journal":{"name":"GEN biotechnology","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136361925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"What Is a Drug? Enabling the Bioeconomy Through Updated Food and Drug Administration Policy","authors":"Alison L. Van Eenennaam","doi":"10.1089/genbio.2023.0003","DOIUrl":"https://doi.org/10.1089/genbio.2023.0003","url":null,"abstract":"","PeriodicalId":73134,"journal":{"name":"GEN biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48302630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GEN biotechnologyPub Date : 2023-02-01DOI: 10.1089/genbio.2023.29079.bjl
Benjamin J. Lesch, M. Cromer
{"title":"The Technologist's Dilemma","authors":"Benjamin J. Lesch, M. Cromer","doi":"10.1089/genbio.2023.29079.bjl","DOIUrl":"https://doi.org/10.1089/genbio.2023.29079.bjl","url":null,"abstract":"","PeriodicalId":73134,"journal":{"name":"GEN biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46663324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GEN biotechnologyPub Date : 2023-02-01Epub Date: 2023-02-15DOI: 10.1089/genbio.2022.0034
Yingye Fang, Princess I Imoukhuede
{"title":"Axl and Vascular Endothelial Growth Factor Receptors Exhibit Variations in Membrane Localization and Heterogeneity Across Monolayer and Spheroid High-Grade Serous Ovarian Cancer Models.","authors":"Yingye Fang, Princess I Imoukhuede","doi":"10.1089/genbio.2022.0034","DOIUrl":"10.1089/genbio.2022.0034","url":null,"abstract":"<p><p>Vascular endothelial growth factor receptors (VEGFRs) and Axl are receptor tyrosine kinases (RTK) that are targeted in ovarian cancer therapy. Two-dimensional monolayer culture and three-dimensional spheroids are common models for RTK-targeted drug screening: monolayers are simple and economical while spheroids include several genetic and histological tumor features. RTK membrane localization dictates RTK signaling and drug response, however, it is not characterized in these models. We quantify plasma membrane RTK concentrations and show differential RTK abundance and heterogeneity in monolayers versus spheroids. We show VEGFR1 concentrations on the plasma membrane to be 10 times higher in OVCAR8 spheroids than in monolayers; OVCAR8 spheroids are more heterogeneous than monolayers, exhibiting a bimodal distribution of a low-Axl (6200/cell) and a high-Axl subpopulation (25,000/cell). In addition, plasma membrane Axl concentrations differ by 100 times between chemosensitive (OVCAR3) and chemoresistant (OVCAR8) cells and by 10 times between chemoresistant cell lines (OVCAR5 vs. OVCAR8). These systematic findings can guide ovarian cancer model selection for drug screening.</p>","PeriodicalId":73134,"journal":{"name":"GEN biotechnology","volume":"2 1","pages":"43-56"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9143707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GEN biotechnologyPub Date : 2023-02-01DOI: 10.1089/genbio.2023.29081.editorial
Hana El-Samad
{"title":"Animal Alternatives for Drug Development","authors":"Hana El-Samad","doi":"10.1089/genbio.2023.29081.editorial","DOIUrl":"https://doi.org/10.1089/genbio.2023.29081.editorial","url":null,"abstract":"","PeriodicalId":73134,"journal":{"name":"GEN biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42367084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GEN biotechnologyPub Date : 2023-01-01DOI: 10.1089/genbio.2023.29111.editorial
Hana El-Samad
{"title":"Lessons from the Minimal Cell","authors":"Hana El-Samad","doi":"10.1089/genbio.2023.29111.editorial","DOIUrl":"https://doi.org/10.1089/genbio.2023.29111.editorial","url":null,"abstract":"","PeriodicalId":73134,"journal":{"name":"GEN biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41672910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GEN biotechnologyPub Date : 2022-12-14DOI: 10.1089/genbio.2022.29072.htg
H. Greely
{"title":"CRISPR Babies and the Great Wall of Silence","authors":"H. Greely","doi":"10.1089/genbio.2022.29072.htg","DOIUrl":"https://doi.org/10.1089/genbio.2022.29072.htg","url":null,"abstract":"","PeriodicalId":73134,"journal":{"name":"GEN biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45410585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}