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Opening a Crack in the Door: An Interview with Haydar Frangoul 打开门的裂缝——海达尔·弗兰古尔访谈录
GEN biotechnology Pub Date : 2023-02-01 DOI: 10.1089/genbio.2023.29082.hfr
H. Frangoul, Kevin Davies
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引用次数: 1
Driving the Chimeric Antigen Receptor: The Road Ahead for Cell Therapy 驱动嵌合抗原受体:细胞治疗的未来之路
GEN biotechnology Pub Date : 2023-02-01 DOI: 10.1089/genbio.2023.29084.gli
G. Livshits
{"title":"Driving the Chimeric Antigen Receptor: The Road Ahead for Cell Therapy","authors":"G. Livshits","doi":"10.1089/genbio.2023.29084.gli","DOIUrl":"https://doi.org/10.1089/genbio.2023.29084.gli","url":null,"abstract":"","PeriodicalId":73134,"journal":{"name":"GEN biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49030815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Health Equity in Sickle Cell Research and Access to Therapy 镰状细胞研究和获得治疗的健康公平
GEN biotechnology Pub Date : 2023-02-01 DOI: 10.1089/genbio.2023.29077.asa
Anjali A. Sarkar
{"title":"Health Equity in Sickle Cell Research and Access to Therapy","authors":"Anjali A. Sarkar","doi":"10.1089/genbio.2023.29077.asa","DOIUrl":"https://doi.org/10.1089/genbio.2023.29077.asa","url":null,"abstract":"","PeriodicalId":73134,"journal":{"name":"GEN biotechnology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61126900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Special Issue: Spatial Omics 特刊:空间组学
GEN biotechnology Pub Date : 2023-02-01 DOI: 10.1089/genbio.2023.29076.cfp
Rong Fan, O. Bayraktar
{"title":"Special Issue: Spatial Omics","authors":"Rong Fan, O. Bayraktar","doi":"10.1089/genbio.2023.29076.cfp","DOIUrl":"https://doi.org/10.1089/genbio.2023.29076.cfp","url":null,"abstract":"","PeriodicalId":73134,"journal":{"name":"GEN biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43215442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How to Develop a Rare Disease Treatment 如何开发罕见病治疗方法
GEN biotechnology Pub Date : 2023-02-01 DOI: 10.1089/genbio.2023.29075.sek
S. Ekins
{"title":"How to Develop a Rare Disease Treatment","authors":"S. Ekins","doi":"10.1089/genbio.2023.29075.sek","DOIUrl":"https://doi.org/10.1089/genbio.2023.29075.sek","url":null,"abstract":"","PeriodicalId":73134,"journal":{"name":"GEN biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47982077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acknowledgment of Reviewers 2022 审稿人致谢
GEN biotechnology Pub Date : 2023-02-01 DOI: 10.1089/genbio.2022.29070.ack
{"title":"Acknowledgment of Reviewers 2022","authors":"","doi":"10.1089/genbio.2022.29070.ack","DOIUrl":"https://doi.org/10.1089/genbio.2022.29070.ack","url":null,"abstract":"GEN BiotechnologyVol. 2, No. 1 AcknowledgmentFree AccessAcknowledgment of Reviewers 2022Published Online:15 Feb 2023https://doi.org/10.1089/genbio.2022.29070.ackAboutSectionsPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail Critical evaluations of articles by expert reviewers make a vital contribution to ensuring the high quality of a journal's content. The editorial leadership of GEN Biotechnology is very grateful for the support of the highly qualified peer reviewers who have dedicated their time and effort to reviewing our articles. We would like to show our appreciation by thanking the following individuals for their assistance with the review of articles for the journal in 2022.Kiana AranSimone BiancoHenk BuckWeidong ChenYu-Chih ChenNathalie ClementJamie DaviesGozde DemirerStacey FinleyKaitlin FoggTimothy FreiBruno GailletHector Garcia MartinPerry HackettXucheng HouKejin HuLesley JonesAhmad KhalilBen KleinstiverAlexis KomorSimon LillicoJulius LucksJianzhu MaShaohua MaDaniel MaedaGus McFarlaneMaryam MoarefianSarah MojaradVaskar MukherjeeKen NishimuraTony NolanAlessandro PoggiKrishanu SahaMaurizio ScarpaMichael SmanskiLaura SoucekYing TangKaren UsdinKristin WhitworthStephanie M. WillerthLulu XueVikramaditya YadavPeter ZandstraBernd ZetscheMin ZhaoFiguresReferencesRelatedDetails Volume 2Issue 1Feb 2023 InformationCopyright 2023, Mary Ann Liebert, Inc., publishersTo cite this article:Acknowledgment of Reviewers 2022.GEN Biotechnology.Feb 2023.57-57.http://doi.org/10.1089/genbio.2022.29070.ackPublished in Volume: 2 Issue 1: February 15, 2023PDF download","PeriodicalId":73134,"journal":{"name":"GEN biotechnology","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136361925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What Is a Drug? Enabling the Bioeconomy Through Updated Food and Drug Administration Policy 什么是药物？通过更新食品药品监督管理局政策促进生物经济
GEN biotechnology Pub Date : 2023-02-01 DOI: 10.1089/genbio.2023.0003
Alison L. Van Eenennaam
{"title":"What Is a Drug? Enabling the Bioeconomy Through Updated Food and Drug Administration Policy","authors":"Alison L. Van Eenennaam","doi":"10.1089/genbio.2023.0003","DOIUrl":"https://doi.org/10.1089/genbio.2023.0003","url":null,"abstract":"","PeriodicalId":73134,"journal":{"name":"GEN biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48302630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Technologist's Dilemma 技术专家的困境
GEN biotechnology Pub Date : 2023-02-01 DOI: 10.1089/genbio.2023.29079.bjl
Benjamin J. Lesch, M. Cromer
{"title":"The Technologist's Dilemma","authors":"Benjamin J. Lesch, M. Cromer","doi":"10.1089/genbio.2023.29079.bjl","DOIUrl":"https://doi.org/10.1089/genbio.2023.29079.bjl","url":null,"abstract":"","PeriodicalId":73134,"journal":{"name":"GEN biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46663324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Axl and Vascular Endothelial Growth Factor Receptors Exhibit Variations in Membrane Localization and Heterogeneity Across Monolayer and Spheroid High-Grade Serous Ovarian Cancer Models. Axl和血管内皮生长因子受体在单层和球状高分化浆液性卵巢癌模型中的膜定位和异质性变化
GEN biotechnology Pub Date : 2023-02-01 Epub Date: 2023-02-15 DOI: 10.1089/genbio.2022.0034
Yingye Fang, Princess I Imoukhuede
{"title":"Axl and Vascular Endothelial Growth Factor Receptors Exhibit Variations in Membrane Localization and Heterogeneity Across Monolayer and Spheroid High-Grade Serous Ovarian Cancer Models.","authors":"Yingye Fang, Princess I Imoukhuede","doi":"10.1089/genbio.2022.0034","DOIUrl":"10.1089/genbio.2022.0034","url":null,"abstract":"<p><p>Vascular endothelial growth factor receptors (VEGFRs) and Axl are receptor tyrosine kinases (RTK) that are targeted in ovarian cancer therapy. Two-dimensional monolayer culture and three-dimensional spheroids are common models for RTK-targeted drug screening: monolayers are simple and economical while spheroids include several genetic and histological tumor features. RTK membrane localization dictates RTK signaling and drug response, however, it is not characterized in these models. We quantify plasma membrane RTK concentrations and show differential RTK abundance and heterogeneity in monolayers versus spheroids. We show VEGFR1 concentrations on the plasma membrane to be 10 times higher in OVCAR8 spheroids than in monolayers; OVCAR8 spheroids are more heterogeneous than monolayers, exhibiting a bimodal distribution of a low-Axl (6200/cell) and a high-Axl subpopulation (25,000/cell). In addition, plasma membrane Axl concentrations differ by 100 times between chemosensitive (OVCAR3) and chemoresistant (OVCAR8) cells and by 10 times between chemoresistant cell lines (OVCAR5 vs. OVCAR8). These systematic findings can guide ovarian cancer model selection for drug screening.</p>","PeriodicalId":73134,"journal":{"name":"GEN biotechnology","volume":"2 1","pages":"43-56"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9143707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nancy Hopkins: Consummate Scientist, Reluctant Feminist 南希霍普金斯：完美的科学家，不情愿的女权主义者
GEN biotechnology Pub Date : 2023-02-01 DOI: 10.1089/genbio.2023.29085.jle
Julianna LeMieux
{"title":"Nancy Hopkins: Consummate Scientist, Reluctant Feminist","authors":"Julianna LeMieux","doi":"10.1089/genbio.2023.29085.jle","DOIUrl":"https://doi.org/10.1089/genbio.2023.29085.jle","url":null,"abstract":"","PeriodicalId":73134,"journal":{"name":"GEN biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46183625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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