Gastro hep advances最新文献

{"title":"Hepatocellular Cancer in the Real World—Rising Detection With Same Outcomes","authors":"Ali S. Taha , Lana Stevenson , Caroline McCloskey , Wilson J. Angerson","doi":"10.1016/j.gastha.2026.100913","DOIUrl":"10.1016/j.gastha.2026.100913","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"5 5","pages":"Article 100913"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147603657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recompensation as a Clinical End Point in Alcohol-Associated Cirrhosis: Gaps in Evidence and Priorities Ahead of Baveno VIII","authors":"Manuel Mendizabal, Juan Pablo Arab","doi":"10.1016/j.gastha.2026.100927","DOIUrl":"10.1016/j.gastha.2026.100927","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"5 5","pages":"Article 100927"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147657393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient Loss of Esophageal Striated Muscle Contractility After Cricopharyngeal Botulinum Toxin Injection for Retrograde Cricopharyngeal Dysfunction","authors":"Anisa Shaker , Karla O’Dell , Edy Soffer","doi":"10.1016/j.gastha.2026.100925","DOIUrl":"10.1016/j.gastha.2026.100925","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"5 5","pages":"Article 100925"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147710897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover: Fibrotic MASH as Treatment Indication for Semaglutide Largely Overlaps With Conventional Indications","authors":"","doi":"10.1016/j.gastha.2026.100977","DOIUrl":"10.1016/j.gastha.2026.100977","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"5 5","pages":"Article 100977"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147859137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Cause of Gastrointestinal Bleeding: Endoscopic Resection of a Large Brunner Gland Hamartoma","authors":"Alexander Siegel, Shalini Jain","doi":"10.1016/j.gastha.2026.101000","DOIUrl":"10.1016/j.gastha.2026.101000","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"5 8","pages":"Article 101000"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148146612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Dysfunction–Associated Steatotic Liver Disease Is Associated With Impaired Health-Related Quality of Life in People With HIV","authors":"Felice Cinque ,&nbsp;Michael Nudo ,&nbsp;Sahar Saeed ,&nbsp;Jihoon Lim ,&nbsp;Dana Kablawi ,&nbsp;Gabrielle Mariano ,&nbsp;Amanda Lupu ,&nbsp;Wesal Elgretli ,&nbsp;Erica E.M. Moodie ,&nbsp;Colleen Price ,&nbsp;Ken Monteith ,&nbsp;Curtis Cooper ,&nbsp;Sharon Walmsley ,&nbsp;Nadine Kronfli ,&nbsp;Joseph Cox ,&nbsp;Cecilia Costiniuk ,&nbsp;Alexandra De Pokomandy ,&nbsp;Jean-Pierre Routy ,&nbsp;Marina B. Klein ,&nbsp;Bertrand Lebouche ,&nbsp;Giada Sebastiani","doi":"10.1016/j.gastha.2026.100966","DOIUrl":"10.1016/j.gastha.2026.100966","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Metabolic dysfunction–associated steatotic liver disease (MASLD) is common in people with HIV (PWH), yet its impact on health-related quality of life (HRQoL) remains poorly characterized. We evaluated the association between MASLD and both generic and liver-specific HRQoL.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional analysis within a national multicenter cohort of PWH. MASLD was defined as hepatic steatosis (controlled attenuation parameter &gt;248 dB/m) plus at least metabolic comorbidity and significant liver fibrosis as liver stiffness measurement ≥8 kPa on FibroScan. Generic HRQoL was assessed using the Short Form-36 and liver-specific HRQoL using the Chronic Liver Disease Questionnaire (CLDQ). Adjusted estimated mean differences were estimated using multivariable linear regression.</div></div><div><h3>Results</h3><div>Among 519 participants, the prevalence of MASLD and significant liver fibrosis was 41.4% and 7.2%, respectively. MASLD was independently associated with lower generic HRQoL, including reduction of physical functioning (−4.6; 95% confidence interval [CI] −9.12 to −0.01) and general health (−4.5; 95% CI −8.58 to −0.48) on the Short Form-36. Liver-specific HRQoL was more affected; MASLD was associated with a lower overall CLDQ score (−0.29; 95% CI −0.49 to −0.09), driven by worse fatigue, systemic symptoms, emotional symptoms, and worry. Among PWH with MASLD, increasing metabolic comorbidity burden was associated with a dose–response decline in physical HRQoL, whereas liver-specific HRQoL did not differ across comorbidity strata. Significant fibrosis was associated with lower CLDQ activity (−0.62; 95% CI −1.20 to −0.05) and worry (−0.60; 95% CI −1.15 to −0.05).</div></div><div><h3>Conclusion</h3><div>In PWH, MASLD is associated with impaired HRQoL, particularly fatigue, systemic symptoms, and emotional well-being. Greater metabolic burden and liver fibrosis further worsen patient-reported outcomes.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"5 7","pages":"Article 100966"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147872046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Protein Synthesis With Reduced Endoplasmic Reticulum Stress Defines a Specific Adaptation in Pancreatic Acinar Metaplasia","authors":"Maxime Libert ,&nbsp;Sophie Quiquempoix ,&nbsp;Leyre López-Muneta ,&nbsp;Ludivine Wacheul ,&nbsp;Sabine Cordi ,&nbsp;Christiane Zorbas ,&nbsp;Patrick Jacquemin","doi":"10.1016/j.gastha.2026.100931","DOIUrl":"10.1016/j.gastha.2026.100931","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Tumorigenesis is usually associated with increased protein synthesis rates coupled with increased endoplasmic reticulum (ER) stress. In the pancreas, acinar cells already exhibit a very high protein synthesis rate in normal physiological conditions, which raises the question of how this cell type adapts during pancreatic tumor formation. Here, we characterize how acinar cells modulate their protein synthesis rate in metaplastic lesions, which are precursor lesions of pancreatic ductal adenocarcinoma.</div></div><div><h3>Methods</h3><div>We evaluated protein synthesis by puromycin incorporation assays and investigated the control of translation and ER stress by transcriptomic analyses and phenotyping of a mouse model of pancreatic ductal adenocarcinoma. We also assessed the level of ribosomal RNA methylation systematically using a deep sequencing–based technique, RiboMethSeq.</div></div><div><h3>Results</h3><div>During pancreatic tumorigenesis, protein synthesis rates were significantly increased in acinar-to-ductal metaplasia compared with normal acinar cells. This was associated with enhanced expression and activity of translation initiation factors, and with increased production of ribosomal components and ribosome assembly factors. We detected differential ribosomal RNA methylation at conserved ribosomal positions near the peptidyl transferase center and the exit tunnel, suggesting a potential role in modulating translation and/or cotranslational protein folding. Despite increased protein synthesis, ER stress was reduced, which was associated with an overall reduction in N-linked glycosylation and increased expression of proteasome components.</div></div><div><h3>Conclusion</h3><div>Our findings reveal a pancreas-specific adaptation of the translational machinery during tumorigenesis, characterized by the production of differentially modified ribosomes and a combination of increased protein synthesis rate and decreased ER stress. This highlights the diversity of adaptive protein synthesis in transforming tissues.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"5 6","pages":"Article 100931"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147804479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial and Ethnic Differences in the Clinical Presentation of Celiac Disease in the United States: A Multi-institutional Retrospective Analysis","authors":"Joy Zhao ,&nbsp;John C. Lin ,&nbsp;Jason C. Lin ,&nbsp;Stephanie M. Moleski","doi":"10.1016/j.gastha.2026.100940","DOIUrl":"10.1016/j.gastha.2026.100940","url":null,"abstract":"","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"5 6","pages":"Article 100940"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147804480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Gut-Brain Axis—From Science to Clinical Practice","authors":"Eamonn M.M. Quigley","doi":"10.1016/j.gastha.2026.100975","DOIUrl":"10.1016/j.gastha.2026.100975","url":null,"abstract":"<div><div>While the idea that the gut and brain communicate has been appreciated for centuries and commented on in many literary works, the formal introduction of the term “gut-brain axis” was much more recent. To the lay person, the operations of this axis are best represented by the effects of stress on gastrointestinal function. Indeed, exactly how stress impacts on such functions as motility and secretion has been extensively studied and its modus operandi revealed. Brain-to-gut communications can be effected via the autonomic nervous system or the hypothalamic pituitary adrenal axis. The recognition that the vagus nerve is predominantly comprised of sensory neurons led to the realization that gut-to-brain traffic is ubiquitous and largely subconscious only achieving conscious recognition at times of alarm or when the gut is injured or diseased. As the field of neurogastroenterology has developed, our understanding of the parallel involvement of “big” and “little” brains by neurodegenerative diseases has increased with Parkinson disease being the exemplar. Of late, the microbiome has entered the fray, and the concept of the microbiome-gut-brain axis emerged. Animal studies have provided considerable evidence to indicate that the gut microbiome can influence brain morphology and function and, thereby, modify behavior. Studies in animal models have also revealed that signals from on high can alter microbiome composition and function. For understandable reasons, it has proven more challenging to explore the microbiota-gut-brain axis and its implications to health and disease in humans. Nevertheless, the possibility that microbiome modulation could exert positive impacts on neurologic and psychological disorders has attracted considerable interest and some hints of efficacy have begun to emerge. For now, pending further studies in humans caution needs to be exerted in assigning pathogenic significance to interactions between the gut microbiome and the brain.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"5 7","pages":"Article 100975"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147993928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilirubin-Driven Phenotype Identifies Higher Mortality Risk in Severe Alcohol-Associated Hepatitis","authors":"Tewodros T. Ayele ,&nbsp;Tomohiro Tanaka","doi":"10.1016/j.gastha.2026.100982","DOIUrl":"10.1016/j.gastha.2026.100982","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Among patients with severe alcohol-associated hepatitis (AH), the prognostic relevance of the dominant component of Maddrey’s Discriminant Function (MDF) is unclear.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study of adults with AH treated with corticosteroids at a US academic center (January 2016–December 2024). Using K-means clustering of the bilirubin and prothrombin time (PT) components of MDF, patients were classified into “PT-driven” vs “bilirubin-driven” phenotypes. The primary outcome was 90-day all-cause mortality. Inverse probability of treatment weighting-weighted Cox proportional hazards models were performed under an intention-to-treat framework, in which patients were not censored at liver transplantation. Secondary analyses used Fine-Gray competing risk models with liver transplantation as a competing event.</div></div><div><h3>Results</h3><div>Among 212 patients, 56 (26.4%) died within 90 days. Despite a similar Model for End-Stage Liver Disease, the bilirubin-driven group (n = 100) had significantly lower MDF scores and less hepatic encephalopathy compared to the PT-driven group (n = 112). Nevertheless, in the inverse probability of treatment weighting-weighted Cox proportional hazards model, the bilirubin-driven phenotype was associated with higher 90-day mortality (hazard ratio, 2.06; 95% confidence interval, 1.05–4.04). Findings were consistent in the Fine-Gray competing risks model (subdistribution hazard ratio, 2.11; 95% confidence interval, 1.03–4.35).</div></div><div><h3>Conclusion</h3><div>A bilirubin-dominant phenotype in severe AH was associated with significantly higher 90-day mortality, highlighting disease heterogeneity and suggesting potential value for risk stratification and for guiding future research on individualized care and optimal timing of liver transplant evaluation.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"5 7","pages":"Article 100982"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147993967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}