Frontiers in pain research (Lausanne, Switzerland)最新文献

{"title":"Redox reactions in chronic pain: mechanisms and relevance in fibromyalgia.","authors":"Tim Ho, Mark Ryan, Jonas Holle","doi":"10.3389/fpain.2025.1593908","DOIUrl":"10.3389/fpain.2025.1593908","url":null,"abstract":"<p><p>Fibromyalgia (FM) is increasingly recognized as a disorder driven by oxidative stress, mitochondrial dysfunction, and neuroinflammation, contributing to pain sensitization and fatigue. This review explores the role of redox imbalance in FM and evaluates potential therapeutic interventions. A scoping literature search was conducted using PubMed, Scopus, and Google Scholar. Findings indicate elevated oxidative stress markers (MDA, 4-HNE), impaired antioxidant defenses [CoQ10 (Coenzyme Q10), SOD, catalase], and mitochondrial dysfunction in FM patients. Preclinical and small-scale clinical studies suggest potential benefits of NRF2 activation, high-dose thiamine, CoQ10, molecular hydrogen, and oxygen-ozone (O₂O₃) therapy. However, human trial evidence is limited, and standardized treatment protocols are lacking. Given the absence of robust RCTs, oxidative stress modulation in FM remains investigational. Future research should prioritize high-quality RCTs to establish the efficacy, safety, and clinical application of redox-targeted therapies.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1593908"},"PeriodicalIF":2.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From didactic explanations to co-design, sequential art and embodied learning: challenges, criticisms and future directions of patient pain education.","authors":"G Lorimer Moseley, Amelia Mardon, James Watson, Felicity Braithwaite, Monique V Wilson, Trevor Barker, James Lawrence, Dianne Sheppard, Michiel F Reneman, Jennifer Stinson, Cormac G Ryan","doi":"10.3389/fpain.2025.1536112","DOIUrl":"10.3389/fpain.2025.1536112","url":null,"abstract":"<p><p>Pain Neuroscience Education (PNE) emerged over two decades ago in response to the incoherence between evidence-based pain management strategies, and consumer and clinician understandings of \"how pain works\". Many clinical trials have investigated the effects of PNE either as a standalone intervention or embedded within a more complex care package, with mixed results. A range of research methods have been used to explore the inconsistent effects of PNE. Together they (i) identify significant shortcomings and limitations of PNE and (ii) raise the possibility that gaining a broadly scientifically accurate understanding of \"how pain works\" may be critical for subsequent pain and disability improvements. Both learnings strongly suggest that we need to do better. Extensive research incorporating several interest-holders has led to updated content and language and criticisms of both are addressed. The method of PNE has also been updated, with integration of educational frameworks, teaching strategies and tactics, patient resources and clinical tools that all aim to promote the likelihood that patients will learn key concepts and operationalise them to improve their pain, function and quality of life. Pain Science Education is used to differentiate the new approach from PNE.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1536112"},"PeriodicalIF":2.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early post-trauma wound microbiota and its association with pain outcomes and mental health in combat-related extremity injuries: a prospective analysis.","authors":"Kateryna Ksenchyna, Dmytro Dmytriiev, Kostiantyn Volanskyi, Oleh Ksenchyn, Oleksandr Nazarchuk","doi":"10.3389/fpain.2025.1564994","DOIUrl":"10.3389/fpain.2025.1564994","url":null,"abstract":"<p><strong>Introduction: </strong>Given that many armed conflicts are currently ongoing worldwide, a thorough study of issues related to providing medical care for the wounded is essential.</p><p><strong>Material and methods: </strong>We included 45 participants aged 20-60 years with limb injuries in our study. The participants were surveyed using a visual analog pain scale, the PHQ-9, and the PTSD-5. We formed three groups: the first group included patients with limb amputations, the second group consisted of patients with limb trauma, and the third group involved patients with limb burns.</p><p><strong>Results: </strong>We found that the average pain level in Group 1 was higher, though statistical significance was not achieved (<i>p</i> > 0,05). According to the PHQ-9, all participants exhibited depressive symptoms of varying severity. In the trauma group, patients reported fewer PTSD symptoms. Among the amputees, a significant predominance of Gram-negative microorganisms was noted. The correlation between the slightly higher pain levels and the significant predominance of Gram-negative flora in amputee patients was negative (<i>P</i> > 0.05).</p><p><strong>Conclusions: </strong>In the amputee group, there was a trend toward higher mean pain scores compared to the other groups (<i>p</i> > 0,05). The same presence and distribution of depressive and PTSD symptoms were observed across all groups. Correlation analysis between pain intensity and contamination with Gram-negative bacteria did not reveal a relationship between these two variables. The study requires a larger patient sample. Gram-negative pathogens such as Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella oxytoca, and Proteus mirabilis were found more frequently among all patients.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1564994"},"PeriodicalIF":2.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between frailty and pain in older people at high risk of future hospitalization.","authors":"Huan-Ji Dong, Joakim Yang, Maria M Johansson, Anneli Peolsson, Marco Barbero, Magnus Nord","doi":"10.3389/fpain.2025.1576691","DOIUrl":"10.3389/fpain.2025.1576691","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have demonstrated an independent association between pain and frailty, but knowledge about this association with different pain characteristics is limited.</p><p><strong>Objective: </strong>This study was embedded in a prospective, pragmatic, matched-control multicenter trial at 19 primary care practices in south-eastern Sweden (ClinicalTrials.gov 170608, ID: NCT03180606), aiming to investigate the association between frailty and pain characteristics among older people (75+) at high risk of hospitalization.</p><p><strong>Methods: </strong>High risk of hospitalization was identified using case-finding algorithm including 32 diagnostic codes of morbidities and healthcare use. Frailty was assessed by a nurse-physician team using Clinical Frailty Scale (<i>N</i> = 389). Data on pain aspects, physical and ADL functioning were collected in the self-reported questionnaires.</p><p><strong>Results: </strong>One in three (<i>n</i> = 133, 34%) was classified as frail. About 36% (<i>n</i> = 142) reported frequent pain (from several times per week to constantly). Slightly over 40% reported pain lasting longer than 3 months (<i>n</i> = 163, 41.9%) and/or having regional or widespread pain (<i>n</i> = 165, 42.4%). In comparison to non-frail peers, frail participants reported higher pain intensity, more ADL-dependency, less physical activity, and more anxiety/depression (<i>p</i> < 0.01). In logistic regression analysis, pain frequency [Odds Ratio (OR) 1.8, 95% confidence interval (CI): 1.2-2.8] was associated with frailty. However, the models with ADL-staircase score (OR: 1.4, 95% CI: 1.2-1.6) had a higher explanatory power (Nagelkerke <i>R</i> ²: 0.39) in predicting frailty than those without this aspect (<i>R</i> ²: 0.10 and 0.13).</p><p><strong>Conclusion: </strong>In older people at high risk of hospitalization, pain frequency seemed to be related to frailty, whilst ADL dependency demonstrated a stronger association.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1576691"},"PeriodicalIF":2.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Women in science: musculoskeletal pain.","authors":"John Shannonhouse, Yu Shin Kim","doi":"10.3389/fpain.2025.1599967","DOIUrl":"https://doi.org/10.3389/fpain.2025.1599967","url":null,"abstract":"","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1599967"},"PeriodicalIF":2.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term pain and health economic outcomes in adults receiving multidisciplinary CBT for chronic pain: the role of psychological inflexibility.","authors":"Sophia Åkerblom, Lance M McCracken, Marcelo Rivano Fischer, Sean Perrin","doi":"10.3389/fpain.2025.1547540","DOIUrl":"https://doi.org/10.3389/fpain.2025.1547540","url":null,"abstract":"<p><strong>Background: </strong>Little is known about whether the recommended, non-pharmacological treatments for chronic pain yield reductions in healthcare utilization, social costs and increased productivity in actual practice.</p><p><strong>Methods: </strong>The primary aim of this study (<i>n</i> = 232) was to conduct secondary analyses of health economic outcomes using data from national registries combined with clinical outcome data from a large pain center in Sweden conducting multidisciplinary treatment based on a cognitive behavioral approach. Specifically, pain-related and health economic outcomes at post-treatment and one, two and three years after discharge were examined. In an exploratory fashion, we also investigated whether sociodemographic characteristics, pain-related variables, and psychological <i>in</i>flexibility predicted these long-term pain-related and health economic outcomes. We also examined psychological <i>in</i>flexibility as a potential mediator of these outcomes.</p><p><strong>Results: </strong>Small and moderate sized improvements in pain, pain interference, and depression observed at post-treatment were mostly maintained at both the 1- and 3-year follow-up. A very similar pattern was observed for health economic outcomes, with 1-year follow-up gains being maintained at long-term follow-up. Baseline psychological <i>in</i>flexibility predicted long-term pain-related outcomes, but not health economic outcomes. Changes in psychological <i>in</i>flexibility during treatment and follow-up mediated long-term pain-related outcomes and the total number of health care visits.</p><p><strong>Conclusions: </strong>The present findings add to a small body of literature indicating that the improvements in pain and related difficulties following multidisciplinary, pain-focused, CBT programs persist at least three years following treatment, and these are accompanied by modest improvements in health economic outcomes over the same interval. Psychological <i>in</i>flexibility seems to be predominately associated with long-term clinical outcomes in pain management, and it also appears relevant to the number of health care visits.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1547540"},"PeriodicalIF":2.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial influences on pain in transgender individuals.","authors":"Kelly S Clemens, John Matkovic, Abby Odelson, Audrey Strain, Eric D Wesselmann","doi":"10.3389/fpain.2025.1546526","DOIUrl":"https://doi.org/10.3389/fpain.2025.1546526","url":null,"abstract":"<p><p>Pain is an unpleasant and unavoidable part of the human experience, but the prevalence and impact of pain disproportionately impacts marginalized groups, including transgender and gender-diverse people. While there are many bases of pain, psychosocial variables, including cognitions (e.g., outcome and interpersonal expectations, social gender norms), affect (e.g., negative affectivity, emotional distress), and social factors (e.g., social exclusion) may be particularly relevant in the pain experiences of transgender individuals. The coalescence of these factors is discussed in this review, where authors specifically consider how these cognitive, affective, and social factors may contribute to pain disparities seen in transgender individuals. Patient-centered communication is presented as a potential avenue to directly mitigate the effect of these psychosocial variables on pain in transgender individuals by reducing feelings of social exclusion transgender patients may experience in the medical office, and the authors call for additional experimental research and the development of educational interventions for providers.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1546526"},"PeriodicalIF":2.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain kept under wraps of myelin sheath.","authors":"Veronica I Shubayev","doi":"10.3389/fpain.2025.1569515","DOIUrl":"https://doi.org/10.3389/fpain.2025.1569515","url":null,"abstract":"<p><p>The myelin sheath serves both as insulator and metabolic powerhouse for large-diameter dorsal root ganglia (DRG) neurons-some of the longest cells in the body-transmitting sensory impulses from the periphery to the spinal cord. When myelin is damaged, bioactive fragments of myelin basic protein (MBP) are released, playing a pivotal role in pathological pain. MBP-derived peptides (MBPd) emerge as a ubiquitous yet sex-specific mediator of pain. In females, MBPd triggers a widespread transcriptional response across the peripheral nerve, DRG, and spinal cord, leading to persistent, treatment-resistant tactile allodynia-pain from normally innocuous touch. In contrast, males exhibit only a localized transcriptional response, confined to the nerve, which does not extend to the DRG or spinal cord or induce pain. The sex difference is driven by MBPd's interaction with lipids and regulation of nuclear receptor transcription factors, including the estrogen receptor (ESR) and the liver X receptor (LXR)/retinoid × receptor (RXR) complex-key regulators of lipid and cholesterol metabolisms mounting sex-dependent immunity. By unraveling these fundamental mechanisms of myelin remodeling, this work opens the door to innovative, non-addictive, personalized therapeutics and diagnostics for chronic pain.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1569515"},"PeriodicalIF":2.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudo-labeling based adaptations of pain domain classifiers.","authors":"Tobias B Ricken, Sascha Gruss, Steffen Walter, Friedhelm Schwenker","doi":"10.3389/fpain.2025.1562099","DOIUrl":"https://doi.org/10.3389/fpain.2025.1562099","url":null,"abstract":"<p><strong>Introduction: </strong>Each human being experiences pain differently. In addition to the highly subjective phenomenon, only limited labeled data, mostly based on short-term pain sequences recorded in a lab setting, is available. However, human beings in a clinic might suffer from long painful time periods for which even a smaller amount of data, in comparison to the short-term pain sequences, is available. The characteristics of short-term and long-term pain sequences are different with respect to the reactions of the human body. However, for an accurate pain assessment, representative data is necessary. Although pain recognition techniques, reported in the literature, perform well on short-term pain sequences. The collection of labeled long-term pain sequences is challenging and techniques for the assessment of long-term pain episodes are still rare. To create accurate pain assessment systems for the long-term pain domain a knowledge transfer from the short-term pain domain is inevitable.</p><p><strong>Methods: </strong>In this study, we adapt classifiers for the short-term pain domain to the long-term pain domain using pseudo-labeling techniques. We analyze the short-term and long-term pain recordings of physiological signals in combination with electric and thermal pain stimulation.</p><p><strong>Results and conclusions: </strong>The results of the study show that it is beneficial to augment the training set with the pseudo labeled long-term domain samples. For the electric pain domain in combination with the early fusion approach, we improved the classification performance by 2.4% to 80.4% in comparison to the basic approach. For the thermal pain domain in combination with the early fusion approach, we improved the classification performance by 2.8% to 70.0% in comparison to the basic approach.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1562099"},"PeriodicalIF":2.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recognition and treatment of attention deficit-hyperactivity disorder in patients with treatment-resistant burning mouth syndrome: a retrospective case study.","authors":"Kaori Takahashi, Satoshi Kasahara, Miwako Takahashi, Taito Morita, Naoko Sato, Toshimitsu Momose, Ko Matsudaira, Shin-Ichi Niwa, Kanji Uchida, Toshiyuki Handa, Tatsuya Ichinohe, Ken-Ichi Fukuda","doi":"10.3389/fpain.2025.1536584","DOIUrl":"https://doi.org/10.3389/fpain.2025.1536584","url":null,"abstract":"<p><strong>Introduction: </strong>Burning mouth syndrome (BMS) is an idiopathic oral pain disorder characterized by burning sensations and dysesthesia, often complicated by psychosocial factors and psychiatric comorbidities, necessitating a multidisciplinary approach. BMS, classified as nociplastic pain (NcplP), frequently involves central sensitization. Attention-deficit/hyperactivity disorder (ADHD), a neurodevelopmental disorder, is commonly comorbid with NcplP, and ADHD-targeted treatment has shown efficacy in NcplP management. However, the role of ADHD diagnosis and treatment on BMS and associated brain function abnormalities remains unexplored. Therefore, we aimed to investigate the prevalence of ADHD comorbidity and its assessment using ADHD scales and the therapeutic efficacy of an ADHD-focused algorithm, including pre- and post-treatment cerebral blood flow single-photon emission computed tomography (SPECT) results, in patients with treatment-resistant BMS referred from the outpatient clinic of dental psychosomatic specialists at a tertiary care institution for multidisciplinary treatment.</p><p><strong>Methods: </strong>We retrospectively analyzed data from 14 patients with treatment-resistant BMS who received multidisciplinary care, including psychiatric evaluation and SPECT imaging. Clinical assessments included the Conners' Adult ADHD Rating Scale (CAARS-S and CAARS-O), Pain Numerical Rating Scale, Hospital Anxiety and Depression Scale, and Pain Catastrophizing Scale. Algorithm-based pharmacotherapy using ADHD-effective medications (methylphenidate, atomoxetine, guanfacine, aripiprazole, venlafaxine, and duloxetine) was administered.</p><p><strong>Results: </strong>ADHD was diagnosed in 13 patients (92.9%), with 57.2% exhibiting borderline or clinical-level symptoms. Clinically significant improvements were observed in all clinical scales among the 10 patients who completed algorithm-based treatment. Brain perfusion SPECT identified hypoperfusion in the frontal lobe and hyperperfusion in the perigenual anterior cingulate cortex, insular cortex, posterior cingulate gyrus, and precuneus in 90% of cases, with improvements noted following treatment.</p><p><strong>Conclusions: </strong>ADHD is frequently comorbid in patients with treatment-resistant BMS, and ADHD-targeted pharmacotherapy may help alleviate pain, cognitive dysfunction, and brain perfusion abnormalities. These findings suggest that ADHD screening, diagnosis, and multidisciplinary management involving psychiatrists could play a crucial role in optimizing clinical outcomes in patients with BMS.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1536584"},"PeriodicalIF":2.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}