Frontiers in ophthalmology最新文献

{"title":"Real-world impact of latanoprostene bunod ophthalmic solution 0.024% in glaucoma therapy: a narrative review.","authors":"W Daniel Stamer, Thomas Chiu, Da-Wen Lu, Tsing Hong Wang, Prin Rojanapongpun, Ngamkae Ruangvaravate, Youn Hye Jo, Marlene R Moster, Murray Fingeret, Nora Lee Cothran, Jessica Steen, Ian Benjamin Gaddie, Ömür Uçakhan-Gündüz, Wesam Shamseldin Shalaby, Cindy M L Hutnik","doi":"10.3389/fopht.2025.1554777","DOIUrl":"https://doi.org/10.3389/fopht.2025.1554777","url":null,"abstract":"<p><p>Latanoprostene bunod ophthalmic solution (LBN) 0.024% is a topical nitric oxide (NO)-donating prostaglandin F2α (PGF2α) analog first approved in November 2017 for reduction of intraocular pressure (IOP) in patients with ocular hypertension (OHT) or open-angle glaucoma (OAG). This narrative review describes the unique mechanism of action of LBN and summarizes available real-world data. Upon instillation, LBN is metabolized into latanoprost acid and butanediol mononitrate, which is further reduced to NO and an inactive metabolite. Latanoprost acid increases aqueous humor outflow primarily through the uveoscleral (unconventional) pathway, whereas NO increases outflow through the trabecular (conventional) pathway. Eight studies were identified: 2 studies in newly diagnosed, treatment-naïve patients with OHT or OAG, 4 studies of adjunctive therapy in patients with glaucoma receiving other IOP-lowering therapies, and 2 studies in which patients with glaucoma switched to LBN monotherapy or adjunctive therapy. Decreases in IOP after initiating LBN in newly diagnosed patients or adding/switching to LBN were generally consistent with reductions observed in clinical trials and sustained throughout the studies. Rates of discontinuation due to inadequate IOP lowering ranged from 12.2% to 17.1%. LBN was generally well tolerated in real-world studies; the most common adverse events were consistent with the known safety profile of LBN. Data from real-world studies provide important insights regarding the potential effectiveness and tolerability of LBN in the clinical setting and suggest that LBN is well tolerated and associated with significant, clinically meaningful, and durable reductions in IOP.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1554777"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11985852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: ROSAH syndrome presents diagnostic and therapeutic challenges.","authors":"Jenny Shunyakova, Margaret Reynolds, Amal Taylor, Erin G Sieck, James T Walsh, Lynn M Hassman","doi":"10.3389/fopht.2025.1535805","DOIUrl":"10.3389/fopht.2025.1535805","url":null,"abstract":"<p><strong>Background: </strong>Retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and headache (ROSAH) syndrome is an autosomal dominant disorder caused by a heterozygous missense mutation in alpha kinase 1 (ALPK1). This series reports the presentation and treatment outcomes of three first-degree relatives with ROSAH syndrome.</p><p><strong>Methods: </strong>Retrospective chart review, whole exome sequencing.</p><p><strong>Results: </strong>A 16-year-old male presented with bilateral optic disc edema, macular edema, retinal degeneration, and vitreous inflammation. His mother and brother had similar clinical features. Whole exome gene sequencing identified a shared heterozygous mutation in the ALPK1 gene c.710C>T, consistent with ROSAH syndrome. Ophthalmic manifestations in this family included optic nerve edema, macular edema, panuveitis, glaucoma, and widespread retinal cone and rod dysfunction. While the proband's macular edema improved with intravitreal dexamethasone and systemic tocilizumab, immune suppression did not prevent retinal degeneration.</p><p><strong>Conclusion: </strong>A diagnosis of ROSAH syndrome, suggested by the concomitant presentation of optic disc edema, uveitis, and retinal degeneration, can be made by targeted genetic sequencing of the ALKP1 gene. While ROSAH-associated ocular inflammation and macular edema may respond to local steroids and immune suppression, retinal degeneration may progress despite these therapies.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1535805"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors of retinal vein occlusion in East Asia: a meta-analysis.","authors":"Xinyue Qiu, Ziman Jiao, Yuxin Liu, Yunhao Zhou, Haiyu Li, Xin Chen, Guanghui Liu","doi":"10.3389/fopht.2025.1545602","DOIUrl":"10.3389/fopht.2025.1545602","url":null,"abstract":"<p><strong>Objective: </strong>With the intention of developing a more targeted control strategy for retinal vein occlusion (RVO) in East Asian populations, a meta-analysis was conducted to evaluate the risk factors associated with RVO in this region.</p><p><strong>Methods: </strong>PubMed, Web of Science, Cochrane Library, CNKI, Wanfang and VIP databases were searched for studies that reported risk factors of RVO in East Asia, published from the establishment of the database to May 2024. To further filter the articles, Newcastle-Ottawa Scale (NOS) evaluation method was utilized to assess the quality of selected articles. After valid data were extracted, Meta-analysis was performed by Review Manager software.</p><p><strong>Results: </strong>A total of 21 literatures were included, including 27561 cases in the RVO group (Case group) and 514578 cases in the non-retinal vein occlusion (NRVO) group (Control group). Results of meta-analysis showed that chronic kidney disease [odds ratio (OR)=4.14, 95% confidence interval (CI): (1.86%, 9.24%)], hypertension [OR=4.11, 95% CI: (3.09%, 5.48%)], hyperlipidemia [OR=3.45, 95%CI: (2.32%, 5.12%)], diabetes mellitus [OR=3.00, 95%CI: (1.88%, 4.80%)], homocysteine [OR=0.87, 95%CI: (0.59%, 1.15%)], have statistically significant differences between the RVO group and the NRVO group(<i>P</i><0.05).</p><p><strong>Conclusion: </strong>The occurrence of RVO is closely related to its risk factors, such as chronic kidney disease, hypertension, hyperlipidemia, diabetes mellitus and high homocysteine. In the process of diagnosis and treatment of RVO, doctors should focus on the above risk factors to prevent the occurrence of the disease.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1545602"},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between refractive error components and higher-order aberrations in simple myopia and compound myopic astigmatism.","authors":"Sahar Mohaghegh, Shahram Bamdad, Haleh Kangari, Saeed Rahmani","doi":"10.3389/fopht.2025.1532931","DOIUrl":"10.3389/fopht.2025.1532931","url":null,"abstract":"<p><strong>Aim: </strong>To investigate associations between refractive error components and higher-order aberrations (HOAs) in adult myopic subjects.</p><p><strong>Methods: </strong>A total of 1370 myopia right eyes, aged 18-40, were included in a cross-sectional study. Subjective cycloplegic refractions and distance aberrometry measured with a Shack-Hartmann device were analyzed. Zernike components of horizontal coma (Z₃ ¹), vertical coma (Z₃ ^-1), oblique trefoil (Z₃ ³), vertical trefoil (Z₃ ^-3), spherical aberration, and total root-mean-square (RMS) wave-front error for 6 mm pupil were analyzed. Pearson's correlations were calculated between sphero-cylindrical components and HOAs based on vector analysis for the astigmatism axis. Total subjects were divided into two subgroups: simple myopia (SMY, 648 eyes) and compound myopic astigmatism (CMA, 722 eyes). HOAs were compared between the two subgroups.</p><p><strong>Results: </strong>Total RMS wave-front error correlates with spherical equivalent myopia (r = -0.1, P<0.05) and J45 (r = 0.1, P<0.001). J0 correlates positively with vertical coma (Z₃ ^-1) (r = 0.1 p <0.001) and negatively with oblique trefoil (Z₃ ³) and vertical trefoil (Z₃ ^-3), (r = -0.1, p < 0.001; r = -0.1, P < 0.05). The total RMS wavefront-error was larger in the CMA (|0.37| ± 0.18 µm) compared to the SMY (|0.34| ± 0.16 µm, P <0.001). The mean values of vertical coma (Z₃ ^-1), vertical trefoil (Z₃ ^-3), and oblique trefoil (Z₃ ³) differed between the two subgroups.</p><p><strong>Conclusion: </strong>Total RMS wave-front error increases with increasing myopia and astigmatism. Increasing myopia power does not show a systematic correlation with HOAs components. A weak systematic correlation is suggested between astigmatism direction and third-order aberrations.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1532931"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric orbital fractures in Singapore: demographics, etiology, and the role of bioresorbable implants.","authors":"Emmanuel Lee Boniao, Alexander Gungab, Blanche Xiao Hong Lim, Gangadhara Sundar","doi":"10.3389/fopht.2025.1506445","DOIUrl":"10.3389/fopht.2025.1506445","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to analyze the demographic characteristics, etiology, fracture types, interventions and treatment outcomes, with a focus on the increasing role of bioresorbable implants compared to traditional non-resorbable implants in pediatric orbital fractures.</p><p><strong>Methods: </strong>This was a retrospective cohort study conducted at the Department of Ophthalmology, National University Hospital, Singapore, of pediatric patients (aged 18 years or younger) treated surgically for orbital fractures from January 2005 to May 2023. Data was extracted from the hospital's electronic medical records, including demographic details, causes of fractures, types of fractures, implants used (bioresorbable and non-bioresorbable), and clinical outcomes.</p><p><strong>Results: </strong>43 cases of pediatric orbital and orbitofacial fractures met the criteria undergoing surgical intervention. Most occurred in males (81.4%, n=35). Causes of fractures were sports-related incidents and play (46.5%, n=20), assault (30.2%, n=13), road-traffic accidents (16.3%, n=7), and non-play related accidents (7%, n=3). Most pediatric orbital fractures were unilateral (88%, n=38). While most were pure or simple orbital fractures (74.4% n=32), 25.6% (n=11) were complex orbitofacial fractures. Amongst simple orbital fractures, blowout fractures (91%, n=29) were the most common, involving the inferior (58.6%, n=17), combined floor and medial wall (20.6%, n=6), medial wall (13.8%, n=4) and roof (6.9%, n=2). Amongst the complex fractures, zygomaticomaxillary complex fractures were the most frequent (45.4%, n=5), followed by cranioorbital fractures (27.3%, n=3) and Le Fort II & III fractures (27.3%, n=3). Orbital tissue entrapment was common (56%, n=24), and most patients with entrapment underwent urgent surgical intervention (65%, n=28), usually within 24 hours (53%, n=23). The majority of those who underwent surgery had implants placed (89%, n=25), with most being bioresorbable (64.3%, n=18). All patients (100%) who underwent surgery showed clinical improvement without significant complications.</p><p><strong>Conclusion: </strong>Although simple pediatric orbital blowout fractures are still the most common among pediatric patients, the study showed that a quarter of them presented with complex orbitofacial fractures requiring multidisciplinary management. Most fractures occurred in males and typically associated with increasing play and physical activity in teenagers. The study also showed that early intervention is crucial to better outcome, with the increasing role of bioresorbable implants in this population reducing long term implant related complications.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1506445"},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levitation of posteriorly dislocated intraocular lens: I.V. catheter connected to the vitreotome aspiration.","authors":"Ruiping Gu, Yue Guo, Yuan Zong, Rui Jiang, Zhongcui Sun","doi":"10.3389/fopht.2025.1547363","DOIUrl":"10.3389/fopht.2025.1547363","url":null,"abstract":"<p><strong>Background: </strong>To introduce a new, simple, and affordable technique that uses a 22G intravenous (I.V.) catheter connected to the vitreotome aspiration to lift the intraocular lens (IOLs) off the retina.</p><p><strong>Methods: </strong>This retrospective, non-comparative, single surgeon, interventional, consecutive case series examined 4 patients (4 eyes) who underwent the surgical procedure from March 12 and October 22, 2023. Reliability, reproducibility, and intraoperative and postoperative complications of the technique were analyzed.</p><p><strong>Results: </strong>Four patients presenting with posteriorly dislocated IOLs were included. After a complete 23G vitrectomy under wide-angle viewing system or high magnification contact lens, the 22G I.V. catheter was connected to the vitreotome aspiration and active aspiration was applied. When the IOLs were lifted towards the posterior chamber by continuous vacuum aspiration, they were be safely grasped using intraocular forceps and reposited with scleral fixation suturing or removed through a limbal incision. None of the IOLs fell during active aspiration.</p><p><strong>Conclusion: </strong>Connection of I.V. catheter with vitreotome aspiration to lift the IOLs off the retina was a new, simple, safe, and affordable technique.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1547363"},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proportion and associated factors of glaucoma among outpatient department at university of Gondar comprehensive specialized hospital tertiary eye care and training center, northwest Ethiopia, 2021.","authors":"Banchamelak Zeraye Yekunoamelak, Fisseha Admassu Ayele, Zinachew Mulat Bogale, Endalew Mulugeta Worku","doi":"10.3389/fopht.2025.1521263","DOIUrl":"10.3389/fopht.2025.1521263","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to measure the proportion, types of glaucoma, and associated factors among outpatient departments at the University of Gondar Comprehensive Specialized Hospital Tertiary Eye Care and Training Center, Northwest Ethiopia.</p><p><strong>Methods: </strong>An institution-based cross-sectional study design was conducted on 934 participants who were selected by a simple random sampling method at entrance of tertiary eye care and training Center from September to November 2021. A structured questionnaire was used to collect the data through interviews, and the presence or absence, type, and stage of glaucoma were determined by reviewing the chart. The questionnaire was adapted from a previous study, and the data were entered into Epi Info version 7 and analyzed using SPSS version 20. Descriptive data were analyzed in terms of proportion, frequency, mean, and standard deviation. Binary logistic regression was utilized to identify determinant factors, with significance considered at a p-value less than 0.05.</p><p><strong>Results: </strong>A total of 934 study participants with an 85.33% response rate took part in the study. The mean age of the study participants was 55.67 SD ± 13.21 years. The proportion of glaucoma was 13.4% [(95% CI: (10.9, 15.8)], with Primary Open Angle glaucoma accounting for 96.3% of the total number of glaucoma cases. The age groups of 56-66 [AOR=3.80(95% CI: 1.99-7.26)], 67-87 [AOR=5.34(95% CI: 2.70-10.45)] and those who completed college or university [(AOR= 5.41(95% CI: 2.12-13.82)] were significantly associated with the presence of glaucoma.</p><p><strong>Conclusion: </strong>This study shows a high proportion of glaucoma compared to other studies, with Primary Open Angle Glaucoma being the most prevalent type. Increasing age and higher education level were significantly linked to the presence of glaucoma. Further research is needed to explore the relationship between education level and glaucoma.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1521263"},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular symptoms in COVID-19 patients with a history of hospitalization in the first pandemic wave in Styria, Austria.","authors":"Andreas Guttmann, Astrid Heidinger, Nora Woltsche, Marianne Brodmann, Katharina Kurzmann-Gütl, Viktoria Nemecz, Matthias Kaindl, Herbert Wurzer, Gerold Schwantzer, Jutta Horwath-Winter","doi":"10.3389/fopht.2025.1540904","DOIUrl":"10.3389/fopht.2025.1540904","url":null,"abstract":"<p><strong>Purpose: </strong>Our study aimed to investigate the prevalence and timing of ocular surface manifestations in hospitalized COVID-19 patients, providing insights into the occurrence of eye involvement before, during, or after the illness. This study contributes to understanding the extent of ocular involvement in COVID-19, which has been suggested to occur due to potential viral entry through the eyes.</p><p><strong>Methods: </strong>451 confirmed COVID-19 patients had a history of hospitalization in Styria, Austria. The study included 176 patients aged 18-95 years who tested positive for SARS-CoV-2 in nasopharyngeal swabs by RT-PCR and received treatment at two hospitals. Telephone interviews were conducted after recovery, focusing on ocular symptoms and medical history (openMEDOCS).</p><p><strong>Results: </strong>Seventeen percent (n=30) reported new-onset ocular symptoms in the context of COVID-19. Patients with ocular symptoms were younger (p<0.001). Sore throat (p=0.013) and high fever (p=0.038) were significantly more prevalent in patients with new-onset ocular symptoms. Persistent ocular symptoms beyond the duration of hospitalization affected more than half (56.7%) of the participants with new-onset ocular symptoms. However, there were no differences in blood parameters, lung imaging, or comorbidities between groups with and without ocular symptoms.</p><p><strong>Conclusions: </strong>In hospitalized COVID-19 patients, ocular symptoms occur with a significant prevalence of 17%. Younger age (p<0.001) and the presence of sore throat (p=0.013) are associated with an increased risk of developing new-onset ocular symptoms in the context of COVID-19.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1540904"},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secukinumab in refractory non-infectious anterior uveitis.","authors":"Otto M Olivas-Vergara, Inés Hernanz, Pablo E Borges-Deniz, Fredeswinda Romero-Bueno, Olga Sanchez-Pernaute, Ester Carreño","doi":"10.3389/fopht.2025.1491981","DOIUrl":"10.3389/fopht.2025.1491981","url":null,"abstract":"<p><strong>Background: </strong>Secukinumab is a monoclonal antibody that selectively neutralizes interleukin-17A and has shown efficacy in the treatment of psoriatic arthritis, psoriasis, and axial spondyloarthritis. Its use in non-anterior non-infectious uveitis is controversial, with evidence generally not supporting its effectiveness in these conditions. However, the role of secukinumab in anterior non-infectious uveitis remains unclear.</p><p><strong>Methods: </strong>Case series. Five patients with biological therapy-refractory non-infectious anterior uveitis who were treated with secukinumab were included.</p><p><strong>Results: </strong>All 5 patients experienced a uveitis flare-up during treatment, and secukinumab failed to induce long-term remission in 2 of these patients, who also had uncontrolled systemic disease.</p><p><strong>Conclusion: </strong>Secukinumab failed to prevent uveitis flare-up in these patients with biological therapy-refractory disease. Further studies are necessary to determine the potential role of secukinumab in the treatment of anterior uveitis.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1491981"},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrobulbar/intraconal tube placement in patients with glaucoma: Ahmed FP-7 and tube extender case series with 1 year follow-up.","authors":"Daniel Laroche, Brian Grodecki, Kara Rickford Grimes, Chester Ng","doi":"10.3389/fopht.2025.1408897","DOIUrl":"10.3389/fopht.2025.1408897","url":null,"abstract":"<p><strong>Purpose: </strong>The Ahmed FP-7 valve is useful in the management of refractory glaucoma. However, this can often have ocular hypertensive phase and subconjunctival fibrosis that can lead to increased medication use and failure. We report how retrobulbar and intraconal plate placement with tube extension can avoid the ocular hypertensive phase, lower intraocular pressure, and reduce medication burden.</p><p><strong>Patients and methods: </strong>This is a retrospective case series of 4 patients with glaucoma who underwent Ahmed FP-7 valve and retrobulbar/intraconal tube placement with a one-year follow-up.</p><p><strong>Results: </strong>One-year results in 4 patients with advanced glaucoma and pseudophakia revealed a pre-operative intraocular pressure of 21 mmHg on 5.5 medications. At one year, the post-operative intraocular pressure was 10.25 on 0 medications. The vision and visual fields were stable. One patient required drainage of a choroidal effusion and one patient required burping of viscoelastic on post-operative day one.</p><p><strong>Conclusions: </strong>The combined insertion of the Ahmed FP-7 valve and silicone tube inserted into the retrobulbar/intraconal space has been shown to prevent ocular hypertensive phase, lower intraocular pressure, and reduce medication burden at one year.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1408897"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}