Frontiers in ophthalmology最新文献

{"title":"Correction: Intramuscular orbital schwannoma: case report and review of the literature.","authors":"Hammam A Alotaibi, Firas Madani, Rawan N Althaqib, Hamad M AlSulaiman","doi":"10.3389/fopht.2025.1655719","DOIUrl":"https://doi.org/10.3389/fopht.2025.1655719","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fopht.2025.1586465.].</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1655719"},"PeriodicalIF":0.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: The role of IL-6 in thyroid eye disease: an update on emerging treatments.","authors":"Jennifer Murdock, John Nguyen, Brady J Hurtgen, Cathy Andorfer, John Walsh, Andrea Lin, Christopher Tubbs, Kristine Erickson, Kimberly Cockerham","doi":"10.3389/fopht.2025.1641164","DOIUrl":"https://doi.org/10.3389/fopht.2025.1641164","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fopht.2025.1544436.].</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1641164"},"PeriodicalIF":0.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of a novel surgical approach: sutureless correction of conjunctivochalasis using new conjunctival forceps combined with high-frequency electrocautery.","authors":"Tingting Song, Xianjun Liang, Yingjie Lin, Huihui Luo","doi":"10.3389/fopht.2025.1554316","DOIUrl":"10.3389/fopht.2025.1554316","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the efficiency, efficacy, and safety of application new conjunctival forceps combined with high-frequency electrocautery-assisted for treatment of conjunctivochalasis (Cch).</p><p><strong>Methods: </strong>This study included data from 19 patients (22 eyes)with conjunctivochalasis who underwent treatment from January to December 2023. Cch correction was performed with our new conjunctival forceps (Patent Number: ZL 2022 2 0320601.0), which offers enhanced precision and stability in grasping the conjunctiva, combined with high-frequency electrocautery (Ellman, America) for sutureless correction. Surgical duration was recorded. Cch severity, assessed with lip-parallel conjunctival folds (LIPCOF), along with discomfort scored by Ocular Surface Disease Index (OSDI), were compared pre- and post-operatively. A reduction in LIPCOF grade and complete healing of the conjunctival epithelium post-surgery within one month were considered successful outcomes. Healing and potential complications were checked at one week and one month.</p><p><strong>Results: </strong>The mean surgical duration was 6.9 ± 1.5 minutes. Significant improvement in LIPCOF grades was observed over time (χ²=62.824, p<0.01), with 59.1% of eyes achieving grade 0 at 1 week postoperatively, increasing to 95.5% at 1 month. OSDI scores showed no difference between preoperative (38.54) and 1-week postoperative (41.67) values (p=0.922), but significantly decreased by 1 month (16.67, p<0.001). Complete healing was noted at electrode contact sites by 1 week, while incisions managed with novel conjunctival forceps showed 75% healing rate; all incisions were fully healed by 1 month. Mild postoperative congestion and edema resolved completely without major complications.</p><p><strong>Conclusion: </strong>The new conjunctival forceps with high-frequency electrocautery for sutureless Cch correction proved to be efficient, effective, and safe.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1554316"},"PeriodicalIF":0.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12289505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stakeholders' perspectives on a digital myopia screening program in children: a qualitative analysis.","authors":"Casper van der Zee, Janneau L J Claessens, Petra T Rausch-Koster, Saskia M Imhof, Ruth M A van Nispen, Robert P L Wisse, Hilde P A van der Aa","doi":"10.3389/fopht.2025.1585320","DOIUrl":"10.3389/fopht.2025.1585320","url":null,"abstract":"<p><strong>Purpose: </strong>This study was aimed at identifying barriers and opportunities to use a self-administered online refractive eye test by various stakeholders of a pediatric vision screening program.</p><p><strong>Methods: </strong>This qualitative study performed semi-structured interviews with myopic children and their parents, eye care professionals, and policymakers. Three topic lists were developed, delineating themes to identify gaps, barriers, and opportunities. Interviews were anonymously recorded, transcribed, and coded using thematic analysis. Quantitative data was acquired from a concomitant clinical validation study.</p><p><strong>Results: </strong>In total, 14 interviews were conducted, of which seven were with children and their parents, four with eye care professionals, and three with policymakers. The patients and parents were positive about the instructions and age appropriateness. They noted that the test could be designed as more child-friendly and preferred receiving feedback during the test. Eye care professionals and policymakers saw potential for using the test in children aged ≥12 without high refractive errors, yet they also underlined the false-positives rates, impacting care demand and costs. The population refraining from participation was expected to have higher health gains, yet including them was expected to be challenging without facilitating awareness.</p><p><strong>Conclusions: </strong>This qualitative study shows the perspectives for an online pediatric refractive screening. The patients and parents were open to self-administered screening and suggested improvements. The eye care professionals and policymakers were receptive to screening but also cautious, highlighting costs and scientific reliability. For better implementation, the policymakers underlined the relevance of the screening criteria, while the eye care professionals recommended targeting a specific population at risk that benefits most rather than screening the whole population.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1585320"},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral optic perineuritis: a rare manifestation of giant cell arteritis - case report and literature review.","authors":"Jnadi Madkhali, Ahmed B Aba Alkhail, Mohammed A Aldriweesh, Yaser Al Malik","doi":"10.3389/fopht.2025.1598302","DOIUrl":"10.3389/fopht.2025.1598302","url":null,"abstract":"<p><strong>Background: </strong>Giant cell arteritis (GCA) is a granulomatous vasculitis in older individuals that primarily affects medium-to-large vessels. Owing to the involvement of the ophthalmic arteries, GCA can lead to severe ischemic complications, including vision loss. Optic perineuritis (OPN) is characterized by inflammation around the optic nerve sheath and is a rare manifestation of GCA with diagnostic and therapeutic challenges.</p><p><strong>Case presentation: </strong>This case study reports a 75-year-old female presenting with subacute constitutional symptoms of fever and poor appetite with bilateral eye pain and visual disturbance. The patient had elevated inflammatory markers, specifically an erythrocyte sedimentation rate of 120 mm/h, with imaging findings consistent with bilateral OPN and temporal artery biopsy-proven GCA. Treatment with high-dose dexamethasone, followed by oral prednisolone and tocilizumab, led to symptomatic improvement in vision stabilization.</p><p><strong>Conclusion: </strong>This case highlights the importance of recognizing OPN as a possible manifestation of GCA. Although cases of OPN are mostly idiopathic, it can rarely represent the first manifestation of GCA. Therefore, prompt diagnosis through brain imaging and temporal artery biopsy is essential, and aggressive treatment with steroids is crucial for managing GCA-associated OPN to prevent irreversible vision loss.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1598302"},"PeriodicalIF":0.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12270863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related macular degeneration associated with optic disc drusen.","authors":"Anas Alkhabaz, Min Young Kim, Rishita Pujari, Jamie Zhang, Yulan Ren, Loh-Shan Bryan Leung, Yaping Joyce Liao","doi":"10.3389/fopht.2025.1620616","DOIUrl":"10.3389/fopht.2025.1620616","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to investigate the risk of age-related macular degeneration (AMD) in association with optic disc drusen (ODD).</p><p><strong>Design: </strong>This was an observational, cross-sectional study.</p><p><strong>Participants: </strong>Participants were consecutive patients with and without ODD from the neuro-ophthalmology clinic. Ten patients with concomitant ODD-AMD were sub-analyzed.</p><p><strong>Methods: </strong>The two cohorts were identified from a prospectively recruited dataset between July 2022 and June 2024. Patients received formal diagnoses of ODD and AMD after ophthalmic and imaging assessment. A logistic regression model was utilized in calculating AMD risk to account for demographic differences.</p><p><strong>Results: </strong>A total of 94 patients with ODD (median age: 44 [Q1: 20, Q3: 69], 64% women) and 100 patients without ODD (median age: 60 [Q1: 44, Q3: 69], 48% women) were identified. AMD was observed in 9.6% and 3% of the ODD and non-ODD cohorts, respectively. The risk of AMD was higher in the ODD group (OR = 3.93, 95% CI: 0.89-21.85, <i>p</i> = 0.084). Although the association was not statistically significant, a logistic regression model attributed that to the age difference between the two cohorts. Of the 10 patients with ODD-AMD, 70% had a family history of AMD. These patients were all Caucasians and had a median age of 75 years (range: 56-91); 70% were women. Only 30% were smokers. On optic disc imaging, 70% of eyes demonstrated moderate-to-severe ODD.</p><p><strong>Conclusion: </strong>Patients with ODD might be at a higher risk of AMD compared to patients without ODD, and AMD screening might be warranted. A family history of AMD is often present, indicating shared genetic risk factors.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1620616"},"PeriodicalIF":0.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound biomicroscopic imaging analysis of lens position and stability in acute and chronic angle-closure glaucoma.","authors":"Zhiying Yu, Xinyu Wang, Haitao Wang, Jing Han, Jing Fu, Licun Wang, Ling Wang","doi":"10.3389/fopht.2025.1624876","DOIUrl":"10.3389/fopht.2025.1624876","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to compare the characteristics and differences in lens position and stability in patients with acute and chronic angle-closure glaucoma (ACG) using ultrasound biomicroscopy (UBM) to provide a basis for selecting treatment regimens for primary ACG (PACG).</p><p><strong>Methods: </strong>This prospective study included 82 eyes of patients with PACG, of which, 45 eyes with acute PACG (APACG), 37 with chronic PACG (CPACG). Axial length (AL) and lens thickness (LT) were measured using A-scan ultrasonography. Anterior chamber depth (ACD), pupil diameter (PD), and lens vault (LV) were measured using UBM for each group. Additionally, trabecular-iris angle (TIA), angle opening distance (AOD₅₀₀), iris-lens angle (ILA), and iris-lens contact distance (ILCD) were measured in four quadrants (superior, inferior, nasal, and temporal) with UBM. The corresponding lens position (LP), relative lens position (RLP), and lens thickness/axial length factor (LAF) were calculated. Normally distributed data were compared between the two groups using an independent samples t-test. Data that did not follow a normal distribution were compared using the Mann-Whitney U test. Differences were considered statistically significant when <i>P</i> < 0.05, and they were considered highly statistically significant when <i>P</i> < 0.01.</p><p><strong>Results: </strong>The values for angle-related parameters, including the mean TIA, TIA_max-min, mean AOD₅₀₀, AOD_{500 max-min}, and ACD, were significantly lower in the APACG group than in the CPACG group (all <i>P</i> < 0.05). The LP and RLP values of the APACG group were also lower than those of the CPACG group, but only the difference in LP values being statistically significant (<i>P</i> = 0.038). The LT, LV, LAF, mean ILCD, and ILCD_max-min values were higher than those of the CPACG group, with the differences reaching statistical significance (all <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>The APACG eyes had a thicker and more-anteriorly positioned lens than those with CPACG, which results in a shallower anterior chamber and narrower anterior chamber angle. In the APACG group, the lens exhibited nonuniform laxity of the suspensory ligament across the various quadrants, poor stability, and greater susceptibility for anterior displacement or even deviation.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1624876"},"PeriodicalIF":0.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real world outcomes of Kahook Dual Blade goniotomy in black and Afro-Latinx adult patients with glaucoma: a 2-year retrospective study.","authors":"Ayobami Adebayo, Chester Ng, Daniel Laroche","doi":"10.3389/fopht.2025.1573937","DOIUrl":"10.3389/fopht.2025.1573937","url":null,"abstract":"<p><strong>Background: </strong>The Kahook Dual Blade goniotomy has been shown to be efficacious in the treatment of open angle glaucoma. We previously reported 6 months results using the Kahook Dual Blade in Black and Afro-Latino patients.</p><p><strong>Objectives: </strong>The purpose of this study was to determine the effectiveness and safety of Kahook Dual Blade (KDB) goniotomy alone or coupled with phacoemulsification cataract surgery to minimize intraocular pressure, number of medications used and visual field preservation in Black patients or Afro-Latinx who have open-angle glaucoma (OAG).</p><p><strong>Design: </strong>This was a retrospective, nonrandomized study that was carried out at two private practices in Harlem, NY and Queens, NY.</p><p><strong>Methods: </strong>This study consisted of patients with OAG who underwent phacoemulsification combined with goniotomy (PE + KDB) or goniotomy alone (KDB). The Kahook dual blade was used to perform goniotomy in all patients. Reduction of intraocular pressure (IOP) and alleviating the burden of medications were both considered indications for glaucoma surgery. Our research included information on IOP before and after surgery, the number of medications to decrease IOP pressure, visual field mean deviation, during a follow-up period of two years.</p><p><strong>Results: </strong>At two years we identified 31 patients who had surgery. The preoperative IOP of all 31 eyes which had surgery was 16.7 mmHg which decreased to 14.0 mmHg after two years. The baseline number of topical IOP-lowering medications was 2.4 ± 1.4 at baseline which decreased to 1.6 ± 1.4 (P = 0.02) after two years. The average visual field mean deviation was stable in both groups after two years. Postoperative adverse events were mild and included transient hyphema, IOP spikes, posterior capsule opacification, tearing, glare and mild pain.</p><p><strong>Conclusion: </strong>In Black or Afro-Latinx patients with open-angle glaucoma, phacoemulsification coupled with Kahook dual-blade goniotomy considerably reduces IOP and the number of medications.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1573937"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current understanding on Retinitis Pigmentosa: a literature review.","authors":"Naning Suleman","doi":"10.3389/fopht.2025.1600283","DOIUrl":"10.3389/fopht.2025.1600283","url":null,"abstract":"<p><p>Retinitis Pigmentosa (RP) refers to a group of inherited retinal disease, often leading to legal and sometimes complete blindness. It is estimated that over a million people are afflicted with RP all over the world and show tremendous genetic and phenotypic heterogeneity, involving over 90 genes in its causation. The present literature review intends to present a qualitative overview of the genetic mechanisms, clinical features, and diagnostic methods of RP, emphasizing genotype-phenotype correlation. Therapeutic advances in gene therapy, stem cell therapies, optogenetics, retinal prosthetics, and pharmacotherapy are reviewed, and the article notes the crucial role that next-generation sequencing has had in facilitating accurate diagnoses and tailored treatment strategies. While no curative treatments have been proposed, emerging therapeutic strategies are claimed to be effective in blunting disease advancement and maintaining or restoring visual function. Patients who are afflicted with RP often undergo a variety of both physical and mental difficulties, hence requiring several eventual, timely interventions for their social-emotional conflicts. This review aims to present insightful information about the paradigm shift in RP diagnosis and treatment, serving as a complete basis for clinicians and researchers working toward the management of retinal diseases.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1600283"},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Advanced ophthalmic imaging in glaucoma and other optic neuropathies.","authors":"Yukihiro Shiga, Takashi Nishida, Jin Wook Jeoung, Brad Fortune","doi":"10.3389/fopht.2025.1629342","DOIUrl":"10.3389/fopht.2025.1629342","url":null,"abstract":"","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1629342"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}