Frontiers in ophthalmology最新文献

{"title":"Real world outcomes of Kahook Dual Blade goniotomy in black and Afro-Latinx adult patients with glaucoma: a 2-year retrospective study.","authors":"Ayobami Adebayo, Chester Ng, Daniel Laroche","doi":"10.3389/fopht.2025.1573937","DOIUrl":"10.3389/fopht.2025.1573937","url":null,"abstract":"<p><strong>Background: </strong>The Kahook Dual Blade goniotomy has been shown to be efficacious in the treatment of open angle glaucoma. We previously reported 6 months results using the Kahook Dual Blade in Black and Afro-Latino patients.</p><p><strong>Objectives: </strong>The purpose of this study was to determine the effectiveness and safety of Kahook Dual Blade (KDB) goniotomy alone or coupled with phacoemulsification cataract surgery to minimize intraocular pressure, number of medications used and visual field preservation in Black patients or Afro-Latinx who have open-angle glaucoma (OAG).</p><p><strong>Design: </strong>This was a retrospective, nonrandomized study that was carried out at two private practices in Harlem, NY and Queens, NY.</p><p><strong>Methods: </strong>This study consisted of patients with OAG who underwent phacoemulsification combined with goniotomy (PE + KDB) or goniotomy alone (KDB). The Kahook dual blade was used to perform goniotomy in all patients. Reduction of intraocular pressure (IOP) and alleviating the burden of medications were both considered indications for glaucoma surgery. Our research included information on IOP before and after surgery, the number of medications to decrease IOP pressure, visual field mean deviation, during a follow-up period of two years.</p><p><strong>Results: </strong>At two years we identified 31 patients who had surgery. The preoperative IOP of all 31 eyes which had surgery was 16.7 mmHg which decreased to 14.0 mmHg after two years. The baseline number of topical IOP-lowering medications was 2.4 ± 1.4 at baseline which decreased to 1.6 ± 1.4 (P = 0.02) after two years. The average visual field mean deviation was stable in both groups after two years. Postoperative adverse events were mild and included transient hyphema, IOP spikes, posterior capsule opacification, tearing, glare and mild pain.</p><p><strong>Conclusion: </strong>In Black or Afro-Latinx patients with open-angle glaucoma, phacoemulsification coupled with Kahook dual-blade goniotomy considerably reduces IOP and the number of medications.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1573937"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current understanding on Retinitis Pigmentosa: a literature review.","authors":"Naning Suleman","doi":"10.3389/fopht.2025.1600283","DOIUrl":"10.3389/fopht.2025.1600283","url":null,"abstract":"<p><p>Retinitis Pigmentosa (RP) refers to a group of inherited retinal disease, often leading to legal and sometimes complete blindness. It is estimated that over a million people are afflicted with RP all over the world and show tremendous genetic and phenotypic heterogeneity, involving over 90 genes in its causation. The present literature review intends to present a qualitative overview of the genetic mechanisms, clinical features, and diagnostic methods of RP, emphasizing genotype-phenotype correlation. Therapeutic advances in gene therapy, stem cell therapies, optogenetics, retinal prosthetics, and pharmacotherapy are reviewed, and the article notes the crucial role that next-generation sequencing has had in facilitating accurate diagnoses and tailored treatment strategies. While no curative treatments have been proposed, emerging therapeutic strategies are claimed to be effective in blunting disease advancement and maintaining or restoring visual function. Patients who are afflicted with RP often undergo a variety of both physical and mental difficulties, hence requiring several eventual, timely interventions for their social-emotional conflicts. This review aims to present insightful information about the paradigm shift in RP diagnosis and treatment, serving as a complete basis for clinicians and researchers working toward the management of retinal diseases.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1600283"},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Advanced ophthalmic imaging in glaucoma and other optic neuropathies.","authors":"Yukihiro Shiga, Takashi Nishida, Jin Wook Jeoung, Brad Fortune","doi":"10.3389/fopht.2025.1629342","DOIUrl":"10.3389/fopht.2025.1629342","url":null,"abstract":"","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1629342"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on interdisciplinary measurement and evolutionary path in the field of ophthalmology.","authors":"Lu Chunji, Liu Yuwei, Zhang Fangyuan, Nie Zihan","doi":"10.3389/fopht.2025.1578956","DOIUrl":"10.3389/fopht.2025.1578956","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Interdisciplinary collaboration is an inevitable trend in solving complex problems. As medical research deepens, the integration of theories, methods, and technologies from other disciplines with medicine has become an effective means to promote the development of medical research and address issues in the medical field.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;There are significant differences in disciplinary intersections in different subfields of medicine, and this study, using ophthalmology as an example, aims to tap into the complex interrelationships between ophthalmology and other disciplines, to reveal interdisciplinary themes in ophthalmology, and to track the development and evolution of trans-ophthalmologic research.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This article takes ophthalmology as an example and uses the Rao-Stirling index to calculate the disciplinary distribution of journals cited in the literature of this field. By setting a threshold, it identifies interdisciplinary literature. Based on the LDA model, it conducts topic identification for the interdisciplinary literature to discover the interdisciplinary themes. Furthermore, it analyzes the evolution trends of these themes using the principle of similarity and visualizes the evolutionary paths.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The paper successfully linked 85,401 pieces of literature with WOS subject classifications, involving a total of 250 WOS subjects. The top 10 cited subjects are: Ophthalmology, Neurosciences, Surgery, Multidisciplinary Sciences, Biochemistry & Molecular Biology, Psychology, Medicine: Genetics & Heredity, Cell Biology, Genetics & Heredity, Clinical Neurology. A total of 18,573 pieces of literature with a Rao-Stirling index greater than 0.7 were selected as high interdisciplinary literature in Ophthalmology. The literature was divided into time slices of two years each, and scores for thematic coherence and thematic perplexity were calculated. Ultimately, twelve themes were identified for 2014-2015, eleven themes for 2016-2017, eleven themes for 2018-2019, ten themes for 2020-2021, and nine themes for 2022-2023. Based on the calculation of thematic similarity, three main evolutionary paths were summarized. The evolutionary paths are: \"1-1, 1-2, 1-3, 1-5, 1-6, 1-9,1-10→2-1, 2-4, 2-7, 2-8, 2-9, 2-10→3-4, 3-8, 3-10→4-1, 4-5, 4-8, 4-10→5-5, 5-8, 5-9\", \"1-1, 1-2, 1-3, 1-5, 1-6, 1-9,1-10→2-1, 2-4, 2-7, 2-8, 2-9, 2-10→3-4, 3-8, 3-10→4-1, 4-5, 4-8, 4-10→5-5, 5-8, 5-9\".&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;This study conducts a comprehensive analysis of interdisciplinary themes in ophthalmology through the application of the Rao-Stirling index and the LDA model, revealing trends of multidisciplinary collaboration and evolving topics. To facilitate the integration of these themes, the research proposes several recommendations: first, to promote interdisciplinary collaboration in order to establish an innovative ecosystem that spans various fields","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1578956"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12186160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploiting induced pluripotent stem cell-derived retinal pigment epithelium to unravel host-pathogen interaction in ocular tuberculosis: a reverse translational <i>in vitro</i> model.","authors":"Ikhwanuliman Putera, Sanne van de Meerendonk, Nicole M A Nagtzaam, Rina La Distia Nora, Saskia M Rombach, Jurriaan E M de Steenwinkel, Johannes R Vingerling, Willem A Dik, P Martin van Hagen","doi":"10.3389/fopht.2025.1610215","DOIUrl":"10.3389/fopht.2025.1610215","url":null,"abstract":"<p><p><i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) can infect the retinal pigment epithelium (RPE) cells. Current <i>in vitro</i> research models for ocular tuberculosis (OTB) only rely on RPE cell culture approaches. Until now it remains unclear why only a minority of patients with active systemic tuberculosis (TB) develops concurrent OTB. There is significant variation in the clinical manifestations of OTB, which is potentially influenced by ethnic differences and diversity in mycobacterial strains. To better understand the immunopathobiology of OTB, particularly an individual's susceptibility to <i>Mtb</i>-infection and the specific host response, cell culture systems utilizing induced pluripotent stem cells (iPSC)-derived RPE cells offer a promising <i>in vitro</i> model to better mimic the disease. With this technology, RPE cells can be generated from specific patients of interest, enabling to test hypotheses in a bench to bedside or reverse manner. In this current study, we explore the utility of iPSC-derived RPE cells as an <i>in vitro</i> model for OTB. Such an approach would overcome drawbacks associated with the currently commonly used \"general\" RPE cell lines as disease model. The application of iPSC-derived RPE cells offers promising options for the identification of novel biomarkers and to study individualized drug screening methods for host-directed therapy of OTB, in order to restore and maintain vision in OTB patients with sight-threatening disease.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1610215"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Development of severe inflammatory orbitopathy after immune checkpoint inhibitor initiation.","authors":"Samantha Madala, Alomi Parikh, Kendra Hong, Michael Burnstine","doi":"10.3389/fopht.2025.1574643","DOIUrl":"10.3389/fopht.2025.1574643","url":null,"abstract":"<p><p>We report a case of thyroid eye disease (TED) reactivation, review the literature, and raise awareness of severe ophthalmopathy and myositis following the initiation of cancer treatment with an immune checkpoint inhibitor (ICI). In this case, after starting nivolumab, a 68-year-old woman with a past medical history of stage 2C uterine carcinoma status post-hysterectomy and past ocular history of thyroid eye disease developed ophthalmoplegia, proptosis, decreased color vision, optic disc hemorrhage, and ocular inflammation. Halting nivolumab and starting 2 weeks of intravenous steroids, one dose of teprotumumab, and low-dose orbital radiation resulted in an improvement in her orbitopathy. ICIs have become popular in oncologic treatment regimens, but they can have serious adverse effects including thyroiditis, Hashimoto's hypothyroidism, or Graves' disease complicated by TED. Multiple cases have been reported in the literature of both the reactivation of TED and the presentation of a TED-like orbital inflammation, which we summarize here. Awareness of orbital inflammation due to ICI use is critical, and ICIs should be used with caution in patients with a history of thyroid disease due to the risk of TED reactivation.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1574643"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of regular, glulisine, and aspart insulin on vascular endothelial growth factor and angiotensinogen expression in hyperglycemic retinal pigment epithelial (RPE) and human retinal endothelial cells (HRECs).","authors":"Fatemeh Sanie-Jahromi, Abtin Khosravi, Hooman Hadianfard, M Hossein Nowroozzadeh","doi":"10.3389/fopht.2025.1570232","DOIUrl":"10.3389/fopht.2025.1570232","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetic retinopathy (DR) is a leading cause of vision loss and is primarily driven by chronic hyperglycemia, which induces retinal vascular damage through mechanisms involving vascular endothelial growth factor (VEGF) and the renin-angiotensin system (RAS). This study investigated the effects of hyperglycemia and different insulin formulations-regular, glulisine, and aspart-on VEGF-A and angiotensinogen (AGT) gene expression in two human retinal cell types: retinal pigment epithelial (RPE) cells and human retinal microvascular endothelial cells (HRECs).</p><p><strong>Methods: </strong>Cells were cultured from donor tissue and exposed to physiologic and hyperglycemic glucose concentrations, with or without insulin treatment. Gene expression levels were quantified using real-time PCR.</p><p><strong>Results: </strong>Hyperglycemia significantly upregulated VEGF-A and AGT in both RPE and HREC cells (e.g., VEGF-A in RPE: 2.62-fold, <i>P</i> = 0.001; AGT in RPE: 3.32-fold, <i>P</i> = 0.093), supporting a role for both osmotic and glucose-specific pathways. Among insulin treatments, regular insulin significantly reduced VEGF-A expression in both RPE (0.72-fold, <i>P</i> = 0.033) and HRECs (0.57-fold, <i>P</i> = 0.009). In contrast, aspart and glulisine had modest effects on VEGF-A in HRECs (0.82-fold each; <i>P</i> = 0.035 and <i>P</i> = 0.060, respectively) and no significant impact in RPE cells. Regarding AGT, aspart insulin showed the most consistent suppressive effect, reducing expression in both RPE (0.15-fold, <i>P</i> < 0.001) and HRECs (0.22-fold, <i>P</i> = 0.004). Glulisine significantly increased AGT in RPE (1.56-fold, <i>P</i> = 0.009) but reduced it in HRECs (0.58-fold, <i>P</i> = 0.074). Regular insulin showed no effect on AGT in RPE (<i>P</i> = 0.680) and a non-significant increase in HRECs (1.36-fold, <i>P</i> = 0.097).</p><p><strong>Discussion: </strong>These findings highlight the differential biological effects of insulin analogues and suggest that aspart insulin, in particular, may offer therapeutic benefits beyond glycemic control by modulating both VEGF-A and RAS-related pathways. Tailored insulin therapies could represent innovative strategies for managing or slowing the progression of diabetic retinopathy.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1570232"},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative evaluation of fibrosis in idiopathic orbital inflammatory pseudotumor by IVIM-DWI.","authors":"Jian Pu, Xing Xu, Peng Wang, Wei Su, Juwei Shao, Yinhua Yang, Mingqin Li, Jianbo Li","doi":"10.3389/fopht.2025.1545761","DOIUrl":"10.3389/fopht.2025.1545761","url":null,"abstract":"<p><strong>Objective: </strong>To quantitatively evaluate the degree of fibrosis in Idiopathic Orbital Inflammatory Pseudotumor (IOIP) using Intravoxel Incoherent Motion Diffusion-Weighted Imaging (IVIM-DWI).</p><p><strong>Methods: </strong>Twenty eight patients (32 eyes) with idiopathic orbital inflammatory pseudotumor were pathologically diagnosed in the Affiliated Hospital of Yunnan University from August 2019 to August 2024. Routine orbital MRI plain scan and ivim-dwi scan were completed before surgery, and the true diffusion coefficient (d), pseudo diffusion coefficient (d*) and perfusion fraction (f) were obtained. According to the proportion of chronic inflammatory cells and fibrous tissue components in postoperative histopathological sections, it was defined that fibrous cells accounted for less than 10% of the total number of cells as negative (-), and > 10% as positive (+), of which 10%%25% were +, 25%%50% were + +, 50%%75% were + + +, and > 75% were + + +. Taking the proportion of fibrocytes in histopathological sections as the standard of fibrosis degree, the correlation between ivim-dwi parameters and the proportion of fibrocytes in pathological sections was analyzed. Data were analyzed by SPSS 19.0 statistical software package, and P < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Among 28 cases (32 eyes) with idiopathic orbital inflammatory pseudotumor, there was no statistical difference between gender, age and the degree of IOIP fibrosis (P > 0.05). There was a statistically significant difference between the proportion of IOIP fiber composition and the D value and F value in IVIM-DWI parameters (P < 0.05), and the sensitivity of F value was higher than D value in the comparison of the two parameters combined with ROC curve analysis; There was no statistical difference between the D * value and the degree of fibrosis (P > 0.05).</p><p><strong>Conclusion: </strong>The D value and F value of IVIM-DWI showed a correlation with the proportion of IOIP fiber components, and the sensitivity of F value was higher than D value. Ivim-dwi examination parameters can be used as quantitative and objective indicators to evaluate the degree of fibrosis of lesions before IOIP.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1545761"},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent visual impairments following mild-to-moderate ischemic stroke.","authors":"Chamini Niroshika Wijesundera, Sheila Gillard Crewther, Tissa Wijeratne, Algis J Vingrys","doi":"10.3389/fopht.2025.1505836","DOIUrl":"10.3389/fopht.2025.1505836","url":null,"abstract":"<p><strong>Background: </strong>Vision is rarely appraised either acutely or during recovery, following acute ischemic stroke. Our previous study found significant deficits in visual function after 2 to 3 days in ~68% of hospitalized mild-to-moderate acute ischemic stroke (AIS) patients with no comorbid eye disease. The purpose of this study was to evaluate recovery in vision after 2-6 months in a subgroup of the original participants.</p><p><strong>Methods: </strong>Visual assessments were performed within the first week of admission and 2-6 months later. Testing was achieved on an iPad and included visual acuity (VA), VA-in-noise, visual field, visual neglect, and time to complete an eye-hand coordination (EHC) task. All cases were radiologically confirmed, and 10 had left hemisphere lesions. The outcomes were compared to 20 age-matched healthy controls who were tested and retested over a similar duration using the same vision tests. The testing took 12 min.</p><p><strong>Results: </strong>During the first week of admission, 19/20 (95%) AIS patients returned normal visual acuity (>6/12 VA, <i>p</i> = 0.11), yet 11/20 (55%) had reduced VA-in-noise (<i>p</i> < 0.000).Visual neglect was present in 2/20 cases. Visual field defects were present in 16/20 (80%, <i>p</i> < 0.001), with 7/16 (44%) being unaware of their visual field loss. All of the patients chose to use their dominant right hand despite 10 having left hemisphere lesions and 13/20 (65%, <i>p</i> < 0.001) returning longer times to complete the EHC tracing tasks. After 2-6 months of recovery, all stroke patients returned normal visual attention, although 3/20 (15%) continued to show reduced VA in the presence of noise masks. Seven out of 20 (35%) retained visual field defects, and 8/20 (40%, three right and five left hemisphere lesions) had visuomotor impairment. Posterior circulation territory strokes and left hemisphere lesions were more likely to result in a persistent visual field loss and visuomotor deficit.</p><p><strong>Conclusion: </strong>Given that stroke is the leading cause of neurological disability affecting over 110 million people, our findings highlight the necessity for both acute and longitudinal vision assessments subsequent to mild stroke. Exposing the persistent limitations in visual functions could aid in identifying suitability for driving and the visuomotor rehabilitation of stroke survivors.</p><p><strong>Clinical trial registration: </strong>https://www.ANZCTR.org.au/ACTRN12618001111268.aspx, identifier ACTRN12618001111268.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1505836"},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intramuscular orbital schwannoma: case report and review of the literature.","authors":"Hammam A Alotaibi, Firas Madani, Rawan N Althaqib, Hamad M AlSulaiman","doi":"10.3389/fopht.2025.1586465","DOIUrl":"10.3389/fopht.2025.1586465","url":null,"abstract":"<p><p>Orbital schwannomas are benign tumors that arise from Schwann cells in the peripheral nerves in the orbit. They typically present after the second decade of life given their slow growth and rarely before then. Diagnosis is based on clinical course and specific imaging modalities; however, the definitive diagnosis is by lesion biopsy. Surgical removal is typically curative. Herein we present the case of an 8-year-old boy with proptosis and diplopia where he exhibited the clinical findings of an orbital mass, however, the characteristic picture of orbital schwannoma was observed on imaging yet found within the inferior rectus muscle, a rare finding indeed.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1586465"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}