Frontiers in ophthalmology最新文献

{"title":"Exploiting induced pluripotent stem cell-derived retinal pigment epithelium to unravel host-pathogen interaction in ocular tuberculosis: a reverse translational <i>in vitro</i> model.","authors":"Ikhwanuliman Putera, Sanne van de Meerendonk, Nicole M A Nagtzaam, Rina La Distia Nora, Saskia M Rombach, Jurriaan E M de Steenwinkel, Johannes R Vingerling, Willem A Dik, P Martin van Hagen","doi":"10.3389/fopht.2025.1610215","DOIUrl":"10.3389/fopht.2025.1610215","url":null,"abstract":"<p><p><i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) can infect the retinal pigment epithelium (RPE) cells. Current <i>in vitro</i> research models for ocular tuberculosis (OTB) only rely on RPE cell culture approaches. Until now it remains unclear why only a minority of patients with active systemic tuberculosis (TB) develops concurrent OTB. There is significant variation in the clinical manifestations of OTB, which is potentially influenced by ethnic differences and diversity in mycobacterial strains. To better understand the immunopathobiology of OTB, particularly an individual's susceptibility to <i>Mtb</i>-infection and the specific host response, cell culture systems utilizing induced pluripotent stem cells (iPSC)-derived RPE cells offer a promising <i>in vitro</i> model to better mimic the disease. With this technology, RPE cells can be generated from specific patients of interest, enabling to test hypotheses in a bench to bedside or reverse manner. In this current study, we explore the utility of iPSC-derived RPE cells as an <i>in vitro</i> model for OTB. Such an approach would overcome drawbacks associated with the currently commonly used \"general\" RPE cell lines as disease model. The application of iPSC-derived RPE cells offers promising options for the identification of novel biomarkers and to study individualized drug screening methods for host-directed therapy of OTB, in order to restore and maintain vision in OTB patients with sight-threatening disease.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1610215"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Development of severe inflammatory orbitopathy after immune checkpoint inhibitor initiation.","authors":"Samantha Madala, Alomi Parikh, Kendra Hong, Michael Burnstine","doi":"10.3389/fopht.2025.1574643","DOIUrl":"10.3389/fopht.2025.1574643","url":null,"abstract":"<p><p>We report a case of thyroid eye disease (TED) reactivation, review the literature, and raise awareness of severe ophthalmopathy and myositis following the initiation of cancer treatment with an immune checkpoint inhibitor (ICI). In this case, after starting nivolumab, a 68-year-old woman with a past medical history of stage 2C uterine carcinoma status post-hysterectomy and past ocular history of thyroid eye disease developed ophthalmoplegia, proptosis, decreased color vision, optic disc hemorrhage, and ocular inflammation. Halting nivolumab and starting 2 weeks of intravenous steroids, one dose of teprotumumab, and low-dose orbital radiation resulted in an improvement in her orbitopathy. ICIs have become popular in oncologic treatment regimens, but they can have serious adverse effects including thyroiditis, Hashimoto's hypothyroidism, or Graves' disease complicated by TED. Multiple cases have been reported in the literature of both the reactivation of TED and the presentation of a TED-like orbital inflammation, which we summarize here. Awareness of orbital inflammation due to ICI use is critical, and ICIs should be used with caution in patients with a history of thyroid disease due to the risk of TED reactivation.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1574643"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of regular, glulisine, and aspart insulin on vascular endothelial growth factor and angiotensinogen expression in hyperglycemic retinal pigment epithelial (RPE) and human retinal endothelial cells (HRECs).","authors":"Fatemeh Sanie-Jahromi, Abtin Khosravi, Hooman Hadianfard, M Hossein Nowroozzadeh","doi":"10.3389/fopht.2025.1570232","DOIUrl":"10.3389/fopht.2025.1570232","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetic retinopathy (DR) is a leading cause of vision loss and is primarily driven by chronic hyperglycemia, which induces retinal vascular damage through mechanisms involving vascular endothelial growth factor (VEGF) and the renin-angiotensin system (RAS). This study investigated the effects of hyperglycemia and different insulin formulations-regular, glulisine, and aspart-on VEGF-A and angiotensinogen (AGT) gene expression in two human retinal cell types: retinal pigment epithelial (RPE) cells and human retinal microvascular endothelial cells (HRECs).</p><p><strong>Methods: </strong>Cells were cultured from donor tissue and exposed to physiologic and hyperglycemic glucose concentrations, with or without insulin treatment. Gene expression levels were quantified using real-time PCR.</p><p><strong>Results: </strong>Hyperglycemia significantly upregulated VEGF-A and AGT in both RPE and HREC cells (e.g., VEGF-A in RPE: 2.62-fold, <i>P</i> = 0.001; AGT in RPE: 3.32-fold, <i>P</i> = 0.093), supporting a role for both osmotic and glucose-specific pathways. Among insulin treatments, regular insulin significantly reduced VEGF-A expression in both RPE (0.72-fold, <i>P</i> = 0.033) and HRECs (0.57-fold, <i>P</i> = 0.009). In contrast, aspart and glulisine had modest effects on VEGF-A in HRECs (0.82-fold each; <i>P</i> = 0.035 and <i>P</i> = 0.060, respectively) and no significant impact in RPE cells. Regarding AGT, aspart insulin showed the most consistent suppressive effect, reducing expression in both RPE (0.15-fold, <i>P</i> < 0.001) and HRECs (0.22-fold, <i>P</i> = 0.004). Glulisine significantly increased AGT in RPE (1.56-fold, <i>P</i> = 0.009) but reduced it in HRECs (0.58-fold, <i>P</i> = 0.074). Regular insulin showed no effect on AGT in RPE (<i>P</i> = 0.680) and a non-significant increase in HRECs (1.36-fold, <i>P</i> = 0.097).</p><p><strong>Discussion: </strong>These findings highlight the differential biological effects of insulin analogues and suggest that aspart insulin, in particular, may offer therapeutic benefits beyond glycemic control by modulating both VEGF-A and RAS-related pathways. Tailored insulin therapies could represent innovative strategies for managing or slowing the progression of diabetic retinopathy.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1570232"},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative evaluation of fibrosis in idiopathic orbital inflammatory pseudotumor by IVIM-DWI.","authors":"Jian Pu, Xing Xu, Peng Wang, Wei Su, Juwei Shao, Yinhua Yang, Mingqin Li, Jianbo Li","doi":"10.3389/fopht.2025.1545761","DOIUrl":"10.3389/fopht.2025.1545761","url":null,"abstract":"<p><strong>Objective: </strong>To quantitatively evaluate the degree of fibrosis in Idiopathic Orbital Inflammatory Pseudotumor (IOIP) using Intravoxel Incoherent Motion Diffusion-Weighted Imaging (IVIM-DWI).</p><p><strong>Methods: </strong>Twenty eight patients (32 eyes) with idiopathic orbital inflammatory pseudotumor were pathologically diagnosed in the Affiliated Hospital of Yunnan University from August 2019 to August 2024. Routine orbital MRI plain scan and ivim-dwi scan were completed before surgery, and the true diffusion coefficient (d), pseudo diffusion coefficient (d*) and perfusion fraction (f) were obtained. According to the proportion of chronic inflammatory cells and fibrous tissue components in postoperative histopathological sections, it was defined that fibrous cells accounted for less than 10% of the total number of cells as negative (-), and > 10% as positive (+), of which 10%%25% were +, 25%%50% were + +, 50%%75% were + + +, and > 75% were + + +. Taking the proportion of fibrocytes in histopathological sections as the standard of fibrosis degree, the correlation between ivim-dwi parameters and the proportion of fibrocytes in pathological sections was analyzed. Data were analyzed by SPSS 19.0 statistical software package, and P < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Among 28 cases (32 eyes) with idiopathic orbital inflammatory pseudotumor, there was no statistical difference between gender, age and the degree of IOIP fibrosis (P > 0.05). There was a statistically significant difference between the proportion of IOIP fiber composition and the D value and F value in IVIM-DWI parameters (P < 0.05), and the sensitivity of F value was higher than D value in the comparison of the two parameters combined with ROC curve analysis; There was no statistical difference between the D * value and the degree of fibrosis (P > 0.05).</p><p><strong>Conclusion: </strong>The D value and F value of IVIM-DWI showed a correlation with the proportion of IOIP fiber components, and the sensitivity of F value was higher than D value. Ivim-dwi examination parameters can be used as quantitative and objective indicators to evaluate the degree of fibrosis of lesions before IOIP.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1545761"},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent visual impairments following mild-to-moderate ischemic stroke.","authors":"Chamini Niroshika Wijesundera, Sheila Gillard Crewther, Tissa Wijeratne, Algis J Vingrys","doi":"10.3389/fopht.2025.1505836","DOIUrl":"10.3389/fopht.2025.1505836","url":null,"abstract":"<p><strong>Background: </strong>Vision is rarely appraised either acutely or during recovery, following acute ischemic stroke. Our previous study found significant deficits in visual function after 2 to 3 days in ~68% of hospitalized mild-to-moderate acute ischemic stroke (AIS) patients with no comorbid eye disease. The purpose of this study was to evaluate recovery in vision after 2-6 months in a subgroup of the original participants.</p><p><strong>Methods: </strong>Visual assessments were performed within the first week of admission and 2-6 months later. Testing was achieved on an iPad and included visual acuity (VA), VA-in-noise, visual field, visual neglect, and time to complete an eye-hand coordination (EHC) task. All cases were radiologically confirmed, and 10 had left hemisphere lesions. The outcomes were compared to 20 age-matched healthy controls who were tested and retested over a similar duration using the same vision tests. The testing took 12 min.</p><p><strong>Results: </strong>During the first week of admission, 19/20 (95%) AIS patients returned normal visual acuity (>6/12 VA, <i>p</i> = 0.11), yet 11/20 (55%) had reduced VA-in-noise (<i>p</i> < 0.000).Visual neglect was present in 2/20 cases. Visual field defects were present in 16/20 (80%, <i>p</i> < 0.001), with 7/16 (44%) being unaware of their visual field loss. All of the patients chose to use their dominant right hand despite 10 having left hemisphere lesions and 13/20 (65%, <i>p</i> < 0.001) returning longer times to complete the EHC tracing tasks. After 2-6 months of recovery, all stroke patients returned normal visual attention, although 3/20 (15%) continued to show reduced VA in the presence of noise masks. Seven out of 20 (35%) retained visual field defects, and 8/20 (40%, three right and five left hemisphere lesions) had visuomotor impairment. Posterior circulation territory strokes and left hemisphere lesions were more likely to result in a persistent visual field loss and visuomotor deficit.</p><p><strong>Conclusion: </strong>Given that stroke is the leading cause of neurological disability affecting over 110 million people, our findings highlight the necessity for both acute and longitudinal vision assessments subsequent to mild stroke. Exposing the persistent limitations in visual functions could aid in identifying suitability for driving and the visuomotor rehabilitation of stroke survivors.</p><p><strong>Clinical trial registration: </strong>https://www.ANZCTR.org.au/ACTRN12618001111268.aspx, identifier ACTRN12618001111268.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1505836"},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intramuscular orbital schwannoma: case report and review of the literature.","authors":"Hammam A Alotaibi, Firas Madani, Rawan N Althaqib, Hamad M AlSulaiman","doi":"10.3389/fopht.2025.1586465","DOIUrl":"10.3389/fopht.2025.1586465","url":null,"abstract":"<p><p>Orbital schwannomas are benign tumors that arise from Schwann cells in the peripheral nerves in the orbit. They typically present after the second decade of life given their slow growth and rarely before then. Diagnosis is based on clinical course and specific imaging modalities; however, the definitive diagnosis is by lesion biopsy. Surgical removal is typically curative. Herein we present the case of an 8-year-old boy with proptosis and diplopia where he exhibited the clinical findings of an orbital mass, however, the characteristic picture of orbital schwannoma was observed on imaging yet found within the inferior rectus muscle, a rare finding indeed.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1586465"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Eyelid reconstruction using intact fish skin xenograft following periorbital necrotizing fasciitis.","authors":"Molly Shott, Diane Wang, John Nguyen","doi":"10.3389/fopht.2025.1589771","DOIUrl":"10.3389/fopht.2025.1589771","url":null,"abstract":"<p><p>Periorbital necrotizing fasciitis (NF) is a rare, vision-threatening soft tissue infection that requires rapid antimicrobial treatments to minimize devastating soft tissue destruction, and debridement of affected tissue results in extensive defects requiring various techniques of reconstruction. We herein describe a case of a 58-year-old male with periorbital NF who underwent eyelid repair with intact fish skin grafts. To our knowledge, this is the first case report of fish skin grafts being used in eyelid wound management after periorbital NF.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1589771"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative analysis of idiopathic epiretinal membrane traction: an updated version of the relaxation index.","authors":"Davide Allegrini, Raffaele Raimondi, Giovanni Montesano, Marco Caruso, Giovanna Lionetti, Adriano Carnevali, Tania Sorrentino, Vincenzo Scorcia, Mario R Romano","doi":"10.3389/fopht.2025.1528766","DOIUrl":"10.3389/fopht.2025.1528766","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this work was to track tangential traction of idiopathic epiretinal membrane from an initial assessment to the immediate post-operative phase using an enhanced version of the relaxation index (RI).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 9 patients who underwent peeling surgery for idiopathic, symptomatic, and progressive epiretinal membrane. The RI assesses the displacement of vascular crossings in time from a fixed point, which is the retinal pigmented epithelium. This updated iteration integrates infrared images paired with OCT scans instead of OCTA.</p><p><strong>Results: </strong>The study encompassed three timepoints: T1 (initial appointment), T2 (1 week pre-surgery), and Post (1 month post-surgery). T1 was 12± 9 months prior to surgery. A statistically significant difference (p<0.001) in RI was observed across all three timepoints; however, there was no significant correlation between RI and visual acuity (p>0.05).</p><p><strong>Conclusion: </strong>The RI emerges as a comprehensive and direct parameter for objectively assessing and monitoring tangential traction in three dimensions across an extensive area of the posterior pole. Further streamlining of the process is necessary to integrate this feature into clinical practice effectively.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1528766"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orbital inflammatory disease in a primarily black patient population.","authors":"Gabriel Kabarriti, Ali Elsayed, Giannis A Moustafa, Nickisa Hodgson","doi":"10.3389/fopht.2025.1576929","DOIUrl":"10.3389/fopht.2025.1576929","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to characterize orbital inflammatory disease (OID) in a primarily Black patient population, examining their demographics, presentations, workup, treatment, and outcome.</p><p><strong>Methods: </strong>A retrospective study was performed from January 2005 to June 2022 at two academic institutions in Brooklyn, NY. Patients included met criteria for one of the following OID conditions: non-specific orbital inflammation; nonbacterial dacryoadenitis; Tolosa-Hunt; orbital myositis; definite, possible, or probable IgG4-related ophthalmic disease; and sclerosing orbital inflammation. Data reviewed included orbital inflammatory labs, imaging, pathology, and treatment. Treatment was considered successful if a patient had complete resolution of symptoms.</p><p><strong>Results: </strong>Thirty-nine patients met criteria for this study. 35.9% were diagnosed with dacryoadenitis, 28.2% with NSOI, 12.8% with myositis, 5.1% with possible IgG-ROD, 7.7% with probable IgG4-ROD, 7.7% with Tolosa Hunt, and 2.6% with sclerosing OI. 91% were started on steroids; 12.8% required transition to steroid-sparing therapy. 85% had a successful outcome with a resolution of symptoms.</p><p><strong>Conclusions: </strong>This study characterizes OID in a Black patient population and compares it to prior studies done on OID. Research on underrepresented patient populations is needed to understand differences in disease presentation and improve patient outcomes.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1576929"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low anterior chamber volume as a risk factor in non-arteritic anterior ischemic optic neuropathy.","authors":"Durgul Acan, Beyza Betul Cakar, Eyyup Karahan","doi":"10.3389/fopht.2025.1554279","DOIUrl":"10.3389/fopht.2025.1554279","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to compare the anterior chamber depth (ACD), anterior chamber volume (ACV), and iridocorneal angle (ICA) of the eyes of patients with non-arteritic anterior ischemic optic neuropathy (NAION) and normal eyes.</p><p><strong>Methods: </strong>In this cross-sectional study, 28 patients with NAION who were admitted to our institution were examined. Central corneal thickness (CCT), ACV, ACD, and ICA of all eyes were measured using corneal topography (Sirius, CSO, Italy). Axial lengths (ALs) were measured using an IOL-Master 500 (Carl Zeiss, Meditec). The eyes of these patients were compared with the eyes of 29 healthy individuals of similar age and gender.</p><p><strong>Results: </strong>The mean ALs of the eyes with NAION and those in the control group were not statistically different, measuring 22.95 ± 0.68 mm and 23.13 ± 0.80mm, respectively (p=0.651). While the average ACV was 137.93 ± 41.01 mm³ in the control group, it was significantly lower at 117.86 ± 22.23 mm³ in the patients with NAION (p=0.038). The mean ACD, ICA, and CCT values in the control and study groups were not statistically different, with 2.82 ± 0.57 mm and 2.64 ± 0.31 mm, 41.62 ± 6.99° and 40.14 ± 7.04°, and 542.48 ± 19.39µm and 544.68 ± 31.26 µm, respectively (p1 = 0.236, p2 = 0.693, and p3 = 0.959). No statistical differences were found between the eyes with NAION and their fellow eyes in terms of AL, CCT, ACD, ACV, and ICA (p>0.05).</p><p><strong>Conclusion: </strong>Differences in anterior segment morphology were observed in eyes with NAION compared to healthy eyes. Decreased ACV may be a risk factor for NAION.</p>","PeriodicalId":73096,"journal":{"name":"Frontiers in ophthalmology","volume":"5 ","pages":"1554279"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12129766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}