Frontiers in neuroengineering最新文献

{"title":"Photosensitive-polyimide based method for fabricating various neural electrode architectures.","authors":"Yasuhiro X Kato,&nbsp;Shigeto Furukawa,&nbsp;Kazuyuki Samejima,&nbsp;Naoyuki Hironaka,&nbsp;Makio Kashino","doi":"10.3389/fneng.2012.00011","DOIUrl":"https://doi.org/10.3389/fneng.2012.00011","url":null,"abstract":"<p><p>An extensive photosensitive-polyimide (PSPI)-based method for designing and fabricating various neural electrode architectures was developed. The method aims to broaden the design flexibility and expand the fabrication capability for neural electrodes to improve the quality of recorded signals and integrate other functions. After characterizing PSPI's properties for micromachining processes, we successfully designed and fabricated various neural electrodes even on a non-flat substrate using only one PSPI as an insulation material and without the time-consuming dry etching processes. The fabricated neural electrodes were an electrocorticogram (ECoG) electrode, a mesh intracortical electrode with a unique lattice-like mesh structure to fixate neural tissue, and a guide cannula electrode with recording microelectrodes placed on the curved surface of a guide cannula as a microdialysis probe. In vivo neural recordings using anesthetized rats demonstrated that these electrodes can be used to record neural activities repeatedly without any breakage and mechanical failures, which potentially promises stable recordings for long periods of time. These successes make us believe that this PSPI-based fabrication is a powerful method, permitting flexible design, and easy optimization of electrode architectures for a variety of electrophysiological experimental research with improved neural recording performance.</p>","PeriodicalId":73093,"journal":{"name":"Frontiers in neuroengineering","volume":"5 ","pages":"11"},"PeriodicalIF":0.0,"publicationDate":"2012-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3389/fneng.2012.00011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30706847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive proactive inhibitory control for embedded real-time applications.","authors":"Shufan Yang,&nbsp;T Martin McGinnity,&nbsp;Kongfatt Wong-Lin","doi":"10.3389/fneng.2012.00010","DOIUrl":"https://doi.org/10.3389/fneng.2012.00010","url":null,"abstract":"<p><p>Psychologists have studied the inhibitory control of voluntary movement for many years. In particular, the countermanding of an impending action has been extensively studied. In this work, we propose a neural mechanism for adaptive inhibitory control in a firing-rate type model based on current findings in animal electrophysiological and human psychophysical experiments. We then implement this model on a field-programmable gate array (FPGA) prototyping system, using dedicated real-time hardware circuitry. Our results show that the FPGA-based implementation can run in real-time while achieving behavioral performance qualitatively suggestive of the animal experiments. Implementing such biological inhibitory control in an embedded device can lead to the development of control systems that may be used in more realistic cognitive robotics or in neural prosthetic systems aiding human movement control.</p>","PeriodicalId":73093,"journal":{"name":"Frontiers in neuroengineering","volume":"5 ","pages":"10"},"PeriodicalIF":0.0,"publicationDate":"2012-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3389/fneng.2012.00010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30695019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PEDOT-CNT Composite Microelectrodes for Recording and Electrostimulation Applications: Fabrication, Morphology, and Electrical Properties.","authors":"Ramona Gerwig,&nbsp;Kai Fuchsberger,&nbsp;Birgit Schroeppel,&nbsp;Gordon Steve Link,&nbsp;Gerhard Heusel,&nbsp;Udo Kraushaar,&nbsp;Wolfgang Schuhmann,&nbsp;Alfred Stett,&nbsp;Martin Stelzle","doi":"10.3389/fneng.2012.00008","DOIUrl":"10.3389/fneng.2012.00008","url":null,"abstract":"<p><p>Composites of carbon nanotubes and poly(3,4-ethylenedioxythiophene, PEDOT) and layers of PEDOT are deposited onto microelectrodes by electropolymerization of ethylenedioxythiophene in the presence of a suspension of carbon nanotubes and polystyrene sulfonate. Analysis by FIB and SEM demonstrates that CNT-PEDOT composites exhibit a porous morphology whereas PEDOT layers are more compact. Accordingly, capacitance and charge injection capacity of the composite material exceed those of pure PEDOT layers. In vitro cell culture experiments reveal excellent biocompatibility and adhesion of both PEDOT and PEDOT-CNT electrodes. Signals recorded from heart muscle cells demonstrate the high S/N ratio achievable with these electrodes. Long-term pulsing experiments confirm stability of charge injection capacity. In conclusion, a robust fabrication procedure for composite PEDOT-CNT electrodes is demonstrated and results show that these electrodes are well suited for stimulation and recording in cardiac and neurophysiological research.</p>","PeriodicalId":73093,"journal":{"name":"Frontiers in neuroengineering","volume":"5 ","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2012-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3389/fneng.2012.00008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30617392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-linear blend coding in the moth antennal lobe emerges from random glomerular networks.","authors":"Alberto Capurro,&nbsp;Fabiano Baroni,&nbsp;Shannon B Olsson,&nbsp;Linda S Kuebler,&nbsp;Salah Karout,&nbsp;Bill S Hansson,&nbsp;Timothy C Pearce","doi":"10.3389/fneng.2012.00006","DOIUrl":"https://doi.org/10.3389/fneng.2012.00006","url":null,"abstract":"<p><p>Neural responses to odor blends often exhibit non-linear interactions to blend components. The first olfactory processing center in insects, the antennal lobe (AL), exhibits a complex network connectivity. We attempt to determine if non-linear blend interactions can arise purely as a function of the AL network connectivity itself, without necessitating additional factors such as competitive ligand binding at the periphery or intrinsic cellular properties. To assess this, we compared blend interactions among responses from single neurons recorded intracellularly in the AL of the moth Manduca sexta with those generated using a population-based computational model constructed from the morphologically based connectivity pattern of projection neurons (PNs) and local interneurons (LNs) with randomized connection probabilities from which we excluded detailed intrinsic neuronal properties. The model accurately predicted most of the proportions of blend interaction types observed in the physiological data. Our simulations also indicate that input from LNs is important in establishing both the type of blend interaction and the nature of the neuronal response (excitation or inhibition) exhibited by AL neurons. For LNs, the only input that significantly impacted the blend interaction type was received from other LNs, while for PNs the input from olfactory sensory neurons and other PNs contributed agonistically with the LN input to shape the AL output. Our results demonstrate that non-linear blend interactions can be a natural consequence of AL connectivity, and highlight the importance of lateral inhibition as a key feature of blend coding to be addressed in future experimental and computational studies.</p>","PeriodicalId":73093,"journal":{"name":"Frontiers in neuroengineering","volume":" ","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2012-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3389/fneng.2012.00006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40180656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synaptic inhibition controls transient oscillatory synchronization in a model of the insect olfactory system.","authors":"Collins Assisi,&nbsp;Maxim Bazhenov","doi":"10.3389/fneng.2012.00007","DOIUrl":"https://doi.org/10.3389/fneng.2012.00007","url":null,"abstract":"<p><p>In a variety of neuronal systems it has been hypothesized that inhibitory interneurons corral principal neurons into synchronously firing groups that encode sensory information and sub-serve behavior (Buzsáki and Chrobak, 1995; Buzsáki, 2008). This mechanism is particularly relevant to the olfactory system where spatiotemporal patterns of projection neuron (PN) activity act as robust markers of odor attributes (Laurent et al., 1996; Wehr and Laurent, 1996). In the insect antennal lobe (AL), a network of local inhibitory interneurons arborizes extensively throughout the AL (Leitch and Laurent, 1996) providing inhibitory input to the cholinergic PNs. Our theoretical work has attempted to elaborate the exact role of inhibition in the generation of odor specific PN responses (Bazhenov et al., 2001a,b; Assisi et al., 2011). In large-scale AL network models we characterized the inhibitory sub-network by its coloring (Assisi et al., 2011) and showed that it can entrain excitatory PNs to the odor specific patterns of transient synchronization. In this focused review, we further examine the dynamics of entrainment in more detail by simulating simple model networks in various parameter regimes. Our simulations in conjunction with earlier studies point to the key role played by lateral (between inhibitory interneurons) and feedback (from inhibitory interneurons to principal cells) inhibition in the generation of experimentally observed patterns of transient synchrony.</p>","PeriodicalId":73093,"journal":{"name":"Frontiers in neuroengineering","volume":" ","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2012-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3389/fneng.2012.00007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40180657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dorsal premotor cortex is involved in switching motor plans.","authors":"Alexandre Pastor-Bernier, Elsa Tremblay, Paul Cisek","doi":"10.3389/fneng.2012.00005","DOIUrl":"10.3389/fneng.2012.00005","url":null,"abstract":"<p><p>Previous studies have shown that neural activity in primate dorsal premotor cortex (PMd) can simultaneously represent multiple potential movement plans, and that activity related to these movement options is modulated by their relative subjective desirability. These findings support the hypothesis that decisions about actions are made through a competition within the same circuits that guide the actions themselves. This hypothesis further predicts that the very same cells that guide initial decisions will continue to update their activities if an animal changes its mind. For example, if a previously selected movement option suddenly becomes unavailable, the correction will be performed by the same cells that selected the initial movement, as opposed to some different group of cells responsible for online guidance. We tested this prediction by recording neural activity in the PMd of a monkey performing an instructed-delay reach selection task. In the task, two targets were simultaneously presented and their border styles indicated whether each would be worth 1, 2, or 3 juice drops. In a random subset of trials (FREE), the monkey was allowed a choice while in the remaining trials (FORCED) one of the targets disappeared at the time of the GO signal. In FORCED-LOW trials the monkey was forced to move to the less valuable target and started moving either toward the new target (Direct) or toward the target that vanished and then curved to reach the remaining one (Curved). Prior to the GO signal, PMd activity clearly reflected the monkey's subjective preference, predicting his choices in FREE trials even with equally valued options. In FORCED-LOW trials, PMd activity reflected the switch of the monkey's plan as early as 100 ms after the GO signal, well before movement onset (MO). This confirms that the activity is not related to feedback from the movement itself, and suggests that PMd continues to participate in action selection even when the animal changes its mind on-line. These findings were reproduced by a computational model suggesting that switches between action plans can be explained by the same competition process responsible for initial decisions.</p>","PeriodicalId":73093,"journal":{"name":"Frontiers in neuroengineering","volume":"5 ","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2012-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30568204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mind-body relationships in elite apnea divers during breath holding: a study of autonomic responses to acute hypoxemia.","authors":"Marco Laurino,&nbsp;Danilo Menicucci,&nbsp;Francesca Mastorci,&nbsp;Paolo Allegrini,&nbsp;Andrea Piarulli,&nbsp;Enzo P Scilingo,&nbsp;Remo Bedini,&nbsp;Alessandro Pingitore,&nbsp;Mirko Passera,&nbsp;Antonio L'abbate,&nbsp;Angelo Gemignani","doi":"10.3389/fneng.2012.00004","DOIUrl":"10.3389/fneng.2012.00004","url":null,"abstract":"<p><p>The mental control of ventilation with all associated phenomena, from relaxation to modulation of emotions, from cardiovascular to metabolic adaptations, constitutes a psychophysiological condition characterizing voluntary breath-holding (BH). BH induces several autonomic responses, involving both autonomic cardiovascular and cutaneous pathways, whose characterization is the main aim of this study. Electrocardiogram and skin conductance (SC) recordings were collected from 14 elite divers during three conditions: free breathing (FB), normoxic phase of BH (NPBH) and hypoxic phase of BH (HPBH). Thus, we compared a set of features describing signal dynamics between the three experimental conditions: from heart rate variability (HRV) features (in time and frequency-domains and by using nonlinear methods) to rate and shape of spontaneous SC responses (SCRs). The main result of the study rises by applying a Factor Analysis to the subset of features significantly changed in the two BH phases. Indeed, the Factor Analysis allowed to uncover the structure of latent factors which modeled the autonomic response: a factor describing the autonomic balance (AB), one the information increase rate (IIR), and a latter the central nervous system driver (CNSD). The BH did not disrupt the FB factorial structure, and only few features moved among factors. Factor Analysis indicates that during BH (1) only the SC described the emotional output, (2) the sympathetic tone on heart did not change, (3) the dynamics of interbeats intervals showed an increase of long-range correlation that anticipates the HPBH, followed by a drop to a random behavior. In conclusion, data show that the autonomic control on heart rate and SC are differentially modulated during BH, which could be related to a more pronounced effect on emotional control induced by the mental training to BH.</p>","PeriodicalId":73093,"journal":{"name":"Frontiers in neuroengineering","volume":"5 ","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2012-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3389/fneng.2012.00004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30539461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dominant Lyapunov exponent and approximate entropy in heart rate variability during emotional visual elicitation.","authors":"Gaetano Valenza,&nbsp;Paolo Allegrini,&nbsp;Antonio Lanatà,&nbsp;Enzo Pasquale Scilingo","doi":"10.3389/fneng.2012.00003","DOIUrl":"https://doi.org/10.3389/fneng.2012.00003","url":null,"abstract":"<p><p>In this work we characterized the non-linear complexity of Heart Rate Variability (HRV) in short time series. The complexity of HRV signal was evaluated during emotional visual elicitation by using Dominant Lyapunov Exponents (DLEs) and Approximate Entropy (ApEn). We adopted a simplified model of emotion derived from the Circumplex Model of Affects (CMAs), in which emotional mechanisms are conceptualized in two dimensions by the terms of valence and arousal. Following CMA model, a set of standardized visual stimuli in terms of arousal and valence gathered from the International Affective Picture System (IAPS) was administered to a group of 35 healthy volunteers. Experimental session consisted of eight sessions alternating neutral images with high arousal content images. Several works can be found in the literature showing a chaotic dynamics of HRV during rest or relax conditions. The outcomes of this work showed a clear switching mechanism between regular and chaotic dynamics when switching from neutral to arousal elicitation. Accordingly, the mean ApEn decreased with statistical significance during arousal elicitation and the DLE became negative. Results showed a clear distinction between the neutral and the arousal elicitation and could be profitably exploited to improve the accuracy of emotion recognition systems based on HRV time series analysis.</p>","PeriodicalId":73093,"journal":{"name":"Frontiers in neuroengineering","volume":" ","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2012-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3389/fneng.2012.00003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40142614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Olfactory sensor processing in neural networks: lessons from modeling the fruit fly antennal lobe.","authors":"J Henning Proske,&nbsp;Marco Wittmann,&nbsp;C Giovanni Galizia","doi":"10.3389/fneng.2012.00002","DOIUrl":"https://doi.org/10.3389/fneng.2012.00002","url":null,"abstract":"<p><p>The insect olfactory system can be a model for artificial olfactory devices. In particular, Drosophila melanogaster due to its genetic tractability has yielded much information about the design and function of such systems in biology. In this study we investigate possible network topologies to separate representations of odors in the primary olfactory neuropil, the antennal lobe. In particular we compare networks based on stochastic and homogeneous connection weight distributions to connectivities that are based on the input correlations between the glomeruli in the antennal lobe. We show that moderate homogeneous inhibition implements a soft winner-take-all mechanism when paired with realistic input from a large meta-database of odor responses in receptor cells (DoOR database). The sparseness of representations increases with stronger inhibition. Excitation, on the other hand, pushes the representation of odors closer together thus making them harder to distinguish. We further analyze the relationship between different inhibitory network topologies and the properties of the receptor responses to different odors. We show that realistic input from the DoOR database has a relatively high entropy of activation values over all odors and receptors compared to the theoretical maximum. Furthermore, under conditions in which the information in the input is artificially decreased, networks with heterogeneous topologies based on the similarity of glomerular response profiles perform best. These results indicate that in order to arrive at the most beneficial representation for odor discrimination it is important to finely tune the strength of inhibition in combination with taking into account the properties of the available sensors.</p>","PeriodicalId":73093,"journal":{"name":"Frontiers in neuroengineering","volume":"5 ","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2012-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3389/fneng.2012.00002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30470728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of a clinical olfactory test with an artificial nose.","authors":"David J Yáñez,&nbsp;Adolfo Toledano,&nbsp;Eduardo Serrano,&nbsp;Ana M Martín de Rosales,&nbsp;Francisco B Rodríguez,&nbsp;Pablo Varona","doi":"10.3389/fneng.2012.00001","DOIUrl":"https://doi.org/10.3389/fneng.2012.00001","url":null,"abstract":"<p><p>Clinical olfactory tests are used to address hyposmia/anosmia levels in patients with different types of olfactory impairments. Typically, a given test is employed clinically and then replaced by a new one after a certain period of use which can range from days to several months. There is a need to assess control quality of these tests and also for a procedure to quantify their degradation over time. In this paper we propose a protocol to employ low-cost artificial noses for the quantitative characterization of olfactory tests used in clinical studies. In particular, we discuss a preliminary study on the Connecticut Chemosensorial Clinical Research Center Test kit which shows that some odorants, as sensed by an artificial nose, seem to degrade while others are potentiated as the test ages. We also discuss the need to establish a map of correspondence between human and machine olfaction when artificial noses are used to characterize or compare human smell performance in research and clinical studies.</p>","PeriodicalId":73093,"journal":{"name":"Frontiers in neuroengineering","volume":"5 ","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2012-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3389/fneng.2012.00001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30470727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}