Frontiers in global women's health最新文献

{"title":"Genetic and biomarker approaches to uterine fibroids: toward precision medicine.","authors":"Pooja Mukherjee","doi":"10.3389/fgwh.2025.1581823","DOIUrl":"https://doi.org/10.3389/fgwh.2025.1581823","url":null,"abstract":"<p><p>Uterine fibroids (UFs) are the most common benign tumors of the female reproductive system, affecting 70%-80% of women by age 50. Early detection is challenging due to the absence of initial symptoms, and diagnosis primarily relies on ultrasound and magnetic resonance imaging (MRI). However, biomarker-driven approaches could enable earlier and more precise detection. This review explores emerging biomarkers and genetic factors in fibroid pathogenesis. Potential biomarkers, including <i>PLP1, FOS, versican, LDH,</i> and <i>IGF-1</i>, show promise for diagnosis and recurrence prediction. Genetic studies have identified key mutations in <i>MED12, FH, HMGA2,</i> and <i>COL4A5-COL4A6</i>, alongside genome-wide association studies (GWAS) that highlight fibroid risk loci. Interestingly, biomarkers may also be mutation-type specific, suggesting potential for more precise molecular classification. Gene therapy offers an innovative treatment approach but the genetic landscape of fibroids remains underexplored, limiting advancements in research and funding. Integrating biomarker-based diagnostics and genetic profiling could transform fibroid detection and management, reducing reliance on invasive procedures. This review highlights the urgent need for improved diagnostic tools, prognostic markers, and targeted therapies for uterine fibroids.</p>","PeriodicalId":73087,"journal":{"name":"Frontiers in global women's health","volume":"6 ","pages":"1581823"},"PeriodicalIF":2.3,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contested narratives: a qualitative analysis of abortion testimonies in Louisiana legislature.","authors":"Martha Silva, Jeni Stolow, Micki Burdick, Amy Mercieca","doi":"10.3389/fgwh.2025.1533813","DOIUrl":"https://doi.org/10.3389/fgwh.2025.1533813","url":null,"abstract":"<p><strong>Introduction: </strong>Following the Supreme Court's 2022 decision in <i>Dobbs v. Jackson Women's Health Organization</i>, Louisiana enacted a \"trigger law\" banning nearly all abortions. Attempts to reform existing restrictive legislation so as to allow for abortions under exceptions have been unsuccessful to date. This study aims to describe how abortion discourse is framed in public testimony around House Bill 346 in the 2023 Louisiana legislative session, which attempted to pass an abortion exception for pregnancy in the case of rape or incest.</p><p><strong>Methods: </strong>We conducted a conventional qualitative content analysis utilizing a rhetorical lens, using testimony transcripts from the May 10, 2023, Louisiana Administration of Criminal Justice Committee hearing. An iterative coding approach allowed us to categorize salient themes, language patterns, speaker characteristics, emotional tones, and rhetorical strategies. Demographic characteristics were ascribed to speakers based on perceived gender and race when not self-identified.</p><p><strong>Results: </strong>Testimony analysis revealed four primary themes: (1) conflicting representations of abortion, (2) religion's role in shaping discourse, (3) humanization of fetuses vs. pregnant individuals, and (4) debate over available resources for survivors and children. Abortion is represented as being traumatic, adding to the trauma caused by sexual violence, while representing childbearing as healing from trauma. Being conceived as a result of sexual violence is used as an identity marker worthy of protection. Religious rhetoric permeates testimony both in support and in opposition to abortion exceptions, making a \"pro-life\" stance the starting point for debate. Lastly, we find evidence of dehumanization of survivors' and others' experience.</p><p><strong>Conclusions: </strong>The testimonies around HB346 expose deeply polarized discourse that reflects moral, religious, and ethical conflicts, as well as mismatched conversations that are unlikely to persuade opposing sides. Addressing these dissonant narratives requires nuanced advocacy strategies and resources to support effective testimony.</p>","PeriodicalId":73087,"journal":{"name":"Frontiers in global women's health","volume":"6 ","pages":"1533813"},"PeriodicalIF":2.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Labour monitoring and decision support: a machine-learning-based paradigm.","authors":"Mariana Nogueira, Sergio Sanchez-Martinez, Gemma Piella, Mathieu De Craene, Carlos Yagüe, Pablo-Miki Marti-Castellote, Mercedes Bonet, Olufemi T Oladapo, Bart Bijnens","doi":"10.3389/fgwh.2025.1368575","DOIUrl":"https://doi.org/10.3389/fgwh.2025.1368575","url":null,"abstract":"<p><strong>Introduction: </strong>A machine-learning-based paradigm, combining unsupervised and supervised components, is proposed for the problem of real-time monitoring and decision support during labour, addressing the limitations of current state-of-the-art approaches, such as the partograph or purely supervised models.</p><p><strong>Methods: </strong>The proposed approach is illustrated with World Health Organisation's Better Outcomes in Labour Difficulty (BOLD) prospective cohort study data, including 9,995 women admitted for labour in 2014-2015 in thirteen major regional health care facilities across Nigeria and Uganda. Unsupervised dimensionality reduction is used to map complex labour data to a visually intuitive space. In this space, an ongoing labour trajectory can be compared to those of a historical cohort of women with similar characteristics and known outcomes-this information can be used to estimate personalised \"healthy\" trajectory references (and alert the healthcare provider to significant deviations), as well as draw attention to high incidences of different interventions/adverse outcomes among similar labours. To evaluate the proposed approach, the predictive value of simple risk scores quantifying deviation from normal progress and incidence of complications among similar labours is assessed in a caesarean section prediction context and compared to that of the partograph and state-of-the-art supervised machine-learning models.</p><p><strong>Results: </strong>Considering all women, our predictors yielded sensitivity and specificity of ∼0.70. It was observed that this predictive performance could increase or decrease when looking at different subgroups.</p><p><strong>Discussion: </strong>With a simple implementation, our approach outperforms the partograph and matches the performance of state-of-the-art supervised models, while offering superior flexibility and interpretability as a real-time monitoring and decision-support solution.</p>","PeriodicalId":73087,"journal":{"name":"Frontiers in global women's health","volume":"6 ","pages":"1368575"},"PeriodicalIF":2.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Women's knowledge and attitudes toward female genital mutilation and associated factors in Diguna Fango, a rural district in southern Ethiopia: a community-based mixed study.","authors":"Tamirat Beyene Gerete, Asresash Demissie, Enatfenta Sewmehone, Wubishet Gezimu","doi":"10.3389/fgwh.2025.1516925","DOIUrl":"https://doi.org/10.3389/fgwh.2025.1516925","url":null,"abstract":"<p><strong>Background: </strong>Female genital mutilation (FGM) is a widely practiced custom in Ethiopia. The women's knowledge and attitudes toward it and influencing factors have not been explored in Ethiopia, particularly in the rural districts. Hence, this study assessed women's knowledge and attitudes toward female genital mutilation and associated factors in Diguna Fango, a rural district in southern Ethiopia.</p><p><strong>Methods: </strong>This study adopted a community-based cross-sectional study design using a sequential mixed-method explanatory approach. It was conducted from May 20, 2023, to June 30, 2023, among 821 participants selected using a multistage sampling technique. The quantitative data were collected using a structured interviewer-administered questionnaire. A key informant interview was conducted to collect the qualitative data. A binary logistic regression analysis was conducted to identify factors associated with the outcome variables. A <i>p</i>-value <0.05 at a 95% CI was used to declare statistical significance.</p><p><strong>Results: </strong>Of the 821 participants included in the study, 53.2% had good knowledge and 46% had an unfavorable attitudes towards female genital mutilation, respectively. Monthly income (AOR = 1.61; 95% CI: 1.39-2.95) and partners' educational status (AOR = 2.17; 95% CI: 1.37-4.89) were significantly associated with knowledge, whereas being a government employee (AOR = 2.12; 95% CI = 1.45-3.11) and private employee (AOR = 3.99; 95% CI = 1.63-6.77), having student partners (AOR = 2.64; 95% CI = 1.40-4.95), circumcision history (AOR = 2.58; 95% CI = 1.41-4.71), and knowledge (AOR = 1.48; 95% CI = 1.11-1.98) were shown to be associated with attitude towards female genital mutilation. Moreover, sociocultural drivers, awareness of adverse health effects, religious attributes, and sexuality concerns were explored as attributes of knowledge and attitudes toward female genital mutilation/cutting.</p><p><strong>Conclusion: </strong>Compared to previous similar local and global findings, lower levels of knowledge and higher levels of support for female genital mutilation were observed in the area. Sociocultural, religious, and sexual concerns influence knowledge and attitudes toward female genital mutilation. Therefore, the concerned bodies need to mobilize the community and work closely with the health development armies and religious institutions to boost women's knowledge and change favorable attitudes towards FGM/C.</p>","PeriodicalId":73087,"journal":{"name":"Frontiers in global women's health","volume":"6 ","pages":"1516925"},"PeriodicalIF":2.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12037511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Being in the zone during physiological birth: a comparative study of hospital and home birth environments.","authors":"Orli Dahan, Alon Goldberg","doi":"10.3389/fgwh.2025.1573688","DOIUrl":"https://doi.org/10.3389/fgwh.2025.1573688","url":null,"abstract":"<p><strong>Introduction: </strong>A flow experience typically occurs when the challenge of a demanding physical activity aligns with an individual's abilities, resulting in a sense of empowerment and fulfillment. Experiencing flow during physiological childbirth occurs in various birth environments, but quantitative studies comparing home birth and hospital birth in this respect are scarce. Childbirth is a psychological, social, and physiological event; thus, the birthing environment probably crucially affects the mental state of birthing women. We hypothesized that home birth will be positively correlated with a heightened flow state experienced by women during physiological labor, differing significantly from the experience of women birthing in a hospital.</p><p><strong>Method: </strong>Israeli women with physiological childbirth experience were recruited through social media. Participants (<i>n</i> = 421) completed the Flow State Scale (FSS) and a demographic questionnaire.</p><p><strong>Results: </strong>Comparing hospital births and home births, our research reveals a significant correlation between home birth environment and heightened birthing women's flow state. In physiological childbirth, women birthing at home report higher flow states compared to women in hospitals.</p><p><strong>Discussion: </strong>The observed differences indicate a compelling connection between the birthing environment and the women's experience during labor. The heightened flow state during home births is explained in measured flow dimensions: challenge-skill balance, action-awareness merging, clear goals, unambiguous feedback, concentration, and joy. By comparing correlations of birthing environments and birthing women's flow state, this research contributes a novel perspective to the ongoing discourse on optimizing childbirth experience.</p>","PeriodicalId":73087,"journal":{"name":"Frontiers in global women's health","volume":"6 ","pages":"1573688"},"PeriodicalIF":2.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12037561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of nurses, midwives, and doulas on breastfeeding: changes during the COVID-19 pandemic.","authors":"Shubhecchha Dhaurali, Shikhar Shrestha","doi":"10.3389/fgwh.2025.1469428","DOIUrl":"https://doi.org/10.3389/fgwh.2025.1469428","url":null,"abstract":"<p><strong>Introduction: </strong>The COVID-19 pandemic has significantly altered maternal healthcare delivery, including breastfeeding practices. Our study investigated the influence of nurses, midwives, and doulas on breastfeeding education and rates, with a specific focus on changes that transpired during the COVID-19 pandemic.</p><p><strong>Methods: </strong>Using a cross-sectional design, we performed a secondary data analysis on a stratified systematic sample of forty-six U.S. states and New York City respondents who completed the Pregnancy Risk Assessment Monitoring System (PRAMS) Phase 7 (2012-2015) and Phase 8 (2016-2020) surveys (<i>n</i> = 193,068). Descriptive analyses and adjusted multivariable logistic regression models reporting adjusted odds ratios (aORs) and 95% confidence intervals (95% CIs) were used to assess associations between the provision of breastfeeding guidance to mothers from nurses, doulas, or midwife healthcare professionals; breastfeeding/pumping rates; and the COVID-19 pandemic. Cox-proportional hazard models were used to examine the association between breastfeeding guidance and breastfeeding duration.</p><p><strong>Results: </strong>Our findings revealed that participants who received breastfeeding guidance from nurses, midwives, or doulas were twice as likely to have engaged in breastfeeding or milk pumping for their infants than participants who did not receive breastfeeding education (aOR = 1.99, 95% CI: 1.89-2.11, <i>p</i> < 0.0001). Additionally, participants who gave birth during the COVID-19 pandemic were notably less likely to receive breastfeeding education from a nurse, midwife, or doula than were those who gave birth before the pandemic (aOR = 0.92, 95% CI: 0.88-0.96, <i>p</i> < 0.0001). We also find that the hazard of stopping breastfeeding was lower among participants who received breastfeeding guidance (HR = 0.94, 95% CI: 0.91-0.97, <i>p</i> < 0.0001). Additionally, the hazard of stopping breastfeeding was lower during COVID-19 (HR = 0.94, 95% CI: 0.91-0.97, <i>p</i> = 0.001).</p><p><strong>Discussion: </strong>Our study underscores the vital role that healthcare professionals play in educating, advocating for, and promoting breastfeeding behaviors. This further highlights the pressing need for sustained efforts to support breastfeeding initiatives and address disparities in maternal and child health, particularly in the context of the challenges presented by the COVID-19 pandemic.</p>","PeriodicalId":73087,"journal":{"name":"Frontiers in global women's health","volume":"6 ","pages":"1469428"},"PeriodicalIF":2.3,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Vaccinating a child is upon the woman\": implications for improving uptake for the recently introduced second dose of measles-containing vaccine based on a rapid community assessment in Uganda.","authors":"Adelline Twimukye, Nessa Ryan, Flavia Vivian Najjuma, Yvette Wibabara, Judith Nanyondo, Shillah Nakato, Maria Sarah Nabaggala, Ciara Sugerman, Daniel Kadobera, Rita Atugonza, John Kamulegeya, Joseph Magoola, Racheal Beyagira, Mohammed Lamorde, Alex Riolexus Ario, Alfred Driwale, Shibani Kulkarni","doi":"10.3389/fgwh.2025.1441242","DOIUrl":"https://doi.org/10.3389/fgwh.2025.1441242","url":null,"abstract":"<p><strong>Background: </strong>Caregiver barriers to accessing immunizations are a key factor influencing childhood vaccination. In preparation for the rollout of the second dose measles-containing vaccine (MCV2) in Uganda in October 2022, we aimed to identify possible barriers specific to female caregivers that could influence MCV2 implementation and suggest initiatives to facilitate MCV2 uptake.</p><p><strong>Methods: </strong>In September 2022, we conducted a rapid community assessment in 18 districts in Uganda. We conducted key informant interviews with 17 district health managers and 18 community leaders, and 18 focus group discussions, one in each district, with caregivers of immunization-eligible children. We conducted a rapid analysis based of debriefing notes and in-depth thematic analysis of translated transcripts. Data were analyzed using NVivo version 12, wherein we used the framework analysis approach to define and structure codes deductively and inductively to identify themes. We mapped themes onto the socio-ecological model to examine factors that influence immunization at individual, household, community, and health system level.</p><p><strong>Results: </strong>We found that individual, household, and health system factors influenced childhood vaccination and could be potential barriers to MCV2 uptake. At the individual level, female caregiver's heavy workload and limited decision-making power hindered their ability to take children for vaccination, with mothers often relying on fathers and depended on men for transport costs to immunization centers. At the household level, participants mothers were primarily responsible for taking children to vaccination centers, while fathers were less involved in child health. Health workers often gave preferential treatment to fathers over mothers at the health facility when they brought the child in for vaccination Participants suggested that approaches that ensure the involvement of fathers, other family members and mother-to-mother peer groups could address the barriers specific to female caregivers.</p><p><strong>Conclusion: </strong>Role differentiation between female and male caregivers affect childhood vaccination practices within communities in Uganda, potentially exacerbating challenges in accessing vaccines for children in the second year of life. Integrating interventions responsive to specific caregiver needs and that improve family participation may improve childhood vaccination in Uganda.</p>","PeriodicalId":73087,"journal":{"name":"Frontiers in global women's health","volume":"6 ","pages":"1441242"},"PeriodicalIF":2.3,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and determinants of contraceptive discontinuation among reproductive age women: analysis of Tanzania demographic health survey.","authors":"Bezawit Melak Fente, Angwach Abrham Asnake, Yohannes Mekuria Negussie, Meklit Melaku Bezie, Zufan Alamrie Asmare, Hiwot Altaye Asebe, Beminate Lemma Seifu","doi":"10.3389/fgwh.2025.1393020","DOIUrl":"https://doi.org/10.3389/fgwh.2025.1393020","url":null,"abstract":"<p><strong>Background: </strong>Abortions performed unsafely, unintended births, and missed and unwanted pregnancies are linked to discontinuation of contraception for reasons other than wanting to become pregnant, and these situations raise the risk of maternal morbidity and death. However, a study on the determination of factors contributing to contraceptive discontinuation in Tanzania is limited. Therefore, we aimed to investigate the prevalence and determinants of contraceptive discontinuation among reproductive-age women in Tanzania using recent Tanzania Demographic Health Surveys.</p><p><strong>Method: </strong>A cross-sectional study was conducted using secondary data analysis from of 2022 Tanzania Demographic Health Survey (DHS). A total weighted sample of 6,467 reproductive-age women were included. To account for the clustering effects of DHS data and the binary nature of the outcome variable, a multilevel binary logistic regression model was applied. An adjusted odds ratio with a 95% confidence interval was reported to declare the statistical significance. In addition, the model that had the lowest deviance was the one that best fit the data.</p><p><strong>Result: </strong>The prevalence of discontinuation for all contraceptive methods among reproductive-age women was 34% (95% CI: 31.3%, 34.7%). Women who age group of 20-29 years (AOR = 4.45, 95% CI: 1.11, 17.78), women with no formal education (AOR = 1.94, 95% CI: 1.71, 2.93), women having no children (AOR = 4.25, 95% CI: 3.47, 8.06) women who want another child (AOR = 1.89, 95% CI: 1.76, 3.46), distance to the health facility as a big problem (AOR = 2.43, 95% CI: 1.38, 4.26), rural residence (AOR = 1.67, 95% CI: 1.48, 3.23) Were factors strongly associated with contraceptives discontinuation.</p><p><strong>Conclusion: </strong>Among women of reproductive age, the withdrawal of contraception was 34% and it was determined by several factors. Providing a variety of contraceptive techniques and spreading knowledge about family planning are the primary goals of contraceptive counseling. It is also suggested by prospective investigators to use primary data to address independent factors that were missing.</p>","PeriodicalId":73087,"journal":{"name":"Frontiers in global women's health","volume":"6 ","pages":"1393020"},"PeriodicalIF":2.3,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of long-acting family planning utilization among reproductive-age women in Ethiopia: further analysis of recent demographic and health survey data.","authors":"Melsew Setegn Alie, Gossa Fetene Abebe, Yilkal Negesse, Desalegn Girma","doi":"10.3389/fgwh.2025.1480509","DOIUrl":"https://doi.org/10.3389/fgwh.2025.1480509","url":null,"abstract":"<p><strong>Background: </strong>Despite advancements in modern contraceptive use in Ethiopia, the uptake of long-acting family planning services remains low due to various factors. To our knowledge, there is currently no national evidence regarding the prevalence of long-acting family planning methods. Therefore, this study aimed to identify the determinants of long-acting family planning utilization among women of reproductive age in Ethiopia.</p><p><strong>Method: </strong>A secondary data analysis was conducted using the 2019 Ethiopian Demographic and Health Survey data. The data were extracted from the child record file using STATA version 15. A total of 4,782 reproductive-age women were selected for the study. After applying appropriate weighting, generalized estimating equation modeling was performed using the xtgee command in STATA. Model selection was based on the quasi-likelihood criteria, and model fitting was carried out using two proposed working correlation structures: exchangeable and independent. The generalized estimating equations modeling of the study parameters was assessed accordingly.</p><p><strong>Result: </strong>The magnitude of long-acting family planning utilization in this study was 8.6 [95% confidence interval (CI): 7.8-9.4]. Determinants of long-acting family planning utilization were age of women 40-49 years [odds ratio (OR) = 1.87, 95% CI: 1.7-4.7], rural residence (OR = 0.47, 95% CI: 0.19-0.89], female head of household (OR = 1.67, 95% CI: 1.5-2.2), family size ≥13 (OR = 0.04, 95 CI: 0.003-0.68), and number of children aged under 5 years ≥4 (OR = 0.26, 95% CI: 0.09-0.68).</p><p><strong>Conclusion: </strong>The utilization of long-acting family planning methods among women in Ethiopia is relatively low compared to the Ethiopian government's plan. Key factors influencing this utilization include age, place of residence, head of household, family size, and number of children aged under 5 years. These findings suggest that the country should enhance the use of long-acting family planning by focusing on improving access for young and adolescent women, empowering women, and addressing the needs of households with larger family sizes. Reproductive health interventions, including family planning services, should specifically target rural, male-headed households with young women who have more than four children aged under 5 years to increase the uptake of long-acting family planning methods.</p>","PeriodicalId":73087,"journal":{"name":"Frontiers in global women's health","volume":"6 ","pages":"1480509"},"PeriodicalIF":2.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12018466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing adverse maternal outcomes among adolescent and adult women in North Wollo Zone governmental hospitals, northern Ethiopia.","authors":"Tadele Emagneneh, Chalie Mulugeta, Belay Susu, Negesse Belayneh, Delelegn Tsegaye","doi":"10.3389/fgwh.2025.1336661","DOIUrl":"https://doi.org/10.3389/fgwh.2025.1336661","url":null,"abstract":"<p><strong>Background: </strong>Adolescents differ from adults in biological, social, and psychological characteristics, which can impact maternal health outcomes during pregnancy and childbirth. Research suggests that adolescents are at a higher risk of experiencing adverse maternal outcomes. However, the extent to which these differences are driven by various mediating factors-such as biological, lifestyle, or socioeconomic conditions-remains unclear. This study aimed to compare adverse maternal outcomes between adolescent and adult mothers in public hospitals in North Wollo Zone, northern Ethiopia, while adjusting for potential confounders such as healthcare access, antenatal care, and pregnancy intentions.</p><p><strong>Methods: </strong>A comparative cross-sectional study was conducted from November 2022 to February 2023 involving 488 mothers. Data were collected through interviews and clinical chart reviews and then entered into EpiData version 4.6.6.0 and analyzed using SPSS version 26. Descriptive statistics were used to summarize the data, and logistic regression was applied to identify significant variables (<i>p</i> < 0.05). To correct for multiple testing, the false discovery rate method, using the Benjamini-Hochberg procedure, was applied with a threshold of adjusted <i>p</i>-values <0.1.</p><p><strong>Results: </strong>Adolescent mothers exhibited significantly higher rates of adverse outcomes compared to adult mothers, including preterm labor (7.0% vs. 2.0%, <i>p</i> = 0.04), antepartum hemorrhage (11.9% vs. 4.9%, <i>p</i> = 0.014), anemia (19.3% vs. 10.2%, <i>p</i> = 0.006), pregnancy-induced hypertension (11.9% vs. 7.0%, <i>p</i> = 0.047), malpresentation (9.0% vs. 2.5%, <i>p</i> = 0.008), cephalopelvic disproportion (6.1% vs. 1.2%, <i>p</i> = 0.046), major perineal tears (8.6% vs. 3.3%, <i>p</i> = 0.016), and cesarean delivery (16.0% vs. 9.8%, <i>p</i> = 0.04).</p><p><strong>Conclusion: </strong>Adolescent pregnancy was strongly linked to a range of adverse maternal outcomes, including preterm labor, antepartum hemorrhage, malpresentation, oligohydramnios, anemia, major perineal tears, and an increased likelihood of cesarean delivery. To mitigate these risks, it is crucial to implement targeted community and health facility-based interventions that focus on preventing adolescent pregnancies and addressing contributing factors, ultimately improving maternal health outcomes among adolescents.</p>","PeriodicalId":73087,"journal":{"name":"Frontiers in global women's health","volume":"6 ","pages":"1336661"},"PeriodicalIF":2.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12018451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}