Frontiers in allergy最新文献

{"title":"Tissue eosinophil level as a predictor of control, severity, and recurrence of Chronic Rhinosinusitis with Nasal Polyps.","authors":"Julissa Vizcarra-Melgar, Serafín Sánchez-Gómez, Nuria López-González, Ramón Moreno-Luna, Jaime González-García, Juan Maza-Solano","doi":"10.3389/falgy.2025.1549332","DOIUrl":"10.3389/falgy.2025.1549332","url":null,"abstract":"<p><strong>Introduction: </strong>The histopathologic study of nasal polyps establishes endotype features of chronic rhinosinusitis (CRS). A tissular eosinophil count greater than 10 per high power field (HPF) classifies this condition as type 2 inflammation. Blood and mucosal eosinophils are suggested as biomarkers of severity and control of CRS. Additionally, a tissular eosinophil count greater than 55 per HPF has been related to a high risk of recurrence in the Asian population. Our study aims to determine whether tissue eosinophil count is associated with the control, severity, and recurrence of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP).</p><p><strong>Methods: </strong>An observational study of patients with CRSwNP who underwent nasal mucosa biopsy was conducted between June 2021 and November 2023. Histopathologic features, asthma control, CRSwNP control and severity according to the POLINA consensus, quality of life parameters, recurrence of CRSwNP, and laboratory markers were recorded and compared with the tissular eosinophil count.</p><p><strong>Results: </strong>A total of 108 cases were included. The majority (70.4%) had concomitant asthma, with 31.5% of the cases having well-controlled disease. Most patients had uncontrolled (57.4%) and severe (62%) CRSwNP. Fifty-four cases underwent surgery and 43.5% experienced recurrence. More than half had a SNOT-22 score greater than 50 points. Eighty-one percent of patients had a tissular eosinophil count greater than 10 per HPF, and 60.2% had blood eosinophilia greater than <math><mn>0.3</mn> <mo>×</mo> <msup><mn>10</mn> <mn>3</mn></msup> </math> . Blood eosinophilia was related to CRSwNP severity and control. No significant differences were found between tissue eosinophil count and the severity, control, and recurrence of CRSwNP.</p><p><strong>Conclusion: </strong>Tissue eosinophil levels were not a marker of control, severity, and recurrence of CRSwNP in our data. Blood eosinophil levels, however, were a marker of CRSwNP control and severity.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1549332"},"PeriodicalIF":3.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired cell viability and mitochondrial respiration by disperse textile dyes.","authors":"Lizette M Cortes, Nelson R Vinueza","doi":"10.3389/falgy.2025.1547225","DOIUrl":"https://doi.org/10.3389/falgy.2025.1547225","url":null,"abstract":"<p><p>In recent years, the use of synthetic textile dyes has increased. The effects of these chemicals or their metabolites on our skin and our immune system have not been well studied. However, skin irritants have been reported to break the dermal barrier to start a chain of reactions that dysregulate the immune system. In the last decades, the incidence of atopic diseases and cancer has been increasing. There is an urgent need to identify the environmental triggers that fuel these conditions. This study aimed to investigate the effects of some of the common disperse textile dyes on the viability, and mitochondrial function of cultures of mouse keratinocytes (MPEK-BL6 line) and intestinal porcine epithelial cells (IPEC-J2 cells). The cells were cultured with Disperse (D) dyes Red 11, Orange 37, Blue 1, Blue 124, Blue 291, Blue 79.1, and Brown 1 as well as Quinone and Tartrazine, and PPD as control. At concentrations representative of human exposure from 30 min to 3 days. Cell viability, Oxygen Consumption Rate (OCR) and Extracellular Acidification Rate (ECAR) were quantified. Disperse Blue 1, Blue 124, and Brown 1 impaired cell viability and mitochondrial function as early as 3 h after exposure with IPEC-J2 and MPEK-BL6 cells. However, D. Blue 79.1 and Blue 291 did not have those effects. These data suggest that common disperse textile dyes can influence cell viability and mitochondrial function. This effect could be related to their chemical structure and physicochemical properties, such as size and polarity giving them differences in membrane permeability.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1547225"},"PeriodicalIF":3.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Women in science: allergy research.","authors":"Gemma Carreras-Badosa, Vanesa Esteban, Vivian Hernandez-Trujillo, Elina Toskala, Manali Mukherjee, Saba Al Heialy, Karin Fieten","doi":"10.3389/falgy.2025.1601916","DOIUrl":"https://doi.org/10.3389/falgy.2025.1601916","url":null,"abstract":"","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1601916"},"PeriodicalIF":3.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: An unusual case of cardiac anaphylaxis in the maintenance phase of <i>vespula</i> venom immunotherapy.","authors":"Silvia Brunetto, Federica Buta, Sebastiano Gangemi, Luisa Ricciardi","doi":"10.3389/falgy.2025.1583909","DOIUrl":"https://doi.org/10.3389/falgy.2025.1583909","url":null,"abstract":"<p><strong>Background: </strong>Cardiac involvement in anaphylaxis remains difficult to assess; however, histamine release during an anaphylactic reaction can induce functional and metabolic alterations in the myocardium. Mast cells, identified within myocardial fibers, perivascular tissue, and arterial structures, play a crucial role in systemic and cardiac anaphylaxis through the release of inflammatory mediators, including histamine, platelet-activating factor, cytokines, chemokines, tryptase, chymase, prostaglandins, and leukotrienes. Hymenoptera venom immunotherapy (VIT) is the most effective strategy for preventing systemic reactions in sensitized individuals. Although VIT is generally well tolerated, severe allergic reactions can occur, particularly during the build-up phase, while they are rare in the maintenance phase.</p><p><strong>Case report: </strong>We present the case of a 57-year-old male with a history of severe systemic reactions (SSR) to Vespula stings who experienced cardiac anaphylaxis during the maintenance phase of VIT. He started VIT with a conventional up-dosing schedule, which was well-tolerated. However, during the third monthly maintenance dose, he developed an anaphylactic syncopal episode with a right bundle branch block (RBBB) on ECG. He was treated promptly with adrenaline, corticosteroids, and antihistamines, and his ECG normalized within 20 days.</p><p><strong>Conclusions: </strong>This case underscores the potential cardiac involvement in anaphylaxis during VIT maintenance and highlights the need to systematically evaluate cardiovascular manifestations during anaphylaxis episodes to optimize risk assessment and management.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1583909"},"PeriodicalIF":3.3,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular allergen sensitization profile and casein threshold determination predicting the persistence of cow's milk protein allergy in Tunisia (North Africa).","authors":"Yasmina Ouerdani, Imen Zamali, Yousr Galai, Ahlem Ben Hmid, Yosra Nasri, Ines Ben Sghaier, Hayet Kebaier, Hechmi Louzir, Jihene Bouguila, Nissaf Ben Alaya Bouafif, Mélika Ben Ahmed, Samar Samoud","doi":"10.3389/falgy.2025.1564564","DOIUrl":"https://doi.org/10.3389/falgy.2025.1564564","url":null,"abstract":"<p><strong>Background: </strong>Cow's milk protein allergy (CMPA) represents a major health concern in Tunisia, with diagnostic challenges influencing disease prognosis. Molecular allergen testing has emerged as a valuable tool to enhance diagnostic accuracy and predict disease persistence.</p><p><strong>Objective: </strong>This study aims to characterize the clinical and epidemiological features of CMPA in a Tunisian population, with a particular focus on the role of molecular allergens in assessing disease chronicity.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 262 cases of IgE-mediated CMPA diagnosed at the Pasteur Institute of Tunis between 2020 and 2023. Sensitization to molecular allergens was assessed using ImmunoCAP (Phadia 100).</p><p><strong>Results: </strong>CMPA symptoms predominantly manifested in infancy (94%, 246/262), with a male predominance (sex ratio: 1.6). Acute reactions were the most frequent presentation (69.9%, 79/113), and polysensitization was common (81%, 212/262), particularly to β-lactoglobulin. Spontaneous resolution occurred in approximately 33% of cases (29/87), with a mean age of 3 years and 8 months. Persistent CMPA was significantly associated with elevated IgE levels to whole milk, β-lactoglobulin, and casein (<i>p</i> < 0.05). ROC curve analysis identified predictive thresholds for disease persistence, including 4.2 kU/L for whole milk-specific IgE and 0.37 kU/L for casein-specific IgE (<i>p</i> = 0.006).</p><p><strong>Conclusion: </strong>Molecular allergen testing improves CMPA diagnosis and offers critical prognostic insights. The identification of IgE thresholds may facilitate early risk stratification and guide personalized management strategies.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1564564"},"PeriodicalIF":3.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of an elusive <i>SERPING1</i> deletion in a family with hereditary angioedema type I utilizing soft clipping.","authors":"Keith Wetherby, Joseph Chiao, Emily Faulkner, Yongjian Guo, Shaobin Hou, J Joanna Yu, Jinguo Chen, Lili Wan, H Henry Li","doi":"10.3389/falgy.2025.1565283","DOIUrl":"https://doi.org/10.3389/falgy.2025.1565283","url":null,"abstract":"<p><strong>Background: </strong>Hereditary angioedema (HAE) is an autosomal dominant genetic disorder caused by mutations in the C1 esterase inhibitor gene, SERPING1, leading to overproduction of bradykinin and debilitating swelling attacks. Variants in the <i>SERPING1</i> gene are typically detected in a clinical setting by DNA sequencing or multiplex ligation-dependent probe amplification (MLPA), with over 893 total variants identified. Approximately 5% of patients with C1-esterase inhibitor deficiencies do not have detectable <i>SERPING1</i> pathogenic variants. We further investigated a family with laboratory-confirmed HAE type I despite previous negative genetic test results for <i>SERPING1</i> mutations.</p><p><strong>Methods: </strong>We consented and collected whole blood samples from three family members with clinical diagnoses of HAE. The samples underwent genomic DNA extraction and evaluation for purity prior to sequencing. The DNA samples were processed through a semi-automated whole exome library prep pipeline and sequenced. <i>SERPING1</i> MLPA was performed to assess exon-level copy number variation (CNV) for exons 1 through 8. Additionally, we incorporated a well-established bioinformatics technique called soft clipping into our variant analysis pipeline to detect structural variants.</p><p><strong>Results: </strong>Clinical variant analysis revealed two common benign variants of <i>SERPING1</i> in the proband. NGS and MLPA did not detect any <i>SERPING1</i> pathogenic variants or genomic rearrangements, but additional structural variant analysis identified a high rate of soft clipping in exon 6 of the <i>SERPING1</i> gene. Sanger sequencing of exon 6 revealed a heterozygous 56-base-pair deletion [NC_000011.10: g.57606508-57606563del, NM_000062(<i>SERPING1</i>): c.990_1029 + 16del] spanning the 3' exon-intron boundary in all three subjects.</p><p><strong>Summary: </strong>Without additional techniques following NGS and MLPA, such as a soft clipping analysis method, many difficult-to-detect large insertions and deletions may go undetected. We propose that a systematic approach to undetected HAE-causing mutation analysis, incorporating soft clipping as part of an overall strategy, would be more effective in identifying a small percentage of causal variants in approximately 5% of C1-esterase inhibitor HAE cases where no mutation is found by standard laboratory procedures, especially when there are high clinical suspicions of a familiar disorder.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1565283"},"PeriodicalIF":3.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to outdoor aerospora and associated respiratory health risks among adults in Potchefstroom, North-West province, South Africa.","authors":"Dorra Gharbi, Frank Harald Neumann, Keneilwe Podile, Marinda McDonald, Jo-Hanné Linde, Megan Frampton, Jennifer Leigh Liebenberg, Sarel Cilliers, Tshiamo Mmatladi, Phumelele Nkosi, Keamogestswe Paledi, Stuart Piketh, Jurgens Staats, Roelof P Burger, Henno Havenga, Rebecca M Garland, Petra Bester, Pedro Humberto Lebre, Cristian Ricci","doi":"10.3389/falgy.2025.1568669","DOIUrl":"https://doi.org/10.3389/falgy.2025.1568669","url":null,"abstract":"<p><strong>Background: </strong>Data on allergic rhinitis and respiratory health metrics are limited for South Africa, with grass pollen as a key outdoor aeroallergen. Exotic trees such as plane trees and ragweed produce highly allergenic pollen, dominating indigenous trees and weeds. Pollen allergy prevalence data is lacking in cities of North-West province such as Potchefstroom.</p><p><strong>Objectives: </strong>This study aimed to (i) assess the prevalence of allergies to major aeroallergens, including Poaceae (grasses), <i>Cupressus/Hesperocyparis</i> (cypresses), <i>Platanus</i> (plane tree), <i>Ulmus</i> (elm), <i>Quercus</i> (oak), <i>Betula</i> (birch), <i>Olea</i> (olive), <i>Artemisia</i> (sagebrush), <i>Amaranthus</i> (amaranth), <i>Plantago</i> (plantain), <i>Morus</i> (mulberry), and <i>Ambrosia</i> (ragweed), along with fungal spores such as <i>Alternaria</i>, <i>Cladosporium</i>, and <i>Penicillium/Aspergillus</i>, and (ii) investigate the monthly incidence of major aeroallergens and reactivity levels in sensitized adults in Potchefstroom.</p><p><strong>Methods: </strong>Skin prick tests (SPTs) were performed on 202 adults aged 18-64 years with confirmed allergic symptoms during a field campaign at North-West University (NWU)'s Potchefstroom campus. A test panel of grass, weed, tree, and fungal spore extracts previously identified via aerobiological monitoring was used. Symptom scores were recorded using ISAAC questionnaires; <i>Spearman</i>'s statistical correlation between symptom frequency and monthly aeroallergen concentrations were analyzed.</p><p><strong>Results: </strong>Among the participants, 184 (91%) exhibited positive SPT reactions: 104 (57%) are monosensitized to pollen, 45 (24%) to fungal spores, and 35 (19%) are polysensitized. Aeroallergen prevalence was higher in females (73%) than in males (27%). The most common pollen allergens were <i>Cynodon dactylon</i> (Bermuda grass) (85%), <i>Zea mays</i> (maize) (46%), <i>Platanus</i> spp. (plane tree) (35%), and <i>Ulmus campestris</i> (field elm) (33%). Among fungal spores, <i>Alternaria</i> was the most common (93%), followed by <i>Cladosporium</i> (27%). A significant and positive statistical correlation was found between allergic rhinitis symptoms and monthly pollen concentrations of <i>Betula</i>, <i>Morus</i>, <i>Platanus</i>, and <i>Quercus</i>.</p><p><strong>Discussion & conclusion: </strong>This pilot study linked aeroallergens detected in Potchefstroom with allergy profiles of local residents. The findings highlight the need for more comprehensive regional studies that integrate allergen testing with aerobiological data. Raising awareness and implementing health strategies are essential for managing allergic rhinitis in South Africa. More affordable and available SPTs kits, adapted to allergy prevalence in South Africa, are strongly suggested.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1568669"},"PeriodicalIF":3.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12037600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized controlled trial evaluating prophylactic treatment of <i>Artemisia</i> pollinosis using azelastine hydrochloride and fluticasone propionate nasal spray.","authors":"Le Cui, Na Gao, Cairong Bai, Yali Zuo, Wendong Hao, Kai Guan","doi":"10.3389/falgy.2025.1559201","DOIUrl":"https://doi.org/10.3389/falgy.2025.1559201","url":null,"abstract":"<p><strong>Background: </strong>Prophylactic treatment for pollinosis is advantageous for managing nasal symptoms in patients with seasonal allergic rhinitis. Inadequate control of rhinitis symptoms increases the risk of acute asthma attacks. Nevertheless, there is limited research on the use of nasal glucocorticoids and antihistamines for the preventive treatment of pollinosis.</p><p><strong>Objective: </strong>This study aimed to assess the efficacy of prophylactic treatment for nasal symptoms and acute asthma attacks by enrolling patients with <i>Artemisia</i> pollinosis to use a combined device of azelastine hydrochloride and fluticasone nasal spray prior to the pollen season.</p><p><strong>Methods: </strong>The study was registered at Chictr.org.cn (ChiCTR2300073758). A total of 120 patients with <i>Artemisia</i> pollinosis were randomly assigned to either a prophylactic treatment group or a control group at a 1:1 ratio. In the prophylactic treatment group, the nasal spray was initiated approximately two weeks before the onset of the pollen season.</p><p><strong>Results: </strong>During both the pollen season and the concurrent medication period, the prophylactic treatment group presented significantly lower total nasal symptom scores (TNSS) (means of 5.97 and 5.94) than the control group (means of 7.86 and 7.80) (<i>P</i> = 0.015 and 0.016). Although the prophylactic treatment group had a lower asthma attack rate than the control group, the difference was not statistically significant (<i>P</i> = 0.284).</p><p><strong>Conclusions: </strong>Prophylactic treatment with azelastine hydrochloride and fluticasone propionate nasal sprays can alleviate nasal symptoms and may reduce acute asthma attacks during the pollen season.</p><p><strong>Clinical trial registration: </strong>[Chictr.org.cn], identifier (ChiCTR2300073758).</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1559201"},"PeriodicalIF":3.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12018361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of eosinophil recruitment and heterogeneity during allergic airway inflammation.","authors":"Lisa-Marie Graf, Daniel Radtke, David Voehringer","doi":"10.3389/falgy.2025.1585142","DOIUrl":"https://doi.org/10.3389/falgy.2025.1585142","url":null,"abstract":"<p><p>Eosinophils represent a granulocyte cell type that is strongly associated with type 2 inflammatory conditions. During steady state conditions few eosinophils are found in lung tissue, though they may contribute to homeostasis. In allergic airway inflammation, eosinophils are strongly increased and associated to disease severity. The underlying type 2 immune response tightly regulates eosinophil development, recruitment, survival, and heterogeneity. Inflammatory eosinophils in the lung are unfavourable, as they can cause tissue damage, amplify type 2 immunity and induce bronchial obstruction by expelling granular proteins and cytokines. In this review we provide an overview about mechanisms regulating development of eosinophils in the bone marrow and their extravasation into the lung including recent findings on induction and diversity of eosinophilia in allergic airway inflammation.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1585142"},"PeriodicalIF":3.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12018390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the CALLY index, vitamin D, and asthma: insights from NHANES.","authors":"Yachun Liu, Yufeng Wei","doi":"10.3389/falgy.2025.1557677","DOIUrl":"https://doi.org/10.3389/falgy.2025.1557677","url":null,"abstract":"<p><strong>Purpose: </strong>The CALLY index integrates C-reactive protein (CRP), albumin and lymphocyte counts to accurately reflect the inflammatory, nutritional and immune status of the body. Multiple studies have indicated that the CALLY index plays a key role in a variety of diseases, especially asthma, and is closely associated with inflammatory response, airway remodeling and immune imbalance in asthma. Research has shown that vitamin D is associated with asthma susceptibility, severity, and control, and its levels may influence inflammatory and immune markers associated with the CALLY index, which may play a role in the association between the CALLY index and asthma.</p><p><strong>Patients: </strong>Using data from the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2010, the association between CALLY index and asthma and the role of vitamin D in American adults were analyzed in depth. Through multiple logistic regression, subgroup analysis, and other statistical means, the potential pathophysiological links between the three are revealed, providing theoretical support for the prevention and treatment of related diseases.</p><p><strong>Results: </strong>A total of 17,946 individuals were included in this study, of which 2,317 were diagnosed with asthma. Fully adjusted multivariate logistic regression analysis revealed that the CALLY index was significantly negatively associated with asthma, with an odds ratio (OR) of 0.996 [95% confidence interval (CI) 0.993-0.999]. Specifically, each unit increase in the CALLY index was associated with a 0.996-fold reduction in asthma risk. In addition, mediation effect analysis showed that vitamin D partially mediated the association between the CALLY index and asthma, with a mediation ratio of 3.36%.</p><p><strong>Conclusion: </strong>This study reveals an association between the CALLY index and reduced risk of asthma in the US population and suggests that vitamin D plays an incomplete mediating role. This finding provides a new theoretical basis for the diagnosis, treatment, and prevention of asthma and is expected to be a potential biomarker.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1557677"},"PeriodicalIF":3.3,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}