Frontiers in allergy最新文献

{"title":"Pollen-induced allergic rhinitis in the central region of Inner Mongolia, China: prevalence, risk factors, and regional characteristics.","authors":"Ting-Ting Ma, Mei-Rong Yang, Zi-Lu Cheng, Xiang-Dong Wang, Guang-Liang Shan, Yao-da Hu, Yong-Fei Bai, Hui-Yu Ning, Jian-Ling Yang, Yan-Lei Chen, Hong-Tian Wang, Qing-Yu Wei, Luo Zhang, Shu-Lin Li, Xue-Yan Wang","doi":"10.3389/falgy.2026.1800197","DOIUrl":"10.3389/falgy.2026.1800197","url":null,"abstract":"<p><strong>Background: </strong>Pollen-induced allergic rhinitis (PIAR) is a major public health burden in high-pollen regions of northern China (e.g., Ordos, southern Inner Mongolia Plateau). However, regional variations in PIAR across ecological zones (urban, agropastoral, desert, and mining zones), dominant allergens, and key risk factors remain understudied due to prior small-sample or narrow-scope research.</p><p><strong>Objective: </strong>This study aimed to investigate the prevalence, major risk factors, and current treatment patterns for PIAR in Ordos.</p><p><strong>Methods: </strong>From March to July 2023, a multicenter, randomized, stratified cross-sectional survey was conducted across nine areas in Ordos. Participants were recruited to complete in-person questionnaires and undergo skin prick tests (SPTs) for 16 common allergens. Pollen was collected and counted to monitor exposure levels.</p><p><strong>Results: </strong>Among the 4,303 participants, the prevalence rates of self-reported allergic rhinitis (SRAR), physician-diagnosed allergic rhinitis (PDAR), and PIAR were 52.89% (2,276/4,303), 34.70% (1,493/4,303), and 31.51% (1,356/4,303), respectively. The prevalence rates of PIAR in urban, agropastoral, desert, and mining areas were 30.46%, 39.55%, 29.09%, and 19.72%, respectively. Among patients with PIAR, the incidence of symptom onset was highest among urban residents and lowest among mining area residents. <i>Poplar</i> pollen allergen dominated in spring, whereas in autumn, <i>Artemisia</i> pollen was predominant. Clinical symptoms were greatest in July, preceding the autumn pollen peak in September.</p><p><strong>Conclusion: </strong>PIAR is highly prevalent in northern China's grasslands, with marked zone-specific variations. <i>Artemisia</i> pollen exposure is the main sensitization driver, supporting targeted PIAR prevention/control.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"7 ","pages":"1800197"},"PeriodicalIF":3.4,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13199316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148038133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-targeted protection of Yuping Tongqiao against allergic rhinitis: suppression of inflammatory response via TSLP signaling and reinforcement of epithelial barrier integrity via AhR signaling.","authors":"Zhixin Wang, Jingqi Cai, Jiahao Wu, Haoran Zheng, Min Shi, Yanan Tong, Yunlong Hou, Zhenhua Jia, Hui Qi","doi":"10.3389/falgy.2026.1824120","DOIUrl":"10.3389/falgy.2026.1824120","url":null,"abstract":"<p><strong>Background: </strong>Allergic rhinitis (AR) is a prevalent chronic inflammatory disorder characterized by persistent inflammation and nasal epithelial barrier disruption. Restoring epithelial integrity and modulating the inflammatory cascade are considered promising therapeutic strategies for AR.</p><p><strong>Purpose: </strong>This study aims to systematically investigate the therapeutic efficacy of Yuping Tongqiao Tablet (YPTQ), a traditional Chinese medicine formula, in the treatment of AR and to decipher its potential mechanisms and active ingredients focusing on inflammation amelioration and barrier restoration.</p><p><strong>Methods: </strong>An AR model was established in Sprague-Dawley rats that were sensitized and challenged with OVA. After intervention with different doses of YPTQ, nasal pathological injury and inflammatory cell infiltration were evaluated. <i>In vitro</i>, a human nasal epithelial cell (RPMI-2650) injury model was induced using house dust mites (HDM). Following YPTQ treatment, the expression levels of inflammatory factors and barrier-related proteins were assessed. Furthermore, the potential mechanisms and targets of YPTQ and its active monomers against AR were investigated by integrating network pharmacology analysis and molecular docking with <i>in vitro</i> experiments.</p><p><strong>Results: </strong>In the OVA-induced AR rat model, YPTQ effectively alleviated nasal symptoms, reduced histopathological damage and inflammatory cell infiltration, and suppressed overall inflammatory levels. In the HDM-induced RPMI-2650 cell injury model, YPTQ significantly inhibited inflammatory cytokines release and upregulated the tight junction protein ZO-1, thereby enhancing epithelial barrier function. Moreover, integrated analysis combining network pharmacology, molecular docking, and both <i>in vitro</i> and <i>in vivo</i> validation confirmed that YPTQ and its active ingredient, kaempferol, exert therapeutic effects through two main pathways. Firstly, they down-regulated the expression of TSLP and inhibited the migration of DCs, which subsequently alleviated nasal inflammation. Secondly, they up-regulated and activated the expression of AhR and the downstream CYP1A1, which in turn promoted the expression of a barrier-associated protein, contributing to the restoration of nasal epithelial barrier integrity.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"7 ","pages":"1824120"},"PeriodicalIF":3.4,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13194122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tobacco smoking and occupational hand eczema severity in a North African adult population: a cross-sectional analytical study.","authors":"Kacem Imène, Chouchane Asma, Ben Yahia Mounira, Aloui Aloui, Gaddour Asma, Bouhoula Maroua, Brahem Aicha, Kalboussi Houda, Chatti Souhail, Maoua Maher, El Maalel Olfa, Mrizak Nejib","doi":"10.3389/falgy.2026.1723516","DOIUrl":"10.3389/falgy.2026.1723516","url":null,"abstract":"<p><strong>Background: </strong>Hand Eczema (HE) is one of the most common occupational diseases worldwide. Various lifestyle factors have been implicated in HE; however, the influence of tobacco smoking on the severity of HE has not been well studied.</p><p><strong>Aim: </strong>The objective of this study is to investigate a possible association between the severity of HE and tobacco smoking.</p><p><strong>Methods: </strong>This cross-sectional analytical study included 150 patients with HE seen at the Dermatology and Allergology Unit of the Occupational Department, Farhat Hached Teaching Hospital, Sousse, Tunisia, over a period of 20 months. Data were collected using a pre-established questionnaire completed during an interview with the patient. Tobacco use was self-reported. The assessment of HE severity was based on the Osnabrück Hand Eczema Severity Index score (OHSI). Multivariate analysis was performed using multiple binary logistic regressions. Independent variables were included in the regression models when their significance level was less than 0.2.</p><p><strong>Results: </strong>In total, 150 HE patients met the inclusion criteria. The mean age of our population was 41.05 (10.3) years, with a slight female predominance (51.3% vs. 49.7%) and a sex ratio of 0.94. Almost a third of participants-or 46 (30.9%)-were smokers. The average pack years of cigarette smoking was 18.56 (12.85). The OHSI score indicated severe HE in 97 patients (64.7%). In multivariate analysis, smoking (adjusted OR: 2.83, CI: 0.99-8.14, <i>p</i> = 0.005) and perceived stress (adjusted OR: 1.06, CI: 1 -1.13, <i>p</i> = 0.01) were associated with severe HE. Similarly, having a leisure activity was inversely associated with severe HE (adjusted OR: 0.18, CI: 0.06-0.50, <i>p</i> = 0.001]).</p><p><strong>Conclusion: </strong>It is important to consider smoking cessation as an important target in the prevention and management of HE.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"7 ","pages":"1723516"},"PeriodicalIF":3.4,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13190559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpretable machine learning classification of cedar and cypress pollen on routine Durham slides for environmental exposure assessment.","authors":"Nobuyoshi Suzuki, Kenjiro Sugiyama, Katsuhiko Kobayashi, Hisakuni Fukuoka, Yutaka Takumi","doi":"10.3389/falgy.2026.1805985","DOIUrl":"10.3389/falgy.2026.1805985","url":null,"abstract":"<p><p>Accurate discrimination of <i>Cryptomeria japonica</i> (cedar) and <i>Chamaecyparis obtusa</i> (cypress) pollen on routine Durham slides is clinically and environmentally important, because local pollen counts influence patient visits and regional exposure assessment. However, manual counting is time-consuming and often complicated by debris, air bubbles, and burst pollen, which is morphologically distinct from intact grains. In this methodological proof-of-concept study, we evaluated whether machine learning could classify particles cropped from real-world Durham slides collected under routine field conditions. We collected five routine slides from two sites in Nagano Prefecture and obtained 1,480 particle images categorized into five classes: cedar, cypress, burst cedar, burst cypress, and dust/miscellaneous artifacts. We extracted interpretable morphological and textural descriptors and trained a support vector machine using nested 5-fold stratified cross-validation. Using an optimized, interpretable feature set, the model achieved a macro-F1 score of 0.833 ± 0.025 and an overall accuracy of 0.863. Classification of intact cedar and cypress pollen was good, whereas discrimination between the two burst classes was more difficult. Misclassifications were concentrated mainly between cedar and cypress, and between burst cedar and morphologically similar particles such as burst cypress or dust. In contrast, dust was rarely misclassified as intact cedar or intact cypress. One-vs.-rest ROC-AUC values were high across classes (0.93-0.98), although performance was lower for burst pollen than for intact pollen. Among the extracted descriptors, size-related features, particularly area and radius, contributed most strongly to classification. These findings show that interpretable machine learning can distinguish intact cedar and cypress pollen on routine Durham slides under real-world conditions, while burst pollen remains a major source of classification difficulty. Further refinement of feature design for burst pollen will be necessary for routine application.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"7 ","pages":"1805985"},"PeriodicalIF":3.4,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13189800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Case of severe allergic reaction in a child caused by chlorhexidine skin disinfectant.","authors":"Yujing Zhao, Yingqian Zhang, Juncong Kang, Jingli Zhang, Chenchu Duan","doi":"10.3389/falgy.2026.1812841","DOIUrl":"10.3389/falgy.2026.1812841","url":null,"abstract":"<p><p>Chlorhexidine is extensively utilized as a skin antiseptic in routine clinical practice. In recent years, reports of life-threatening hypersensitivity reactions induced by chlorhexidine have been increasing progressively. Nevertheless, severe allergic events attributable to chlorhexidine-containing skin disinfectants are frequently misdiagnosed in clinical settings. Herein, we present a pediatric case with recurrent severe allergic reactions following exposure to chlorhexidine-based skin disinfection. This report aims to raise clinicians' awareness of chlorhexidine hypersensitivity.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"7 ","pages":"1812841"},"PeriodicalIF":3.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13180728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147977560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced maternal age and childhood allergy: marker or mechanism?","authors":"Cristiana Indolfi, Angela Klain, Carolina Grella, Giulio Dinardo, Salvatore Cascone, Michele Miraglia Del Giudice","doi":"10.3389/falgy.2026.1825315","DOIUrl":"10.3389/falgy.2026.1825315","url":null,"abstract":"","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"7 ","pages":"1825315"},"PeriodicalIF":3.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13180957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147977518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world retrospective study on allergy screening and its effect on specialist referral patterns.","authors":"Inês Costa Farinha, Milagros Lázaro-Sastre, Rosita Castillo Loja, Adelaida Cabrera, Nerea Otero-Fernández, Elena Laffond Yges, Sonia Arriba-Méndez, Ignacio Dávila","doi":"10.3389/falgy.2026.1744703","DOIUrl":"10.3389/falgy.2026.1744703","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Accurate diagnosis of IgE-mediated diseases requires identifying relevant allergens to guide appropriate clinical management and reduce healthcare costs (1). The ImmunoCAP Phadiatop (Thermo Fisher Scientific) is an <i>in vitro</i> assay detecting that detects IgE antibodies against a balanced mixture of common inhalant allergens, serving as a first-level screening tool for sensitization in patients with suspected airway allergies, and guiding subsequent management. This study aimed to evaluate test results, the impact on clinical decision-making, and its role in managing allergic conditions.</p><p><strong>Materials and methods: </strong>A real-world retrospective observational study was conducted in a tertiary hospital allergy department (June 2021-June 2023). Data were collected using the Modulab Laboratory Information System (Werfen, Spain) and stored in a dissociated database. The Ethics Committee of Salamanca approved the study protocol. Phadiatop values above 0.35 PAU/l were considered positive. In case of repeated samples, the first was selected. Variables analyzed included test results, patient demographics, requesting departments, and allergy referrals, a well-balanced mixture of common inhalant allergens with regional adaptation. The allergen groups included were comprise: house dust mites, (e.g., Dermatophagoides pteronyssinus, D. farinae), pollens, from grasses (e.g., timothy, ryegrass), trees (e.g., birch, olive), and weeds (e.g., mugwort, plantain, ragweed), molds (e.g., Alternaria, Cladosporium, Aspergillus, Penicillium), and animal dander (e.g., cat, dog).</p><p><strong>Results: </strong>The study included 596 patients (median age 46, 64.1% female). Of these, 12.6% were under 18 years old. Most patients (95.8%) were referred from primary care, with 83.1% of them from urban areas. A total of 37.9% of patients had a positive result (median IgE 7.81 PAU/l). Most positive patients resided in urban areas (82.3%), were aged <18 years of age (<i>p</i> = 0.001), and were male (<i>p</i> < 0.001). Patients aged >59 (26.3%) presented mainly negative results (82.2%). Of the positive cases, 31.4% were referred to an allergist, with higher Phadiatop values increasing associated with increased referrals (<i>p</i> = 0.001).</p><p><strong>Conclusions: </strong>Phadiatop was mainly utilized in primary care. One-third of patients tested positive; of those, only one-third were referred to allergists, with higher Phadiatop values increasing associated with higher referral rates. Positivity was higher in males and younger people.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"7 ","pages":"1744703"},"PeriodicalIF":3.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13180721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147977495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cultural sensitivity and patient-centered care regarding incense and candle smoke emissions.","authors":"Gomeo Lam, Cameron Nejat, Mary F Lee-Wong","doi":"10.3389/falgy.2026.1807883","DOIUrl":"10.3389/falgy.2026.1807883","url":null,"abstract":"<p><p>Incense and candles are commonly utilized for relaxation, deodorization, aesthetics, and religious observance. Both are used ubiquitously and viewed innocuously. However, both modalities release a multitude of compounds, including carbon monoxide, benzene, acrolein, and polycyclic aromatic hydrocarbons, that carry documented risks for cardiovascular disease, pulmonary dysfunction, and cancer. Incense particulate matter generates 45 mg/g vs. 10 mg/g from cigarette smoke. The following two clinical cases illustrate this challenge: an 87-year-old woman with chronic obstructive pulmonary disease and asthma whose acute dyspnea was temporally associated with incense burning during ancestral worship and a 31-year-old atopic asthmatic woman whose symptoms were repeatedly triggered by meditative relaxation through lighting candles. For many patients worldwide, these practices are inseparable from cultural identity and religious devotion, rendering simple cessation counseling insufficient. This article explores the current evidence on health hazards from incense and candle smoke, synthesizes their cultural and religious significance across major traditions, and proposes a structured framework for clinician communication. Practical recommendations, including electronic alternatives, burn duration reduction, improved ventilation, and culturally sensitive phrasing, are presented to help clinicians navigate these conversations effectively. A summary table comparing health risks, cultural roles, and alternative options is provided as a practical clinical reference. Recognizing the cultural and religious significance of incense and candle use across diverse populations is a prerequisite for delivering care that is both clinically effective and respectful of patient values.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"7 ","pages":"1807883"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13176265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147966160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging perspectives in respiratory allergic diseases: a review of future directions.","authors":"Rafael Durán, Sergio E Chiarella, Thanai Pongdee, Juyoung Choi, Martin Maillo, Cesar A Galván","doi":"10.3389/falgy.2026.1819491","DOIUrl":"10.3389/falgy.2026.1819491","url":null,"abstract":"<p><strong>Background: </strong>Respiratory allergic diseases are experiencing changes influenced by genetic factors, environmental shifts, and social and demographic elements. These evolving patterns, together with rapid advances in diagnosis and treatment, require a thorough review of emerging trends.</p><p><strong>Objective: </strong>To examine future directions in managing respiratory allergic diseases, focusing on changing disease patterns, environmental factors, diagnostic innovations, and therapeutic advances toward precision medicine. A literature search was conducted in PubMed and Scopus databases covering 2015-2025. Studies addressing human populations with allergic rhinitis or asthma were included, emphasizing emerging patterns, environmental factors, diagnostic technologies, and therapeutic innovations, while reviews, conference proceedings, case reports, and studies without clinical relevance were excluded. Initial screening identified 52 studies, and 21 additional studies were identified through complementary searches, resulting in 73 studies in the final analysis.</p><p><strong>Summary of findings: </strong>Climate change is a key factor affecting disease patterns, with pollen seasons starting 10-40 days earlier and yearly emissions increasing by up to 200%. Regarding pathogenesis, early-life rhinovirus C infections with IgE sensitization significantly increase asthma risk (HR = 4.06), while severe asthma shows 40-84% eosinophilic patterns, depending on the assessment approach. On the diagnostic front, advances include multiplex platforms, proteomic biomarkers, and microRNAs. Therapeutically, innovations encompass biologics combined with allergen immunotherapy, nanobody-based therapeutics, and microbiota interventions.</p><p><strong>Conclusions: </strong>These developments point toward personalized management of respiratory allergic diseases. However, challenges remain in research with underrepresented populations and accessibility. Moving forward, the key priority is integrating this diverse knowledge into practical strategies that advance precision medicine in respiratory allergic diseases.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"7 ","pages":"1819491"},"PeriodicalIF":3.4,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13168022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147943858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitization to 19 allergen sources in 2,124 children in Kashi Prefecture, China: a single-center cross-sectional retrospective study.","authors":"Riziwanguli Maitusong, Asimuguli Wubuli, Ayiguli Saimaier, Lifang Li, Gumina Kamili, Muyesaier Maimaiti, Rexiati Dawuti","doi":"10.3389/falgy.2026.1795685","DOIUrl":"10.3389/falgy.2026.1795685","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the sensitization to common allergen sources among children in Kashi Prefecture and offer a scientific foundation for preventing allergic diseases in this demographic.</p><p><strong>Methods: </strong>The study retrospectively collected the detection results of serum allergen-specific IgE antibodies from 2,124 children at the First People's Hospital of Kashi Prefecture from January 2022 to December 2024.</p><p><strong>Results: </strong>The overall sensitization rate detected by sIgE was 42.70%. Within the sensitization cases, inhalant allergens had a sensitization rate of 29.52%. The most frequent allergen sources included tree combinations (330 cases, 15.54%), cat fur (243, 11.44%), and <i>Artemisia argyi</i> (195, 9.18%). The sensitization rate for food allergens was 24.01%, with egg whites (229, 10.78%), milk (130, 6.12%), and peanuts (99, 4.66%) being the most frequent sources. Sensitization to tree combinations, <i>Ambrosia artemisiifolia</i>, cat fur, and peanuts was significantly higher in boys compared to girls. Tree combinations, <i>Ambrosia artemisiifolia</i>, <i>Artemisia argyi</i>, house dust, cat fur, mold combinations, and <i>Humulus scandens</i> exhibited an increasing trend in sensitization rate with age, whereas egg whites, milk, and beef exhibited decreasing trends with age. The sensitization rates for tree combinations, house dust, and mutton displayed significant seasonal variations.</p><p><strong>Conclusions: </strong>Sensitization to common allergens was prevalent among children in Kashi, although only a small number exhibited allergic symptoms. The sensitization rates for common allergens varied significantly based on sex, age and season. These results suggest that sIgE detection of specific allergens can aid in identifying triggering factors, which is crucial for preventing allergic diseases.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"7 ","pages":"1795685"},"PeriodicalIF":3.4,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13168159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147943887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}