Frontiers in allergy最新文献

{"title":"Efficacy of index of reactivity-liquid sublingual immunotherapy in allergic rhinoconjunctivitis: a systematic review and meta-analysis of randomized studies.","authors":"Danilo Di Bona, Andrea Di Biase, Giovanni Paoletti, Rosanna Villani, Gaetano Serviddio, Josiane Cognet-Sicé, Silvia Scurati, Giorgio Walter Canonica","doi":"10.3389/falgy.2025.1597003","DOIUrl":"10.3389/falgy.2025.1597003","url":null,"abstract":"<p><strong>Introduction: </strong>Allergen immunotherapy (AIT) is a well-established treatment with demonstrated efficacy and safety. However, variability in study outcomes remains a challenge, driven by differences in patient characteristics, study designs, and treatment durations. Moreover, disparities in allergen composition and quality of AIT products across manufacturers contribute to significant heterogeneity, complicating the interpretation of efficacy and safety data. This meta-analysis focuses on assessing the efficacy and safety of a single manufacturer's liquid sublingual immunotherapy (SLIT) for allergic rhinoconjunctivitis (ARC). By narrowing the scope to one specific product, this study seeks to reduce variability linked to product differences, aligning with recommendations from the World Allergy Organization to improve the reliability of meta-analytic findings.</p><p><strong>Methods: </strong>Randomized controlled trials (RCTs) on index of reactivity (IR) SLIT liquid formulations of various allergens were identified through comprehensive searches in electronic databases (MEDLINE, ISI Web of Science, the Cochrane Library, and ClinicalTrial.gov) up to December 2024, complemented by manual searches. Data on populations, treatments, and outcomes were extracted. Efficacy was evaluated by calculating the standardized mean difference (SMD) for symptoms and medication use. Subgroup analyses were performed by age, allergen type and sensitization status. Asthma comorbidity, dose and duration of SLIT were evaluated using meta-regression.</p><p><strong>Results: </strong>A total of 25 RCTs (1,830 patients) provided data on symptom scores (SS), and 19 RCTs (1,555 patients) reported on medication scores (MS). Analysis revealed that IR-SLIT-liquid was significantly more effective than placebo in reducing both SS (SMD: -0.30; 95% CI: -0.41 to -0.18; <i>P</i> < 0.0001) and MS (SMD: -0.51; 95% CI: -0.72 to -0.29; <i>P</i> < 0.0001). Efficacy outcomes were consistent regardless of factors such as age, allergen type (grass, house dust mites, trees, weeds), sensitization status, asthma presence, or cumulative dose, while longer treatment durations were associated with improved efficacy. No significant adverse events were reported.</p><p><strong>Discussion: </strong>This meta-analysis underscores the clinical effectiveness and safety of IR-SLIT-liquid, confirming its role as a reliable etiologic treatment for patients with ARC, for all allergens and age groups. The effect size is comparable to other immunotherapy options. The low rates of adverse events and treatment withdrawals highlight favorable tolerability and high level of patient adherence.</p><p><strong>Systematic review registration: </strong>https://inplasy.com/wp-content/uploads/2025/01/INPLASY-Protocol-7305.pdf, INPLASY 202510049.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1597003"},"PeriodicalIF":3.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetic modifications are associated with mRNA and cytokine expression changes in chronic rhinosinusitis: a multiomics study from the United States.","authors":"Devyani Lal, Tripti Brar, Chantal McCabe, Erik Jessen, Nitish Kumar, Pedro Lança Gomes, Michael J Marino, Amar Miglani, Hirohito Kita","doi":"10.3389/falgy.2025.1606255","DOIUrl":"10.3389/falgy.2025.1606255","url":null,"abstract":"<p><strong>Objectives/hypothesis: </strong>Chronic rhinosinusitis (CRS) may be triggered by environmental insults. We hypothesized that CRS results from epigenetic modifications of host DNA from external insults, leading to downstream RNA/DNA gene expression changes and immuno-mechanical disruptions. We therefore performed a multi-omics study integrating epigenetic (DNA methylation), transcriptomic (mRNA), and proteomic (cytokine) data of CRS sinonasal tissue to visualize interactions amongst these modalities to study our hypothesis.</p><p><strong>Methods: </strong>Sinonasal tissue was collected from 14 prospectively enrolled CRS and control subjects. Cytokine, mRNA transcriptome, and DNA methylome analysis were performed. Multi-omics analysis via joint dimensional reduction (JDR) was conducted.</p><p><strong>Results: </strong>Multi-omics unsupervised clustering separated subjects into two distinct groups: one cluster of 9 CRS subjects and another with 3 controls and 2 non-eosinophilic CRSsNP subjects. DNA methylation, followed by mRNA expression, contributed most to cluster assignment. DNA methylation was the most significant data modality contributing to total variance on JDR. Cytokines critical in CRS (IL-5, IL-13, IL-10, IFN<i>γ</i>, IL-6) associated with hundreds of differentially methylated regions (DMRs) and mRNA. On conjoint analyses, common upstream DMRs and mRNAs were linked to cytokines IL-5 and IL-13, cytokines IL-10 and IFN<i>γ</i>, and cytokines IFN<i>γ</i> and IL-6, respectively.</p><p><strong>Conclusions: </strong>Our results support the hypothesis that environmental insults may be significant drivers of CRS pathogenesis through epigenetic mechanisms that result in dysregulated mRNA transcription and cytokine expression. The most novel part of this study is our multi-omics approach that used integration of epigenetic (DNA methylation), transcriptomic (mRNA), and proteomic (cytokine) data to uncover insights into CRS pathogenesis; this is the first of its kind in CRS etiopathogenesis. The multi-omics analysis clearly separated clusters of control and CRS subjects, demonstrating its validity in future research. The study also identified interactions of methylated DNA, mRNA, and cytokines in CRS pathogenesis, highlighting novel molecules and pathways that may be potential therapeutic targets.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1606255"},"PeriodicalIF":3.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From skin testing to molecular diagnostics: the precision leap in dust mite allergy diagnosis and clinical translation challenges.","authors":"Ming Han, Jindan Luo, Wenjing Zhou, Shuhui Wen, Yi Zhou, Yanjuan Ye, Xiaoli Ge","doi":"10.3389/falgy.2025.1598575","DOIUrl":"10.3389/falgy.2025.1598575","url":null,"abstract":"<p><p>Dust mites are ubiquitous in human living environments and represent the primary source of indoor air allergens worldwide. They are capable of triggering allergic rhinitis, conjunctivitis, asthma, atopic dermatitis, and other allergic conditions. Long-term avoidance of dust mite allergens should decrease sensitization, significantly improves skin lesions, and reduces both the development and severity of respiratory diseases. Therefore, early diagnosis of dust mite allergy is critical for effective treatment and intervention. This review summarizes the existing methods for detecting dust mite allergy, which include both <i>in vivo</i> and <i>in vitro</i> approaches-such as skin prick testing(SPT), atopy patch testing(APT), provocation tests, basophil activation test (BAT), and molecular component-resolved diagnostics(CRD)-and analyzes the underlying principles, advantages, and limitations of each method to serve as a reference for the development of future detection methods.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1598575"},"PeriodicalIF":3.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute airway eosinophilic inflammation model in mice induced by ovalbumin, house dust mite, or shrimp tropomyosin: a comparative study.","authors":"Liangyu Xu, Zichen Wei, Rongfang Wu, Siqi Kong, Jinlian Bin, Yuxin Gao, Lei Fang","doi":"10.3389/falgy.2025.1594028","DOIUrl":"10.3389/falgy.2025.1594028","url":null,"abstract":"<p><strong>Background: </strong>Ovalbumin (OVA) and house dust mite (HDM) are widely used allergenic proteins in murine models of allergic asthma. In our previous studies, shrimp tropomyosin (ST) was shown to induce type I hypersensitivity, including asthma-like responses. Here, we compared airway eosinophilic inflammation models induced by OVA, HDM, or ST using a protocol of three intraperitoneal (i.p.) sensitizations followed by a single intratracheal (i.t.) allergen challenge.</p><p><strong>Methods: </strong>C57BL/6J mice were sensitized via three i.p. injections of OVA, HDM, or ST mixed with Al(OH)₃, followed by a single i.t. challenge with the respective allergen. Lung transcriptomic analysis, plasma IgE levels, bronchoalveolar lavage (BAL) fluid cell counts, cytokine and chemokine mRNA levels, and histopathological assessments were performed to evaluate airway inflammation.</p><p><strong>Results: </strong>A single i.t. challenge with ST or HDM significantly increased the lung-to-body weight ratio, eosinophil infiltration, and mucus hypersecretion, accompanied by elevated mRNA levels of Th2 cytokines (<i>Il-4</i>, <i>Il-5</i>, <i>Il-13</i>) and increased the total cell count and eosinophil count in the BAL fluid. In contrast, OVA induced only mild eosinophilic inflammation, suggesting that repeated exposures may be required to elicit a robust allergic response. RNA sequencing and qRT-PCR further identified key chemokines associated with eosinophil recruitment (<i>Ccl-11</i>, <i>Ccl-24</i>), Th2 polarization (<i>Ccl-17</i>), and neutrophil activation (<i>Cxcl-1</i>).</p><p><strong>Conclusion: </strong>A single i.t. challenge of ST, similar to HDM, exhibits a potent ability to induce eosinophilic inflammation and Th2-type immune responses in a murine model of allergic asthma, surpassing the effects of OVA.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1594028"},"PeriodicalIF":3.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Two cases of hereditary angioedema in a Chinese family.","authors":"Yuanli Guo, Manli Qi, Jinluan Ding","doi":"10.3389/falgy.2025.1587904","DOIUrl":"10.3389/falgy.2025.1587904","url":null,"abstract":"<p><strong>Background: </strong>Hereditary angioedema (HAE) is a life-threatening condition characterized by repeated asymmetric cutaneous and mucosal edema. It is a rare autosomal dominant genetic disease with a mortality rate of 8.6%. Family survey of HAE in China is seldom reported since it is still under recognized.</p><p><strong>Case report: </strong>We reported two cases of HAE and a family survey conducted in Hebei Province, China. The proband was a woman who had edema for over 7 years. She was diagnosed with type I HAE in her 50s after a life-threatening asphyxia attack. Her elder brother was initially diagnosed with mild symptoms.</p><p><strong>Conclusion: </strong>Two diagnosed and three suspected patients were identified in our family survey. Family surveys are important method for identifying asymptomatic patients and preventing attacks. It is valuable for rescuing people from sudden death, particularly from asphyxia.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1587904"},"PeriodicalIF":3.3,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiplex IgE peanut panels: a critical appraisal of assay designs and the good, the bad, and the ugly features of the applied allergen components.","authors":"D de Boer, C J J Bijnens, M C Slot, C M G Nieuwhof, J A P Bons","doi":"10.3389/falgy.2025.1515294","DOIUrl":"10.3389/falgy.2025.1515294","url":null,"abstract":"<p><strong>Background: </strong>Multiplex allergy assays are currently well-established in allergy diagnostics. However, the different assays in terms of designs and performance are also claimed to be heterogeneous as no agreed standards and requirements are available.</p><p><strong>Objective: </strong>We aimed to compare the analytical assay designs of the ISAC, ALEX, and EUROLINE peanut (Ara h) panels and the features of the applied isoallergens and variants to create more awareness of the heterogeneity of multiplex allergy assays.</p><p><strong>Methods: </strong>We conducted a multi-source survey in publicly available data sources and among manufacturers and performed correlation studies using patients' serum samples.</p><p><strong>Results: </strong>The survey proved that the panels are indeed very heterogeneous in many ways, especially regarding the allergen component origin and isoallergen composition. Despite that, we found adequate correlations between IgE against the clinically relevant Ara h storage proteins measured by the panels. However, for the clinically relevant lipid transfer protein Ara h 9, the correlations were less adequate, which could be caused by the different Ara h 9 isoallergens used in the studied panels. For cross-reactive carbohydrate determinants (CCDs), the results were complicated, which also corresponds to the complex nature of CCDs and the different inhibition procedures. The detection of subpopulations of patients for all panallergens illustrated the heterogeneous nature of peanut IgE in general and of the peanut panels studied. Regarding the overall features provided for the three panels, we classified the peanut allergen components and CCDs by their good, bad, and even ugly features when used within these panels.</p><p><strong>Conclusions: </strong>Knowledge of the origin and respective isoallergen specifications of the peanut allergen components including the exact CCD composition is essential. Together with that of the variants, this should be documented more adequately in scientific studies and in the respective instructions for the use of multiplex allergy assays.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1515294"},"PeriodicalIF":3.3,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing allergy diagnosis: mass spectrometry as a complementary technique to the basophil activation test.","authors":"Nicole Wheeler, Miloslav Sanda, Lanya Rasool, Noha Elemary, Arda Alpan, Hamed Safi, Denise Loizou, Matthew Plassmeyer, Mikell Paige, Soren Ulrik Sonder, Oral Alpan, Michael Girgis","doi":"10.3389/falgy.2025.1568670","DOIUrl":"10.3389/falgy.2025.1568670","url":null,"abstract":"<p><p>Accurate diagnostic tools for allergic conditions are essential for effective treatment. Traditional methods, such as skin prick tests (SPT) and specific IgE measurements are widely used, but they have limitations in sensitivity and specificity for certain allergens. While the Basophil Activation Test (BAT) offers improved specificity, particularly for allergens such as peanuts and sesame, its practicality and accessibility remain challenges. Mass spectrometry (MS) has recently gained recognition as a promising complementary tool in allergy diagnostics, offering high analytical precision and the capability to detect a wide range of allergen-specific biomarkers. This review explores the integration of MS into allergy diagnostics, emphasizing its potential to enhance BAT applications, particularly for non-responders. We discuss the underlying mechanisms, recent research highlighting its efficacy, and the technical challenges that must be addressed for clinical adoption. Additionally, we examine the standardization requirements and ethical considerations necessary for MS to become a routine diagnostic tool. Finally, we consider the future of allergy diagnostics, highlighting how MS technology could contribute to more precise, personalized, and patient-centered care in allergy management.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1568670"},"PeriodicalIF":3.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluticasone propionate in chronic rhinosinusitis with nasal polyps (CRSwNP): an artificial intelligence-driven consensus.","authors":"Emilio Avallone, Raffaella Iannella, Antonella Di Lullo, Michele Grasso, Salvatore Musto, Enzo Piermichele Troncone, Giuseppe Tortoriello, Bernardino Cassiano, Simona Nappi, Gianluca Bava, Giovanna Piazzetta, Giovanni Tomacelli, Aurelio D'Ecclesia, Giacomo Spinato, Giacomo Matrone, Doriano Politi, Carlo De Luca, Claudio Caporale, Livio Presutti, Gabriele Molteni, Ernesto Pasquini, Francesco Panu, Simonetta Masieri, Stefano Di Girolamo, Giulio Cesare Passali, Luca de Campora, Giandomenico Maggiore, Domenico Di Maria","doi":"10.3389/falgy.2025.1594655","DOIUrl":"10.3389/falgy.2025.1594655","url":null,"abstract":"<p><strong>Introduction: </strong>Fluticasone propionate (FP) is a topical corticosteroid used to treat rhinosinusitis with nasal polyposis (CRSwNP). However, the need for a consensus on its use stems from the increasing focus on optimizing topical therapies to improve clinical outcomes and minimize systemic side effects.</p><p><strong>Materials and methods: </strong>The Butterfly Decisions AI platform facilitated the collection and integration of evaluations and feedback, facilitating an expert consensus on 13 statements.</p><p><strong>Results: </strong>The participants agreed highly on the different statements. The experts agreed that FP effectively reduces the need for surgery and controls the symptoms of CRSwNP. The use of advanced delivery systems significantly improved drug delivery and therapeutic outcomes. Treatment with FP was associated with a reduction in the recurrence of nasal polyps and an improvement in the patient's quality of life.</p><p><strong>Conclusions: </strong>FP, as other equal corticosteroids, represents a first-line local therapy for patients with CRSwNP without complicating comorbidities due to its high efficacy and low systemic bioavailability. The Butterfly Decisions platform has demonstrated the effectiveness of integrating AI tools into clinical decision-making, improving the transparency and objectivity of assessments.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1594655"},"PeriodicalIF":3.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of tryptase genotyping in the screening, diagnosis, and management of systemic mastocytosis.","authors":"Jeremy C McMurray, Brandon J Schornack, Joaquin Villar, Tracy I George, Nathan A Boggs","doi":"10.3389/falgy.2025.1599358","DOIUrl":"10.3389/falgy.2025.1599358","url":null,"abstract":"<p><p>Tryptase genotyping has an expanding role in the screening, diagnosis, and management of patients with systemic mastocytosis (SM). Reference ranges for basal serum tryptase (BST) based on increased <i>TPSAB1</i> gene copy number can guide whether a patient's BST value is normal according to their specific tryptase genotype. Patients with an elevated BST based upon their tryptase genotype should be offered a bone marrow biopsy with sample evaluation by a hematopathologist. Tryptase genotyping is required when assessing patients for the WHO minor criterion, BST > 20 ng/ml, especially in those with monoclonal mast cell activation syndrome, bone marrow mastocytosis (BMM), and indolent systemic mastocytosis (ISM) when the major criterion is not met. Additionally, in patients with non-advanced SM, tryptase genotyping helps determine whether a patient with hereditary-alpha tryptasemia (HαT) has BMM with a BST < 125 ng/ml or fulfills the B-finding of BST > 200 ng/ml through application of a correction factor. Understanding a patient's BST level based upon their tryptase genotype also is helpful in guiding when to pursue a repeat bone marrow biopsy in patients with SM treated with a tyrosine kinase inhibitor (TKI). However, TKIs have variable KIT D816V as well as wild type KIT inhibition. Given this variable KIT inhibition, ongoing and future clinical trials with selective TKIs should report whether patients with SM and HαT experience normalization or persistent elevation of BST values as this is essential in understanding the expected treatment response and when to assess for pathological remission in the bone marrow.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1599358"},"PeriodicalIF":3.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Urticaria and mimickers of urticaria.","authors":"R Maximiliano Gomez, Beré Kezia Mahoney","doi":"10.3389/falgy.2025.1625291","DOIUrl":"https://doi.org/10.3389/falgy.2025.1625291","url":null,"abstract":"","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1625291"},"PeriodicalIF":3.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}