Frontiers in allergy最新文献

{"title":"Real world evidence of dupilumab effectiveness in a Colombian cohort of patients diagnosed with severe asthma.","authors":"Abraham Alí-Munive, Josefina Zakzuk, Nelson J Alvis-Zakzuk, Elizabeth García, Claudia Diaz Bossa, Diana Jimena Cano Rosales, Fabio Bolívar, Alejandro Carreño, Paula Rodríguez-Ordoñez, Natalia Gómez-Ardila, Gabriel Patiño, Sergio Londoño, Carlos A Torres-Duque","doi":"10.3389/falgy.2025.1564033","DOIUrl":"10.3389/falgy.2025.1564033","url":null,"abstract":"<p><strong>Background: </strong>Real-world effectiveness and safety of dupilumab for asthma treatment have been evaluated in USA and Europe, but research from Latin America is lacking. We aimed to describe the effectiveness of dupilumab in terms of changes in the annual rate of asthma exacerbations (AER) and their impact on lung function in Colombian patients.</p><p><strong>Methods: </strong>Real-world, descriptive, and multi-centric (five clinical centers located in four different cities in Colombia) retrospective study that included patients aged ≥18 years with severe asthma, as defined by the GINA criteria. Data were collected from medical records of medical centers specialized in pulmonology or allergy care) spanning from 12 months before the prescription of dupilumab (baseline) to 25 months later. Follow-up data were categorized at various time points (2-4, 5-7, 8-10, 11-13, 14-18, and 19-25 months). Main outcomes were annual rates of asthma exacerbations (emergency visits or hospitalizations due to asthma), lung function measured through FEV₁ and percent predicted FEV₁ (FEV₁pp), and Asthma Control Test (ACT) scores. Outcome rates were compared between baseline and follow-up data points. FeNO and absolute eosinophil counts throughout the observed period was also explored.</p><p><strong>Results: </strong>A total of 98 patients were included. At baseline, the mean AER was 0.61 ± 1.45 per adult. Lower AER were observed after one (0.11 ± 0.54) or two-years (0.08 ± 0.20) of dupilumab treatment (<i>p</i> = 0.03). FEV1 measurements after one or two years of dupilumab treatment were significantly lower than baseline (<i>p</i> = 0.03). Mean change from baseline in FEV₁ was 302.1 ± 481.97 ml (<i>n</i> = 19), 282.00 ± 231.99 ml (<i>n</i> = 10), and 248.18 ± 281.21 ml (<i>n</i> = 11) in the 2-4-, 11-13-, and 19-25-month follow-up periods, respectively. FEV₁pp showed higher but not significant values from the 2-4-month period, with a median change of 12.5% (IQR: 0.3, 21.5). The proportion of patients with uncontrolled asthma (ACT ≤15) decreased from 68% at baseline to 19% and 20% at year-one and second year of treatment, respectively (<i>p</i> = 0.003). The proportion of patients reaching FeNO values below 25 ppb was lower after dupilumab treatment than in baseline (<i>p</i> < 0.0001). Of the total cohort (<i>n</i> = 99), 15 (15.2%) experienced an adverse event (AE). Three patients discontinued dupilumab permanently, and two discontinued dupilumab due to AEs.</p><p><strong>Conclusions: </strong>Dupilumab is an effective and well-tolerated treatment for severe asthma in Colombia, resulting in reduced exacerbations and improved asthma control, lung function, and FeNO levels.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1564033"},"PeriodicalIF":3.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining \"Normal\" basal serum tryptase levels: a context-dependent approach to improve diagnostics in systemic mastocytosis.","authors":"Francesca Crupi, Jessica Caroprese, Francesco Mannelli","doi":"10.3389/falgy.2025.1592001","DOIUrl":"10.3389/falgy.2025.1592001","url":null,"abstract":"<p><p>Serum tryptase level has long been used as a biomarker in clinical practice to suspect mast-cell associated disorders. Basal serum tryptase (BST) above 20 ng/ml represents a minor criterion according to WHO and ICC for the diagnosis of systemic mastocytosis (SM) although normal BST value does not exclude the diagnosis. Nevertheless, BST can be elevated also due to non-SM related diseases as well as hereditary alpha-tryptasemia (H<i>α</i>T), an autosomal dominant germline condition that consists in the increase of the number of copies of the <i>TPSAB1</i> gene encoding the alpha isoform of tryptase. The prevalence of H<i>α</i>T is estimated at around 5% of the general population. Individuals with H<i>α</i>T genotype can be asymptomatic; however, some of them can experience a range of symptoms with a large variability in type and severity, posing a problem of differential diagnosis with SM. The increasing awareness on a potentially SM underlying diverse clinical manifestations has led to excessive BST testing by several specialists, a trend that risks over interpreting some borderline results. The interpretation of elevated BST should thus be carefully appraised in specific clinical contexts on individual basis. This review is intended to examine the existing literature on this topic and offers a guide for interpreting the BST to rationalize the application of invasive diagnostic procedures.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1592001"},"PeriodicalIF":3.3,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics technology reveals the changes in gut microbiota to stimulate aromatic amino acid metabolism in children with allergic rhinitis and constipation.","authors":"Chunyan Wang, Haiying Liu, Xiaoli Li, Wei Kong, Hui Wu, Congfu Huang","doi":"10.3389/falgy.2025.1562832","DOIUrl":"10.3389/falgy.2025.1562832","url":null,"abstract":"<p><strong>Background: </strong>Comorbid allergic rhinitis and constipation (ARFC) in children are associated with gut microbiota (GM) dysbiosis and metabolic perturbations; however, the underlying mechanistic interplay remains unclear.</p><p><strong>Objective: </strong>This multi-omics study aimed to characterize GM and fecal metabolomic signatures in preschool ARFC children and elucidate microbial-metabolite interactions driving dual symptomatology.</p><p><strong>Methods: </strong>Fecal samples from 16 ARFC and 15 healthy control (HC) children underwent high-throughput absolute quantification 16S rRNA sequencing and untargeted metabolomics. Differential taxa and metabolites were identified via LEfSe and OPLS-DA (VIP > 1, false discovery rate (FDR) <i>q</i> < 0.05). Microbial-metabolite networks were reconstructed using genome-scale metabolic modeling and KEGG pathway analysis.</p><p><strong>Results: </strong>The ARFC group exhibited distinct β-diversity (<i>P</i> = 0.031), marked by elevated <i>Hungatella</i>, <i>Tyzzerella</i>, and <i>Bifidobacterium longum</i> (<i>P</i> < 0.05). Metabolomics revealed upregulated aromatic amino acids (AAAs), neurotransmitters, and bile acids (FDR <i>q</i> < 0.05), with enrichment in tryptophan/tyrosine pathways (<i>P</i> < 0.01). Bioinformatic modeling linked <i>Hungatella</i> to tryptophan hydroxylase (EC:1.14.16.4), driving serotonin synthesis, and <i>Tyzzerella</i> to indoleamine 2,3-dioxygenase (EC:1.13.11.52), promoting kynurenine production. <i>Bifidobacterium longum</i> correlated with phenylalanine hydroxylase (EC:1.14.16.1), enhancing phenylalanine derivatives. A combined GM-metabolite diagnostic model demonstrated robust accuracy (AUC = 0.8).</p><p><strong>Conclusion: </strong>GM dysbiosis in ARFC children activates AAA metabolism, generating neuroactive and pro-inflammatory metabolites that may exacerbate allergic and gastrointestinal symptoms. These findings highlight microbial-metabolite axes as therapeutic targets. Study limitations include cohort size and lack of disease-specific controls, necessitating validation in expanded cohorts.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1562832"},"PeriodicalIF":3.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of seasonal exposure in aeroallergen-sensitised patients with irritable bowel syndrome-diarrhoea.","authors":"Carlo Maria Rossi, Marco Vincenzo Lenti, Stefania Merli, Martina Fiorita, Antonio Lo Bello, Mario Andrea Latorre, Paola Ilaria Bianchi, Nicola Aronico, Annalisa De Silvestri, Antonio Di Sabatino","doi":"10.3389/falgy.2025.1568595","DOIUrl":"10.3389/falgy.2025.1568595","url":null,"abstract":"<p><strong>Background: </strong>Pollen allergy may influence irritable bowel syndrome (IBS) symptoms; however, available data are scant.</p><p><strong>Aims: </strong>This study aims to assess symptom variability in atopic IBS patients.</p><p><strong>Methods: </strong>We retrospectively analysed consecutive adult IBS patients evaluated between 2021 and 2024. Patients from the overall IBS cohort and the IBS-diarrhoea (IBS-D) subgroup were classified according to their sensitisation into grass-positive, house dust mite (HDM)-positive, or unsensitised. Symptom burden was assessed using the gastrointestinal symptom rating scale (GSRS) and a visual analogue scale for abdominal pain/distension, both outside the season period (T0) and during the pollination season (T1).</p><p><strong>Results: </strong>A total of 61 IBS patients were recruited (median age 34 years, IQR 25-50, F:M ratio 3.6:1), including 38 patients (62.8%) with IBS-D (median age 30 years, IQR 28-47, F:M ratio 2.8:1). Atopy was common in the IBS-D subgroup, particularly with respiratory manifestations. The mean GSRS significantly (<i>p</i> < 0.01) increased at T1 (variance of 3.4 points) only in grass-sensitised patients as opposed to those sensitised to HDM or unsensitised ones; this effect was present only in the IBS-D subgroup, while no significant variation was observed in the overall cohort.</p><p><strong>Conclusions: </strong>Pollination season influences symptoms in IBS-D patients sensitised to seasonal allergens.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1568595"},"PeriodicalIF":3.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the multicomponent ALEX array data to examine patterns of sensitization in Cape Town, South Africa.","authors":"Sarah Pedretti, Alexander Sittmann, Arné Von Hagen, Jonny Peter","doi":"10.3389/falgy.2025.1572509","DOIUrl":"10.3389/falgy.2025.1572509","url":null,"abstract":"<p><strong>Introduction: </strong>This study analysed allergen sensitization patterns in Cape Town, a biodiversity-rich region with a Mediterranean climate, using ALEX® and ALEX²® multiplex component-resolved diagnostics tools. It aimed to address gaps in allergen sensitisation pattern data and complement aerobiological monitoring.</p><p><strong>Methods and results: </strong>A retrospective review of 708 adults and children attending two tertiary allergy clinics (2019-2024) found that house dust mites were the most common allergens, affecting 50%-60% of participants, with Der p 23 particularly prevalent (53%). Grass pollen sensitization was also high (46%), with 85% sensitised to the C4 grass Bermuda. Tree pollen sensitisation occurred in 29% with 14% sensitised to a diverse range of trees but neither London plane nor Cypress currently recommended in limited testing panels. Common food allergens included fruits (30%), seafood (27%), and nuts (25%), often linked to pollen cross-reactivity.</p><p><strong>Conclusion: </strong>Our study confirms a known pattern of aeroallergen sensitisation for a coastal temperate region, with increasing pollen sensitisation, particular C4 grasses. Clinicians should be aware of the diversity of tree pollen sensitisation, cross-reactivity patterns between food and pollen sensitisations and rates of minor allergen sensitisations for Blomia and animal danders when considering allergen-immunotherapies.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1572509"},"PeriodicalIF":3.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A deep dive into shrimp allergy: clinical spectrum of shrimp allergy in a Tunisian pilot study.","authors":"Dhouha Krir, Imen Zamali, Yousr Galai, Ahlem Ben Hmid, Ines Ben Sghaier, Yosra Nasri, Hayet Kebaier, Hechmi Louzir, Nissaf Ben Alaya Bouafif, Mélika Ben Ahmed, Samar Samoud","doi":"10.3389/falgy.2025.1568475","DOIUrl":"https://doi.org/10.3389/falgy.2025.1568475","url":null,"abstract":"<p><p>Shrimp allergy has emerged as a growing health concern in Tunisia, likely due to changing dietary habits. This study aimed to characterize the clinical features of shrimp-allergic patients and investigate potential cross-reactivity with house dust mites (HDMs) and snails using <i>in vitro</i> diagnostic methods. Thirty-one patients with a self-reported history of shrimp allergy were referred to the Clinical Immunology Department of the Pasteur Institute of Tunis. Total IgE and Serum-specific IgE (sIgE) levels to shrimp, snail, and HDMs, as well as recombinant allergens rPen a1 and rDer p10, were measured using the ImmunoCAP® immunoassay. The study population consisted mainly of young adults [mean age: 15.5 years (10-27.2)], with a male-to-female ratio of 1.4. The most common symptoms were oropharyngeal pruritus and urticaria. Shrimp allergy was confirmed in 54.8% of patients, with a median sIgE titer of 0.18 [0.03-28.8] kUA/L. Among these patients, 58.8% exhibited cross-reactivity, predominantly with snails [median sIgE: 3.07 (0.04-16.85) kUA/L]. Among shrimp-allergic patients, 70.5% tested positive for rPen a1 [median sIgE: 28.42 (5.78-51.05) kUA/L], while 58.8% were positive for rDer p10 (median sIgE: 0.56 [5 × 10^-5-87.95] kUA/L). The median total IgE level was 297 [158.6-475] IU/ml, significantly higher in shrimp-allergic patients (<i>p</i> = 0.005). The median shrimp sIgE/total IgE ratio was 0.001 [0-0.069], also significantly elevated in shrimp-sensitized individuals (<i>p</i> = 0.005). Multivariable analysis showed significant correlations between total IgE and shrimp sIgE, rPen a1, and rDer p10 levels (<i>p</i> = 0.043, <i>p</i> = 0.045, <i>p</i> = 0.043, respectively), while no correlation was found with d1 or snail sIgE after adjusting for age. rDer p10 and f24 were the strongest predictors of sIgE to snail, with standardized coefficients of 8.785 and -5.028, respectively. However, these associations did not reach statistical significance. This study underscores the critical role of tropomyosin as a primary allergen in shrimp allergy in Tunisia, highlighting its importance in immunodiagnosis and its strong association with HDMs and snail sensitization. Further research is needed to explore HDMs sensitization in patients who are negative for rPen a1 and rDer p10.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1568475"},"PeriodicalIF":3.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"T2 cytokine-driven alarmin and antiviral responses in asthma: insights into immune modulation and the role of IL-4Rα targeting.","authors":"Jelena Pesic, Juan José Nieto-Fontarigo, Katerina Pardali, Stephen Delaney, Henric Olsson, Lena Uller","doi":"10.3389/falgy.2025.1576816","DOIUrl":"https://doi.org/10.3389/falgy.2025.1576816","url":null,"abstract":"<p><strong>Introduction: </strong>Severe asthma is a heterogeneous condition characterized by distinct phenotypes and endotypes based on clinical or biological characteristics. Interleukin (IL) 4 and IL-13 are central cytokines in the type 2 (T2) immune response, crucial for T2 inflammation. Biologic therapies targeting the IL-4/IL-13 pathway, such as anti-IL-4Rα monoclonal antibodies (mAbs), have shown improvements in lung function and reductions in exacerbation rates for severe asthma. However, the precise role of early innate immune responses in mediating these therapeutic benefits remains unclear. This study investigates the acute and chronic effects of T2 cytokines on healthy and asthmatic bronchial epithelial cells (BECs), addressing the mechanisms underlying IL-4Rα mAb therapy in acute T2-driven inflammatory conditions and rhinoviral infection in asthma BECs.</p><p><strong>Methods: </strong>Human BECs from healthy and asthma donors were cultured at the air-liquid interface (ALI) and stimulated with IL-4 and IL-13, acutely or chronically, with or without IL-4Rα mAb, followed by rhinovirus (RV) infection. Cells were harvested 24 h post-infection. Expression levels of chemokines, alarmins, and antiviral mediators were quantified using RT-qPCR and multiplex ELISA.</p><p><strong>Results: </strong>CCL26 expression increased in response to IL-4 or IL-13 in healthy and asthmatic BECs, and this effect was significantly more pronounced in asthmatic BECs. IL-4Rα mAb treatment effectively inhibited CCL26 production in BECs from asthma patients. IL-4 and RV infection induced a significant increase in thymic stromal lymphopoietin (TSLP) levels in BECs from asthma compared with healthy, which was normalized by IL-4Rα mAb. No significant effects of T2 cytokines on alarmins were observed in healthy BECs. Chronic exposure to T2 cytokines following RV infection significantly decreased TSLP and IFN<i>λ</i>1 but increased IFNβ, specifically in asthmatic BECs.</p><p><strong>Conclusions: </strong>Our study on T2 cytokines' effects on BECs reveals that asthma BECs have an increased inflammatory response to IL-4 and IL-13. These responses, marked by increased CCL26 and TSLP, were effectively mitigated by IL-4Rα mAb. Importantly, this treatment maintained essential antiviral defenses, such as IFNβ, even post-rhinoviral infection. Our results suggest a novel mechanism by which IL-4Rα mAb controls exacerbations and improves lung function.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1576816"},"PeriodicalIF":3.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The changing epidemiology of paediatric childhood asthma and allergy in different regions of the world.","authors":"D J Adamko, Kyla J Hildebrand","doi":"10.3389/falgy.2025.1584928","DOIUrl":"https://doi.org/10.3389/falgy.2025.1584928","url":null,"abstract":"<p><p>Allergic disorders encompass a variety of conditions including asthma, atopic dermatitis, food allergy, allergic rhinitis, and eosinophilic esophagitis. These atopic disorders are connected via an abnormal host immune response to the environment. A series of longitudinal cross-sectional studies conducted over the past 3 decades have reported on the epidemiological trends that contribute towards the development of pediatric asthma and allergic disease. Infant birth cohort studies assessing the microbiome have offered clues as to the underlying biological mechanisms and basis for allergic disease. Why this abnormal immune response is occurring is the basis of decades of research and the reasons for this chapter. Our understanding of the biology of the immune system has increased exponentially with the advances in genomic testing, providing further opportunity for targeted treatments and more importantly, primary prevention of atopic disease.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1584928"},"PeriodicalIF":3.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Identification of a novel mutation, c.1067T > A, in the <i>SERPING1</i> gene in a Chinese male with type 1 hereditary angioedema.","authors":"Wenjin Du, Ke Yang, Qiuxing Zhang, Xianghua Lin, Wenchao Zhang, Weili Guo, Zhaoji Meng, Siqin Wang","doi":"10.3389/falgy.2025.1554940","DOIUrl":"10.3389/falgy.2025.1554940","url":null,"abstract":"<p><p>Hereditary angioedema (HAE) is a rare autosomal dominant genetic disorder characterized by recurrent, unpredictable episodes of angioedema that commonly involve the face, limbs, respiratory tract, and gastrointestinal tract. Clinical presentations vary substantially among individuals, increasing the likelihood of misdiagnosis or missed diagnosis. In severe cases, if not properly managed, laryngeal edema can result in asphyxiation or even death. Here, we report a Chinese male patient who experienced recurrent limb swelling and abdominal pain. Laboratory tests revealed low levels of complement C4 and C1 inhibitors, along with impaired C1 inhibitor function. Genomic DNA extracted from peripheral blood samples underwent PCR amplification and Sanger sequencing, which identified a <i>de novo</i> heterozygous mutation in the <i>SERPING1</i> gene at chr11:57379227, confirming a novel missense mutation NM_000062.c.1067T > A (p.V356E). Ultimately, the patient was diagnosed with HAE-C1INH-Type1 and successfully protected from recurrent attacks through subcutaneous administration of lanadelumab.</p>","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1554940"},"PeriodicalIF":3.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: The socio-economic burden of food allergy: from households to healthcare systems.","authors":"Jennifer L P Protudjer, Lucy A Bilaver","doi":"10.3389/falgy.2025.1608998","DOIUrl":"https://doi.org/10.3389/falgy.2025.1608998","url":null,"abstract":"","PeriodicalId":73062,"journal":{"name":"Frontiers in allergy","volume":"6 ","pages":"1608998"},"PeriodicalIF":3.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}