Free neuropathology最新文献

{"title":"Trends in neuropathology training in Sub-Saharan Africa - current curricula, resource gaps, and the potential of virtual microscopy and telemedicine.","authors":"Habiblah Jagunmolu, Emmanuel Oyetola, Kamil Ajagbe, Samuel Oyelude, Muminat Jubreel, Oluwatosin Afolayan, Dorothy Abimbola, AbdurRoqeeb Ismail, Kaothar Oyeniran, Mukhtar Ibrahim, Bright Oguntola","doi":"10.17879/freeneuropathology-2026-9140","DOIUrl":"10.17879/freeneuropathology-2026-9140","url":null,"abstract":"<p><p><b>Introduction</b>: Neuropathology is important in the diagnosis of neurologic and neuro-oncologic diseases. But despite its immense importance, it remains underrepresented in medical training across different parts of Sub-Saharan Africa. Training in this region is limited by a low number of specialists (e.g., a ratio of 1.7 million inhabitants per an unspecialized pathologist), fragmented data, poor infrastructure, and minimal exposure. Most times, neuropathology is embedded in general pathology curricula with limited mentorship, specialized facilities, and tailored subspecialty pathways (e.g., Nigeria, Tanzania). But despite these prevailing challenges, digital tools like telepathology and virtual microscopy may help bridge those gaps. <b>Aim</b>: This scoping review aims to understand the structure of existing neuropathology training and identify important gaps in structure and resources across Sub-Saharan Africa. It also seeks to explore how regional and global collaborations and digital innovations can be integrated to bridge these gaps. <b>Methodology</b>: Using PRISMA-ScR guidelines, we searched literature published between 2000 and 2025 across major databases such as PubMed, Scopus, Web of Science, AJOL, and grey sources. We included and thematically analyzed studies that focused on training in neuropathology, workforce, and digital tools in Sub-Saharan Africa. We mapped out data to capture country, program type, curriculum content, resource availability, and digital tool integration. Quantitative synthesis summarized the frequency and geographic distribution of programs, while qualitative thematic analysis identified recurring patterns in training gaps, infrastructural limitations, and the application of virtual microscopy and telepathology. <b>Result</b>: We reviewed eleven studies that indicate limited neuropathology programs, an extremely low number of neuropathologists (e.g., 0.4-0.6 per million in many Sub-Saharan Africa nations), inadequate mentorship, and limited training resources. However, telepathology and virtual microscopy show improved accuracy in diagnosis and quality training (e.g., Tanzania recorded a 35 % increment in accuracy by specialized pathologists using telepathology over general pathologists). Strengthening international collaborations also demonstrates feasibility and enhanced quality training. <b>Conclusion</b>: Neuropathology in Sub-Saharan Africa is underdeveloped and fragmented; however, the increasing access to newer digital solutions presents low-cost options as practical alternatives for overcoming diagnostic and training obstacles. To narrow these gaps, the track toward becoming a subspecialist in neuropathology should be formed, accessible digital libraries of learning materials must be developed, and regional and international telepathology networks should be strengthened.</p>","PeriodicalId":73056,"journal":{"name":"Free neuropathology","volume":"7 ","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12801552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145992039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central nervous system schwannoma, VGLL-fused (EWSR1::VGLL1 fusion) with neuroblastoma-like cell dense areas in the frontal lobe of a young man with schwannomatosis due to a germline LZTR1 mutation.","authors":"David G Munoz, Sunit Das, Ju-Yoon Yoon, Robert Siddaway, Adrian Levine, Kenneth D Aldape","doi":"10.17879/freeneuropathology-2026-8898","DOIUrl":"10.17879/freeneuropathology-2026-8898","url":null,"abstract":"<p><p>We report a central nervous system schwannoma, <i>VGLL</i>-fused in a young man's frontal lobe. Somatic abnormalities included an <i>EWSR1::VGLL1</i> fusion, which incorporated the entire translated region of <i>VGLL1</i>, but excluded most domains of <i>EWSR1</i>. The tumor histologically merged with the brain, and showed both schwannoma-like and neuroblastoma-like areas. A germline <i>LZTR1</i> mutation was subsequently identified, implying the patient suffered from schwannomatosis.</p>","PeriodicalId":73056,"journal":{"name":"Free neuropathology","volume":"7 ","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12782191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145954174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"65th Annual Meeting of the Canadian Association of Neuropathologists - Association canadienne des neuropathologistes (CANP-ACNP): October 23^rd-25^th, 2025 Banff, Alberta.","authors":"","doi":"10.17879/freeneuropathology-2025-9165","DOIUrl":"https://doi.org/10.17879/freeneuropathology-2025-9165","url":null,"abstract":"","PeriodicalId":73056,"journal":{"name":"Free neuropathology","volume":"6 ","pages":"23"},"PeriodicalIF":0.0,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12676885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145702787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Free Neuropathology: A bibliometric impact analysis.","authors":"Georg Haase, Marta Margeta, Ralf Mersmann, Werner Paulus","doi":"10.17879/freeneuropathology-2025-9124","DOIUrl":"10.17879/freeneuropathology-2025-9124","url":null,"abstract":"","PeriodicalId":73056,"journal":{"name":"Free neuropathology","volume":"6 ","pages":"22"},"PeriodicalIF":0.0,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12642952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145607816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histologic and molecular characterization of a <i>MAZ::NCOA2</i> fusion-positive intracranial neoplasm.","authors":"Elliot Stalter, Claire Voyles, Leonardo F Freitas, Martha M Quezado, Brian J Dlouhy, Andrew Groves, Osorio Lopes Abath Neto","doi":"10.17879/freeneuropathology-2025-9012","DOIUrl":"10.17879/freeneuropathology-2025-9012","url":null,"abstract":"","PeriodicalId":73056,"journal":{"name":"Free neuropathology","volume":"6 ","pages":"21"},"PeriodicalIF":0.0,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12612709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145544080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical perfusion in brain banking: methods of assessment and relationship to the postmortem interval.","authors":"Macy Garrood, Alicia Keberle, Gabriel A Taylor, Emma L Thorn, Claudia De Sanctis, Kurt Farrell, John F Crary, Jordan S Sparks, Andrew T McKenzie","doi":"10.17879/freeneuropathology-2025-8880","DOIUrl":"10.17879/freeneuropathology-2025-8880","url":null,"abstract":"<p><p>The mechanical perfusion of solutions through the cerebrovascular system is critical for several types of postmortem research. However, achieving consistently high-quality perfusion in this setting is challenging. Several previous studies have reported that longer postmortem intervals are associated with decreased perfusion quality, but the mechanisms and temporal progression of perfusion impairment are poorly understood. In this study, we describe our experience in developing a protocol for <i>in situ</i> perfusion of the postmortem brain in human whole-body donors (n = 77). Through the evaluation of different approaches, we found that cannulation of the internal carotid arteries combined with clamping of the vertebral arteries allows targeted perfusion of the brain. We evaluated perfusion quality through three complementary methods: gross anatomical appearance, CT imaging, and histology. These quality assessment measures were partially correlated across donors, indicating that they offer complementary perspectives on perfusion quality. Correlational analysis of our cohort of banked brains confirms that perfusion quality decreases as the postmortem interval increases, with a heterogenous pattern across brain regions. Our findings provide data for optimizing brain banking protocols and suggest future directions for investigating the mechanisms of postmortem perfusion impairment.</p>","PeriodicalId":73056,"journal":{"name":"Free neuropathology","volume":"6 ","pages":"20"},"PeriodicalIF":0.0,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12557960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145395769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ACOX1 gain-of-function post-mortem neuropathology is distinct from ACOX1 loss-of-function: case report and literature review.","authors":"Zita Hubler, Kaleigh Filisa Roberts, Nima Sharifai, Julia Sim, Sophia A Hung, Grace E Robvais, Alan Pestronk, Robert E Schmidt, Sonika Dahiya, Robert C Bucelli","doi":"10.17879/freeneuropathology-2025-8894","DOIUrl":"10.17879/freeneuropathology-2025-8894","url":null,"abstract":"","PeriodicalId":73056,"journal":{"name":"Free neuropathology","volume":"6 ","pages":"19"},"PeriodicalIF":0.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12519239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145304533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A malignant choroid plexus tumor with heterologous differentiation and BAP1 deletion suggesting choroid plexus blastoma.","authors":"Arnault Tauziède-Espariat, Alice Métais, Léa Guerrini-Rousseau, Farah Sassi, Lauren Hasty, Raphaël Saffroy, Volodia Dangouloff-Ros, Kévin Beccaria, Euphrasie Servant, Pascale Varlet","doi":"10.17879/freeneuropathology-2025-8899","DOIUrl":"10.17879/freeneuropathology-2025-8899","url":null,"abstract":"","PeriodicalId":73056,"journal":{"name":"Free neuropathology","volume":"6 ","pages":"18"},"PeriodicalIF":0.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"69th Annual Meeting of the German Society of Neuropathology and Neuroanatomy (DGNN) - Meeting Abstracts: September 25-27, 2025 Frankfurt am Main, Germany.","authors":"","doi":"10.17879/freeneuropathology-2025-8974","DOIUrl":"https://doi.org/10.17879/freeneuropathology-2025-8974","url":null,"abstract":"<p><p>Sehr geehrte Damen und Herren, liebe Kolleginnen und Kollegen, im Namen der Deutschen Gesellschaft für Neuropathologie und Neuroanatomie heiße ich Sie herzlich willkommen zur 69. Jahrestagung unserer Fachgesellschaft, die in diesem Jahr zudem das 75-jährige Jubiläum der DGNN feiert. Dieses besondere Jubiläum gibt uns Anlass, auf die Wurzeln und die beeindruckende Entwicklung unserer Fachgesellschaft zurückzublicken. Die Frankfurter Schule mit Persönlichkeiten wie Carl Weigert und Ludwig Edinger legte wesentliche Grundlagen für die Neurowissenschaften, deren Bedeutung bis heute kaum zu überschätzen ist. Ein entscheidender Schritt in der Geschichte unseres Faches war der Zusammenschluss der Neuropathologen in der \"Arbeitsgemeinschaft morphologisch arbeitender Neurologen und Psychiater\". Unterstützt durch den Pathologen Prof. Lauche und die Frankfurter Edinger-Stiftung fanden im Mai 1950 Vorgespräche statt, die schließlich am 7. Oktober 1950 zur Gründungsversammlung der \"Vereinigung Deutscher Neuropathologen\" führten. Diese Gründung legte den Grundstein für die heutige DGNN, die seit 75 Jahren als wissenschaftliche Plattform für Austausch und Fortschritt im Bereich der neuropathologischen Forschung dient. Besonders hervorheben möchte ich den hohen Stellenwert der Nachwuchsförderung in unserer Gesellschaft. Seit jeher ist es ein zentrales Anliegen der DGNN, junge Wissenschaftlerinnen und Wissenschaftler zu unterstützen, zu fördern und ihnen eine Plattform für ihre wissenschaftliche Entwicklung zu bieten. Nur durch die gezielte Förderung des wissenschaftlichen Nachwuchses können wir die Zukunft unseres Fachgebiets sichern und kontinuierlich neue Impulse für die Neuropathologie setzen. Der Kongress 2025 in Frankfurt am Main bietet uns erneut die Gelegenheit, in Vorträgen und Diskussionen die neuesten wissenschaftlichen Erkenntnisse zu erörtern sowie den kollegialen Austausch zu pflegen. Besonders freue ich mich auf das breite Spektrum an Themen und den angeregten Dialog, der unsere Fachgesellschaft lebendig hält. Mein Dank gilt allen Mitgliedern und Unterstützern, die die DGNN mit ihrem Engagement und ihrer Leidenschaft prägen und voranbringen. Ich wünsche uns allen einen erfolgreichen und inspirierenden Kongress sowie ein bedeutungsvolles Jubiläumsjahr. Mit herzlichen Grüßen Karl Heinz Plate Frankfurt am Main, im August 2025.</p>","PeriodicalId":73056,"journal":{"name":"Free neuropathology","volume":"6 ","pages":"17"},"PeriodicalIF":0.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathologic evidence of intimal hyperplasia in carotid artery webs associated with stroke.","authors":"Farhan Khan, Alisa Nobee, Skylar Lewis, John E Donahue, Shadi Yaghi","doi":"10.17879/freeneuropathology-2025-7139","DOIUrl":"10.17879/freeneuropathology-2025-7139","url":null,"abstract":"<p><p><b>Background:</b> Carotid artery webs (CWs) are an underrecognized cause of ischemic stroke, particularly in younger patients who lack conventional vascular risk factors. CWs are thought to represent an intimal variant of fibromuscular dysplasia (FMD); however, histopathologic data supporting this hypothesis remain limited. We report a case series of three patients with CW-related ischemic stroke who underwent carotid endarterectomy (CEA), allowing for histological analysis of the resected specimens. <b>Methods:</b> We retrospectively reviewed patients admitted to a Comprehensive Stroke Center between January 2015 and April 2025 with ischemic stroke or transient ischemic attack attributed to an ipsilateral carotid web who subsequently underwent carotid endarterectomy. Clinical data, imaging findings, and histopathologic features were analyzed. All cases met criteria for embolic stroke of undetermined source (ESUS) prior to surgery. <b>Results:</b> Three patients with CW-related stroke underwent carotid endarterectomy following recurrent events or high embolic risk. In two cases, superimposed thrombi led to initial misdiagnoses such as soft plaque or dissection. Histopathologic analysis consistently demonstrated fibrovascular tissue with intimal fibroid hyperplasia and myxoid degeneration, without lipid-rich plaques or inflammatory infiltrates. No patients experienced recurrent stroke or TIA by the time of their last documented follow-up. <b>Conclusions:</b> CWs represent a distinct non-atherosclerotic pathology characterized by intimal hyperplasia and myxoid degeneration. Superimposed thrombus may complicate diagnosis, often mimicking plaque or dissection. Advanced imaging, including MR vessel wall imaging and intravascular optical coherence tomography (OCT), can aid in accurate identification. Carotid revascularization may be effective in selected patients, particularly those with recurrence or ESUS. Prospective studies are needed to inform standardized diagnostic and therapeutic strategies.</p>","PeriodicalId":73056,"journal":{"name":"Free neuropathology","volume":"6 ","pages":"16"},"PeriodicalIF":0.0,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}