Fortune journal of health sciences最新文献_第4页

Technological Innovations in COVID-19 Diagnostics in Singapore 新加坡COVID-19诊断技术创新

Fortune journal of health sciences Pub Date : 2023-01-01 DOI: 10.26502/fjhs.127

Wenfa Ng

引用次数: 0

Transcriptome of Left Ventricle and Sinoatrial Node in Young and Old C57 Mice. 青年和老年C57小鼠左心室和窦房结的转录组。

Fortune journal of health sciences Pub Date : 2023-01-01 Epub Date: 2023-09-27 DOI: 10.26502/fjhs.134

Jia-Hua Qu, Kirill V Tarasov, Yelena S Tarasova, Khalid Chakir, Edward G Lakatta

{"title":"Transcriptome of Left Ventricle and Sinoatrial Node in Young and Old C57 Mice.","authors":"Jia-Hua Qu, Kirill V Tarasov, Yelena S Tarasova, Khalid Chakir, Edward G Lakatta","doi":"10.26502/fjhs.134","DOIUrl":"10.26502/fjhs.134","url":null,"abstract":"<p><p>Advancing age is the most important risk factor for cardiovascular diseases (CVDs). Two types of cells, within the heart pacemaker, sinoatrial node (SAN), and within the left ventricle (LV), control two crucial characteristics of heart function, heart beat rate and contraction strength. As age advances, the heart's structure becomes remodeled, and SAN and LV cell functions deteriorate, thus increasing the risk for CVDs. However, the different molecular features of age-associated changes in SAN and LV cells have never been compared in omics scale in the context of aging. We applied deep RNA sequencing to four groups of samples, young LV, old LV, young SAN and old SAN, followed by numerous bioinformatic analyses. In addition to profiling the differences in gene expression patterns between the two heart chambers (LV vs. SAN), we also identified the chamber-specific concordant or discordant age-associated changes in: (1) genes linked to energy production related to cardiomyocyte contraction, (2) genes related to post-transcriptional processing, (3) genes involved in KEGG longevity regulating pathway, (4) prolongevity and antilongevity genes recorded and curated in the GenAge database, and (5) CVD marker genes. Our bioinformatic analysis also predicted the regulation activities and mapped the expression of upstream regulators including transcription regulators and post-transcriptional regulator miRNAs. This comprehensive analysis promotes our understanding of regulation of heart functions and will enable discovery of gene-specific therapeutic targets of CVDs in advanced age.</p>","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":"6 3","pages":"332-356"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microsatellite Instability with BRAF V600E Associated with Delayed Presentation but Poor Survival in Stage III Colorectal Cancer. BRAF V600E微卫星不稳定性与癌症III期大肠癌的延迟表现但生存率低相关。

Fortune journal of health sciences Pub Date : 2023-01-01 Epub Date: 2023-04-19 DOI: 10.26502/fjhs.112

Sophiya Karki, Weijing Sun, Rashna Madan, Kamal Lamsal, Sarah Schmitt, Andrew K Godwin, Anup Kasi

{"title":"Microsatellite Instability with BRAF V600E Associated with Delayed Presentation but Poor Survival in Stage III Colorectal Cancer.","authors":"Sophiya Karki, Weijing Sun, Rashna Madan, Kamal Lamsal, Sarah Schmitt, Andrew K Godwin, Anup Kasi","doi":"10.26502/fjhs.112","DOIUrl":"https://doi.org/10.26502/fjhs.112","url":null,"abstract":"Colorectal cancer (CRC) has tremendous molecular and genetic heterogeneity, making it a difficult cancer to treat. Two of the key prognostic indicators of CRC include microsatellite instability (MSI) and BRAF V600E mutation. Here, we performed a retrospective survival analysis on 145 stage II and III CRC patients treated at the University of Kansas Cancer Center between 2009 and 2020. Of the 145 patients, BRAF V600E was observed in 15% patients and MSI in 28% patients. Median survival was not reached for stage II. For stage III, patients with BRAF V600E showed poor overall survival, which worsened with concurrent presence of MSI [χ2=6.4, p=0.01]. Eighty-five percent of this group was found to have right-sided CRC. For stage III, overall survival (OS) was 27 months, 37 months, 87 months and not reached for MSI-H/BRAF V600E, MSS/BRAF V600E, MSS/BRAF WT and MSI-H/BRAF WT, respectively. Although associated with poor prognosis, presence of MSI in BRAF V600E patients was associated with delayed disease presentation (mean age 77) compared to those with stable microsatellite (mean age 63) [p=0.01]. Although median survival between the groups could not be assessed for stage II due to very few deaths and/or inadequate length of study, comparison of survival trend suggests that BRAF V600E, rather than MSI, is what drives prognosis in stage II CRC. Our findings suggest that prognostic value of MSI is more relevant for stage III than stage II CRC. Patients with MSI-H and BRAF V600E have advantage of late presentation, although at the cost of poor overall prognosis.","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":"6 2","pages":"167-173"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/36/92/nihms-1896281.PMC10512748.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41166930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A New Format for the Italian National Health System: from Hospital to Patient-Centric Care 意大利国家卫生系统的新形式:从医院到以患者为中心的护理

Fortune journal of health sciences Pub Date : 2023-01-01 DOI: 10.26502/fjhs.124

Matteo Maria Cati

引用次数: 0

Prevalence and risk of Propagation of Covid-19 Infection among Prisoners in Niamey-Niger 尼亚美-尼日尔囚犯中Covid-19感染的流行和传播风险

Fortune journal of health sciences Pub Date : 2023-01-01 DOI: 10.26502/fjhs.125

A. Lagaré, Zaliha A. Lahama, Fatima Hassane, Wilfried Hounkanrin, H. Yayé

引用次数: 0

Moderate Production of Biofilm by Clinical isolates of E. coli and Pseudomonas spp in Burkina Faso 布基纳法索临床分离的大肠杆菌和假单胞菌适度生产生物膜

Fortune journal of health sciences Pub Date : 2023-01-01 DOI: 10.26502/fjhs.129

Albert Oueremi, A. Ouattara, A. M. Dabiré, Rahimatou Yasmine Wendkuni Tiemtoré, Serge Sougué, Jacques Simpor

{"title":"Moderate Production of Biofilm by Clinical isolates of E. coli and Pseudomonas spp in Burkina Faso","authors":"Albert Oueremi, A. Ouattara, A. M. Dabiré, Rahimatou Yasmine Wendkuni Tiemtoré, Serge Sougué, Jacques Simpor","doi":"10.26502/fjhs.129","DOIUrl":"https://doi.org/10.26502/fjhs.129","url":null,"abstract":"Background: I nfections caused by biofilm-producing microbes are associated with common human illnesses that are difficult to treat due to antibiotic resistance, especially when the bacteria also produce beta-lactamases. The aim of the present study was to evaluate the ability of clinical strains of Escherichia coli and Pseudomonas spp that produce beta-lactamases to produce biofilm. Methods: The study involved two clinical strains of Escherichia coli and Pseudomonas spp that produce beta-lactamases and were isolated from pus samples at the Centre Hospitalier Universitaire Pédiatrique Charles de Gaulle of Ouagadougou, Burkina Faso. Biofilm production was assessed using the microtiter plate-based crystal violet assay, with the PA01 WT strain used as a positive control for biofilm production. Biofilm was quantified by measuring optical densities with a spectrophotometer. Results: The E. coli strain was resistant to cefotaxime, ceftriaxone, and ceftazidime, while in addition to these antibiotics, Pseudomonas spp was resistant to imipenem. Both strains were beta-lactamase producers confirmed by the detection of bla NDM and bla IMP genes in E. coli and bla NDM , bla CTX and bla SHV in Pseudomonas spp . Optical density measurements after crystal violet staining showed that both strains were moderate biofilm producers. Conclusions: This study highlights that clinical isolates of E. coli and Pseudomonas spp , which are responsible for human infections and produce beta-lactamases, are also moderate biofilm producers. This is a real public health concern requiring surveillance efforts and investigations to prevent and effectively combat this form of resistance.","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of Severity of Acute Pancreatitis by Biochemical Markers: A Tertiary Care Hospital Study 生化指标预测急性胰腺炎严重程度:一项三级医院研究

Fortune journal of health sciences Pub Date : 2023-01-01 DOI: 10.26502/fjhs.132

Shanjidah Hoque, Rifat Hassan, Naheen Rezuan Shehran Asif

引用次数: 0

Prevalence and Risk Factors of Gestational Diabetes Mellitus in Likasi, in The Democratic Republic of The Congo: A Preliminary Study 在利卡西，在刚果民主共和国妊娠糖尿病的患病率和危险因素:初步研究

Fortune journal of health sciences Pub Date : 2023-01-01 DOI: 10.26502/fjhs.137

Hénoch Kabala Tshasuma, Chamy Lubamba Cham, Joseph Bulanda Nsambi, Charles Wembonyama Mpoy

引用次数: 0

Validation of CTP, MELD & MELD Na Scoring Systems for Predicting Treatment Outcome of Cirrhotic patients in Bangladesh- An observational study 验证CTP, MELD和MELD Na评分系统预测孟加拉国肝硬化患者治疗结果-一项观察性研究

Fortune journal of health sciences Pub Date : 2023-01-01 DOI: 10.26502/fjhs.115

Syeda Nur-E-Jannat, Dewan Saifuddin Ahmed

引用次数: 0

Metadichol; An Agonist that Expresses the Anti-aging gene Klotho in Various Cell Lines Metadichol;在多种细胞系中表达抗衰老基因Klotho的激动剂

Fortune journal of health sciences Pub Date : 2023-01-01 DOI: 10.26502/fjhs.135

Palayakotai R. Raghavan

{"title":"Metadichol; An Agonist that Expresses the Anti-aging gene Klotho in Various Cell Lines","authors":"Palayakotai R. Raghavan","doi":"10.26502/fjhs.135","DOIUrl":"https://doi.org/10.26502/fjhs.135","url":null,"abstract":"Klotho is a well-known tumor suppressor hormone that exhibits anti-cancer and anti-aging properties. Klotho levels are low or non-existent in cancer patients. Klotho protein levels decrease with aging; maintaining consistent levels may prevent disease and promote healthier aging. Metadichol is a nanoemulsion of long-chain alcohols C26, C28, and C30, of which C-28 constitutes over 85%. Any small molecule that can elevate Klotho can, in principle, help reverse many diseases in which Klotho levels are low. Previously, we showed that treatment of the pancreatic cancer cell lines PANC1, MIA-PACA, and COLO-205, combined with Metadichol, a lipid emulsion consisting of long-chain alcohols at 1-100 pg/mL concentrations, resulted in a 4- to 10-fold increase in Klotho expression as determined by qRT-PCR, This study aimed to demonstrate that Metadichol promotes Klotho expression in a wide variety of cell lines, such as primary cancer, stem, and somatic cell lines. Cells were treated with various concentrations of Metadichol ranging from 1 pg (picogram) to 1µg 9microgram). Three-to-fifteen-fold increase in Klotho expression was observed compared with baseline, as measured by qRT-PCR and qualified by western blot analysis. Metadichol is a natural agonist of Klotho expression and is non-toxic at levels up to 5000 mg/kg in rats. and has a potential therapeutic role in cancer and reversing aging.","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135953450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0