Focus (American Psychiatric Publishing)最新文献_第3页

Psilocybin Therapy for Females With Anorexia Nervosa: A Phase 1, Open-Label Feasibility Study. 针对女性厌食症患者的迷幻药疗法：一期开放标签可行性研究。

Focus (American Psychiatric Publishing) Pub Date : 2024-07-01 Epub Date: 2024-06-28 DOI: 10.1176/appi.focus.24022013

Stephanie Knatz Peck, Samantha Shao, Tessa Gruen, Kevin Yang, Alexandra Babakanian, Julie Trim, Daphna M Finn, Walter H Kaye

{"title":"Psilocybin Therapy for Females With Anorexia Nervosa: A Phase 1, Open-Label Feasibility Study.","authors":"Stephanie Knatz Peck, Samantha Shao, Tessa Gruen, Kevin Yang, Alexandra Babakanian, Julie Trim, Daphna M Finn, Walter H Kaye","doi":"10.1176/appi.focus.24022013","DOIUrl":"https://doi.org/10.1176/appi.focus.24022013","url":null,"abstract":"Anorexia nervosa (AN) is a deadly illness with no proven treatments to reverse core symptoms and no medications approved by the US Food and Drug Administration. Novel treatments are urgently needed to improve clinical outcomes. In this open-label feasibility study, 10 adult female participants (mean body mass index 19.7 kg m-2; s.d. 3.7) who met Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for AN or pAN (partial remission) were recruited to a study conducted at an academic clinical research institute. Participants received a single 25-mg dose of synthetic psilocybin in conjunction with psychological support. The primary aim was to assess safety, tolerability and feasibility at post-treatment by incidences and occurrences of adverse events (AEs) and clinically significant changes in electrocardiogram (ECG), laboratory tests, vital signs and suicidality. No clinically significant changes were observed in ECG, vital signs or suicidality. Two participants developed asymptomatic hypoglycemia at post-treatment, which resolved within 24 h. No other clinically significant changes were observed in laboratory values. All AEs were mild and transient in nature. Participants' qualitative perceptions suggest that the treatment was acceptable for most participants. Results suggest that psilocybin therapy is safe, tolerable and acceptable for female AN, which is a promising finding given physiological dangers and problems with treatment engagement. ClinicalTrials.gov identifier NCT04661514. Appeared originally in Nat Med 2023; 29:1947-1953.","PeriodicalId":73036,"journal":{"name":"Focus (American Psychiatric Publishing)","volume":"22 3","pages":"381-387"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11231470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethical Challenges in the Treatment of Patients With Severe Anorexia Nervosa. 治疗严重厌食症患者的伦理挑战。

Focus (American Psychiatric Publishing) Pub Date : 2024-07-01 Epub Date: 2024-06-28 DOI: 10.1176/appi.focus.20230035

Patricia Westmoreland, Joel Yager, Jonathan Treem, Philip S Mehler

引用次数: 0

Improving Access to Evidence-Based Treatments for Eating Disorders Among Youths: Where We are as a Field. 改善青少年饮食失调的循证治疗：我们的领域现状。

Focus (American Psychiatric Publishing) Pub Date : 2024-07-01 Epub Date: 2024-06-28 DOI: 10.1176/appi.focus.20230033

James Lock

引用次数: 0

Charting a Path Toward Improving Detection and Clinical Outcomes for Eating Disorders in Cismales and Gender-Diverse Patients. 为改善对女性和不同性别患者饮食失调的检测和临床结果指明方向。

Focus (American Psychiatric Publishing) Pub Date : 2024-07-01 Epub Date: 2024-06-28 DOI: 10.1176/appi.focus.20230039

Simar Singh, Jonathan T Avila, Sasha Gorrell

{"title":"Charting a Path Toward Improving Detection and Clinical Outcomes for Eating Disorders in Cismales and Gender-Diverse Patients.","authors":"Simar Singh, Jonathan T Avila, Sasha Gorrell","doi":"10.1176/appi.focus.20230039","DOIUrl":"10.1176/appi.focus.20230039","url":null,"abstract":"Historically, eating disorders (EDs) have been conceptualized from a female-centric lens. However, consistent research demonstrates that EDs afflict individuals across the gender spectrum, including cismales and gender-diverse individuals. Despite this evidence, a consensus regarding gender-sensitive assessment practices, theoretical formulations, and treatment considerations has yet to be established. The present review briefly summarizes research to date on the presentation of EDs in cismales and gender-diverse individuals, suggests appropriate assessment and treatment practices, and offers recommendations for gender-inclusive ED treatment. To effectively serve patients with EDs across the gender spectrum, more research is needed to validate gender-sensitive assessment tools, comprehensively study ED pathology within gender-representative samples, and conduct randomized controlled trials that serve cismales and gender-diverse patients. In doing so, clinicians and researchers may better detect EDs across the gender spectrum and implement gender-appropriate, evidence-based interventions, thereby reducing impairment and mortality related to EDs for all patients.","PeriodicalId":73036,"journal":{"name":"Focus (American Psychiatric Publishing)","volume":"22 3","pages":"312-321"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11231465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Why Don't You Just Eat? Neuroscience and the Enigma of Eating Disorders. 你为什么不吃？神经科学与进食障碍之谜。

Focus (American Psychiatric Publishing) Pub Date : 2024-07-01 Epub Date: 2024-06-28 DOI: 10.1176/appi.focus.20240006

Claire K Pinson, Guido K W Frank

引用次数: 0

What Next for Eating Disorder Genetics? Replacing Myths With Facts to Sharpen Our Understanding. 进食障碍遗传学的下一步是什么？用事实取代神话，加深我们的理解。

Focus (American Psychiatric Publishing) Pub Date : 2024-07-01 Epub Date: 2024-06-28 DOI: 10.1176/appi.focus.24022014

Laura M Huckins, Rebecca Signer, Jessica Johnson, Ya-Ke Wu, Karen S Mitchell, Cynthia M Bulik

{"title":"What Next for Eating Disorder Genetics? Replacing Myths With Facts to Sharpen Our Understanding.","authors":"Laura M Huckins, Rebecca Signer, Jessica Johnson, Ya-Ke Wu, Karen S Mitchell, Cynthia M Bulik","doi":"10.1176/appi.focus.24022014","DOIUrl":"https://doi.org/10.1176/appi.focus.24022014","url":null,"abstract":"Substantial progress has been made in the understanding of anorexia nervosa (AN) and eating disorder (ED) genetics through the efforts of large-scale collaborative consortia, yielding the first genome-wide significant loci, AN-associated genes, and insights into metabo-psychiatric underpinnings of the disorders. However, the translatability, generalizability, and reach of these insights are hampered by an overly narrow focus in our research. In particular, stereotypes, myths, assumptions and misconceptions have resulted in incomplete or incorrect understandings of ED presentations and trajectories, and exclusion of certain patient groups from our studies. In this review, we aim to counteract these historical imbalances. Taking as our starting point the Academy for Eating Disorders (AED) Truth #5 \"Eating disorders affect people of all genders, ages, races, ethnicities, body shapes and weights, sexual orientations, and socioeconomic statuses\", we discuss what we do and do not know about the genetic underpinnings of EDs among people in each of these groups, and suggest strategies to design more inclusive studies. In the second half of our review, we outline broad strategic goals whereby ED researchers can expand the diversity, insights, and clinical translatability of their studies. Appeared originally in Mol Psychiatry 2022; 27:3929-3938.","PeriodicalId":73036,"journal":{"name":"Focus (American Psychiatric Publishing)","volume":"22 3","pages":"418-429"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11231467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Avoidant/Restrictive Food Intake Disorder: Review and Recent Advances. 回避型/限制型食物摄入障碍：回顾与最新进展。

Focus (American Psychiatric Publishing) Pub Date : 2024-07-01 Epub Date: 2024-06-28 DOI: 10.1176/appi.focus.20240008

Jessie E Menzel, Taylor R Perry

引用次数: 0

Medical Considerations and Consequences of Eating Disorders. 饮食失调的医学考虑因素和后果。

Focus (American Psychiatric Publishing) Pub Date : 2024-07-01 Epub Date: 2024-06-28 DOI: 10.1176/appi.focus.20230042

Jennifer L Carlson, Diana C Lemly

引用次数: 0

Practice Assessment Tool for the Care of Patients With Eating Disorders. 饮食失调患者护理实践评估工具》。

Focus (American Psychiatric Publishing) Pub Date : 2024-07-01 Epub Date: 2024-06-28 DOI: 10.1176/appi.focus.20240009

Laura J Fochtmann, Jennifer Medicus, Seung-Hee Hong

{"title":"Practice Assessment Tool for the Care of Patients With Eating Disorders.","authors":"Laura J Fochtmann, Jennifer Medicus, Seung-Hee Hong","doi":"10.1176/appi.focus.20240009","DOIUrl":"10.1176/appi.focus.20240009","url":null,"abstract":"Eating disorders are characterized by significant disturbances in eating patterns associated with negative attitudes toward one's body, weight, and shape. They are associated with an increased risk of mortality and morbidity as well as significant health, economic, and psychosocial burdens. Additionally, individuals with eating disorders often hesitate to seek treatment and symptoms may be difficult to ascertain without structured assessment. The American Psychiatric Association Practice Guideline for the Treatment of Patients With Eating Disorders aims to enhance knowledge and increase the appropriate use of interventions for eating disorders, including anorexia nervosa, bulimia nervosa, and binge-eating disorder, thereby improving the quality of care and treatment outcomes. To this end, this evidence-based Performance in Practice tool can facilitate the implementation of a systematic approach to practice improvement for the care of individuals with eating disorders. This practice assessment activity can also be used in fulfillment of Continuing Medical Education and ABPN Continuing Certification, Improvement in Medical Practice.","PeriodicalId":73036,"journal":{"name":"Focus (American Psychiatric Publishing)","volume":"22 3","pages":"350-368"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11231481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eating Disorders: Out With the Old and in With the New. 饮食失调：旧的不去，新的不来。

Focus (American Psychiatric Publishing) Pub Date : 2024-07-01 Epub Date: 2024-06-28 DOI: 10.1176/appi.focus.20240015

Jennifer L Derenne

引用次数: 0