Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)最新文献

{"title":"[INFLUENCE OF INTERMITTENT NORMOBARIC HYPOXIA ON CARDIOVASCULAR SYSTEM AND HEMODYNAMIC PARAMETERS OF CHILDREN LIVED AT RADIATION CONTAMINATED TERRITORIES.]","authors":"L M Lisukha,&nbsp;V Ya Berezovsky","doi":"10.15407/fz62.04.046","DOIUrl":"https://doi.org/10.15407/fz62.04.046","url":null,"abstract":"<p><p>The effect of intermittent normobaric hypoxia (INH) of sanogenic level on the state of the cardiovascular system in 120 children aged from 12 to 17 years was studied. Children were divided into 3 groups. The 1st control group consisted of 20 persons (practically healthy ones), the 2nd group, a group of comparison, included 50 persons, and there were 50 persons in the 3rd group - a main group. Examined patients of two studied groups received the standard therapy, and those of the 3rd group - the seances of intermittent, normobaric hypoxia additionally to standard therapy. Systolic arterial pressure was significantly decreased in the rest from 108,2±1,9 to 103,8±1,1 mm Hg in children of the main group. Comparing the heart rate, systolic arterial pressure and diastolic arterial pressure their statistically decreased values by 9,3 min(-1), 8,36 and 7,84 mm Hg were revealed at 10 minutes of orthostatic, respectively. Autonomic supplying the activity of cardiovascular system with normal type of reaction was 34 % higher than that of the comparison group. It indicates an the improvement in hemodynamics and an increase in adaptation capabilities of the autonomic nervous system.</p>","PeriodicalId":73031,"journal":{"name":"Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)","volume":"62 4","pages":"46-52"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36286468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[REDUCED RESPONSE OF NATURAL KILLER LYMPHOCYTES TO TOLL-LIKE RECEPTOR 3 STIMULATION IN CHILDREN WITH RECURRENT INFECTIONS.]","authors":"D V Osypchuk,&nbsp;V P Chernyshov,&nbsp;L I Chernysheva,&nbsp;N P Kissel,&nbsp;B V Dons'koi,&nbsp;I M Matvienko,&nbsp;V P Rodionov,&nbsp;Y Ua Makovs'ka","doi":"10.15407/fz62.04.012","DOIUrl":"https://doi.org/10.15407/fz62.04.012","url":null,"abstract":"<p><p>In this study, we examined the activation of natural killer(NK)-lymphocytes mediated by Toll-like receptor 3(TLR3), in the group of children with recurrent infections and the group of children with invasive bacterial infections. We examined level of CD69 (marker, of activation) expression on NK - lymphocytes after incubation with TLR3 ligand. There was a significant decrease in the level of an activation marker - 36,3±4,4% in the group of children with recurrent infections, compared with a control group of healthy children (56,5±4,9%) and the group of children with invasive bacterial infections (55,9±4,4%). Also, decreased was an activation potential of NK-lymphocytes - 24,9±L4,5% which was calculated as the difference between the percentage of CD69+ NK - lymphocytes after incubation and spontaneous value (without the addition of activator). There were no correlations between markers of TLR3 mediated activation of NK-cells and the age. Thus, the ability to activate NK - lymphocyte mediated by TLR3, independent of age and reduced in the group of children with recurrent infections. Reduced activation of NK-lymphocytes may contribute to increased susceptibility to viral infections and bacterial complications.</p>","PeriodicalId":73031,"journal":{"name":"Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)","volume":"62 4","pages":"12-17"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36286971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SINGLE-CHANNEL ION CURRENTS IN THE NUCLEAR ENVELOPE OF RAT CARDIOMYOCYTES.","authors":"O A Kotyk,&nbsp;A B Kotliarova,&nbsp;A O Polishchuk,&nbsp;S M Marchenko","doi":"10.15407/fz62.06.003","DOIUrl":"https://doi.org/10.15407/fz62.06.003","url":null,"abstract":"<p><p>Using the patch clamp technique in nucleus attached configuration we have found that the nuclear membrane of rat cardiomyocytes contains different types of ion channels with conductances in the range from 10 to 400 pS. In particular, we recorded inositol 1,4,5-trisphosphate receptors with conductance of 384 ± 5 pS and 209 ± 13 pS cation channels similar to LCC-channels, previously reported in neurons. In addition, we found at least two types of ion channels with significantly higher conductance than that of LCC-channels and several types of ion channels with lower conductance (10-90 pS).</p>","PeriodicalId":73031,"journal":{"name":"Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)","volume":"62 6","pages":"3-8"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40437796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSESSMENT OF FUNCTIONAL CHANGES TEAR PRODUCTION UNDER THE ACTION OF THE EYE DROPS ON THE BASE OF NATURAL MOLECULE OF ECTOINE AND ARTIFICIAL TEARS IN PATIENTS WITH DRY EYE SYNDROME ON THE BACKGROUND OF ENDOCRINE OPHTHALMOPATHY.","authors":"N N Veselovskaya,&nbsp;I B Zherebko","doi":"10.15407/fz62.06.118","DOIUrl":"https://doi.org/10.15407/fz62.06.118","url":null,"abstract":"<p><p>Conducted a comparative analysis of functional changes in tear production in patients with dry eye syndrome and endocrine ophthalmopathy in the conditions of the long-term acting of preservative free medications based on natural substances. A total of 30 people, aged 35 to 53 years old with clinical manifestations of DES on the background of EO were divided on two groups. In I group eye drops of ectoine and in II - artificial tears were administered. The examination included general and specific methods. The term of follow up - 30 days. It was found that long-term use of preservative free eye drops based on ectoine leads to more expressive positive changes in the condition of the anterior surface of the eye and the secretion and quality of the tear.</p>","PeriodicalId":73031,"journal":{"name":"Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)","volume":"62 6","pages":"118-121"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40526531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reparative processes in jaw bones under using of different plastic materials.","authors":"Kh R Pohranychna","doi":"10.15407/fz62.06.110","DOIUrl":"https://doi.org/10.15407/fz62.06.110","url":null,"abstract":"<p><p>The comparative experimental study of osseous tissue regeneration in the createdforaminous mandibular defects being implanted with bioceramics Kergap T-300 and osteoplastic material Osteopor, as well as justifying the possibility ofusing the developed reparative material in the maxillofacial surgery clinics based on the analysis ofhistomorphological research results for are the paper objectives. 78 nonlinearwhite male rats weighing 240-300 g withforaminous mandibular defects were used as models for studying impact on the reparative osteogenesis processes made by the bonegraft material. Reparative changes in the implantation sites were studied in real time with the help of histological drugs under the optical microscopy. The graft components were the morphometry object calculated at the percentage ratio per the graft space unit in three cuts from each section. In 27.7% cases the rats'mandibular defects repair under the natural environment conditions of osseous tissue regeneration achieved with a blood clot was complicated by purulence, the surgical wound dehiscence with pyorrhea or perimandibular abscess. In other cases regeneration caused the development of heterogeneous graft made of chondroid-fibroblastic and osteoid tissues of different organization levels. The comparative experimental morphological and histomorphometric studies of the bone regeneration involving the replacement of created jaw defects with osteoplastic material Kergap-T alone and- in the combination with the lyophilized biological placenta implant Osteopor proved that the latter speeded up the beginning of active regenerative processes promoting the early defect filling with the neogenic organotypic osseous tissue comprising 52(43-63)[46-58]% and 74(57-85)[64-79]% of the bone graft in 60 and 90 days after the surgical intervention correspondingly (being equal to 24(13-29)[20-28]% i 32(27-38)[30-34]% correspondingly in cases when Kergap-Twas applied. According to the morphometric researchfindings, in cases of Osteopor and Kergap-T application the tabular bone element ofthe graft was equal to 53 (43-60) [46-561% and 15(13-18) [14-16]% correspondingly.</p>","PeriodicalId":73031,"journal":{"name":"Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)","volume":"62 6","pages":"110-117"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40537950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE STUDY OF THE RELATIONSHIP BETWEEN THE ACTIVITY OF EPIPHYSIS AND GONADS IN MALE RATS IN DIFFERENT SEASONS.","authors":"V Hnatiuk,&nbsp;N Kononenko","doi":"10.15407/fz62.06.095","DOIUrl":"https://doi.org/10.15407/fz62.06.095","url":null,"abstract":"<p><p>In male rats of different ages, we studied the functional activity of the pineal gland and the gonads during different seasons by determining the levels of melatonin and testosterone in the blood serum. It was found that the highest levels of melatonin observed in male rats in summer and winter, and the lowest - in autumn. The lowest level of melatonin has been established in the group of rats aged 9 months - 127.28+5.11 pmol/l that was 22% lower than the level of melatonin in 3 months old rats (P!0,05), and 20% below the level of melatonin in rats of 15 months old (Ps0,05). The highest level determined in rats aged 3 months (corresponds to the age of man -14 years old), the lowest - in rats 20 months-(corresponds to the age 55-56 years old). At the same time, the low level of melatonin was defined in rats aged 9 months in the autumn (corresponds to the age of man 29-30 years). In the study of testosterone levels in different seasons it was found that the highest level in all age groups presents in autumn, the lowest - in winter. When comparing the levels of testosterone in different age groups, it was determined that the fall of the highest level of testosterone present in the blood of males age 9 months and 15 months, which corresponds to the age of 29-30 and 43-44 of human years. Significant difference between the levels of testosterone in the groups that correspond to the reproductive age - rats of age 3, 9 and 15 months, are present only in the autumn; spring and summer - significant differences between the levels of testosterone absent. The degree of correlation differed in rats of different ages in different seasons: the highest correlation between the levels of melatonin and testosterone was determined in rats aged 9 months in autumn. The correlation coefficients in rats aged 20 months old have been weak - from 0.05 in the spring to 0.17 in autumn that shows the changes in neurohormonal regulation which occur with age.</p>","PeriodicalId":73031,"journal":{"name":"Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)","volume":"62 6","pages":"95-101"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40438304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[DEPENDENCE OF LEVEL OF MYELOPEROXIDASE OF PLASMA OF BLOOD ON FUNCTIONAL STATE OF NEUTROPHILS AT ACUTE INFARCT OF MYOCARDIUM.]","authors":"T I Gavrilenko,&nbsp;N O Ryzhkova,&nbsp;O M Parkhomenko","doi":"10.15407/fz62.04.060","DOIUrl":"https://doi.org/10.15407/fz62.04.060","url":null,"abstract":"<p><p>The purpose of this work was to define dependence of maintenance of myeloperoxidase (MPO) in plasma of blood of patients by the acute infarct of myocardium from the state of oxygen metabolism of neutrophils, which was estimated on activity of myeloperoxidases, superoxid-anion and catalase in cells and on maintenance by peroxigens. 19 is inspected practically healthy volunteers and 56 patients with the the acute infarct of myocardium. The got results testify that maintenance of MPO in plasma of blood of patients with acute infarct of myocardium depends on the functional state of neutrophils, which, in its turn, is related to the clinical features of patients. Low maintenance is associated exceptionally with low activity of MPO of neutrophils, and also other oxygen radicals. High maintenance of MPO in plasma accompanied low or high activity of MPO of neutrophils and is pathognomonic for patients with the acute infarct of myocardium.</p>","PeriodicalId":73031,"journal":{"name":"Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)","volume":"62 4","pages":"60-65"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36286922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE LEVEL OF GENERAL IMMUNOGLOBULIN E (IGE) IN RATS OF DIFFERENT AGE WITH ATOPIC DERMATITIS.","authors":"A I Bereznyakova,&nbsp;O D Jemela,&nbsp;V F Cheremisina","doi":"10.15407/fz62.01.092","DOIUrl":"https://doi.org/10.15407/fz62.01.092","url":null,"abstract":"<p><p>In the article we studied the level of general immunoglobulin E in rats of different age with atopic dermatitis. On the basis of the obtained results characteristics are given of levels the general IgE in rats of different age and it’s increasing with age. In rats which had been experimentally reproduced atopic dermatitis the average value of general IgE was increased in prepubertal rats, mature and old animals significantly (р<0,001). That can have a diagnostic and predictive value of this indicator at atopic dermatitis.</p>","PeriodicalId":73031,"journal":{"name":"Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)","volume":"62 1","pages":"92-4"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35910470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PROSPECTS OF C60 FULLERENE APPLICATION AS A MEAN OF PREVENTION AND CORRECTION OF ISCHEMIC-REPERFUSION INJURY\u0000IN THE SKELETAL MUSCLE TISSUE.","authors":"S Yu Zay,&nbsp;D A Zavodovskyi,&nbsp;K I Bogutska,&nbsp;D N Nozdrenko,&nbsp;Yu I Prylutskyy","doi":"10.15407/fz62.03.066","DOIUrl":"https://doi.org/10.15407/fz62.03.066","url":null,"abstract":"<p><p>lack of accurate diagnostic tests for the rapid detection of\u0000ischemic injury remains an urgent problem. In this context,\u0000a search for specific markers of ischemia as well as new\u0000therapeutic agents for prevention and treatment of ischemic\u0000injury continues. Water-soluble nano-sized C60 fullerenes, as\u0000powerful antioxidants, can act as promising means for correction\u0000of various muscle system states, in the base of which lie\u0000the destructive effects of free radicals.</p>","PeriodicalId":73031,"journal":{"name":"Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)","volume":"62 3","pages":"66-77"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35940407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HEART RATE REGULATION DURING ADAPTATION TO CONDITIONS IN ANTARCTICA.","authors":"V V Kalnish,&nbsp;G Yu Pyshnov,&nbsp;E V Моisеyenko,&nbsp;V V Оpanasenko,&nbsp;L M Аlekseyeva,&nbsp;L G Vysotska","doi":"10.15407/fz62.03.020","DOIUrl":"https://doi.org/10.15407/fz62.03.020","url":null,"abstract":"<p><p>The article deals with topical issues of the problem of studying\u0000the mechanisms of human adaptation to Аntarctic conditions,\u0000in particular, the characteristics of the restructuring regulation\u0000of cardiovascular system during expedition activity at\u0000the Ukrainian Antarctic Station «Academic Vernadsky». The\u0000studies were performed directly in Antarctica with the participation\u0000of winterers, who during a year were surveyed monthly\u0000by cardiointervalography and ECG. As a result of analysis of\u0000variance of heart rate in Antarctic conditions we identified the\u0000phasic restructuring of the regulation of heart rhythm of winterers.\u0000The findings extend the understanding of the peculiarities\u0000of realization of regulating the circulatory system during the\u0000change of adaptation phases. In particular, the RRNN index\u0000has a phasic structure and ranges ± 7-9 c.u. from the beginning\u0000of wintering, and in the last phase is increased to -32 c.u. The\u0000activity of the development of stress condition among winterers\u0000reflects the dynamics of changes in the rate ІNt function,\u0000which from the beginning of wintering till January ranged\u0000from 2-5 c.u. by modulo, and in the months before the return\u0000(February, March), the rate reached 46 c.u. It is established a\u0000dominant role of the time factor in influencing the quality adjustment\u0000of adaptation processes. While during the first half of\u0000the expedition heart rate variability had a balanced regulatory\u0000influence, at the end of the expedition an increased activity\u0000of the sympathetic division of the autonomic nervous system\u0000and stress regulatory mechanisms were observed. This may\u0000indicate for incomplete adaptation that requires the application\u0000of methods of correction of functional state.</p>","PeriodicalId":73031,"journal":{"name":"Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)","volume":"62 3","pages":"20-9"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35939518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}