Extracellular vesicle最新文献_第9页

PD-L1 antibodies-armed exosomal vaccine for enhanced cancer immunotherapy by simultaneously in situ activating T cells and blocking PD-1/PD-L1 axis PD-L1抗体外泌体疫苗通过同时原位激活T细胞和阻断PD-1/PD-L1轴来增强癌症免疫治疗

Extracellular vesicle Pub Date : 2022-12-01 DOI: 10.1016/j.vesic.2022.100012

Xinyue Dai , Zhaoshuo Wang , Miao Fan , Huifang Liu , Xinjian Yang , Xueyi Wang , Xiaohan Zhou , Yunlu Dai , Jinchao Zhang , Zhenhua Li

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引用次数: 4

Heparan sulfate proteoglycan-mediated internalization of extracellular vesicles ameliorates liver fibrosis by targeting hepatic stellate cells 硫酸乙酰肝素蛋白聚糖介导的细胞外小泡内化通过靶向肝星状细胞改善肝纤维化

Extracellular vesicle Pub Date : 2022-12-01 DOI: 10.1016/j.vesic.2022.100018

Rongrong Li , Chen Wang , Manqian Zhou , Yue Liu , Shang Chen , Zihan Chai , Haoyan Huang , Kaiyue Zhang , Zhibo Han , Guoqiang Hua , Nadia Benkirane-Jessel , Zhong-Chao Han , Zongjin Li

{"title":"Heparan sulfate proteoglycan-mediated internalization of extracellular vesicles ameliorates liver fibrosis by targeting hepatic stellate cells","authors":"Rongrong Li , Chen Wang , Manqian Zhou , Yue Liu , Shang Chen , Zihan Chai , Haoyan Huang , Kaiyue Zhang , Zhibo Han , Guoqiang Hua , Nadia Benkirane-Jessel , Zhong-Chao Han , Zongjin Li","doi":"10.1016/j.vesic.2022.100018","DOIUrl":"10.1016/j.vesic.2022.100018","url":null,"abstract":"<div><p>Accumulating evidence shows that stem cell-derived extracellular vesicles (EVs) have shown great promise for tissue regeneration and are considered an alternative to cell-based therapy. However, the mechanisms by which EVs induce tissue repair have not been well demonstrated. Previous work indicates that activation of hepatic stellate cells (HSCs) may contribute to the progression of liver fibrosis. Here, we investigate the therapeutic potential of EVs derived from human placental mesenchymal stem cells (hP-MSCs) for the treatment of carbon tetrachloride (CCl4)-induced liver injury. Our data revealed that EVs derived from hP-MSCs effectively ameliorate liver injury by attenuating inflammation and fibrosis. Further data revealed that heparan sulfate proteoglycans (HSPGs) on the surface of HSCs mediate the internalization of EVs. Furthermore, EVs could inhibit the epithelial–mesenchymal transition (EMT) process in HSCs through the downregulated TGF-<span><math><mi>β</mi></math></span>/Smad pathway, which was mediated by miR-744-5p in EVs. Meanwhile, glycosaminoglycans on the surface of EVs play a crucial anti-inflammatory role. In conclusion, our results provide evidence that hP-MSC-derived EVs promote the recovery of liver injury by targeting HSPGs on HSCs and inhibiting liver inflammation through glycosaminoglycans from EVs. These findings may provide a novel theoretical basis for the treatment of liver fibrosis based on EVs.</p></div>","PeriodicalId":73007,"journal":{"name":"Extracellular vesicle","volume":"1 ","pages":"Article 100018"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773041722000130/pdfft?md5=d75954f4d1b9af37bd48505b0a9c2691&pid=1-s2.0-S2773041722000130-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46753630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

MHC-1B carried exosomes derived from tubular epithelial cell induced by the EGFR mimotope inhibit macrophage activation in renal fibrosis 肾纤维化中巨噬细胞活化受EGFR米托贝诱导，其携带的源自小管上皮细胞的MHC-1B外泌体可抑制巨噬细胞活化

Extracellular vesicle Pub Date : 1900-01-01 DOI: 10.1016/j.vesic.2023.100024

Jin Guo, Xuanqi Liu, Haoming Song, Yong Gu, Jianying Niu, Lin Yang