乳腺癌外泌体驱动液体活检:分离、生物标志物鉴定和检测的最新进展

Junjie Zhao , Lizhou Xu , Dongjie Yang , Huijing Tang , Yalin Chen , Xunzhi Zhang , Yunsheng Xu , Rongying Ou , Danyang Li
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引用次数: 6

摘要

微创液体活检是早期筛查乳腺癌(BrCa)的有力工具。BrCa衍生的外泌体丰富了其亲本细胞的生物学信息,在BrCa的进化和转移中起着至关重要的作用,提供了肿瘤的实时快照。本文综述了液体活检中外泌体研究的最新进展,特别是BrCa。详细比较了几种外泌体的分离方法。讨论了检测BrCa的不同外泌体生物标志物。最后强调了用于BrCa临床诊断的外泌体检测的新方法。我们相信外泌体研究的创新将为BrCa的早期筛查和诊断带来新的突破。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exosome-driven liquid biopsy for breast cancer: Recent advances in isolation, biomarker identification and detection

Liquid biopsy with minimally invasive emerges as a powerful tool for early screening of breast cancer (BrCa). BrCa derived exosomes which enrich with biological information from their parent cells play essential roles in the evolution and metastasis of BrCa, providing a real-time snapshot of the tumor. This review summaries the recent advances of exosomes studies in liquid biopsy, particularly for BrCa. A number of isolation methods for exosomes are compared in detail. Different exosome biomarkers for detection of BrCa are discussed. Novel approaches for the detection of exosomes towards clinical diagnosis of BrCa are highlighted at the end. We believe the innovations in exosome research will lead to new breakthroughs in the early screening and diagnosis of BrCa.

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来源期刊
Extracellular vesicle
Extracellular vesicle Biochemistry, Genetics and Molecular Biology (General)
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