Advances in applied microbiology最新文献

Alpha and beta radioactivity in mushrooms. 蘑菇中的α和β放射性。

2区生物学

Advances in applied microbiology Pub Date : 2026-01-01 Epub Date: 2026-05-05 DOI: 10.1016/bs.aambs.2026.04.004

Dagmara Strumińska-Parulska, Jerzy Falandysz

引用次数: 0

Understanding biofilm formation in acidophilic bioleaching microorganisms: Advances and challenges. 了解嗜酸浸出微生物的生物膜形成：进展和挑战。

2区生物学

Advances in applied microbiology Pub Date : 2026-01-01 Epub Date: 2026-05-05 DOI: 10.1016/bs.aambs.2026.04.003

Beatriz Salas, Mauricio Díaz, Mario Vera

{"title":"Understanding biofilm formation in acidophilic bioleaching microorganisms: Advances and challenges.","authors":"Beatriz Salas, Mauricio Díaz, Mario Vera","doi":"10.1016/bs.aambs.2026.04.003","DOIUrl":"10.1016/bs.aambs.2026.04.003","url":null,"abstract":"Bioleaching of metal sulfides (MS) is driven by acidophilic chemolithotrophic microorganisms that oxidize ferrous ions and reduced inorganic sulfur compounds under extremely acidic conditions. These microorganisms form biofilms on mineral surfaces, influencing their metabolism and bioleaching activity. Studying biofilms in bioleaching acidophiles presents unique challenges, such as the dual role of MS surfaces as electron donors that generate reactive oxygen species, provide selective colonization sites, biofilm mineralization, and limited knowledge of inter- and intra-species interactions. This chapter reviews recent advances in bioleaching biofilm research, focusing on cell-to-cell communication through Quorum Sensing (QS), extracellular polymeric substances (EPS) studies using non-invasive cell labeling, as well as high-throughput image analysis for biofilm quantification. We discuss the effects of acyl homoserine lactone (AHLs)-based and diffusible signal factor (DSF)-based QS systems on the metabolic activity and biofilm formation of bioleaching bacteria. Additionally, we examine evidence suggesting that QS influences biofilm formation and MS bioleaching in mixed acidophilic cultures. We also review recent progress in visualizing acidophilic leaching biofilms by fluorescence microscopy techniques (Epifluorescence and Confocal Laser Scanning Microscopy) to study their establishment on mineral surfaces, EPS production, and interspecies interactions. Finally, we present an improved approach using Open-Source Software to overcome limitations in biofilm quantitative analysis, addressing biases caused by the low number of images frequently analyzed and the absence of robust statistical frameworks for cell and microcolony quantification.","PeriodicalId":7298,"journal":{"name":"Advances in applied microbiology","volume":"133 ","pages":"1-35"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148100962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A One Health approach to Antimicrobial Resistance: Concepts, challenges, and advances in omics. 抗微生物药物耐药性的一种健康方法：组学的概念、挑战和进展。

2区生物学

Advances in applied microbiology Pub Date : 2026-01-01 Epub Date: 2026-07-22 DOI: 10.1016/bs.aambs.2026.07.001

Inês M Ribeiro, Ana C Almeida-Santos, Luísa Peixe, Carla Novais, Ana R Freitas

{"title":"A One Health approach to Antimicrobial Resistance: Concepts, challenges, and advances in omics.","authors":"Inês M Ribeiro, Ana C Almeida-Santos, Luísa Peixe, Carla Novais, Ana R Freitas","doi":"10.1016/bs.aambs.2026.07.001","DOIUrl":"https://doi.org/10.1016/bs.aambs.2026.07.001","url":null,"abstract":"Antimicrobial resistance (AMR) is a global threat driven by the interplay between microbial evolution and human activity. Antimicrobial use in human and veterinary medicine, as well as in agriculture, accelerates the selection and dissemination of resistant bacteria and genes across interconnected human, animal, and environmental reservoirs. These dynamic exchanges render single-sector interventions ineffective. A One Health approach integrating human, animal, and environmental health is therefore essential to understand and mitigate the emergence and spread of AMR. This chapter focuses on bacterial antimicrobial resistance, addressing key concepts, major challenges, and emerging technologies within a One Health framework. Advances in next-generation sequencing and omics technologies have transformed our capacity to resolve AMR at unprecedented scale and resolution. These tools enable the tracking of resistance genes and high-risk clones across ecosystems, uncover transmission pathways, and identify key drivers of dissemination. Such insights support real-time epidemiological surveillance, outbreak detection, and targeted interventions. However, translating these advances into routine practice remains a major challenge, requiring harmonized methodologies, data integration, and cross-sector coordination. Addressing AMR demands sustained collaboration across disciplines and stakeholders, including clinicians, veterinarians, farmers, researchers, policymakers, industry, and the public. And framing AMR as a shared ecological and societal responsibility underscores the urgency of coordinated global action. We call for the urgent integration of One Health principles into surveillance, policy, and innovation to preserve antimicrobial effectiveness and safeguard future health.","PeriodicalId":7298,"journal":{"name":"Advances in applied microbiology","volume":"134 ","pages":"1-101"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigative leads and individualization through forensically relevant human commensal microbiome. 通过法医相关的人类共生微生物组的调查线索和个性化。

2区生物学

Advances in applied microbiology Pub Date : 2026-01-01 Epub Date: 2026-04-20 DOI: 10.1016/bs.aambs.2026.04.001

Hirak Ranjan Dash, Surajit Das

引用次数: 0

Pathobiology of Mycobacterium fortuitum and NTM biofilms: spotlight on emerging therapeutic horizons. 偶发分枝杆菌和NTM生物膜的病理生物学：新兴治疗领域的焦点。

2区生物学

Advances in applied microbiology Pub Date : 2026-01-01 Epub Date: 2026-04-25 DOI: 10.1016/bs.aambs.2026.04.002

Ayushi Sharma, Sourav Kumar, Rahul Shrivastava

{"title":"Pathobiology of Mycobacterium fortuitum and NTM biofilms: spotlight on emerging therapeutic horizons.","authors":"Ayushi Sharma, Sourav Kumar, Rahul Shrivastava","doi":"10.1016/bs.aambs.2026.04.002","DOIUrl":"10.1016/bs.aambs.2026.04.002","url":null,"abstract":"Rapidly growing nontuberculous mycobacteria (NTM) are emerging pathogens that are well-known entities behind pulmonary, extra-pulmonary, cutaneous, subcutaneous, as well as systemic and disseminated infections. Mycobacterium fortuitum is an important human pathogenic NTM. It is a routine nosocomial contaminant capable of forming resilient biofilms that enhance its resistance to antibiotics and disinfectants and contribute to persistent healthcare-associated infections. Moreover, varying symptoms of M. fortuitum infections, long duration therapeutics, and lack of a standardized drug regimen underscores medical significance of the pathogen. Limited knowledge regarding M. fortuitum pathogenesis, however, entices research investigating M. fortuitum planktonic as well as the biofilm phenotype. The review article aims to gather data about the prevalence and clinical significance of NTM in general, with special emphasis on M. fortuitum. It further delves into the biofilm aspect of the pathogen and examines current therapeutic strategies against NTM infections and diseases. Emerging horizons in NTM therapeutics, including repurposing antitubercular drugs, bacteriophage therapy, photodynamic therapy, and advancements in molecular diagnostic techniques are being explored to combat NTM infections. In addition, innovative treatments specifically targeting NTM biofilms, such as combination therapies, liposomal formulations, thiopeptide antibiotics, monoclonal antibodies, and inhibitors of the DosRS system, are under investigation. The concluding section of the article emphasizes the necessity for future research to delve into molecular mechanisms underlying biofilm formation and maintenance, develop targeted therapies, and refine diagnostic tools to effectively manage and treat NTM infections. Collectively, the information will be helpful to the researchers working on strategies and treatments to combat NTM infections.","PeriodicalId":7298,"journal":{"name":"Advances in applied microbiology","volume":"133 ","pages":"113-140"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148100998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploration of extremophilic microorganisms for production and applications of exopolysaccharides. 嗜极微生物在胞外多糖生产和应用中的探索。

2区生物学

Advances in applied microbiology Pub Date : 2026-01-01 Epub Date: 2026-08-10 DOI: 10.1016/bs.aambs.2026.07.003

Pradnya Kanekar, Snehal Kulkarni, Amarja Joshi, Sagar Kanekar, Vedant Kadam, Isha Thakkar, Aditya Patel, Prerana Kale, Poorva Garge, Reeya Tewari-Raje

{"title":"Exploration of extremophilic microorganisms for production and applications of exopolysaccharides.","authors":"Pradnya Kanekar, Snehal Kulkarni, Amarja Joshi, Sagar Kanekar, Vedant Kadam, Isha Thakkar, Aditya Patel, Prerana Kale, Poorva Garge, Reeya Tewari-Raje","doi":"10.1016/bs.aambs.2026.07.003","DOIUrl":"10.1016/bs.aambs.2026.07.003","url":null,"abstract":"Extremophilic microorganisms live in extreme environmental conditions such as high or low temperature, high or low pH, high concentration of salt and accordingly are classified as thermophilic, psychrophilic, alkaliphilic, acidophilic and halophilic respectively. They adapt themselves to the extreme conditions by producing novel biomolecules like heat shock proteins, cold active enzymes, compatible solutes and exopolysaccharides. Extremophilic microorganisms maintain their cellular integrity with the help of exopolysaccharide (EPS) which constitutes slime or a hydrated matrix that keeps the cells embedded. EPS are composed of carbohydrates and some amino acids. Thermophilic microorganisms namely Thermus, Geobacillus, Bacillus, Thermococcus and halophilic microorganisms namely Halomonas, Halobacillus, Haloferax and Halococcus are reported and well-studied for production of EPS. The EPSs exhibit emulsifying, viscofying and antioxidant properties that find applications in food industry, oil recovery and anticancer agents.","PeriodicalId":7298,"journal":{"name":"Advances in applied microbiology","volume":"134 ","pages":"129-158"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbial decaprenoxanthin: From understanding an extremophile-derived C₅₀ carotenoid to its bioprocessing for large-scale applications. 微生物decapreoxanthin：从了解极端微生物衍生的C50类胡萝卜素到大规模应用的生物处理。

2区生物学

Advances in applied microbiology Pub Date : 2026-01-01 Epub Date: 2026-07-17 DOI: 10.1016/bs.aambs.2026.07.002

Cassamo U Mussagy

{"title":"Microbial decaprenoxanthin: From understanding an extremophile-derived C50 carotenoid to its bioprocessing for large-scale applications.","authors":"Cassamo U Mussagy","doi":"10.1016/bs.aambs.2026.07.002","DOIUrl":"https://doi.org/10.1016/bs.aambs.2026.07.002","url":null,"abstract":"Decaprenoxanthin (DPXT) is an unusual bacterial C50 carotenoid that has historically received limited attention despite its well-defined structure. For decades, carotenoid research and industrial development have been dominated by C40 carotenoids, leaving longer-chain carotenoids largely overlooked. Recent discoveries, particularly from microorganisms inhabiting Antarctic and other extreme environments, have repositioned DPXT as an adaptive pigment shaped by intense environmental pressures. Its extended polyene chain and membrane-associated behavior suggest roles in membrane stabilization and protection against ultraviolet radiation and oxidative stress, features that may hold relevance for food and biotechnological applications. This review integrates historical and recent knowledge on DPXT, covering its structural characteristics, biosynthetic pathways, ecological function, and emerging technological relevance. Special attention is given to microbial sources, particularly Actinomycetota from extreme environments, and to recent advances in microbial genomics, metabolic engineering, and sustainable bioprocess development that enable the production and exploration of C50 carotenoids beyond their native extremophilic context. The analysis highlights DPXT as a representative example of stress-resilient carotenoids, with physicochemical and membrane-interacting properties that may offer advantages for future food and biotechnological systems. Although significant challenges remain in cultivation strategies, yield optimization, and downstream recovery, advances in microbial cell factories and green extraction technologies open new opportunities for valorizing C50 carotenoids. This review bridges extremophile microbiology, carotenoid biochemistry, and sustainable food innovation, positioning DPXT as an emerging molecule that may expand the functional and structural landscape of carotenoids relevant to food science.","PeriodicalId":7298,"journal":{"name":"Advances in applied microbiology","volume":"134 ","pages":"103-127"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyanobacterial fatty acids: From biosynthesis to diverse applications. 蓝藻脂肪酸：从生物合成到不同的应用。

2区生物学

Advances in applied microbiology Pub Date : 2025-01-01 Epub Date: 2025-01-06 DOI: 10.1016/bs.aambs.2024.11.002

Akhila Punchakara, Sharon Sunny, Akhil Agrawal

{"title":"Cyanobacterial fatty acids: From biosynthesis to diverse applications.","authors":"Akhila Punchakara, Sharon Sunny, Akhil Agrawal","doi":"10.1016/bs.aambs.2024.11.002","DOIUrl":"10.1016/bs.aambs.2024.11.002","url":null,"abstract":"Blue-green algae, or cyanobacteria, is a diverse category of prokaryotic photosynthetic organisms. The capacity to extract economically viable compounds from cyanobacteria drives continuous scientific research in this domain. The ability to synthesize fatty acids from cyanobacteria makes them a useful substitute for animal and plant-based sources in the synthesis of oils and fats. Their benefits over other sources include their rapid growth rate, higher biomass production and minimal consumption of land. Since these substances build up inside of the cells, effective procedures for their extraction, recovery, and purification are required. The primary procedures in lipid extraction utilizing cyanobacteria are cultivation, biomass collection, cell disruption and lipid transesterification. Fatty acids are essential components of the metabolic pathways that generate and convert the majority of lipid classes. This chapter outlines the metabolic pathway associated with fatty acid biosynthesis, along with various mechanical and chemical methods that can be employed to extract lipids from cyanobacteria. The composition of fatty acids primarily impacts their characteristics and practical use. This chapter also gives a general overview of the variety of fatty acid profiles found in cyanobacteria, including omega-6 and omega-3 fatty acids, as well as odd-chain, long-chain, short-chain, and medium-chain fatty acids and the different uses of cyanobacterial fatty acids in various industries, such as aquaculture, biofuel, food industry, pharmaceuticals, cosmetics and more. In summary cyanobacterial fatty acids are essential in various fields, offering benefits for both ecosystems and emerging industries.","PeriodicalId":7298,"journal":{"name":"Advances in applied microbiology","volume":"130 ","pages":"191-205"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metagenomic analysis of metal(loid)s resistance genes and its environmental applications. 金属抗性基因的宏基因组分析及其在环境中的应用。

2区生物学

Advances in applied microbiology Pub Date : 2025-01-01 Epub Date: 2025-09-04 DOI: 10.1016/bs.aambs.2025.08.001

Padma Dolkar, Sonakshi Modeel, Sneha Siwach, Pankaj Yadav, Meenu Chaurasia, L Themchurin, Aarzoo Yadav, Apoorva Atri, Shrutti Kapoor, Rakesh Kumar Negi, Tarana Negi, Ram Krishan Negi

{"title":"Metagenomic analysis of metal(loid)s resistance genes and its environmental applications.","authors":"Padma Dolkar, Sonakshi Modeel, Sneha Siwach, Pankaj Yadav, Meenu Chaurasia, L Themchurin, Aarzoo Yadav, Apoorva Atri, Shrutti Kapoor, Rakesh Kumar Negi, Tarana Negi, Ram Krishan Negi","doi":"10.1016/bs.aambs.2025.08.001","DOIUrl":"10.1016/bs.aambs.2025.08.001","url":null,"abstract":"Heavy metals are widely used to satiate the demands of growing industrialization and modern life. However, the presence of metal in large quantities in the ecosystem significantly impacts all life forms, particularly microorganisms. Many bacterial strains have developed metal resistance genes (MRG) to survive in extreme conditions through various mechanisms, such as active efflux, sequestration, permeability barriers, or co-resistance with antibiotic resistance genes. Metagenomic analysis is a powerful approach that enables the exploration of the functional repertoire and diversity of microorganisms, providing deeper insights into the mechanisms underlying the development of MRGs, and the active metabolites they produce to adapt to the polluted environments. With the advancement of these techniques, the knowledge can be further applied to environmental applications, such as bioremediation, biomonitoring, and synthetic biology. Bacteria with metal toxicity tolerance can be employed to enhance environmental sustainability and mitigate potential hazards.","PeriodicalId":7298,"journal":{"name":"Advances in applied microbiology","volume":"132 ","pages":"123-168"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in production related petroleum microbiology. 石油微生物学研究进展。

2区生物学

Advances in applied microbiology Pub Date : 2025-01-01 Epub Date: 2025-06-24 DOI: 10.1016/bs.aambs.2025.04.001

Sugandha Mahajan, Abhishek Tyagi, Ganshyam Prajapat, Akhil Agrawal

{"title":"Advances in production related petroleum microbiology.","authors":"Sugandha Mahajan, Abhishek Tyagi, Ganshyam Prajapat, Akhil Agrawal","doi":"10.1016/bs.aambs.2025.04.001","DOIUrl":"10.1016/bs.aambs.2025.04.001","url":null,"abstract":"The understanding of microbial diversity and their metabolic activities inside the oil reservoir is not well understood. The microbial community of the oil reservoir plays diversified roles from souring to microbial enhanced oil recovery. Therefore, studying community dynamics, phylogenetic diversity and ecological roles of the community inside the reservoir is crucial. This chapter discussed different microbial processes taking place in petroleum reservoirs. The study showed the crude oil being the major electron donor inside the reservoir supporting major life forms. The major metabolic reactions taking place are nitrate and nitrite reduction, sulfur and sulfate reduction, iron reduction, fermentation, and methanogenesis. Many of the thermo-tolerant strains that are capable of exploiting numerous energy sources and electron acceptors are among the most often cultured on functional groups, which include sulfate and sulfur reducing bacteria like Desulfacinum infernum, Desulfacinum subterraneum, iron reducing, fermentative such as Thermococcus, Thermotoga, and Thermoanaerobacter species, and methanogenic microorganisms like Methanothermobacter thermautotrophicus. The stimulated growth of microbes could also enhance the oil recovery from the reservoir by 66 percent as proved in some experimental studies. The microbial growth could be increased by injection of nitrate which could also control sulfide production, or nutrients such as sugar molasses that increases fermentative microbial growth, which could improve volumetric sweep efficiency and thus oil recovery. Microbial growth also has the potential for corrosion and souring due to the presence of microbes such as Desulfovibrio¸ Clostridium etc. It could be concluded that the scope of microbial diversity is far more extensive than what is known till date.","PeriodicalId":7298,"journal":{"name":"Advances in applied microbiology","volume":"131 ","pages":"65-90"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0