Comprehensive review of steroid metabolism in Comamonas testosteroni TA441 with insights from other aerobic steroid-degrading bacteria.

2区生物学 Q1 Immunology and Microbiology

Advances in applied microbiology Pub Date : 2025-01-01 Epub Date: 2025-08-07 DOI:10.1016/bs.aambs.2025.06.001

Masae Horinouchi, Toshiaki Hayashi

引用次数: 0

Abstract

Comamonas testosteroni TA441 is a model bacterium for aerobic steroid degradation. This review summarizes its steroid degradation pathways, including the genetic organization and enzymatic mechanisms involved in C17-side chain degradation, A,B-ring cleavage, and β-oxidation of B,C,D-rings. Comparative insights from other aerobic steroid-degrading bacteria highlight the evolutionary conservation of key enzymes. Understanding these pathways provides crucial insights into microbial steroid metabolism and its environmental significance.

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睾酮单胞菌TA441中类固醇代谢的综合综述以及其他有氧类固醇降解细菌的见解。

睾酮单胞菌TA441是一种有氧类固醇降解的模式细菌。本文综述了其甾体降解途径，包括c17侧链降解、A、B环裂解和B、C、d环β-氧化的遗传组织和酶促机制。来自其他有氧类固醇降解细菌的比较见解强调了关键酶的进化守恒。了解这些途径为微生物类固醇代谢及其环境意义提供了重要的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in applied microbiology 生物-生物工程与应用微生物

CiteScore

8.20

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Advances in Applied Microbiology offers intensive reviews of the latest techniques and discoveries in this rapidly moving field. The editors are recognized experts and the format is comprehensive and instructive. Published since 1959, Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in microbiology. Recent areas covered include bacterial diversity in the human gut, protozoan grazing of freshwater biofilms, metals in yeast fermentation processes and the interpretation of host-pathogen dialogue through microarrays.