European burn journal最新文献_第8页

Toxic Epidermal Necrolysis: A Clinical and Therapeutic Review 中毒性表皮坏死松解:临床和治疗综述

European burn journal Pub Date : 2022-08-08 DOI: 10.3390/ebj3030036

Gonçalo Canhão, S. Pinheiro, L. Cabral

{"title":"Toxic Epidermal Necrolysis: A Clinical and Therapeutic Review","authors":"Gonçalo Canhão, S. Pinheiro, L. Cabral","doi":"10.3390/ebj3030036","DOIUrl":"https://doi.org/10.3390/ebj3030036","url":null,"abstract":"Toxic Epidermal Necrolysis is a rare dermatological condition with high mortality and serious consequences on its survivors. Despite having been first described in 1956, its pathophysiology remains uncertain, mainly regarding its mechanisms, although it seems that certain apoptosis pathways are pivotal in starting keratinocytes’ apoptosis and in activating T cells, especially those mediated by tumour necrosis factor, Fas-FasL and granulysin. In general, its aetiology and presentation are consensual, being defined as a generalized necrolysis of the epidermis that occurs as an uncontrolled immune response to a specific drug or one of its metabolites, highlighting cotrimoxazole and allopurinol as the most important. This necrolysis leads to a massive shedding of the epidermal layer of the skin, with stronger incidences in the torso, upper limbs and face. Its complications tend to be severe, noting that septic ones are responsible for over half of the disease’s mortality. Nearly all survivors develop long-term sequelae, namely hypertrophic scarring and skin pigmentation anomalies. Regarding treatment, many different opinions arise, including contradictory ones, regarding more importantly immunomodulation therapies that have been the focus of several studies through the years. It is safe to state that supportive therapy is the only modality that has significantly strong evidence backing its efficacy in reducing mortality and improving prognosis, which have improved in the past years as general health care quality increased. In conclusion, it is imperative to say that more research is needed for new potential therapies with large study populations and more scientific rigor. Likewise, investigation towards its basic pathophysiology should also be promoted, mainly at a biomolecular level, allowing for an improved prevention of this illness.","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89020691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How Did This Happen? Xenograft Conversion to Dermal Scaffolding after Scalding Grease Burn 这是怎么发生的?烫伤性油脂烧伤后异种移植物转化为真皮支架

European burn journal Pub Date : 2022-08-05 DOI: 10.3390/ebj3030035

Aurelie Tran, Elizabeth Windell, Luke Pumiglia, Amanda P Bettencourt, G. Vercruysse

引用次数: 0

Burden and Costs of Severe Burn Injury in Victoria, Australia 澳大利亚维多利亚州严重烧伤的负担和费用

European burn journal Pub Date : 2022-07-13 DOI: 10.3390/ebj3030034

H. Cleland, Ieva Sriubaite, B. Gabbe

{"title":"Burden and Costs of Severe Burn Injury in Victoria, Australia","authors":"H. Cleland, Ieva Sriubaite, B. Gabbe","doi":"10.3390/ebj3030034","DOIUrl":"https://doi.org/10.3390/ebj3030034","url":null,"abstract":"This study examines the costs of severe burn injury in Victoria, Australia. It quantifies the funding generated through an activity-based case-mix system for hospital treatment of acute injury and presentations in the subsequent two years and costs of the longer-term burden of burn injury due to premature burn-related deaths and disability. Severe adult burns cases in Victoria from 2007–2016 were identified using the Victorian State Trauma Registry (VSTR). Cases were linked with the Victorian Admitted Episodes Dataset (VAED), Victoria Emergency Minimum Dataset (VEMD), and the National Coronial Information System (NCIS). Hospital re-imbursements and costs of Disability-Adjusted Life Years (DALYs) were calculated using disability weights derived from the EQ-5D-3L questionnaire responses at 24 months post injury. There were 331 patients hospitalised with a burn ≥20% total body surface area (TBSA) from 2007–2016. Total mean re-imbursement (SD) for the acute treatment episode per patient in Australian dollars (AUD) was $87,570 ($97,913). There was significant variation in the number of cases by year and re-imbursement per patient, with high outliers common. Excluding 2009, when 173 people died in bushfires, there were 7749 DALYs which cost $991,872,000. Severe burns are uncommon and variable. Economic treatment costs of severe burns are high, and among survivors there is high incidence of long-term disability and overall burden of injury.","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85135907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

What Fuels the Fire: A Narrative Review of the Role Social Determinants of Health Play in Burn Injuries 什么燃料火:在烧伤中健康的社会决定因素的作用的叙述回顾

European burn journal Pub Date : 2022-06-16 DOI: 10.3390/ebj3020033

Kimberly H. Khoo, Emily S. Ross, J.-S. Yoon, Tomer Lagziel, Feras Shamoun, Joseph S. Puthumana, J. Caffrey, S. Lerman, C. Hultman

引用次数: 1

“Out of Touch”—Recovering Sensibility after Burn Injury: A Review of the Literature “失联”——烧伤后感性的恢复:文献综述

European burn journal Pub Date : 2022-06-14 DOI: 10.3390/ebj3020032

S. Tsolakidis, Ziyad Alharbi, H. Rennekampff, Markus Schmidhammer, R. Schmidhammer, R. Rosenauer

{"title":"“Out of Touch”—Recovering Sensibility after Burn Injury: A Review of the Literature","authors":"S. Tsolakidis, Ziyad Alharbi, H. Rennekampff, Markus Schmidhammer, R. Schmidhammer, R. Rosenauer","doi":"10.3390/ebj3020032","DOIUrl":"https://doi.org/10.3390/ebj3020032","url":null,"abstract":"Background: Full-thickness burn injuries (FTBI) not only lead to a significant burden in multiple ways, including social life and self-esteem, but have also a tremendous impact on environmental interaction by reducing sensibility in manifold ways. On these grounds, possible ways and solutions to recover sensibility in burn wounds are essentials and should not be overlooked. Methods: A review of experimental, clinical studies and the related literature was performed with the aim to highlight post-burn nerve regeneration and discover ways for sensory re-integration to complement the therapeutic concept. Results: In human burn injuries, it has been hypothesized that grafted cells, partly multipotent stem cells, could be additionally responsible for nerve regeneration in burn wound areas. In addition, burn eschar excision, performed within a short post-burn time frame, can reduce or even avoid long-term nerve damage by reducing post-burn toxic mediator release. Various animal studies could demonstrate sensory reinnervation of different qualities in burn wounds. Post-burn scar tissue prevents, or at least decelerates, nerve reinnervation, but could be reduced by targeted mediators. Conclusion: Sensory loss is present in skin grafted areas following full-thickness burn-wound excision, thereby leading to a reduction in quality of life. In addition, various mediators might reduce or avoid nerve damage and should be considered at an early stage as part of a holistic burn-patient therapeutic approach. In addition, supportive multifaceted physical therapy strategies are essential.","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91204913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Preventable Burns from Domestic Tap Water 可预防的家庭自来水烧伤

European burn journal Pub Date : 2022-05-09 DOI: 10.3390/ebj3020031

Max Prokopenko, Alistair J. M. Reed, M. Chicco, F. Issa

{"title":"Preventable Burns from Domestic Tap Water","authors":"Max Prokopenko, Alistair J. M. Reed, M. Chicco, F. Issa","doi":"10.3390/ebj3020031","DOIUrl":"https://doi.org/10.3390/ebj3020031","url":null,"abstract":"Tap water scalds from domestic outlets can afflict large body surface areas. Such injuries are preventable and carry significant associated morbidity, mortality, and economic burden. Previously identified risk factors include age (<5 or >65 years old) and the presence of physical or mental disabilities. Education campaigns and advances in legislation mandating the restriction of tap water temperature at user outlets have been employed in an attempt to prevent such injuries. Nonetheless, the incidence of these injuries persists, and further mitigating measures must be implemented to minimize their occurrence. The purpose of this study was to determine the groups at risk for such injuries and whether this has recently changed. A retrospective observational study was carried out to include patients admitted with tap water scalds to a regional burn’s unit from October 2016 to September 2020. Twenty-three patients were included, and their incidence was 5.75 cases per year, equating to 5.1% of all scalds requiring inpatient treatment. The very young (<5 years old) and elderly (>65 years old) accounted for the majority of admissions (65.2%), 26.1% had a mental disability, and 30.4% had a physical disability. Tap water scalds continue to cause preventable injuries affecting all ages, and in particular, the elderly and patients with pre-existing disabilities.","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90625821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Is Post-Burn Scarring a Research Priority? 烧伤后疤痕是研究重点吗?

European burn journal Pub Date : 2022-05-03 DOI: 10.3390/ebj3020030

Amber Young, R. Staruch

引用次数: 0

Role, Development, and Value of Enzymatic Debridement as Integral Component in Initial Treatment of Burn Injuries Exemplified by NexoBrid® 以NexoBrid®为例，酶清创在烧伤初始治疗中的作用、发展和价值

European burn journal Pub Date : 2022-04-21 DOI: 10.3390/ebj3020029

Maximilian M. Mattern, P. Fuchs, J. Schiefer

{"title":"Role, Development, and Value of Enzymatic Debridement as Integral Component in Initial Treatment of Burn Injuries Exemplified by NexoBrid®","authors":"Maximilian M. Mattern, P. Fuchs, J. Schiefer","doi":"10.3390/ebj3020029","DOIUrl":"https://doi.org/10.3390/ebj3020029","url":null,"abstract":"Despite intensive research and increased knowledge over the past decades, the handling of severe burn injuries remains complex and is mainly based on clinical experience. High demands in terms of the diagnosis and choice of therapy often confront clinicians with challenging circumstances. Thus, the treatment of burn injuries has predominantly remained under the responsibility of specialised centres. As a new approach in addition to conventional surgery, enzymatically controlled debridement has come into focus for the treatment of burn injuries over the past years. The efficacy and safety of enzymatic debridement has already been implemented by numerous reputable studies. Promising results from the literature are enhanced by feedback from various conference contributions, intradisciplinary exchanges, and international collaborations. The implementation of enzymatic debridement in initial care management was found to be capable of reforming Standards of Care in numerous burn centres by facilitating treatment determinations and reducing the number of classical surgical interventions. Nevertheless, its use is also subject to certain restrictions as usage has shown limitations concerning efficacy when applied to scalds or pre-treated wounds. Enzymatic debridement shows high efficacy in terms of tissue debridement by combining this feature with the minimisation of collateral damage and a broad field of application in burn injuries. Due to their impressive performance in the treatment of burn injuries, enzyme-based techniques have also attracted attention for the treatment of other pathologies such as chronic wounds and are objects of ongoing research in this field. In this article, we illustrate the significance of enzyme-based treatment in initial burn care and shed some light on the potential value of enzymatic approaches in future burn surgery.","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89373213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Techniques to Assess Long-Term Outcomes after Burn Injuries 评估烧伤后长期预后的技术

European burn journal Pub Date : 2022-04-20 DOI: 10.3390/ebj3020028

R. Spiwak, S. Sareen, S. Logsetty

引用次数: 1

Aspects of Clinical Utility of the Distress Thermometer and Problem List after Burns 烧伤后窘迫温度计及问题表的临床应用

European burn journal Pub Date : 2022-04-08 DOI: 10.3390/ebj3020027

H. Hofland, Anneke van de Steenoven, N. V. Van Loey

{"title":"Aspects of Clinical Utility of the Distress Thermometer and Problem List after Burns","authors":"H. Hofland, Anneke van de Steenoven, N. V. Van Loey","doi":"10.3390/ebj3020027","DOIUrl":"https://doi.org/10.3390/ebj3020027","url":null,"abstract":"Burn survivors may benefit from screening for a broad area of problems to improve communication and inform referral needs. Therefore, the aim of this study was to investigate clinical utility aspects such as appropriateness and acceptability to clinicians and completers of an existing, frequently used screening instrument in oncological populations, the Distress Thermometer and Problem List (DT and PL). Methods: Paediatric and adult patients visiting the outpatient clinic after admission to the burn centre were invited to complete the instrument. The DT and (problem domains of) the PL were related and compared to the need to discuss the reported problems. Results: A total of 160 patients were invited to complete the DT and PL, of which 139 agreed. The study shows evidence for appropriateness and high acceptability to clinicians and completers, although the effectiveness of the PL may be lower compared to the DT and needs adaptation to better meet the burn survivors’ situation. Discussion: The use of a screening instrument in the outpatient clinic environment has shown to be appropriate and acceptable and informs clinical practice to identify supportive needs in patients with burns. However, the PL needs to be adapted to the situation of the burn survivors.","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73336212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0