Epilepsy research and treatment最新文献_第8页

Natural history of temporal lobe epilepsy: antecedents and progression. 颞叶癫痫的自然史:前驱和进展。

Epilepsy research and treatment Pub Date : 2012-01-01 Epub Date: 2012-03-26 DOI: 10.1155/2012/195073

Garima Shukla, Asuri N Prasad

{"title":"Natural history of temporal lobe epilepsy: antecedents and progression.","authors":"Garima Shukla, Asuri N Prasad","doi":"10.1155/2012/195073","DOIUrl":"https://doi.org/10.1155/2012/195073","url":null,"abstract":"Temporal lobe epilepsy represents the largest group of patients with treatment resistant/medically intractable epilepsy undergoing epilepsy surgery. The underpinnings of common forms of TLE in many instances begin in early life with the occurrence of an initial precipitating event. The first epileptic seizure often occurs after a variable latency period following this event. The precise natural history and progression following the first seizure to the development of TLE, its subsequent resolution through spontaneous remission or the development of treatment resistant epilepsy remain poorly understood. Our present understanding of the role played by these initial events, the subsequent latency to development of temporal lobe epilepsy, and the emergence of treatment resistance remains incomplete. A critical analysis of published data suggest that TLE is a heterogeneous condition, where the age of onset, presence or absence of a lesion on neuroimaging, the initial precipitating event, association with febrile seizures, febrile status epilepticus, and neurotropic viral infections influence the natural history and outcome. The pathways and processes through which these variables coalesce into a framework will provide the basis for an understanding of the natural history of TLE. The questions raised need to be addressed in future prospective and longitudinal observational studies.","PeriodicalId":72948,"journal":{"name":"Epilepsy research and treatment","volume":" ","pages":"195073"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/195073","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30869696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Changing global trends in seizure outcomes following resective surgery for tuberous sclerosis in children with medically intractable epilepsy. 顽固性癫痫患儿结节硬化切除手术后癫痫发作结果的全球变化趋势。

Epilepsy research and treatment Pub Date : 2012-01-01 Epub Date: 2012-11-25 DOI: 10.1155/2012/135364

George M Ibrahim, Aria Fallah, O Carter Snead, James T Rutka

{"title":"Changing global trends in seizure outcomes following resective surgery for tuberous sclerosis in children with medically intractable epilepsy.","authors":"George M Ibrahim, Aria Fallah, O Carter Snead, James T Rutka","doi":"10.1155/2012/135364","DOIUrl":"https://doi.org/10.1155/2012/135364","url":null,"abstract":"Introduction. Tuberous sclerosis (TS) is the leading cause of genetic epilepsy worldwide. Here, we evaluate changes in seizure outcomes following resective epilepsy surgery in children with TS over time. Methods. A systematic review of the literature was performed to identify studies reporting seizure outcomes following resective epilepsy surgery in children with TS. Using an individual participant meta-analysis approach, seizure outcomes and associated covariates were combined. Multivariate logistic regression was used to determine significant associations between seizure outcomes and time of surgery. Results. Twenty studies from 1966 to present, yielding 186 participants, met the inclusion criteria for the study. On univariate analysis, there was a significant improvement in seizure outcomes in children who underwent resective epilepsy surgery within the last 15 years compared to older cohorts (chi-square 4.1; P = 0.043). On multivariate analysis, adjusting for length of followup, this trend was not significant (OR 0.52; 95% CI 0.23-1.17; P = 0.11). In the last 15 years, a greater proportion of younger children also underwent resective surgery compared to older cohorts (OR 0.93; 95% CI 0.89-0.97; P < 0.01). Conclusions. A trend towards improved seizure outcomes following resective surgery for TS was observed from 1966 to present on multivariate analysis.","PeriodicalId":72948,"journal":{"name":"Epilepsy research and treatment","volume":" ","pages":"135364"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/135364","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31111753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Noninvasive approach to focal cortical dysplasias: clinical, EEG, and neuroimaging features. 局灶性皮质发育不良的无创入路:临床、脑电图和神经影像学特征。

Epilepsy research and treatment Pub Date : 2012-01-01 Epub Date: 2012-03-05 DOI: 10.1155/2012/736784

Gustavo Seifer, Alejandro Blenkmann, Juan Pablo Princich, Damián Consalvo, Cristina Papayannis, Carlos Muravchik, Silvia Kochen

引用次数: 16

Microsurgical anatomy of the temporal lobe and its implications on temporal lobe epilepsy surgery. 颞叶显微外科解剖及其对颞叶癫痫手术的意义。

Epilepsy research and treatment Pub Date : 2012-01-01 Epub Date: 2012-05-21 DOI: 10.1155/2012/769825

Baris Kucukyuruk, R Mark Richardson, Hung Tzu Wen, Juan Carlos Fernandez-Miranda, Albert L Rhoton

引用次数: 51

Epileptic Encephalopathies with Status Epilepticus during Sleep: New Techniques for Understanding Pathophysiology and Therapeutic Options. 睡眠中癫痫持续状态的癫痫性脑病:理解病理生理学和治疗选择的新技术。

Epilepsy research and treatment Pub Date : 2012-01-01 Epub Date: 2012-08-07 DOI: 10.1155/2012/642725

Daniela Brazzo, Maria Carmela Pera, Marco Fasce, Grazia Papalia, Umberto Balottin, Pierangelo Veggiotti

{"title":"Epileptic Encephalopathies with Status Epilepticus during Sleep: New Techniques for Understanding Pathophysiology and Therapeutic Options.","authors":"Daniela Brazzo, Maria Carmela Pera, Marco Fasce, Grazia Papalia, Umberto Balottin, Pierangelo Veggiotti","doi":"10.1155/2012/642725","DOIUrl":"https://doi.org/10.1155/2012/642725","url":null,"abstract":"Encephalopathy with status epilepticus during sleep (ESES) is an epileptic encephalopathy, as defined by the International League Against Epilepsy (ILAE) Task Force on Classification and Terminology, that is, a condition in which the epileptic processes themselves are believed to contribute to the disturbance in cerebral function. Clinical manifestations of ESES are heterogeneous: apart from different seizure types, they consist in combinations of cognitive, motor, and behavioural disturbances associated with a peculiar electroencephalographic pattern of paroxysmal activity significantly activated during slow sleep, which culminates in a picture of continuous spikes and waves during sleep (CSWS). The pathophysiological mechanisms underlying this condition are still incompletely understood. Establishing a clear-cut correlation between EEG abnormalities and clinical data, though interesting, is very complex. Computer-assisted EEG analyses especially if combined with functional magnetic resonance imaging (EEG-fMRI) and metabolic neuroimaging have recently emerged as useful approaches to better understand the pathophysiological processes underlying ESES. Treatment of ESES is not just limited to seizures control but it should be focused on controlling neuropsychological outcome through an improvement of the continuous epileptiform activity. General agreement on treatment guidelines is still lacking. Implementation of new techniques might allow a better understanding of the pathophysiology of ESES and could enhance therapeutics options.","PeriodicalId":72948,"journal":{"name":"Epilepsy research and treatment","volume":" ","pages":"642725"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/642725","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30869072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

The "natural" history of medically treated temporal lobe epilepsy: what can an evidence-based approach tell us? 医学治疗颞叶癫痫的“自然”史:循证方法能告诉我们什么?

Epilepsy research and treatment Pub Date : 2012-01-01 Epub Date: 2012-02-16 DOI: 10.1155/2012/216510

Colin Bruce Josephson, Bernhard Pohlmann-Eden

引用次数: 9

Depression in temporal lobe epilepsy: a review of prevalence, clinical features, and management considerations. 颞叶癫痫中的抑郁症：发病率、临床特征和管理注意事项综述。

Epilepsy research and treatment Pub Date : 2012-01-01 Epub Date: 2011-12-01 DOI: 10.1155/2012/809843

C S Garcia

引用次数: 0

Assessment of psychological distress in epilepsy: perspective from pakistan. 癫痫患者心理困扰的评估:来自巴基斯坦的观点。

Epilepsy research and treatment Pub Date : 2012-01-01 Epub Date: 2012-04-29 DOI: 10.1155/2012/171725

Najam-Us Sahar

{"title":"Assessment of psychological distress in epilepsy: perspective from pakistan.","authors":"Najam-Us Sahar","doi":"10.1155/2012/171725","DOIUrl":"https://doi.org/10.1155/2012/171725","url":null,"abstract":"The unpredictable nature & elongated course of epilepsy affect all dimensions (physical, psychological, and social) of an individual's life. People with the diagnosis of epilepsy are a high-risk group for different psychiatric problems that is anxiety, depression as well as social problems (marriage, education, and daily activities). The findings of present research revealed high rate (70%) of psychological distress among fifty adult individuals with epilepsy. It was also found that people with uncontrolled epilepsy experience high level of psychological distress (100%) as compared to those with controlled (42%). Demographic and clinical factors associated with distress include lack of occupation, the presence of an underlying disabling condition (with treatment), and the severity of epilepsy. The finding generated here showed that 13 out of 19 females with epilepsy reported psychological distress. It was also found that none of these women was employed (a cultural specific phenomenon) with a slightly high number of unmarried females (74%). So by understanding the relationship between clinical and psychosocial variables, a good management plan can be devised with a focus on social and gender differences. The present research can also help to increase the awareness and to lower the stigmatization related to epilepsy.","PeriodicalId":72948,"journal":{"name":"Epilepsy research and treatment","volume":" ","pages":"171725"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/171725","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30866932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Temporal lobe epilepsy surgery failures: a review. 颞叶癫痫手术失败:回顾。

Epilepsy research and treatment Pub Date : 2012-01-01 Epub Date: 2012-04-22 DOI: 10.1155/2012/201651

Adil Harroud, Alain Bouthillier, Alexander G Weil, Dang Khoa Nguyen

{"title":"Temporal lobe epilepsy surgery failures: a review.","authors":"Adil Harroud, Alain Bouthillier, Alexander G Weil, Dang Khoa Nguyen","doi":"10.1155/2012/201651","DOIUrl":"https://doi.org/10.1155/2012/201651","url":null,"abstract":"Patients with temporal lobe epilepsy (TLE) are refractory to antiepileptic drugs in about 30% of cases. Surgical treatment has been shown to be beneficial for the selected patients but fails to provide a seizure-free outcome in 20-30% of TLE patients. Several reasons have been identified to explain these surgical failures. This paper will address the five most common causes of TLE surgery failure (a) insufficient resection of epileptogenic mesial temporal structures, (b) relapse on the contralateral mesial temporal lobe, (c) lateral temporal neocortical epilepsy, (d) coexistence of mesial temporal sclerosis and a neocortical lesion (dual pathology); and (e) extratemporal lobe epilepsy mimicking TLE or temporal plus epilepsy. Persistence of epileptogenic mesial structures in the posterior temporal region and failure to distinguish mesial and lateral temporal epilepsy are possible causes of seizure persistence after TLE surgery. In cases of dual pathology, failure to identify a subtle mesial temporal sclerosis or regions of cortical microdysgenesis is a likely explanation for some surgical failures. Extratemporal epilepsy syndromes masquerading as or coexistent with TLE result in incomplete resection of the epileptogenic zone and seizure relapse after surgery. In particular, the insula may be an important cause of surgical failure in patients with TLE.","PeriodicalId":72948,"journal":{"name":"Epilepsy research and treatment","volume":" ","pages":"201651"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/201651","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30866935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 115

Temporal lobe epilepsy in the elderly. 老年人颞叶癫痫。

Epilepsy research and treatment Pub Date : 2012-01-01 Epub Date: 2011-11-24 DOI: 10.1155/2012/641323

L E Morillo

引用次数: 12