颞叶癫痫的自然史:前驱和进展。

Epilepsy research and treatment Pub Date : 2012-01-01 Epub Date: 2012-03-26 DOI:10.1155/2012/195073
Garima Shukla, Asuri N Prasad
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引用次数: 18

摘要

颞叶癫痫是接受癫痫手术的治疗难治性/医学上难治性癫痫患者中最大的群体。在许多情况下,常见形式的TLE的基础始于生命早期发生的初始沉淀事件。第一次癫痫发作通常发生在此事件后的可变潜伏期之后。确切的自然历史和从首次发作到发展为TLE的进展,其随后通过自发缓解或发展为治疗抵抗性癫痫的解决仍然知之甚少。我们目前对这些初始事件、随后发展为颞叶癫痫的潜伏期以及治疗耐药性的出现所起作用的理解仍然不完整。一项对已发表数据的批判性分析表明,TLE是一种异质性疾病,发病年龄、神经影像学上病变的存在或不存在、最初的诱发事件、与热性癫痫发作、热性癫痫持续状态和嗜神经病毒感染的关联都会影响其自然史和预后。通过这些变量合并成一个框架的途径和过程将为理解TLE的自然历史提供基础。提出的问题需要在未来的前瞻性和纵向观察研究中加以解决。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Natural history of temporal lobe epilepsy: antecedents and progression.

Natural history of temporal lobe epilepsy: antecedents and progression.

Temporal lobe epilepsy represents the largest group of patients with treatment resistant/medically intractable epilepsy undergoing epilepsy surgery. The underpinnings of common forms of TLE in many instances begin in early life with the occurrence of an initial precipitating event. The first epileptic seizure often occurs after a variable latency period following this event. The precise natural history and progression following the first seizure to the development of TLE, its subsequent resolution through spontaneous remission or the development of treatment resistant epilepsy remain poorly understood. Our present understanding of the role played by these initial events, the subsequent latency to development of temporal lobe epilepsy, and the emergence of treatment resistance remains incomplete. A critical analysis of published data suggest that TLE is a heterogeneous condition, where the age of onset, presence or absence of a lesion on neuroimaging, the initial precipitating event, association with febrile seizures, febrile status epilepticus, and neurotropic viral infections influence the natural history and outcome. The pathways and processes through which these variables coalesce into a framework will provide the basis for an understanding of the natural history of TLE. The questions raised need to be addressed in future prospective and longitudinal observational studies.

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