Epilepsy research and treatment最新文献

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Role of functional MRI in presurgical evaluation of memory function in temporal lobe epilepsy. 功能MRI在颞叶癫痫患者术前记忆功能评估中的作用。
Epilepsy research and treatment Pub Date : 2012-01-01 Epub Date: 2012-05-15 DOI: 10.1155/2012/687219
Chusak Limotai, Seyed M Mirsattari
{"title":"Role of functional MRI in presurgical evaluation of memory function in temporal lobe epilepsy.","authors":"Chusak Limotai,&nbsp;Seyed M Mirsattari","doi":"10.1155/2012/687219","DOIUrl":"https://doi.org/10.1155/2012/687219","url":null,"abstract":"<p><p>Many diagnostic tools have been employed to predict the likelihood of a postoperative memory decline after a standard temporal lobectomy, including the intracarotid amobarbital testing (IAT) or Wada, regarded as the gold standard test for over the past half a century. Functional MRI (fMRI) is also a promising tool in that regard. Its routine use to predict the postoperative memory decline has been limited because of the varied study paradigms, discrepancies in analysis, and interpretation of the results. Based on the existing literatures, fMRI cannot replace IAT for the routine presurgical evaluation of the patients with temporal lobe epilepsy (TLE) yet. Large multicentre studies with a panel of memory test are required to determine the full potential of fMRI and use it reliably to replace IAT in the routine clinical practice. In this paper, we review various aspects of memory fMRI, including the experimental designs, data analysis, and findings.</p>","PeriodicalId":72948,"journal":{"name":"Epilepsy research and treatment","volume":" ","pages":"687219"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/687219","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30888245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 46
Active epilepsy as indicator of neurocysticercosis in rural northwest India. 活动性癫痫是印度西北部农村神经囊虫病的指标。
Epilepsy research and treatment Pub Date : 2012-01-01 Epub Date: 2012-06-13 DOI: 10.1155/2012/802747
Sunil Kumar Raina, Sushil Razdan, K K Pandita, Rajesh Sharma, V P Gupta, Shiveta Razdan
{"title":"Active epilepsy as indicator of neurocysticercosis in rural northwest India.","authors":"Sunil Kumar Raina,&nbsp;Sushil Razdan,&nbsp;K K Pandita,&nbsp;Rajesh Sharma,&nbsp;V P Gupta,&nbsp;Shiveta Razdan","doi":"10.1155/2012/802747","DOIUrl":"https://doi.org/10.1155/2012/802747","url":null,"abstract":"<p><p>Objective. To determine the contribution of neurocysticercosis as a cause for active epilepsy and to establish Neurocysticercosis as major definable risk of epilepsy in our setup. Methods. We conducted a door-to-door survey of 2,209 individuals of Bhore Pind and Bhore Kullian villages in Chattah zone of district Jammu (Jumma and Kashmir, Northwest India) to identify patients with symptomatic epilepsy. Patients with active epilepsy were investigated with neuroimaging techniques to establish diagnosis of NCC (neurocysticercosis). Results. Among 25 patients with epilepsy 10(40%) had CT/MR evidence of past or recent NCC infection. This gave us the point prevalence of 4.5/1000 for Neurocysticercosis in our study population. Interpretation. The study shows a high prevalence of NCC accounting for symptomatic epilepsy in our part of India.</p>","PeriodicalId":72948,"journal":{"name":"Epilepsy research and treatment","volume":" ","pages":"802747"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/802747","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30889202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Extrahippocampal desynchronization in nonlesional temporal lobe epilepsy. 非病变颞叶癫痫的海马外失同步。
Epilepsy research and treatment Pub Date : 2012-01-01 Epub Date: 2012-01-04 DOI: 10.1155/2012/823683
Jesús Pastor, Eduardo G Navarrete, Rafael G Sola, Guillermo J Ortega
{"title":"Extrahippocampal desynchronization in nonlesional temporal lobe epilepsy.","authors":"Jesús Pastor,&nbsp;Eduardo G Navarrete,&nbsp;Rafael G Sola,&nbsp;Guillermo J Ortega","doi":"10.1155/2012/823683","DOIUrl":"https://doi.org/10.1155/2012/823683","url":null,"abstract":"<p><p>Although temporal lobe epilepsy (TLE) is traditionally associated with both hypersynchronous activity in the form of interictal epileptic discharges and hippocampal sclerosis, recent findings suggest that desynchronization also plays a central role in the dynamics of this pathology. The objective of this work is to show the imbalance existing between mesial activities in patients suffering from mesial TLE, with normal mesial structures. Foramen ovale recordings from six patients with mesial TLE and one with lateral TLE were analyzed through a cluster analysis and synchronization matrices. None of the patients present findings in the MRI presurgical evaluation. Numerical analysis was carried out in three different situations: awake and sleep interictal and also during the preictal stage. High levels of desynchronization ipsilateral to the epileptic side were present in mesial TLE patients. Low levels of desynchronization were present in the lateral TLE patient during the interictal stage and almost zero in the preictal stage. Implications of these findings in relation with seizure spreading are discussed.</p>","PeriodicalId":72948,"journal":{"name":"Epilepsy research and treatment","volume":" ","pages":"823683"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/823683","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30889204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Beliefs and Attitudes about Childhood Epilepsy among School Teachers in Two Cities of Southeast Brazil. 巴西东南部两个城市学校教师对儿童癫痫的信念和态度
Epilepsy research and treatment Pub Date : 2012-01-01 Epub Date: 2012-10-15 DOI: 10.1155/2012/819859
Karina Piccin Zanni, Thelma Simões Matsukura, Heber de Souza Maia Filho
{"title":"Beliefs and Attitudes about Childhood Epilepsy among School Teachers in Two Cities of Southeast Brazil.","authors":"Karina Piccin Zanni,&nbsp;Thelma Simões Matsukura,&nbsp;Heber de Souza Maia Filho","doi":"10.1155/2012/819859","DOIUrl":"https://doi.org/10.1155/2012/819859","url":null,"abstract":"<p><p>Childhood epilepsy is a chronic neurological disorder associated with profound psychosocial limitations epileptic children's routine. Lack of information and inappropriate beliefs are still the factors that most contribute to the stigma and discrimination. This study aimed at characterizing teacher's beliefs and attitudes at regular and special schools in two cities of southeastern Brazil where students with epilepsy studied. Fifty-six teachers of public regular schools and specialized educational institutions for children with disabilities from two cities of Southeast Brazil who had epileptic children in their classroom completed the Brazilian version of The Epilepsy Beliefs and Attitudes Scale: Adult Version and answered a data sheet about sociodemographic characteristics. The results showed that no significant differences (P ≤ 0.05) have been found between the beliefs and attitudes of teachers in mainstream and special schools but both schoolteachers had more inappropriate beliefs and attitudes than appropriate ones against childhood epilepsy. These findings raise an important issue, providing us with the knowledge that epilepsy is still a condition which is surrounded by wrong beliefs. Also, educational programs could help reduce the gaps in knowledge about how such disease has been perceived worldwide.</p>","PeriodicalId":72948,"journal":{"name":"Epilepsy research and treatment","volume":" ","pages":"819859"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/819859","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31020034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Temporal lobe epilepsy semiology. 颞叶癫痫符号学。
Epilepsy research and treatment Pub Date : 2012-01-01 Epub Date: 2012-03-07 DOI: 10.1155/2012/751510
Robert D G Blair
{"title":"Temporal lobe epilepsy semiology.","authors":"Robert D G Blair","doi":"10.1155/2012/751510","DOIUrl":"10.1155/2012/751510","url":null,"abstract":"<p><p>Epilepsy represents a multifaceted group of disorders divided into two broad categories, partial and generalized, based on the seizure onset zone. The identification of the neuroanatomic site of seizure onset depends on delineation of seizure semiology by a careful history together with video-EEG, and a variety of neuroimaging technologies such as MRI, fMRI, FDG-PET, MEG, or invasive intracranial EEG recording. Temporal lobe epilepsy (TLE) is the commonest form of focal epilepsy and represents almost 2/3 of cases of intractable epilepsy managed surgically. A history of febrile seizures (especially complex febrile seizures) is common in TLE and is frequently associated with mesial temporal sclerosis (the commonest form of TLE). Seizure auras occur in many TLE patients and often exhibit features that are relatively specific for TLE but few are of lateralizing value. Automatisms, however, often have lateralizing significance. Careful study of seizure semiology remains invaluable in addressing the search for the seizure onset zone.</p>","PeriodicalId":72948,"journal":{"name":"Epilepsy research and treatment","volume":" ","pages":"751510"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30889200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional magnetic resonance imaging for language mapping in temporal lobe epilepsy. 颞叶癫痫语言映射的功能磁共振成像。
Epilepsy research and treatment Pub Date : 2012-01-01 DOI: 10.1155/2012/198183
An Wang, Terry M Peters, Sandrine de Ribaupierre, Seyed M Mirsattari
{"title":"Functional magnetic resonance imaging for language mapping in temporal lobe epilepsy.","authors":"An Wang,&nbsp;Terry M Peters,&nbsp;Sandrine de Ribaupierre,&nbsp;Seyed M Mirsattari","doi":"10.1155/2012/198183","DOIUrl":"https://doi.org/10.1155/2012/198183","url":null,"abstract":"<p><p>Functional magnetic resonance imaging (fMRI) is a noninvasive technique that is increasingly used to understand the cerebral cortical networks and organizations. In this paper, we describe the role of fMRI for mapping language networks in the presurgical workup of patients with medically intractable temporal lobe epilepsy (TLE). Studies comparing fMRI with the intracarotid sodium amobarbital (Wada) test and fMRI with intraoperative cortical stimulation mapping for language lateralization and/or localization in medically intractable TLE are discussed.</p>","PeriodicalId":72948,"journal":{"name":"Epilepsy research and treatment","volume":"2012 ","pages":"198183"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/198183","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9375124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Surgical techniques for the treatment of temporal lobe epilepsy. 颞叶癫痫的外科治疗技术。
Epilepsy research and treatment Pub Date : 2012-01-01 Epub Date: 2012-03-22 DOI: 10.1155/2012/374848
Faisal Al-Otaibi, Saleh S Baeesa, Andrew G Parrent, John P Girvin, David Steven
{"title":"Surgical techniques for the treatment of temporal lobe epilepsy.","authors":"Faisal Al-Otaibi,&nbsp;Saleh S Baeesa,&nbsp;Andrew G Parrent,&nbsp;John P Girvin,&nbsp;David Steven","doi":"10.1155/2012/374848","DOIUrl":"https://doi.org/10.1155/2012/374848","url":null,"abstract":"<p><p>Temporal lobe epilepsy (TLE) is the most common form of medically intractable epilepsy. Advances in electrophysiology and neuroimaging have led to a more precise localization of the epileptogenic zone within the temporal lobe. Resective surgery is the most effective treatment for TLE. Despite the variability in surgical techniques and in the extent of resection, the overall outcomes of different TLE surgeries are similar. Here, we review different surgical interventions for the management of TLE.</p>","PeriodicalId":72948,"journal":{"name":"Epilepsy research and treatment","volume":" ","pages":"374848"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/374848","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30886655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 41
Selective amygdalohippocampectomy. 选择性amygdalohippocampectomy。
Epilepsy research and treatment Pub Date : 2012-01-01 Epub Date: 2011-06-20 DOI: 10.1155/2012/382095
David Spencer, Kim Burchiel
{"title":"Selective amygdalohippocampectomy.","authors":"David Spencer,&nbsp;Kim Burchiel","doi":"10.1155/2012/382095","DOIUrl":"https://doi.org/10.1155/2012/382095","url":null,"abstract":"<p><p>Epilepsy surgery can be an effective epilepsy treatment for patients whose seizures do not respond to best medical therapy. For patients with temporal lobe epilepsy, selective amygdalohippocampectomy (SAH) has emerged as a viable alternative to standard anterior temporal lobectomy. This paper reviews the indications for SAH, the technical advances that have led to greater adoption of the procedure, the expectations for seizure control, and the risks of morbidity.</p>","PeriodicalId":72948,"journal":{"name":"Epilepsy research and treatment","volume":" ","pages":"382095"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/382095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30886656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Role of electroencephalography in presurgical evaluation of temporal lobe epilepsy. 脑电图在颞叶癫痫手术前评估中的作用。
Epilepsy research and treatment Pub Date : 2012-01-01 Epub Date: 2012-10-31 DOI: 10.1155/2012/204693
Seetharam Raghavendra, Javeria Nooraine, Seyed M Mirsattari
{"title":"Role of electroencephalography in presurgical evaluation of temporal lobe epilepsy.","authors":"Seetharam Raghavendra, Javeria Nooraine, Seyed M Mirsattari","doi":"10.1155/2012/204693","DOIUrl":"10.1155/2012/204693","url":null,"abstract":"<p><p>Surgery remains a therapeutic option for patients with medically refractory epilepsy. Comprehensive presurgical evaluation includes electroencephalography (EEG) and video EEG in identifying patients who are likely to benefit from surgery. Here, we discuss in detail the utility of EEG in presurgical evaluation of patients with temporal lobe epilepsy along with illustrative cases.</p>","PeriodicalId":72948,"journal":{"name":"Epilepsy research and treatment","volume":" ","pages":"204693"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31088066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determining surgical candidacy in temporal lobe epilepsy. 确定颞叶癫痫的手术适应症。
Epilepsy research and treatment Pub Date : 2012-01-01 Epub Date: 2012-02-21 DOI: 10.1155/2012/706917
Alireza Mansouri, Aria Fallah, Taufik A Valiante
{"title":"Determining surgical candidacy in temporal lobe epilepsy.","authors":"Alireza Mansouri, Aria Fallah, Taufik A Valiante","doi":"10.1155/2012/706917","DOIUrl":"10.1155/2012/706917","url":null,"abstract":"<p><p>Temporal lobe epilepsy (TLE) is the most common form of adult epilepsy that is amenable to surgical treatment. In the carefully selected patient, excellent seizure outcome can be achieved with minimal or no side effects from surgery. This may result in improved psychosocial functioning, achieving higher education, and maintaining or gaining employment. The objective of this paper is to discuss the surgical selection process of a patient with TLE. We define what constitutes a patient that has medically refractory TLE, describe the typical history and physical examination, and distinguish between mesial TLE and neocortical TLE. We then review the role of routine (ambulatory/sleep-deprived electroencephalography (EEG), video EEG, magnetic resonance imaging (MRI), neuropsychological testing, and Wada testing) and ancillary preoperative testing (positron emission tomography, single-photon emission computed tomography (SPECT), subtraction ictal SPECT correlated to MRI (SISCOM), magnetoencephalography, magnetic resonance spectroscopy, and functional MRI) in selecting surgical candidates. We describe the surgical options for resective epilepsy surgery in TLE and its commonly associated risks while highlighting some of the controversies. Lastly, we present teaching cases to illustrate the presurgical workup of patients with medically refractory TLE.</p>","PeriodicalId":72948,"journal":{"name":"Epilepsy research and treatment","volume":" ","pages":"706917"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30888246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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