Endocrinology and disorders : open access最新文献

{"title":"Re-Print Non-Aspirin Nsaids Use is Associated with Lowering of Liver Fibrosis Scores in Patients with Fatty Liver Disease","authors":"I. Ogbu, H. Akhondi, Napatkamon Ayutyanont, A. Manov","doi":"10.31579/2640-1045/071","DOIUrl":"https://doi.org/10.31579/2640-1045/071","url":null,"abstract":"Only a few studies are available with appropriate data on the effects of non-aspirin, non-steroidal anti-inflammatory drugs (NSAID’s) use in patients with fatty liver disease. We performed a retrospective study of 1347 patients with imaging studies that showed fatty liver disease from 2016 through 2019. Then we determined the change in validated indices using Fibrosis-4 (FIB4) and NAFLD fibrosis score (NFS). Patient’s clinical information, including NSAID’s use, was collected at baseline and then yearly. Using generalized linear model, we estimated the association between the non-aspirin NSAID’s use and change in the baseline indices. Non-aspirin NSAID’s use was found to be associated with significant lowering of FIB-4 score (0.596 units lower, p-value <0.0001) and NFS score (0.431 units lower, p-value 0.0027) every year. In this retrospective study of patients with fatty liver disease found on imaging, non-aspirin NSAID’s use was associated with lowering of fibrotic scores, suggesting that non- aspirin containing NSAID’s use might be associated with a lower risk for advanced fibrosis in patients with fatty liver disease. Summary: Non-aspirin NSAID’s use is associated with lowering of hepatic fibrosis scores in patients with fatty liver disease.","PeriodicalId":72909,"journal":{"name":"Endocrinology and disorders : open access","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48605669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic Neuropathic Pain has Endogenous Modulation Depending on the Intensity of Physical Exercise: A Brief Communication","authors":"William Pereira Valadares, D. L. de Almeida","doi":"10.31579/2640-1045/085","DOIUrl":"https://doi.org/10.31579/2640-1045/085","url":null,"abstract":"The opioidergic systems play a key role in endogenous modulation of neuropathic pain, given that Naloxone, a nonselective opioid receptors antagonist at a dose of 100 µg, reverted the antihyperalgesia caused by physical exercise demonstrated in our previous study. Due to the lack of relates regarding the control variables of physical exercise and endogenous modulation in neuropathic diabetic pain, we investigated if such modulation is exercise intensity dependent.","PeriodicalId":72909,"journal":{"name":"Endocrinology and disorders : open access","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48722498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Type 2 Diabetes Mellitus and its Chronic Complications Influence the Level of Maximal Oxygen Uptake of Exercise Participants?","authors":"William Valadares Campos Pereira, Valesca Nayara Silva","doi":"10.31579/2640-1045/088","DOIUrl":"https://doi.org/10.31579/2640-1045/088","url":null,"abstract":"Patients with type 2 diabetes have reduced aerobic capacity, negatively reflecting on their daily life and prompt independence. Greater damage can be harmed by the presence of chronic complications from diabetes, but this can be mitigated by the effects of physical exercise. The aim of the study was to assess the level of maximum oxygen consumption of people with type 2 diabetes who already have chronic complications and exercise practitioners and also compare with the reference value for women of age group, exercisers and without diagnosis of diabetes. The study was characterized as descriptive, a sample composed of 10 women with type 2 diabetes, mean age of 53 ± 13 years, as who had chronic complications from diabetes such as autonomic and peripheral neuropathy, retinopathy and hypertension and who participated in Doce Vida - Supervised Physical Exercise Program for Diabetics / ESEF / UPE. The group participated in a training protocol combined with 20 minutes of walking and 04 strength exercises (protocol A and B) in each physical exercise session. The weekly frequency of training was three times a week, in the morning period. To assess VO2max, the Rockport 1-Mile Walking Test was performed, the volunteers were instructed to walk as fast as possible. For data analysis, the t-test was applied to a sample, with a significance level of p≤0.05. The results obtained showed an average of 16.8 ml / kg / min of VO2max in the volunteers, values ​​lower than the ideal average for the age (53 ± 13 years) of women without diabetes, which corresponds to 28.2 ml / kg / min (p = 0.02). Therefore, it is concluded that women with type 2 diabetes with the presence of chronic complications, similar levels of VO2max complications are lower than recommended for the same age group of women without diabetes. Therefore, it is suggested that women with the profile of the participants in this study should undergo a cautious progression of physical exercise, better adaptation and adherence to physical exercise.","PeriodicalId":72909,"journal":{"name":"Endocrinology and disorders : open access","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44117808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Autonomic Neuropathy in Patients with Diabetes in Cotonou, Benin: A Cross-Sectional Study","authors":"Gninkoun Comlan Jules, Fanou Joseph Soglo, Alassani Adebayo Sabi Cossi, Djrolo François","doi":"10.31579/2640-1045/083","DOIUrl":"https://doi.org/10.31579/2640-1045/083","url":null,"abstract":"Background Diabetes mellitus is well known as a major risk factor for cardiovascular diseases. Cardiovascular autonomic neuropathy is one of the diabetes complications that has a major impact on cardiovascular morbidity and mortality in patients with diabetes. Aim : To determine the prevalence of cardiovascular autonomic neuropathy in patients with diabetes attending the diabetic center in Cotonou and to identify its risk factors. Materials and Methods : It was a cross-sectional study. Cardiovascular autonomic neuropathy was identified using deep breathing test, standind test and the blood pressure response to standing test (orthostatic hypotension). Chi square test was used for statistical analysis and différence was considered significant when p<0.05. Results : A total of 405 subjects were included in the study. Their mean age was 53.67±11,68 years and the mean diabetes duration was 6.66 years. The prevalence of cardiovascular autonomic neuropathy was 65.9%. Regarding the severity of the complication in neuropathic patients, 51.7% of them had an early neuropathy, 41.2% have presented a moderate neuropathy and 7.1% have presented a severe neuropathy. Factors associated with cardiovascular autonomic neuropathy were age of patients (p = 0.0002), diabetes duration (p = 0.0012), hypertension (p =0.0015), dyslipidemia (p = 0.027) and high pulsed blood pressure (p = 0.032) Conclusion : Cardiovascular autonomic neuropathy is a very frequent complication of diabetes mellitus. Unfortunately this complication of diabetes is not often explored in the patient's follow-up examination. As this complication is recognised to be associated with high cardiovascular morbidity and mortality, systematic screening can be recommanded in patients with long duration of diabetes or presenting an other cardiovascular risk factor.","PeriodicalId":72909,"journal":{"name":"Endocrinology and disorders : open access","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48364543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Presentation of Primary Hyperparathyroidism in Lahore, Pakistan – A Single Center Study","authors":"R. Khalid, M. Hassaan, A. Raza","doi":"10.31579/2640-1045/084","DOIUrl":"https://doi.org/10.31579/2640-1045/084","url":null,"abstract":"Aim: To assess different clinical presentations and outcomes of primary hyperparathyroidism in Pakistan. Study Design: Retrospective cross-sectional study. Study Setting: East Surgical Ward, Mayo Hospital, Lahore. Duration: 2011 to 2016 Introduction: PHPT is a common endocrine condition with a wide range of clinical manifestations differing according to geographic. Discussion: The most common clinical presentation in our study was bone pains which were in contrast to the asymptomatic cases being most common manifestation in US and Western countries. 90% (n 36) of the patients had bony involvement while 47.5% (n 19) had renal involvement at the time of presentation. Conclusion: Due to lack of routine biochemical screening tests in developing countries, primary hyperparathyroidism is detected late.","PeriodicalId":72909,"journal":{"name":"Endocrinology and disorders : open access","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47821956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal 3,3'-Diiodothyronine Sulfate Formation from Guinea Pig Placenta Perfused with 3,3',5-Triodothyronine.","authors":"Sing-Yung Wu,&nbsp;Charles H Emerson,&nbsp;Edward Tjioe,&nbsp;Dong-Bao Chen","doi":"10.31579/2640-1045/101","DOIUrl":"10.31579/2640-1045/101","url":null,"abstract":"<p><strong>Objective: </strong>Serum 3, 3',5-triiodothyronine (T₃) remains low in near-term fetus to prevent the growing fetus from undue exposure to its active catabolic effect in mammals. The present study was undertaken to gain insight in the role of placenta in T₃ metabolism, fetal to maternal transfer of T_3, and its metabolites by in situ placenta perfusion with outer-ring labeled [¹²⁵I]-T₃ in pregnant guinea pig, a species showing increased sulfated 3, 3'-diiodothyronine (T₂S) levels in maternal serum in late pregnancy (term = 65 days), similarly to humans in pregnancy.</p><p><strong>Materials and methods: </strong>One-pass placenta perfusions performed on pregnant guinea pigs were studied between 58 - 65 days of gestation. In two separate experiments, the umbilical artery of the guinea pig placenta was perfused in situ at 37°C with outer-ring labeled [¹²⁵I]-T₃. Maternal sera and umbilical effluents were obtained for analysis at the end of a 60-minute perfusion, when the steady-state levels of radioactivity were reached in the placenta effluent after 30-minute.</p><p><strong>Results: </strong>Sulfated [¹²⁵I]-T₂S was readily detected in the maternal serum as the major metabolite of T₃ following the perfusion of placenta with [¹²⁵I]-T₃, suggesting that placental inner-ring deiodinase and sulfotransferase may play an important role in fetal T₃ homeostasis and in the fetal to maternal transfer of sulfated iodothyronine metabolites.</p><p><strong>Conclusions: </strong>The expression of type 3 deiodinase (D3) and thyroid hormone sulfotransferase activity in placenta may play an important role to protect developing organs against undue exposure to active thyroid hormone in late gestation in the fetus. The combined activities of D3 and sulfotransferase promoted a placental transfer of T₂S into maternal circulation. The maternal circulation of T₂S is fetal T3 in origin and its role as a fetal thyroid function biomarker deserves further evaluations and studies.</p>","PeriodicalId":72909,"journal":{"name":"Endocrinology and disorders : open access","volume":"5 7","pages":"01-6"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5b/e8/nihms-1760545.PMC8797160.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39873421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acylated Ghrelin Increases in Young Adults with Obesity Due to Lack of Sleep","authors":"Vicente Beltrán Campos, Reyna-Echeveste Ei","doi":"10.31579/26401045/079","DOIUrl":"https://doi.org/10.31579/26401045/079","url":null,"abstract":"Interruption or lack of sleep has been linked to chronic degenerative diseases including obesity, which has tripled its figures worldwide in the last 40 years according to data from the world Health organization (WHO). Obesity associated with lack of sleep affects the Circadian rhythm which is responsible for synchronizing the energy balance during the sleep- wake cycle, hormonal secretion, homeostasis of food/energy, among the others. The aim of the study was to determine plasma levels of acylated ghrelin in obese young adults with sleep deprivation to plasma levels of acylated ghrelin in obese Young Adults. Study was carried out a total of 56 young adults with obesity, one of the groups had the condition of lack of sleep, n = 28 per group, to determine the relationship between hours of sleep levels of acylated ghrelin Spearman's correlation test was applied, a negative correlation of Rho = -0.293 and p = 0.028 was found the results obtained suggest that lack of sleep may be a factor that alters hormonal regulation and promotes obesity.","PeriodicalId":72909,"journal":{"name":"Endocrinology and disorders : open access","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47058138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review: Predict the COVID-19 Severity by HDL and Triglycerides Level","authors":"Daniel Setiawan Nathan, Hoo Yumilia","doi":"10.31579/2640-1045/076","DOIUrl":"https://doi.org/10.31579/2640-1045/076","url":null,"abstract":"Lipids are a major component in the process of SARS-CoV-2 infection. The clinical significance of plasma lipid profiles during COVID-19 has been described in several studies to date. The purpose of this mini-review is to summarize previous research studies regarding the association of plasma lipid profile with the clinical severity of SARS-CoV-2 infection. This edition presents mini-review reports on research studies related to LDL and TG levels that can predict severity in patients with COVID-19. Atherogenic dyslipidemia that occurs during infection is reported to be very strongly correlated with a more severe prognosis in COVID-19 infection. Therefore, lipid profiles should be performed to indicate acute and measurable inflammation in COVID-19 patients, and fish oil and statin therapy should also be considered to improve the condition.","PeriodicalId":72909,"journal":{"name":"Endocrinology and disorders : open access","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47330414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Efficacy of Ficus Glomerata Leaves in Alloxan Monohydrate Induced Type-1 Diabetes in Albino Rats","authors":"Sanjeev Kumar, N. K. Prasad, K. Shachi","doi":"10.31579/2640-1045/077","DOIUrl":"https://doi.org/10.31579/2640-1045/077","url":null,"abstract":"Present study was aimed to evaluate the anti-diabetic efficacy of Ficus glomerata in Alloxan monohydrate induced albino rats. Oral administration of fresh Ficus glomerataleaves (2 - 4 g/day) for 60 days shows significant blood glucose lowering effect in experimental alloxan induced diabetic rats. These diabetic rats blood glucose level became normal when fed with Ficus glomerata leaves. It is amply revealed that fresh Ficus glomerata indica leaves possessed anti-diabetic properties. The results suggest that statistically significant anti-diabetic potential in alloxan monohydrate induced diabetic rats. The Ficus glomerata leaves to be almost similar effect like insulin treatment in alloxan monohydrate administered animal model. From the present investigation it appeared that Ficus glomerata leaves might have some ingredients to increase the output of insulin by binding to the receptors of the Beta cells of the Langerhans located in the pancreas. Once they bind to the Sulphonyl urea receptors, the K+ -ATP channels are probably closed and therefore the membrane is depolarized and insulin production is stimulated.","PeriodicalId":72909,"journal":{"name":"Endocrinology and disorders : open access","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43830679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity – Can Allium fistulosum L. be a remedy?","authors":"M. Rahmatullah, R. Jahan","doi":"10.31579/2640-1045/078","DOIUrl":"https://doi.org/10.31579/2640-1045/078","url":null,"abstract":"Obesity is one of the major problems facing human beings at present. Because of the consumption of refined sugar and foods rich in carbohydrates, as well as adoption of a more sedentary lifestyle (often by necessity as is the case with most office workers), people in all countries are increasingly getting obese, which in turn is leading to other disorders like diabetes and cardiovascular complications. Existing conventional drugs have adverse side-effects, which is the major cause for scientists to look towards the plant kingdom for discovery of newer drugs with less or no side-effects. The Allium genera of plants are widely known for their medicinal properties, in particular Allium cepa (onion) and Allium sativum (garlic), whose beneficial actions include anti-obesity effects. In this mini review, we examine a lesser known plant of the Allium genera, namely Allium fistulosum L. and review its anti-obesity potential. The conclusion of the present study is that the plant contains phytochemicals like ferulic acid and quercetin, which possess anti-obesity mechanisms of action thus rendering the plant to be of potential use against obesity.","PeriodicalId":72909,"journal":{"name":"Endocrinology and disorders : open access","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42578966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}