Addiction Biology最新文献

{"title":"Correction to “Neural Response to Theta-Burst Stimulation Predicts Long-Term Relapse in Patients with Alcohol Use Disorder: A Pilot fMRI Study”","authors":"","doi":"10.1111/adb.70148","DOIUrl":"10.1111/adb.70148","url":null,"abstract":"<p>\u0000 <span>J.-N. Zhao</span>, <span>C.-Y. Zhao</span>, <span>Y.-Y. Li</span>, <span>L.-P. Liu</span>, and <span>Z.-J. Liu</span>, “ <span>Neural Response to Theta-Burst Stimulation Predicts Long-Term Relapse in Patients With Alcohol Use Disorder: A Pilot fMRI Study</span>,” <i>Addiction Biology</i> <span>31</span>, no. <span>1</span> (<span>2026</span>): e70109, https://doi.org/10.1111/adb.70109.\u0000 </p><p>The affiliations for Chu-Yue Zhao and Zhi-Jun Liu were captured incorrectly. The current information is as follows:</p><p>Chu-Yue Zhao: Harbin Center for Disease Control and Prevention, Harbin, China.</p><p>Zhi-Jun Liu: Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.</p><p>It should have been:</p><p>Chu-Yue Zhao: Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.</p><p>Zhi-Jun Liu: Harbin Center for Disease Control and Prevention, Harbin, China.</p><p>We apologize for this error.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 3","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70148","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Buprenorphine Paradox: How Buprenorphine Triggers and Resolves Opioid Withdrawal","authors":"Mehdi Haghdoost,&nbsp;Jennifer LaBranche,&nbsp;Matthew Roberts,&nbsp;Victor W. Li,&nbsp;Jane J. Kim,&nbsp;James S. H. Wong,&nbsp;Pouya Azar","doi":"10.1111/adb.70126","DOIUrl":"10.1111/adb.70126","url":null,"abstract":"<p>Buprenorphine (BUP) offers a therapeutic approach for opioid use disorder (OUD) due to its unique pharmacodynamic properties, primarily as a partial agonist with high affinity for the mu-opioid receptor (MOR). BUP's partial agonism and ceiling effect on respiratory depression enhance its safety profile. However, BUP can induce precipitated withdrawal when administered after a full agonist, leading to severe withdrawal symptoms. This Perspective builds on prior work that has linked BUP's high-affinity partial agonism to precipitated withdrawal and low-dose induction strategies. We focus on how BUP's capacity to promote MOR externalization, together with its activity at the nociceptin opioid peptide (NOP) receptor, can help explain why it precipitates withdrawal when administered in the presence of full agonists yet relieves withdrawal once spontaneous withdrawal has begun. Understanding these mechanisms is critical for optimizing BUP protocols in OUD treatment and informs the potential development of new biased MOR agonists (i.e., ligands that preferentially activate specific signalling pathways) for addiction therapy.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 3","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12971109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fentanyl, Methamphetamine and Polysubstance Use Differentially Affect Locomotor Sensitisation and Social Behaviour in Rats: Psychedelic Treatment Reverses Social Deficits","authors":"Leah M. Salinsky,&nbsp;Kyra C. Diaz,&nbsp;Joshua L. Fox,&nbsp;Shawn M. Panh,&nbsp;Susan M. Ferguson","doi":"10.1111/adb.70132","DOIUrl":"10.1111/adb.70132","url":null,"abstract":"<p>Polysubstance use of opioids and stimulants is increasingly common among individuals with a substance use disorder, yet most researchers examine these substances in isolation. This gap limits our understanding of the effects of polysubstance use and how these differ from single substance use. Here, we examined the impact of single versus polysubstance exposure of fentanyl and methamphetamine on locomotor sensitisation and social behaviour in male and female rats. In addition, as recent evidence has suggested the potential for psychedelic compounds to decrease facets of both opioid and stimulant use disorders, we tested whether the psychedelic R-(−)2,5-dimethoxy-4-iodoamphetamine (DOI) can reverse drug withdrawal-induced social deficits. Baseline sociability was assessed in male and female Sprague–Dawley rats using DeepLabCut and Simple Behavioral Analysis (SimBA). Rats then received injections of saline, methamphetamine (1 mg/kg) and/or fentanyl (20 μg/kg) for 14 days, and locomotion was measured. All rats then underwent 10 days of withdrawal followed by a reassessment of sociability. The following day, all subjects received DOI (0.3 mg/kg; 30 min) and were reassessed for sociability. Our results indicate that the development of locomotor sensitisation and drug withdrawal-induced social deficits vary as a function of drug class, drug history and sex. In addition, acute DOI treatment is sufficient to reverse social deficits as well as enhance social interactions in females. The findings from these experiments suggest a potential therapeutic role of psychedelics in mitigating the social deficits that are associated with withdrawal from polysubstance use of opioids and stimulants.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 3","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12963791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psilocybin and Ibogaine in Cocaine-Seeking: Extinction Enhancement Without Relapse Prevention","authors":"Isis Rita Anzel Koutrouli,&nbsp;Vojtěch Brejtr,&nbsp;Marek Schwendt,&nbsp;Kacper Witek,&nbsp;Chrysostomos Charalambous,&nbsp;Kristýna Aleksič,&nbsp;Nina Miniariková,&nbsp;Eva Lhotková,&nbsp;Martin Toman,&nbsp;Marek Nikolič,&nbsp;Radek Jurok,&nbsp;Petra Cihlářová,&nbsp;Vladimír Mazoch,&nbsp;Pavel Ryšánek,&nbsp;Martin Kuchař,&nbsp;Klára Šíchová,&nbsp;Tomáš Páleníček","doi":"10.1111/adb.70111","DOIUrl":"10.1111/adb.70111","url":null,"abstract":"<p>Psychedelics have emerged as potential therapeutics for substance use disorders, yet preclinical data validating their efficacy remain limited. Here, we investigated the effects of a clinically inspired dose-escalation protocol of psilocybin and ibogaine on extinction and cue-induced reinstatement in Wistar male rats following intravenous cocaine self-administration (IVSA). Rats were trained on a fixed ratio 1 (FR1) schedule with cocaine dose-escalation during the acquisition phase (0.25 mg/kg/infusion, followed by 0.5 mg/kg/infusion). Following acquisition, animals were randomised into treatment groups and then subjected to 10 days of extinction. Psilocybin (1.25 mg/kg and 5 mg/kg) or ibogaine (10 mg/kg and 40 mg/kg) was administered subcutaneously and intraperitoneally, respectively, on extinction days 1 and 5. A cue-induced reinstatement test was conducted 6 days after the last treatment. Both treatments significantly modulated behaviour during extinction; psilocybin reduced active lever pressing 1 day after the second dose, with a nonsignificant reduction already apparent after the first dose, while the effect of ibogaine was significant even after the first administration. However, neither compound significantly altered reinstatement behaviour, although psilocybin showed a trend toward attenuation. The applied treatment had no side effects on general locomotor activity or anxiety-like behaviour, as measured in the open field test 24 h after each administration. These findings support a role for psilocybin and ibogaine in facilitating extinction learning and suggest possible protective effects against relapse, warranting further research into their antiaddictive efficacy.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 3","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol Use Disorder With Metabolic Dysfunction Is Associated With Adverse Health Impacts in a United States Clinical Setting","authors":"Alexandra C. Wagner,&nbsp;Jeesun Jung,&nbsp;Joshua Reitz,&nbsp;Tyler Perlstein,&nbsp;LaToya Sewell,&nbsp;Melanie L. Schwandt,&nbsp;Nancy Diazgranados,&nbsp;Josephin Wagner,&nbsp;Daniel B. Rosoff,&nbsp;Falk W. Lohoff","doi":"10.1111/adb.70128","DOIUrl":"10.1111/adb.70128","url":null,"abstract":"<p>The combined disease burden of excessive alcohol consumption and metabolic dysfunction (MD) is an escalating global concern. Although it is well established that both factors adversely impact health, the biological characteristics and comorbidities of their overlap remain understudied in the United States. The present study investigated whether concurrent MD and alcohol use disorder (AUD) is associated with worse liver-related and psychiatric health. A total of 1220 participants were recruited through the Natural History Protocol at the National Institutes of Health (NIH) and categorized into the following four groups: healthy controls (HC), individuals with MD (metHC), individuals with current AUD without MD (AUD) and those with both current AUD and MD (metAUD). Sociodemographic and clinical biomarkers, liver injury indices (Fibrosis-4 [FIB-4], LiverRisk, NAFLD fibrosis score [NFS]), liver enzymes and inflammatory markers (GGT, AST, ALT, CRP), liver function tests (albumin, bilirubin, PT-INR), psychiatric and substance use comorbidities as well as current smoking were assessed in the four groups using analysis of covariance (ANCOVA). In addition, the clinical biomarkers were compared across three groups: mild (&lt; 3 MD criteria) and severe (≥ 3) metAUD, as well as AUD only. Liver enzymes, noninvasive liver fibrosis scores and liver function tests showed additive effects across metHC, AUD and metAUD compared to HC, with the largest effects in metAUD for GGT, AST, ALT, CRP, albumin, direct bilirubin, FIB-4, LiverRisk and NFS (<i>p</i> &lt; 0.001). Psychiatric disorders also exhibited the most significant association with metAUD (<i>p</i> &lt; 0.001). Within AUD, greater MD severity was associated with higher GGT, ALT, CRP, NFS and any DSM anxiety disorders (<i>p</i> &lt; 0.05). These findings suggest that MD in the context of AUD is associated with greater liver dysfunction and psychiatric burden, supporting MD-targeted treatment strategies in clinical care for AUD.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 3","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12959954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescent Binge Ethanol Exposure Confers Lasting Adult Alcohol Tolerance due to Neuroimmune Activation: Reversal by Inhibition of HMGB1","authors":"Fulton T. Crews,&nbsp;Ryan P. Vetreno","doi":"10.1111/adb.70119","DOIUrl":"10.1111/adb.70119","url":null,"abstract":"<p>Epidemiological studies suggest heavy adolescent binge drinking is strongly associated with later development of an alcohol use disorder (AUD). Alcohol tolerance (i.e., an acquired reduction in acute alcohol responsivity) is a universally recognized symptom of AUD, but the direct contribution of adolescent binge drinking to adult alcohol tolerance is poorly understood. To investigate the contributions of adolescent binge ethanol exposure to lasting acquisition of acute tolerance, we used our ethanol response battery (ERB) to assess intoxication rating, hypothermia, motor coordination and balance across cumulative ethanol doses (i.e., 0.0, 0.5, 1.0, 2.0 and 3.0 g/kg) in adult female Wistar rats following adolescent intermittent ethanol (AIE), lipopolysaccharide (LPS) and glycyrrhizic acid treatment following AIE. We report AIE confers lasting alcohol tolerance across cumulative ethanol doses and blunts acute ethanol-induced increases in proinflammatory HMGB1 plasma levels. Adolescent LPS (1.0 mg/kg, i.p.) treatment, which mimics AIE-induced HMGB1-mediated neuroinflammation, induces adult alcohol tolerance and blunts HMGB1 release across cumulative ethanol doses on the ERB. Assessment of proinflammatory HMGB1 involvement in AIE-induced acquisition of lasting alcohol tolerance showed that post-AIE administration of the HMGB1 inhibitor glycyrrhizic acid reversed the AIE-induced acquisition of alcohol tolerance in adulthood. These data reveal that (1) adolescent binge drinking confers long-lasting low ethanol responsivity (i.e., tolerance), (2) proinflammatory neuroimmune activation contributes to the development of alcohol tolerance and (3) blockade of proinflammatory HMGB1 signalling reverses AIE-induced acquisition of alcohol tolerance in adulthood. These findings suggest a potential mechanistic target for the development of novel therapeutics for the treatment of AUD.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 3","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12959956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative Urgency Mediates the Effect of Family Conflict on Cannabis Positive Expectancy: The Moderating Role of Anterior Cingulate Cortex","authors":"Rabeeh Azarmehr,&nbsp;Cullin J. Howard,&nbsp;Steven M. Kogan,&nbsp;Charles Geier,&nbsp;Assaf Oshri","doi":"10.1111/adb.70131","DOIUrl":"10.1111/adb.70131","url":null,"abstract":"<p>Cannabis positive expectancies, favourable beliefs about cannabis effects, are a key risk factor for cannabis initiation and problematic use during adolescence. Prior research demonstrated a robust association between cannabis positive expectancies and increased use among adolescents, yet less is known about the developmental aetiology, biobehavioural mechanisms and cognitive context that contribute to these expectancies. The present study examines the intermediary role of negative urgency, a facet of impulsivity characterized by rash action under distress. Additionally, the study investigates whether anterior cingulate cortex (ACC) activation during emotional reward processing moderates this indirect effect. We conducted a longitudinal moderated mediation model with three waves of data from the Adolescent Brain and Cognitive Development (ABCD) study, analysing 6638 youths (baseline M_age = 10.1 years; 47.8% female). Family conflict at baseline predicted increased cannabis positive expectancies ΔT5T7 through increases in negative urgency at T5 (<i>β</i> = 0.017, <i>p</i> &lt; 0.001, 95% CI [0.045, 0.069]). Heightened ACC activity at T5 (anticipatory large loss), including bilateral caudal and rostral regions, intensified negative urgency's impact on cannabis positive expectancy ΔT5T7: Left caudal (<i>β</i> = 0.081, <i>p</i> &lt; 0.001, 95% CI [0.041, 0.122]), right caudal (<i>β</i> = 0.062, <i>p</i> = 0.004, 95% CI [0.020, 0.105]), right rostral (<i>β</i> = 0.041, <i>p</i> = 0.026, 95% CI [0.001, 0.081]) and left rostral (<i>β</i> = 0.052, <i>p</i> = 0.01, 95% CI [0.012, 0.092]). This study highlights how neural activity amplifies stress-related effects on adolescent substance use expectations, suggesting emotional decision-making as a target for prevention.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 2","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12935555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147310914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Topological Properties of White-Matter Functional Networks in Young Smokers","authors":"Zhenzhen Mai,&nbsp;Dahua Yu,&nbsp;Gengdi Huang,&nbsp;Xiaojiao Li,&nbsp;Xuwen Wang,&nbsp;Fang Dong,&nbsp;Yongxin Cheng,&nbsp;Juan Wang,&nbsp;Yuxin Ma,&nbsp;Lin Luo,&nbsp;Kai Yuan,&nbsp;Ting Xue","doi":"10.1111/adb.70125","DOIUrl":"10.1111/adb.70125","url":null,"abstract":"<p>Smoking addiction is a common mental disorder, and numerous imaging studies have shown that adolescents with smoking addiction exhibit abnormalities in brain function and structure. This study aims to investigate changes in the topological characteristics of the white matter (WM) functional network in young smokers. Forty-two young smokers and 42 age-, gender-, and education-matched nonsmokers were included in the study. The functional connectome of white matter and graph theory were used to study these participants. Two-sample <i>t</i>-test were used for the detection of the abnormal graph properties in young smokers. Pearson correlation was applied for the correlation analyses between properties and clinical indicators of smoking. The global level WM functional network analyses showed that the <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <msub>\u0000 <mi>C</mi>\u0000 <mi>p</mi>\u0000 </msub>\u0000 </mrow>\u0000 <annotation>$$ {C}_p $$</annotation>\u0000 </semantics></math> and <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <msub>\u0000 <mi>E</mi>\u0000 <mtext>local</mtext>\u0000 </msub>\u0000 </mrow>\u0000 <annotation>$$ {E}_{local} $$</annotation>\u0000 </semantics></math> values were higher in young smokers than in the control group, and the <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <msub>\u0000 <mi>E</mi>\u0000 <mtext>local</mtext>\u0000 </msub>\u0000 </mrow>\u0000 <annotation>$$ {E}_{local} $$</annotation>\u0000 </semantics></math> was positively correlated with the age of first smoking. At the node level, five nodes of the WM functional network exhibited abnormal node properties in the WM regions of the bilateral hippocampal parahippocampal gyrus (CGH), bilateral superior longitudinal fasciculus (SLF), bilateral inferior frontal gyrus (IFO), middle cerebellar peduncle (MCP), and the bilateral anterior commissure (ACR) in young smokers. The node degree centrality value of MCP was positively correlated with age of first smoking. Our neuroimaging findings provide evidence of WM functional alterations associated with nicotine addiction, which may enhance our understanding of the neural mechanisms underlying smoking addiction in young smokers.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 2","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12932083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to Vape Products Elicits Neural Activity Patterns Indicative of Approach Motivation Among Young People","authors":"Stefan Bode,&nbsp;Daniel Feuerriegel,&nbsp;Jane Yook,&nbsp;Michelle I. Jongenelis","doi":"10.1111/adb.70130","DOIUrl":"10.1111/adb.70130","url":null,"abstract":"<p>Previous research exploring the impact of exposure to e-cigarette (vape) products has been limited by a reliance on self-report measures, responses to which require self-reflection and insight. The present study sought to address these limitations by using novel ‘neural decoding’ techniques to establish whether exposure to e-cigarette products triggers automatic and unconscious product approach tendencies. An electroencephalography (EEG) study was conducted in Australia. Participants (<i>n</i> = 38; 68% women; 17–23 years old) were presented with images of e-cigarette products for several seconds while their brain activity was recorded. The primary outcome variables were brain activity and ratings of product appeal, curiosity and wanting. Results suggest that young people's vape approach tendencies can be predicted from brain activity as early as 100–300 ms after exposure, and then again over a sustained time period 350–800 ms after exposure. These findings were not restricted to those who currently vape, with similar patterns observed in young people who had never vaped or had tried vaping products in the past. Findings provide neuroscientific evidence for the presence of fast and automatic processing of vape products, which results in immediate approach tendencies. This suggests that approach attitudes and behavioural intentions that occur in response to exposure to vape products precede deliberate processing, and that exposure to e-cigarette products has an immediate effect on young people's neural processing. This novel neural approach to understanding marketing for e-cigarettes offers valuable insights into how fast and automatic product-based marketing of e-cigarettes unfolds in young people's brains, with implications for product regulation.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 2","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70130","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146208157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress of Exosome-Derived microRNA in Alcohol Use Disorders: A Critical Review","authors":"Bo Zhang,&nbsp;Ting ting Xie,&nbsp;Qiang Ma,&nbsp;Ya ping Jiang,&nbsp;Yu mei Wang","doi":"10.1111/adb.70124","DOIUrl":"10.1111/adb.70124","url":null,"abstract":"<p>Alcohol use disorder (AUD) is a chronic, relapsing condition that causes extensive systemic damage, yet clinically actionable biomarkers remain lacking. Exosome-derived microRNAs (exo-miRNAs) have emerged as highly stable extracellular indicators of disease state and active regulators of alcohol-induced pathological processes. Unlike proteins or lipids, miRNAs are selectively packaged, cell-type specific and mechanistically linked to inflammation, hepatocellular injury, synaptic dysfunction and neuroimmune signalling. Here, we provide an integrated and updated review of how chronic alcohol exposure reshapes exo-miRNA cargo across organs—particularly the liver, immune system and central nervous system. We summarize the biogenesis and selective sorting of exo-miRNAs, highlight key candidate miRNAs such as miR-122, miR-155, miR-192, miR-29a, miR-30a and miR-124 and analyse their representative gene targets and downstream effects. Furthermore, we distinguish exo-miRNAs with diagnostic potential from those representing promising therapeutic targets and discuss major limitations, including specificity relative to other drugs of abuse. By integrating mechanistic and translational evidence, this review aims to clarify the biological and clinical value of exo-miRNAs and to provide guidance for future precision-medicine strategies in AUD.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 2","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12848780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146068009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}