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Do in vitro fertilization treatments result in healthy babies? 体外受精治疗能产生健康的婴儿吗?
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Noora Kaartinen, Helena Tinkanen
{"title":"Do in vitro fertilization treatments result in healthy babies?","authors":"Noora Kaartinen,&nbsp;Helena Tinkanen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In Finland, the proportion of children born as a result of in vitro fertilization treatments is annually approximately 3.3%, and the percentage proportion of the population is growing. Their general somatic health status and cognitive development do not differ from spontaneously fertilized children. In vitro fertilization treatments are, however, associated with a slightly elevated risk of preterm delivery, low birth weight and structural abnormalities. The risk of childhood cancer does not appear to be increased in IVF children. The in vitro fertilization process affects the embryonic epigenome, which organizes itself during early embryonic development. These changes may influence the phenotype and health profile of the unborn child. The effect of in vitro fertilization treatments on an individual's long-term health is poorly understood, requiring prospective follow-up studies with sufficiently large datasets. In vitro fertilization treatments are the most effective way to treat infertility, and the treatments are generally safe both for the future mother and the baby being born.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35656085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ketamine in the treatment of acute pain. 氯胺酮用于治疗急性疼痛。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Elina Brinck, Vesa Kontinen
{"title":"Ketamine in the treatment of acute pain.","authors":"Elina Brinck,&nbsp;Vesa Kontinen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Ketamine is an old anesthetic agent that relieves pain by reducing central sensitization in the central nervous system. This is advantageous for patients suffering from severe pain prior to surgery or are using a strong opioid. The S enantiomer of ketamine used for anesthesia is more powerful than racemic ketamine. The ideal dose of ketamine for pain relief is not yet known, and its adverse effects on the central nervous system, including hallucinations, sedation, and diplopia have limited its use in pain management. The significance of these effects at low doses is probably less than expected, particularly if benzodiazepines or an alpha-2 agonist, such as dexmedetomidine, are administered in addition to ketamine.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35656164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Osteosclerosis associated with hepatitis C. 与丙型肝炎相关的骨硬化。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Helena E Miettinen, Timo Sane, Antti Lamminen, Matti J Välimäki
{"title":"Osteosclerosis associated with hepatitis C.","authors":"Helena E Miettinen,&nbsp;Timo Sane,&nbsp;Antti Lamminen,&nbsp;Matti J Välimäki","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We describe the first Finnish case of hepatitis C associated osteosclerosis. In which the patient's bone symptoms and bone density were resolved with hepatitis C treatment. Suspecting the possibility of osteosclerosis underlying bone pains in a hepatitis C patient is well-founded, although osteoporotic fractures are a more common problem.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35656168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Gestures facilitate interaction in multicultural primary care consultations]. [手势促进多元文化初级保健咨询中的互动]。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Jenny Paananen
{"title":"[Gestures facilitate interaction in multicultural primary care consultations].","authors":"Jenny Paananen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Using gestures simultaneously with speech prevents and solves problems of understanding in consultations where the doctor and the patient do not share the same cultural and linguistic background. Gestures illustrate what is being said, and highlight the essential information. As gestures are used globally, and can also be interpreted despite limited vocabulary, they make the speech easier to follow. In primary care consultations, the topics are easily expressed by gestures, as they are often related to physical matters such as body parts, symptoms, examinations and treatment. Furthermore, gestural mimicry conveys empathy and willingness to collaborate.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35658733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostics and current care of myasthenia gravis. 重症肌无力的诊断与护理现状。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Sari Atula, Kathrin Pfau, Tapani Salmi, Eero Sihvo, Mikko Haapio, Mika Saarela, Mari Auranen
{"title":"Diagnostics and current care of myasthenia gravis.","authors":"Sari Atula,&nbsp;Kathrin Pfau,&nbsp;Tapani Salmi,&nbsp;Eero Sihvo,&nbsp;Mikko Haapio,&nbsp;Mika Saarela,&nbsp;Mari Auranen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Myasthenia gravis (MG) is the most common neuromuscular transmission disorder, causing weakness of skeletal muscles on exertion. The course of the disease is highly variable, symptoms and signs may change rapidly due to infection or pregnancy. MG is classified using serological, electrophysiological and pharmaceutical tools. A precise diagnosis allows for the choice of right treatment, predicts the course of disease and hence helps with the follow-up. In this review we present Finnish guidelines for diagnostics, treatment and follow-up of MG patients.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35659207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endodontic treatment. 牙髓学的治疗。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
{"title":"Endodontic treatment.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The Finnish guideline on endodontics emphasizes good quality of endodontic treatment and coronal seal of the restoration. For prevention of endodontic treatment need caries control is essential. For deep carious lesions stepwise excavation or partial caries removal are recommended. Partial pulpotomy can be used if bleeding can be controlled. The decision for root canal treatment is based on prognosis, occlusion and general health of the patient. The use of kofferdam is essential in aseptic working. Chemomechanical preparation with NaOCI and root canal filling within 0-2 mm from the apex improve prognosis. Healing should be controlled annually up to four years.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35217615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recurrent pericarditis. 复发性心包炎。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Jukka Lehtonen
{"title":"Recurrent pericarditis.","authors":"Jukka Lehtonen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recurrent pericarditis is the most common and problematic complication of acute pericarditis. After acute pericarditis, the pericarditis recurs in 20 to 50% of the patients. In most cases the etiology of pericarditis remains unclear, although it is generally thought to arise by an immunological mechanism. NSAID medication in combination with colchicine is the cornerstone of the treatment. Corticosteroids should be used mainly for those in whom the first-line drug treatment is not sufficient or first-line treatments are contraindicated.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35310777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Update on Current Care Guideline: Venous insufficiency of the lower limb. 当前护理指南的更新:下肢静脉功能不全。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
{"title":"Update on Current Care Guideline: Venous insufficiency of the lower limb.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Venous insufficiency of the lower limb is a common disease. Diagnosis is based on symptoms, clinical findings and duplex ultrasound. Consideration and planning of invasive treatment cannot be performed without ultrasound. Vast majority of invasive treatments in superficial venous insufficiency can be done by ultrasound-guided endovenous methods with local anesthesia. Thermoablation (laser of radiofrequency) is the first-line treatment. There are promisisng endovenous methods for treatment of deep venous obstruction in selected cases.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35658601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preliminary ethical appraisal of a trial - what's it all about? 一项试验的初步伦理评估——它到底是关于什么的?
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Helena Siipi
{"title":"Preliminary ethical appraisal of a trial - what's it all about?","authors":"Helena Siipi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Preliminary ethical appraisal of medical trials is often based on the following four principles: respect for autonomy, beneficence, non-maleficence, and justice. Preliminary ethical appraisal should, however, not be understood solely as application of these four principles to practice. Ethical committees will inevitably interpret the principles and make decisions about their reciprocal importance in connection with each trial. Reasoning does not always proceed from above towards practical recommendations of action, but can instead also be based on a moral rule or practice relating to a certain action. A good preliminary ethical appraisal will also take into account everyday standards of morality, law and shared moral values of the society.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35658603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adrenomyeloneuropathy due to mutation in the ABCD1 gene as underlying factor in spastic paraparesis. ABCD1基因突变引起的肾上腺神经病变是痉挛性截瘫的潜在因素。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Emil Ylikallio, Elisa Rahikkala, Riikka Keski-Filppula, Mari Auranen, Henna Tyynismaa
{"title":"Adrenomyeloneuropathy due to mutation in the ABCD1 gene as underlying factor in spastic paraparesis.","authors":"Emil Ylikallio,&nbsp;Elisa Rahikkala,&nbsp;Riikka Keski-Filppula,&nbsp;Mari Auranen,&nbsp;Henna Tyynismaa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We present a Finnish family in which adrenomyeloneuropathy (AMN) caused by the mutation in the ABCD1 gene was revealed as the cause of spastic paraparesis. . Two patients had hypoadrenalism, which is in some cases some associated with the disease . AMN is a hereditary disease manifested both in men and women. but owing to the location of the gene in the X chromosome the symptoms are usually more severe in male patients. . Diagnoses was trucked down with gene-panel sequencing and confirmed through detection of an elevated level of very long-chain fatty acids in the serum of the patients. Specific molecular genetic diagnosis is beneficial, because it enables precise genetic counseling as well as recognition and treatment of associated symptoms, such as severe cortisol deficiency.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35658686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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